ES8602814A1 - Un procedimiento para preparar una cefalosporina - Google Patents

Un procedimiento para preparar una cefalosporina

Info

Publication number
ES8602814A1
ES8602814A1 ES541520A ES541520A ES8602814A1 ES 8602814 A1 ES8602814 A1 ES 8602814A1 ES 541520 A ES541520 A ES 541520A ES 541520 A ES541520 A ES 541520A ES 8602814 A1 ES8602814 A1 ES 8602814A1
Authority
ES
Spain
Prior art keywords
formula
translation
preparing
procedure
machine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541520A
Other languages
English (en)
Other versions
ES541520A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP59054522A external-priority patent/JPS60199894A/ja
Priority claimed from JP59062226A external-priority patent/JPS60208986A/ja
Priority claimed from JP59066649A external-priority patent/JPS60214783A/ja
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of ES541520A0 publication Critical patent/ES541520A0/es
Publication of ES8602814A1 publication Critical patent/ES8602814A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D501/06—Acylation of 7-aminocephalosporanic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR UNA CEFALOSPORINA DE FORMULA (I). CONSISTE EN 1) SOMETER A REACCION UN COMPUESTO DE FORMULA (V) DONDE R ES ALQUILO INFERIOR OPCIONALMENTE SUSTITUIDO, R4 ES ALQUILO, ARALQUILO O ARILO, X ES HALOGENO CON TIOUREA EN DISOLVENTE COMO ACETATO DE ETILO U OTROS VARIOS DE -40 A -30C. 2) SOMETER EL PRODUCTO OBTENIDO A REACCION CON UN HALOGENANTE DE -30 A 30 C. 3) EL COMPUESTO OBTENIDO EN 2) DE FORMULA IV SE HACE REACCIONAR CON OTRO DE FORMULA (VI) EN PRESENCIA DE BASE INORGANICA PARA DAR LUGAR A (II); 4) DESHIDRATAR (II) EN PRESENCIA DE ACIDO PARA DAR LUGAR A LA CEFALOSPORINA (I) DONDE R2 ES HIDROGENO Y R3 ES HETEROCICLO SUSTITUIDO O NO. DE APLICACION COMO ANTIBACTERIANO DE AMPLIO ESPECTRO.
ES541520A 1984-03-23 1985-03-22 Un procedimiento para preparar una cefalosporina Expired ES8602814A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP59054522A JPS60199894A (ja) 1984-03-23 1984-03-23 セファロスポリン類の新規製造法
JP59062226A JPS60208986A (ja) 1984-03-31 1984-03-31 新規セファロスポリン類およびその製造法
JP59066649A JPS60214783A (ja) 1984-04-05 1984-04-05 ２―アミノ―４―ヒドロキシチアゾリン誘導体およびその塩ならびにそれらの製造法

Publications (2)

Publication Number Publication Date
ES541520A0 ES541520A0 (es) 1985-12-01
ES8602814A1 true ES8602814A1 (es) 1985-12-01

Family

ID=27295315

Family Applications (1)

Application Number Title Priority Date Filing Date
ES541520A Expired ES8602814A1 (es) 1984-03-23 1985-03-22 Un procedimiento para preparar una cefalosporina

Country Status (10)

Country Link
KR (1) KR870001796B1 (es)
AR (1) AR243192A1 (es)
AT (1) AT386207B (es)
CH (2) CH669383A5 (es)
DK (1) DK132585A (es)
ES (1) ES8602814A1 (es)
FI (1) FI86184C (es)
NO (1) NO167574C (es)
PL (1) PL145915B1 (es)
PT (1) PT80154B (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3165922D1 (en) * 1980-03-28 1984-10-18 Biochemie Gmbh New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production

Also Published As

Publication number Publication date
NO167574C (no) 1991-11-20
NO851166L (no) 1985-09-24
AT386207B (de) 1988-07-25
KR850006420A (ko) 1985-10-05
ES541520A0 (es) 1985-12-01
FI851173L (fi) 1985-09-24
CH669383A5 (en) 1989-03-15
AR243192A1 (es) 1993-07-30
ATA86985A (de) 1987-12-15
PT80154B (pt) 1987-06-17
FI851173A0 (fi) 1985-03-22
FI86184B (fi) 1992-04-15
KR870001796B1 (ko) 1987-10-12
NO167574B (no) 1991-08-12
DK132585A (da) 1985-09-24
CH673460A5 (es) 1990-03-15
FI86184C (fi) 1992-07-27
PT80154A (en) 1985-04-01
PL145915B1 (en) 1988-11-30
PL252525A1 (en) 1985-12-17
DK132585D0 (da) 1985-03-22

Similar Documents

Publication Publication Date Title
ES391299A1 (es) Procedimiento para la preparacion de n-alil 2 - arilamino -imidazolinas (2) sustituidas.
ES8507484A1 (es) Procedimiento de producir compuestos beta-lactamicos y similares
ES8403131A1 (es) Un procedimiento para la preparacion de derivados de 1,1-dioxido del acido penicilanico.
ES448721A1 (es) Un procedimiento para la produccion de compuestos amidicos antibacterianos.
ES400824A1 (es) Procedimiento para la preparacion de amidinocarbamatos.
ES412207A1 (es) Un procedimiento para preparar compuestos antibacterianos de cefalosporinas.
ES8602814A1 (es) Un procedimiento para preparar una cefalosporina
ES404744A1 (es) Un procedimiento para producir derivados de cefalosporina.
ES8601910A1 (es) Un procedimiento para preparar nuevos derivados amidinicos de 4-fenilimidazol sustituido en la posicion 2
ES419739A1 (es) Procedimiento para la preparacion de 2-arilamino-imidazoli-nas (2) sustituidas.
ES432225A1 (es) Procedimiento de preparacion de nuevos compuestos de sulfe-namida.
ES437842A1 (es) Procedimiento para la preparacion de cefalosporinas.
ES448000A1 (es) Procedimiento para la produccion de derivados de ciclopropa-no.
ES435351A1 (es) Procedimiento para preparar 1-(3-fenil-propil)-4-furoilpi- perazinas.
ES442988A1 (es) Un procedimiento de preparacion de nuevos compuestos de sul-fenamida.
GB1500826A (en) Spiro compounds and their use in pharmaceutical compositions
ES401342A1 (es) Procedimiento para la preparacion de nuevos derivados de lapiridina y de sus sales.
ES437041A1 (es) Un procedimiento para preparar derivados de 1-ftalazona.
ES467734A1 (es) Procedimiento para la obtencion de derivados del 5-nitroimi-dazol.
ES364722A1 (es) Procedimiento para la preparacion de nuevos derivados de p-aminoalquil-bencensulfonamida.
ES421810A1 (es) Procedimiento para la preparacion de nuevas pirimido (5,4- d-)pirimidinas.
ES444483A1 (es) Un procedimiento de preparacion de nuevos derivados de acido2,3-alquilen (inferior) penam-3-carboxilico.
ES427622A1 (es) Procedimiento para la preparacion de 2-amino-bencil-aminas.
ES421929A1 (es) Procedimiento para la preparacion de sulfonanilidas susti- tuidas.
ES440094A1 (es) Procedimiento para la preparacion de nuevos derivados de pi-peridina.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010201