ES509741A0 - "procedimiento de sintesis de mononitratos de isosorbido". - Google Patents

"procedimiento de sintesis de mononitratos de isosorbido".

Info

Publication number: ES509741A0
Authority: ES; Spain
Prior art keywords: mononitrate; isosorbido; solvent medium; synthesis procedure; hydrazine derivative
Prior art date: 1981-02-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES509741A

Other languages

English (en)

Other versions

ES8302716A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Societe Nationale des Poudres et Explosifs

Original Assignee

Societe Nationale des Poudres et Explosifs

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-02-27

Filing date

1982-02-19

Publication date

1983-02-01

1982-02-19 Application filed by Societe Nationale des Poudres et Explosifs filed Critical Societe Nationale des Poudres et Explosifs

1983-02-01 Publication of ES509741A0 publication Critical patent/ES509741A0/es

1983-02-01 Publication of ES8302716A1 publication Critical patent/ES8302716A1/es

Status Expired legal-status Critical Current

Links

230000015572 biosynthetic process Effects 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
238000003786 synthesis reaction Methods 0.000 title abstract 2
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
150000002429 hydrazines Chemical class 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
KLDXJTOLSGUMSJ-JGWLITMVSA-N Isosorbide Chemical compound O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 KLDXJTOLSGUMSJ-JGWLITMVSA-N 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
239000003218 coronary vasodilator agent Substances 0.000 abstract 1
229960002479 isosorbide Drugs 0.000 abstract 1
MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 abstract 1
229960000201 isosorbide dinitrate Drugs 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000002798 polar solvent Substances 0.000 abstract 1
238000010992 reflux Methods 0.000 abstract 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ES509741A 1981-02-27 1982-02-19 "procedimiento de sintesis de mononitratos de isosorbido". Expired ES8302716A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8103906A FR2500835A1 (fr)	1981-02-27	1981-02-27	Procede de synthese des mononitrates d'isosorbide

Publications (2)

Publication Number	Publication Date
ES509741A0 true ES509741A0 (es)	1983-02-01
ES8302716A1 ES8302716A1 (es)	1983-02-01

Family

ID=9255675

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES509741A Expired ES8302716A1 (es)	1981-02-27	1982-02-19	"procedimiento de sintesis de mononitratos de isosorbido".

Country Status (11)

Country	Link
US (1)	US4381400A (es)
EP (1)	EP0059664B1 (es)
JP (1)	JPS57156492A (es)
AT (1)	ATE10371T1 (es)
CA (1)	CA1182829A (es)
DE (1)	DE3261256D1 (es)
ES (1)	ES8302716A1 (es)
FR (1)	FR2500835A1 (es)
HU (1)	HU191346B (es)
IE (1)	IE52602B1 (es)
IN (1)	IN157599B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3124410A1 (de) *	1981-06-22	1983-01-05	Heinrich Mack Nachf., 7918 Illertissen	Verfahren zur herstellung von isosorbid-2-nitrat
JPS60149521A (ja) *	1984-01-18	1985-08-07	Eisai Co Ltd	高眼圧・緑内障治療・予防用点眼剤
IT1208537B (it) *	1985-05-10	1989-07-10	Consiglio Nazionale Ricerche	Processo per la preparazione dell'isosorbide-5-monoidrato.
EP0201067B1 (en) *	1985-05-10	1991-08-07	Consiglio Nazionale Delle Ricerche	Process for the preparation of isosorbide-5-mononitrate
FR2601386B1 (fr) *	1986-07-11	1988-11-18	Centre Nat Rech Scient	Procede de bioconversion selective du dinitrate d'isosorbitol
DE3683500D1 (de) *	1986-11-05	1992-02-27	Consiglio Nazionale Ricerche	Verfahren zur selektiven herstellung von isosorbid-2-nitrat, ausgehend vom isosorbid-2,5-dinitrat.
DE4410997A1 (de) *	1994-03-30	1995-10-26	Isis Pharma Gmbh	Pharmazeutische Zubereitungen und Arzneistoffe zur Prävention und Behandlung endothelialer Dysfunktionen
IT1311986B1 (it) *	1999-03-26	2002-03-22	Dinamite Dipharma S P A In For	Procedimento per la preparazione di monoesteri nitrici di compostidiidrossialchilici e diidrossicicloalchilici.
GB9930778D0 (en) *	1999-12-29	2000-02-16	Archimici Ltd	Compound synthesis
DE102008050597A1 (de)	2008-10-09	2010-04-15	Actavis Deutschland Gmbh & Co. Kg	Pharmazeutische Zubereitungen zur Anwendung in einem Verfahren zur therapeutischen Behandlung von Hörsturz
CN104892623B (zh) *	2015-06-11	2017-08-11	山东新时代药业有限公司	一种5‑单硝酸异山梨酯的制备方法
CN113105470A (zh) *	2021-03-15	2021-07-13	海南通用康力制药有限公司	单硝酸异山梨酯的合成方法及应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3886186A (en) *	1971-04-29	1975-05-27	American Home Prod	Mononitrate esters of 1,4:3,6-dianhydro-d-glucitol

1981
- 1981-02-27 FR FR8103906A patent/FR2500835A1/fr active Granted
1982
- 1982-02-11 IN IN113/DEL/82A patent/IN157599B/en unknown
- 1982-02-16 US US06/349,073 patent/US4381400A/en not_active Expired - Lifetime
- 1982-02-19 ES ES509741A patent/ES8302716A1/es not_active Expired
- 1982-02-25 EP EP82400328A patent/EP0059664B1/fr not_active Expired
- 1982-02-25 AT AT82400328T patent/ATE10371T1/de not_active IP Right Cessation
- 1982-02-25 DE DE8282400328T patent/DE3261256D1/de not_active Expired
- 1982-02-25 CA CA000397069A patent/CA1182829A/en not_active Expired
- 1982-02-26 IE IE428/82A patent/IE52602B1/en not_active IP Right Cessation
- 1982-02-26 JP JP57029107A patent/JPS57156492A/ja active Pending
- 1982-02-26 HU HU82603A patent/HU191346B/hu not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES8302716A1 (es)	1983-02-01
US4381400A (en)	1983-04-26
EP0059664B1 (fr)	1984-11-21
FR2500835A1 (fr)	1982-09-03
DE3261256D1 (en)	1985-01-03
HU191346B (en)	1987-02-27
IN157599B (es)	1986-05-03
IE820428L (en)	1982-08-27
EP0059664A1 (fr)	1982-09-08
CA1182829A (en)	1985-02-19
FR2500835B1 (es)	1983-10-21
IE52602B1 (en)	1987-12-23
JPS57156492A (en)	1982-09-27
ATE10371T1 (de)	1984-12-15

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