ES8302025A1 - Procedimiento para la preparacion de 10-alquinil esteroides - Google Patents
Procedimiento para la preparacion de 10-alquinil esteroidesInfo
- Publication number
- ES8302025A1 ES8302025A1 ES503345A ES503345A ES8302025A1 ES 8302025 A1 ES8302025 A1 ES 8302025A1 ES 503345 A ES503345 A ES 503345A ES 503345 A ES503345 A ES 503345A ES 8302025 A1 ES8302025 A1 ES 8302025A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- aromatase inhibitors
- image
- steroids
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEMIENTO PARA LA PREPARACION DE 10-ALQUINIL ESTEROIDES, DE FORMULA GENERAL (I) DONDE <047> REPRESENTA UN ENLACE SIMPLE O DOBLE; R ES METILO O ERILO; R ES (H)(OR ) O =O; R ES H O C <003> ALQUILO; R ES H O C <003> ALQUILO; Y R Y R SON CADA UNO DE ELLOS H O C <003> ALQUILO. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE CLOROETENILO, CON UNA BASE FUERTE EN PRESENCIA DE UN DISOLVENTE INERTE, SEGUIDO DE UN TRATAMIENTO CON ACIDO PARA SEPARAR LOS GRUPOS PROTECTORES. DE APLICACION EN LA OBTENCION DE PREPARADOS FARMACEUTICOS UTILIZADOS EN EL TRATAMIENTO DE LA HIPERESTROGENENCIA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16345180A | 1980-06-27 | 1980-06-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES503345A0 ES503345A0 (es) | 1983-01-01 |
ES8302025A1 true ES8302025A1 (es) | 1983-01-01 |
Family
ID=22590066
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES503345A Expired ES8302025A1 (es) | 1980-06-27 | 1981-06-25 | Procedimiento para la preparacion de 10-alquinil esteroides |
Country Status (23)
Country | Link |
---|---|
US (1) | US4322416A (es) |
JP (1) | JPS5738797A (es) |
AT (1) | AT385510B (es) |
AU (1) | AU542273B2 (es) |
BE (1) | BE889401A (es) |
CA (1) | CA1173431A (es) |
CH (1) | CH646984A5 (es) |
DE (1) | DE3124780A1 (es) |
DK (2) | DK161151C (es) |
ES (1) | ES8302025A1 (es) |
FR (1) | FR2485543A1 (es) |
GB (2) | GB2078749B (es) |
HK (1) | HK72686A (es) |
IE (1) | IE51351B1 (es) |
IL (1) | IL63143A (es) |
IT (1) | IT1171339B (es) |
MY (1) | MY8700055A (es) |
NL (1) | NL8103101A (es) |
NO (1) | NO156693C (es) |
NZ (1) | NZ197494A (es) |
PH (1) | PH16787A (es) |
SE (1) | SE452325B (es) |
ZA (1) | ZA814220B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0100566B1 (en) * | 1982-07-14 | 1986-02-19 | Akzo N.V. | Novel 19-thio-androstane derivatives |
EP0114033B1 (de) * | 1982-12-21 | 1988-10-12 | Ciba-Geigy Ag | Substituierte Azabicycloalkane, ihre Verwendung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verfahren zur Herstellung dieser Verbindungen |
DE3323321A1 (de) * | 1983-06-24 | 1985-01-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Prophylaxe und therapie von koronaren herzkrankheiten durch senkung des oestrogenspiegels |
DE3338212C2 (de) * | 1983-10-18 | 1995-05-18 | Schering Ag | 1-Methyl-androsta-1,4,6-trien-3,17-dione, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate |
US4634694A (en) * | 1984-01-14 | 1987-01-06 | Akzo N.V. | Novel Δ4 - and Δ5 -androstene derivatives and pharmaceutical compositions containing these derivatives |
US4546098A (en) * | 1984-04-13 | 1985-10-08 | The Rockefeller University | Estrogen synthesis inhibitors |
FR2569408B1 (fr) * | 1984-08-24 | 1986-10-03 | Roussel Uclaf | Nouveaux steroides substitues en position 10 par un radical comportant une double ou triple liaison, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant |
GB8531747D0 (en) * | 1985-12-24 | 1986-02-05 | Erba Farmitalia | 10beta-alkynylestrene derivatives |
FR2594829B1 (fr) * | 1986-02-24 | 1988-06-03 | Roussel Uclaf | Nouveaux steroides 9 (11) satures substitues en position 10 par un radical comportant une triple liaison, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant |
FR2594830B1 (fr) * | 1986-02-24 | 1988-06-03 | Roussel Uclaf | Nouveaux 13 epi ou d-homo steroides substitues en position 10b par un radical comportant une double ou triple liaison, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant |
US4874891A (en) * | 1986-05-01 | 1989-10-17 | Washington University | Open "D" ring hormone analogs |
US4910191A (en) * | 1988-06-28 | 1990-03-20 | Merrell Dow Pharmaceuticals Inc. | 19-substituted progesterone derivatives useful as 19-hydroxylase inhibitors |
US4882322A (en) * | 1988-10-27 | 1989-11-21 | Merrell Dow Pharmaceuticals Inc. | 3β,17β-hydroxy-substituted steroids and related steroidal compounds |
FR2640976B1 (es) * | 1988-12-22 | 1994-10-28 | Roussel Uclaf | |
US5162337A (en) * | 1990-10-05 | 1992-11-10 | Merck & Co., Inc. | Animal growth promotion |
US5166201A (en) * | 1990-11-30 | 1992-11-24 | Merrell Dow Pharmaceuticals Inc. | 2β,19-ethylene bridged steroids as aromatase inhibitors |
US5126488A (en) * | 1990-11-30 | 1992-06-30 | Merrell Dow Pharmaceuticals Inc. | 2β,19-methyleneamino bridged steroids as aromatase inhibitors |
CH683151A5 (de) * | 1991-04-24 | 1994-01-31 | Ciba Geigy Ag | Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus. |
FR2677027B1 (fr) * | 1991-05-27 | 1993-09-10 | Roussel Uclaf | Nouveaux produits sterouides substitues en position 6, et comportant, en position 10, un radical thioethyle, leur procede de preparation leurs intermediaires, leur application comme medicaments. |
DE4435368A1 (de) * | 1994-09-22 | 1996-03-28 | Schering Ag | Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann |
US5866558A (en) * | 1997-05-08 | 1999-02-02 | Regents Of The University Of Minnesota | 6-alkynyl steroids |
EP1854465A1 (en) * | 2006-05-12 | 2007-11-14 | Alexander Tobias Teichmann | Use of 4,17 beta-dihydroxyandrost-4-ene-3-one for treating cancers |
CA2794565C (en) | 2010-04-08 | 2018-08-21 | Emory University | Substituted androst-4-ene diones |
EP3666276A1 (en) | 2018-12-14 | 2020-06-17 | dcic Biopharmaceutical Limited | Medication against estrogen-receptor beta (erbeta) positive breast tumor |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3127427A (en) * | 1962-07-17 | 1964-03-31 | Hoffmann La Roche | 10-alkenyl-steroids and process therefor |
US3218316A (en) * | 1963-08-26 | 1965-11-16 | Syntex Corp | 10beta-ethynyl-19-norandrostane derivatives |
-
1981
- 1981-04-27 US US06/258,214 patent/US4322416A/en not_active Expired - Lifetime
- 1981-06-20 IL IL63143A patent/IL63143A/xx not_active IP Right Cessation
- 1981-06-22 ZA ZA814220A patent/ZA814220B/xx unknown
- 1981-06-22 CH CH411981A patent/CH646984A5/de not_active IP Right Cessation
- 1981-06-22 DK DK274681A patent/DK161151C/da not_active IP Right Cessation
- 1981-06-22 NZ NZ197494A patent/NZ197494A/en unknown
- 1981-06-22 PH PH25798A patent/PH16787A/en unknown
- 1981-06-22 CA CA000380295A patent/CA1173431A/en not_active Expired
- 1981-06-24 DE DE19813124780 patent/DE3124780A1/de active Granted
- 1981-06-24 SE SE8103963A patent/SE452325B/sv not_active IP Right Cessation
- 1981-06-25 ES ES503345A patent/ES8302025A1/es not_active Expired
- 1981-06-26 AT AT0285781A patent/AT385510B/de not_active IP Right Cessation
- 1981-06-26 GB GB8119813A patent/GB2078749B/en not_active Expired
- 1981-06-26 IE IE1434/81A patent/IE51351B1/en not_active IP Right Cessation
- 1981-06-26 BE BE0/205229A patent/BE889401A/fr not_active IP Right Cessation
- 1981-06-26 NL NL8103101A patent/NL8103101A/nl not_active IP Right Cessation
- 1981-06-26 JP JP9849481A patent/JPS5738797A/ja active Granted
- 1981-06-26 IT IT8148780A patent/IT1171339B/it active
- 1981-06-26 FR FR8112642A patent/FR2485543A1/fr active Granted
- 1981-06-26 NO NO812197A patent/NO156693C/no not_active IP Right Cessation
- 1981-06-30 AU AU72370/81A patent/AU542273B2/en not_active Ceased
-
1983
- 1983-06-20 GB GB08316702A patent/GB2135314B/en not_active Expired
-
1986
- 1986-09-25 HK HK726/86A patent/HK72686A/xx not_active IP Right Cessation
-
1987
- 1987-12-30 MY MY55/87A patent/MY8700055A/xx unknown
-
1990
- 1990-03-22 DK DK075190A patent/DK162447C/da not_active IP Right Cessation
Also Published As
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