ES412207A1 - Alpha-amino-rho-hydroxyphenylacetamidocephalosporins - Google Patents

Alpha-amino-rho-hydroxyphenylacetamidocephalosporins

Info

Publication number
ES412207A1
ES412207A1 ES412207A ES412207A ES412207A1 ES 412207 A1 ES412207 A1 ES 412207A1 ES 412207 A ES412207 A ES 412207A ES 412207 A ES412207 A ES 412207A ES 412207 A1 ES412207 A1 ES 412207A1
Authority
ES
Spain
Prior art keywords
formula
compound
group
see formula
necessary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES412207A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US262903A external-priority patent/US3867380A/en
Priority claimed from US00289499A external-priority patent/US3855213A/en
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of ES412207A1 publication Critical patent/ES412207A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A procedure for preparing a compound of the formula **(See formula)** wherein R is 1,2,3-triazolyl, unsubstituted or substituted with one or two groups selected from the group consisting of lower alcohol of 1 to 4 carbon atoms and trifluoromethyl, comprising: (1) reacting a compound of acetoxymethyl-cephalosporin of the formula **(See formula)** where R1 is **(See formula)** the NH2 group being suitably protected as necessary, or H, with a heterocyclic thiol compound of the formula HS-R, wherein R is as defined above; (2) when R1 is H, acylate the resulting compound with a p-hydroxyphenylacetic acid compound of the formula **(See formula)** or an acylating or activated derivative thereof, the NH2 group being adequately protected as necessary; (3) then remove any protective groups that have been introduced. (Machine-translation by Google Translate, not legally binding)
ES412207A 1972-06-14 1973-03-01 Alpha-amino-rho-hydroxyphenylacetamidocephalosporins Expired ES412207A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US262903A US3867380A (en) 1971-02-18 1972-06-14 3-Heterocyclic thiomethylcephalosporins
US00289499A US3855213A (en) 1971-02-18 1972-09-15 3-heterocyclic thiomethyl-cephalosporins

Publications (1)

Publication Number Publication Date
ES412207A1 true ES412207A1 (en) 1976-01-01

Family

ID=26949532

Family Applications (2)

Application Number Title Priority Date Filing Date
ES412207A Expired ES412207A1 (en) 1972-06-14 1973-03-01 Alpha-amino-rho-hydroxyphenylacetamidocephalosporins
ES413501A Expired ES413501A1 (en) 1972-06-14 1973-04-09 Alpha-amino-rho-hydroxyphenylacetamidocephalosporins

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES413501A Expired ES413501A1 (en) 1972-06-14 1973-04-09 Alpha-amino-rho-hydroxyphenylacetamidocephalosporins

Country Status (20)

Country Link
JP (2) JPS5518716B2 (en)
AR (1) AR197237A1 (en)
AT (1) AT324560B (en)
AU (1) AU464107B2 (en)
CA (2) CA1076560A (en)
CH (2) CH586709A5 (en)
DD (1) DD105238A5 (en)
DE (1) DE2316867C2 (en)
DK (1) DK142913B (en)
ES (2) ES412207A1 (en)
FI (1) FI56843C (en)
FR (2) FR2187298B1 (en)
GB (2) GB1363833A (en)
HU (1) HU168689B (en)
IE (2) IE37409B1 (en)
IL (1) IL42126A (en)
NL (2) NL7302817A (en)
PH (1) PH9941A (en)
PL (1) PL91074B1 (en)
SE (2) SE416472B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR780000197B1 (en) * 1972-12-26 1978-05-26 Bristol Myers Co Method for preparing antibacterial agent
FR2215942B1 (en) * 1973-01-31 1978-12-22 Bristol Myers Co
GB1476981A (en) * 1974-06-05 1977-06-16 Bristol Myers Co Substituted penicillanic acids
CA1074784A (en) * 1974-09-06 1980-04-01 Sumitomo Chemical Company N-ACYLAMINO-.alpha.-ARYLACETAMIDO CEPHALOSPORINS
JPS5346995A (en) * 1976-10-12 1978-04-27 Sangyo Kagaku Kenkyu Kyokai Antibacterial agents
NL162387C (en) * 1977-09-06 1980-05-16 Gist Brocades Nv PROCESS FOR PREPARING 6- (D-ALPHA-AMINO-P- HYDROXYPHENYLACETAMIDO) PENICILLANIC ACID.
JPS6010226U (en) * 1983-06-30 1985-01-24 松下電工株式会社 lift device
JPS6182606A (en) * 1984-09-29 1986-04-26 東芝ライテック株式会社 Lift

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA698494B (en) * 1969-02-26 1971-07-28 Lilly Co Eli Sulfur-containing cephalosporing antibiotics
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds

Also Published As

Publication number Publication date
AU5234573A (en) 1974-08-22
IE37499L (en) 1973-12-14
SE404190B (en) 1978-09-25
HU168689B (en) 1976-06-28
IE37409L (en) 1973-12-14
AT324560B (en) 1975-09-10
DD105238A5 (en) 1974-04-12
IE37409B1 (en) 1977-07-20
FR2187299A1 (en) 1974-01-18
AU464107B2 (en) 1975-08-14
IL42126A (en) 1975-12-31
ES413501A1 (en) 1976-07-16
JPS4931689A (en) 1974-03-22
DK142913C (en) 1981-09-28
GB1358027A (en) 1974-06-26
CH586709A5 (en) 1977-04-15
DE2316866B2 (en) 1976-10-07
FR2187298A1 (en) 1974-01-18
DK142913B (en) 1981-02-23
FI56843B (en) 1979-12-31
JPS4954393A (en) 1974-05-27
FR2187298B1 (en) 1976-12-03
AR197237A1 (en) 1974-03-22
NL7305206A (en) 1973-12-18
SE416472B (en) 1981-01-05
CA1076560A (en) 1980-04-29
FR2187299B1 (en) 1976-12-03
DE2316866A1 (en) 1974-01-03
JPS5518716B2 (en) 1980-05-21
DE2316867A1 (en) 1974-01-03
CH589093A5 (en) 1977-06-30
DE2316867C2 (en) 1982-05-19
IL42126A0 (en) 1973-06-29
NL7302817A (en) 1973-12-18
PL91074B1 (en) 1977-02-28
CA999293A (en) 1976-11-02
FI56843C (en) 1980-04-10
IE37499B1 (en) 1977-08-03
PH9941A (en) 1976-06-14
GB1363833A (en) 1974-08-21
JPS5953274B2 (en) 1984-12-24

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