ES8404852A1 - Procedimiento para preparar derivados de acidos isoquinolein-4-carboxilicos - Google Patents

Procedimiento para preparar derivados de acidos isoquinolein-4-carboxilicos

Info

Publication number
ES8404852A1
ES8404852A1 ES525441A ES525441A ES8404852A1 ES 8404852 A1 ES8404852 A1 ES 8404852A1 ES 525441 A ES525441 A ES 525441A ES 525441 A ES525441 A ES 525441A ES 8404852 A1 ES8404852 A1 ES 8404852A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
isoquinoline derivatives
isoquinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525441A
Other languages
English (en)
Other versions
ES525441A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES525441A0 publication Critical patent/ES525441A0/es
Publication of ES8404852A1 publication Critical patent/ES8404852A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE ACIDOS ISOQUINOLEIN-4-CARBOXILICOS, DE FORMULA GENERAL (I), EN LA QUE M Y N SIGNIFICAN 1 O 2; X SIGNIFICA OXIGENO O NITROGENO; A SIGNIFICA UN ENLACE O UNA CADENA ALCOHILENO; R SIGNIFICA UN GRUPO AMINO; R SIGNIFICA HIDROGENO, HALOGENO O HIDROXI; Y R SIGNIFICA HIDROGENO, HALOGENO, HIDROXI O NITRO, Y SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES.CONSISTE EN HACER REACCIONAR COMPUESTOS DE FORMULA (II), EN LA QUE M, N, R Y R TIENEN LOS SIGNIFICADOS YA MENCIONADOS; E Y SIGNIFICA HIDROGENO O HALOGENO, CON UNA AMINA OUN ALCOHOL DE FORMULA: HX-A-R, EN LA QUE X, A Y R TIENEN LOS SIGNIFICADOS YA INDICADOS.DE APLICACION EN TERAPEUTICA, ESPECIALMENTE EN EL SISTEMA CIRCULATORIO CARDIACO.
ES525441A 1982-09-09 1983-09-07 Procedimiento para preparar derivados de acidos isoquinolein-4-carboxilicos Expired ES8404852A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823233424 DE3233424A1 (de) 1982-09-09 1982-09-09 Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung

Publications (2)

Publication Number Publication Date
ES525441A0 ES525441A0 (es) 1984-05-16
ES8404852A1 true ES8404852A1 (es) 1984-05-16

Family

ID=6172780

Family Applications (1)

Application Number Title Priority Date Filing Date
ES525441A Expired ES8404852A1 (es) 1982-09-09 1983-09-07 Procedimiento para preparar derivados de acidos isoquinolein-4-carboxilicos

Country Status (19)

Country Link
US (1) US4673682A (es)
EP (1) EP0105210B1 (es)
JP (1) JPS5967270A (es)
KR (1) KR840006206A (es)
AT (1) ATE25679T1 (es)
AU (1) AU1891683A (es)
CA (1) CA1211445A (es)
DE (2) DE3233424A1 (es)
DK (1) DK408083A (es)
ES (1) ES8404852A1 (es)
FI (1) FI833200A (es)
GR (1) GR79382B (es)
HU (1) HU191094B (es)
IL (1) IL69683A0 (es)
NO (1) NO833217L (es)
NZ (1) NZ205513A (es)
PH (1) PH18186A (es)
PT (1) PT77309B (es)
ZA (1) ZA836663B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956371A (en) * 1989-09-19 1990-09-11 Euroceltique, S.A. Substituted isoquinolines and methods of using same
ATE198328T1 (de) * 1992-09-28 2001-01-15 Hoechst Ag Antiarrhythmische und cardioprotektive substituierte 1(2h)-isochinoline, verfahren zu deren herstellung, diese enthaltende arzneimittel und ihre anwendung für die herstellung eines arzneimittels zur behandlung von herzinsuffizienzen
CA2528232C (en) 2003-06-06 2010-05-25 Fibrogen, Inc. Novel nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin
EP2044028B1 (en) 2006-01-27 2012-05-16 Fibrogen, Inc. Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (hif)
WO2007115315A2 (en) * 2006-04-04 2007-10-11 Fibrogen, Inc. Pyrrolo- and thiazolo-pyridine compounds as hif modulators
WO2010056767A1 (en) 2008-11-14 2010-05-20 Fibrogen, Inc. Thiochromene derivatives as hip hydroxylase inhibitors
AU2013229922B2 (en) 2012-03-09 2017-09-28 Fibrogen, Inc. 4 -hydroxy- isoquinoline compounds as HIF hydroxylase inhibitors
EP2872488B1 (en) 2012-07-16 2018-08-22 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
HUE034409T2 (en) 2012-07-16 2018-02-28 Fibrogen Inc Process for the preparation of isoquinoline compounds
US8883823B2 (en) 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
AU2014209319B2 (en) 2013-01-24 2018-04-19 Fibrogen, Inc. Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2054482B1 (es) * 1969-07-11 1973-06-08 Anvar
FR2424270A1 (fr) * 1978-04-24 1979-11-23 Rhone Poulenc Ind Nouveaux derives de l'isoquinoleine, leur preparation et les compositions qui les contiennent
DE2818423A1 (de) * 1978-04-27 1979-11-08 Hoechst Ag Neue isochinolinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
DE3233424A1 (de) 1984-03-15
JPS5967270A (ja) 1984-04-16
EP0105210A2 (de) 1984-04-11
DE3369983D1 (en) 1987-04-09
PT77309B (de) 1986-04-18
DK408083A (da) 1984-03-10
NZ205513A (en) 1986-05-09
HU191094B (en) 1987-01-28
ES525441A0 (es) 1984-05-16
ATE25679T1 (de) 1987-03-15
PT77309A (de) 1983-10-01
GR79382B (es) 1984-10-22
FI833200A0 (fi) 1983-09-07
IL69683A0 (en) 1983-12-30
EP0105210A3 (en) 1984-10-10
NO833217L (no) 1984-03-12
CA1211445A (en) 1986-09-16
US4673682A (en) 1987-06-16
FI833200A (fi) 1984-03-10
DK408083D0 (da) 1983-09-08
EP0105210B1 (de) 1987-03-04
ZA836663B (en) 1984-04-25
AU1891683A (en) 1984-03-15
KR840006206A (ko) 1984-11-22
PH18186A (en) 1985-04-12

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