ES470155A1 - Un procedimiento para la obtencion de derivados de espiroa- mina - Google Patents

Un procedimiento para la obtencion de derivados de espiroa- mina

Info

Publication number
ES470155A1
ES470155A1 ES470155A ES470155A ES470155A1 ES 470155 A1 ES470155 A1 ES 470155A1 ES 470155 A ES470155 A ES 470155A ES 470155 A ES470155 A ES 470155A ES 470155 A1 ES470155 A1 ES 470155A1
Authority
ES
Spain
Prior art keywords
spiro
pharmaceutical compositions
piperidine compounds
activity
represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES470155A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of ES470155A1 publication Critical patent/ES470155A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Un procedimiento para la obtención de derivados de espiroamina de la fórmula: **(formula)** en la que R1 es un átomo de hidrógeno, un grupo alcohilo C1-C4, un grupo fenilo, o un grupo fenilo sustituido con un átomo de halógeno, un grupo alcohilo C1-C4 o un grupo alcoxi C1-C4, R2 es un átomo de hidrógeno, o bien R1 y R2, cuando se consideran juntos, pueden formar un grupo alcohileno C1-C4, W es un átomo de oxígeno o dos átomos de hidrogeno.
ES470155A 1978-02-13 1978-05-24 Un procedimiento para la obtencion de derivados de espiroa- mina Expired ES470155A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1577878A JPS54109983A (en) 1978-02-13 1978-02-13 Novel spiroamine derivative and its preparation

Publications (1)

Publication Number Publication Date
ES470155A1 true ES470155A1 (es) 1979-01-01

Family

ID=11898262

Family Applications (1)

Application Number Title Priority Date Filing Date
ES470155A Expired ES470155A1 (es) 1978-02-13 1978-05-24 Un procedimiento para la obtencion de derivados de espiroa- mina

Country Status (13)

Country Link
US (1) US4233307A (es)
JP (1) JPS54109983A (es)
AT (1) AT356108B (es)
AU (1) AU511735B2 (es)
BE (1) BE867517A (es)
CA (1) CA1092106A (es)
CH (1) CH635841A5 (es)
DE (1) DE2822227A1 (es)
ES (1) ES470155A1 (es)
FR (1) FR2442845A1 (es)
IT (1) IT7849577A0 (es)
NL (1) NL7805814A (es)
SE (1) SE7805949L (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337260A (en) * 1981-09-10 1982-06-29 Yoshitomi Pharmaceutical Industries, Ltd. Imidazopyridine-spiro-piperidine compounds
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
CA2163995A1 (en) * 1993-06-07 1994-12-22 Malcolm Maccoss Spiro-substituted azacycles as neurokinin antagonists
US5763471A (en) * 1994-04-07 1998-06-09 Cemaf Melatoninergic agonist spiro indolepyrrolidine! derivatives, process for their preparation and their use as medicinal products
FR2724170B1 (fr) * 1994-09-02 1997-05-30 Cemaf Nouveaux derives de spiro(indole-pyrrolidine) agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
US5962462A (en) * 1996-12-13 1999-10-05 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
US6013652A (en) * 1997-12-04 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin antagonists
CZ2002203A3 (cs) * 1999-07-21 2002-08-14 Astrazeneca Ab Spirooxindolové deriváty
GB0213715D0 (en) 2002-06-14 2002-07-24 Syngenta Ltd Chemical compounds
CN100402529C (zh) * 2002-09-09 2008-07-16 詹森药业有限公司 用于治疗orl-1受体介导疾病的羟基烷基取代的1,3,8-三氮杂螺[4,5]癸-4-酮衍生物
MX2007002033A (es) 2004-08-19 2007-04-26 Vertex Pharma Moduladores de receptores muscarinicos.
US7786141B2 (en) * 2004-08-19 2010-08-31 Vertex Pharmaceuticals Incorporated Dihydrospiroindene modulators of muscarinic receptors
RU2007124373A (ru) * 2004-11-29 2009-01-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы мускариновых рецептеров
EP1890696A4 (en) * 2005-06-02 2010-05-05 Janssen Pharmaceutica Nv Suitable as new ORL-1 receptor modulators are 3-pyrolytic indolyl derivatives
US8193208B2 (en) 2005-09-09 2012-06-05 Purdue Pharma L.P. Fused and spirocycle compounds and the use thereof
JP2009521483A (ja) * 2005-12-22 2009-06-04 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体のモジュレーター
RU2008137593A (ru) * 2006-02-22 2010-03-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы мускариновых рецепторов
AU2007221220A1 (en) * 2006-02-22 2007-09-07 Vertex Pharmaceuticals Incorporated Spiro condensed piperidnes as modulators of muscarinic receptors
EP2040706A2 (en) * 2006-06-29 2009-04-01 Vertex Pharmceuticals Incorporated Modulators of muscarinic receptors
EP2051712A2 (en) * 2006-08-15 2009-04-29 Vertex Pharmceuticals Incorporated Modulators of muscarinic receptors
JP2010501561A (ja) * 2006-08-18 2010-01-21 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体の調節剤
WO2008067167A1 (en) * 2006-11-28 2008-06-05 Janssen Pharmaceutica N.V. Salts of 3-(3-amino-2-(r)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
WO2008124209A1 (en) * 2007-04-09 2008-10-16 Janssen Pharmaceutica, N.V. 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
US20080306102A1 (en) * 2007-05-18 2008-12-11 Kowa Co., Ltd. Novel spirooxyindole compounds and drugs containing same
EP2207549A1 (en) 2007-10-03 2010-07-21 Vertex Pharmceuticals Incorporated Modulators of muscarinic receptors
WO2023141432A2 (en) * 2022-01-18 2023-07-27 Maze Therapeutics, Inc. Apol1 inhibitors and methods of use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3299075A (en) * 1964-03-12 1967-01-17 Smith Kline French Lab Spiro [3h-indole-3, 3'-pyrrolidine and piperidine] derivatives

Also Published As

Publication number Publication date
IT7849577A0 (it) 1978-05-26
US4233307A (en) 1980-11-11
CA1092106A (en) 1980-12-23
JPS54109983A (en) 1979-08-29
AU511735B2 (en) 1980-09-04
SE7805949L (sv) 1979-08-14
AT356108B (de) 1980-04-10
AU3616978A (en) 1979-11-22
BE867517A (fr) 1978-09-18
DE2822227A1 (de) 1979-08-16
NL7805814A (nl) 1979-08-15
ATA388878A (de) 1979-09-15
FR2442845A1 (fr) 1980-06-27
FR2442845B1 (es) 1981-07-24
CH635841A5 (de) 1983-04-29

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