ES8403911A1 - Procedimiento de preparacion de mononitratos de 1.4,3.6- dianhidro-hexito sustituidos en 2-0 y 5-0 - Google Patents

Procedimiento de preparacion de mononitratos de 1.4,3.6- dianhidro-hexito sustituidos en 2-0 y 5-0

Info

Publication number
ES8403911A1
ES8403911A1 ES503920A ES503920A ES8403911A1 ES 8403911 A1 ES8403911 A1 ES 8403911A1 ES 503920 A ES503920 A ES 503920A ES 503920 A ES503920 A ES 503920A ES 8403911 A1 ES8403911 A1 ES 8403911A1
Authority
ES
Spain
Prior art keywords
mononitrates
processes
preparation
hexite
dianhydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503920A
Other languages
English (en)
Other versions
ES503920A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Willmar Schwabe GmbH and Co KG
Original Assignee
Dr Willmar Schwabe GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Willmar Schwabe GmbH and Co KG filed Critical Dr Willmar Schwabe GmbH and Co KG
Publication of ES8403911A1 publication Critical patent/ES8403911A1/es
Publication of ES503920A0 publication Critical patent/ES503920A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE FORMULA GENERAL (I).COMPRENDE LAS SIGUIENTES FASES: PRIMERA, SE HACE REACCIONAR L-ISOIDIDO, D-ISOSORBIDO O D-ISOMANNIDO, CON UN CLORURO ACIDO DE FORMULA GENERAL: RK-CL, EN LA QUE RK SIGNIFICA UN RESTO DE ACIDO SULFONICO; SEGUNDA, EL PRODUCTO OBTENIDO EN LA REACCION ANTERIOR SE HACE REACCIONAR CON ACIDO NITRICO, CON ACIDO SULFONITRICO O CON UNA MEZCLA DE ACIDO NITRICO Y ACIDO ACETICO GLACIAL-ANHIDRIDO ACETICO; Y POR ULTIMO, EL RESTO ACIDO RK SE PUEDE INTERCAMBIAR MEDIANTE TRANSFORMACION, POR UNA SALREACTIVA DE UN COMPUESTO DE FORMULA: R-OH.DE APLICACION EN EL TRATAMIENTO DE LA ANGINA DE PECHO.
ES503920A 1980-07-25 1981-07-13 Procedimiento de preparacion de mononitratos de 1.4,3.6- dianhidro-hexito sustituidos en 2-0 y 5-0 Granted ES503920A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3028289A DE3028289C2 (de) 1980-07-25 1980-07-25 2-O- und 5-O-substituierte 1.4;3.6-Dianhydro-hexit-mononitrate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen

Publications (2)

Publication Number Publication Date
ES8403911A1 true ES8403911A1 (es) 1984-04-16
ES503920A0 ES503920A0 (es) 1984-04-16

Family

ID=6108129

Family Applications (1)

Application Number Title Priority Date Filing Date
ES503920A Granted ES503920A0 (es) 1980-07-25 1981-07-13 Procedimiento de preparacion de mononitratos de 1.4,3.6- dianhidro-hexito sustituidos en 2-0 y 5-0

Country Status (7)

Country Link
US (1) US4364953A (es)
EP (1) EP0044931B1 (es)
JP (1) JPS5753488A (es)
AT (1) ATE12643T1 (es)
CA (1) CA1184916A (es)
DE (1) DE3028289C2 (es)
ES (1) ES503920A0 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3248548A1 (de) * 1982-12-29 1984-07-05 Heinrich Mack Nachf., 7918 Illertissen Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPH01262171A (ja) * 1988-04-13 1989-10-19 Nec Corp プリンタ
ES2142773B1 (es) 1998-10-07 2001-01-01 Lacer Sa Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
EP2149576A1 (en) * 2008-07-22 2010-02-03 Lacer, S.A. Isosorbide Nitrates having vasodilating activity
EP2199294A1 (en) * 2008-12-19 2010-06-23 Lacer, S.A. New stereospecific method for the preparation of dioxa bicyclooctane nitrate compounds
US9422304B2 (en) * 2013-06-12 2016-08-23 Archer Daniels Midland Company Synthesis of isohexide dicarbamates and derivatives thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1027891A (en) * 1962-01-02 1966-04-27 Aspro Nicholas Ltd Esters of dianhydro-hexitols
US3886186A (en) * 1971-04-29 1975-05-27 American Home Prod Mononitrate esters of 1,4:3,6-dianhydro-d-glucitol
GB1356374A (en) * 1971-04-29 1974-06-12 American Home Prod Mononitrate esters of 1,3 3,6-dianhydro-d-glucitol
US4169152A (en) * 1977-10-31 1979-09-25 Ici Americas Inc. Isohexide and tetrahydrofuran ethers and their carbamates in method of bringing about relaxation of skeletal musculature
DE2903927C2 (de) * 1979-02-02 1981-03-12 Sanol Schwarz-Monheim Gmbh, 4019 Monheim Verfahren zur selektiven Herstellung von Isosorbid-5-nitrat

Also Published As

Publication number Publication date
ATE12643T1 (de) 1985-04-15
JPS5753488A (en) 1982-03-30
DE3028289A1 (de) 1982-02-25
EP0044931B1 (de) 1985-04-10
US4364953A (en) 1982-12-21
CA1184916A (en) 1985-04-02
ES503920A0 (es) 1984-04-16
DE3028289C2 (de) 1986-11-27
JPS637549B2 (es) 1988-02-17
EP0044931A1 (de) 1982-02-03

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506