ES275601A1 - A procedure for the manufacture of benzodiazepine derivatives (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the manufacture of benzodiazepine derivatives (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES275601A1 ES275601A1 ES275601A ES275601A ES275601A1 ES 275601 A1 ES275601 A1 ES 275601A1 ES 275601 A ES275601 A ES 275601A ES 275601 A ES275601 A ES 275601A ES 275601 A1 ES275601 A1 ES 275601A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- translation
- manufacture
- machine
- legally binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A process for the manufacture of benzodiazepine derivatives of the general formula ** (See formula) ** in which R and R1 represent hydrogen or alkyl, and R2, R3 and R4 represent hydrogen, halogen, alkyl, alkoxy, alkylthio, nitro, trifluoromethyl, carboxy, carbalkoxy, carbamyl or cyano, one of at least the radicals designated by R2, R3 and R4 being a carboxy, carbalkoxy, carbamyl group or cyano, and its acid addition salts, characterized in that it comprises reacting a benzophenone derivative of the general formula ** (See formula) ** with an alpha-amino acid of the general formula ** (See formula) ** or an ester of this acid, or reacting said benzophenone derivative with a haloacyl halide of the general formula ** (See formula) ** and treating the haloacylamidobenzophenone obtained with ammonia, as well as, if desired, transforming the product of the reaction into an acid addition salt. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9666361A | 1961-03-20 | 1961-03-20 | |
| US114038A US3153082A (en) | 1961-06-01 | 1961-06-01 | 2-amino-benzophenones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES275601A1 true ES275601A1 (en) | 1962-09-16 |
Family
ID=26791934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES275601A Expired ES275601A1 (en) | 1961-03-20 | 1962-03-17 | A procedure for the manufacture of benzodiazepine derivatives (Machine-translation by Google Translate, not legally binding) |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE615194A (en) |
| CH (2) | CH445500A (en) |
| ES (1) | ES275601A1 (en) |
| GB (2) | GB985657A (en) |
| SE (1) | SE301974B (en) |
-
1962
- 1962-03-09 CH CH288462A patent/CH445500A/en unknown
- 1962-03-09 CH CH551966A patent/CH459239A/en unknown
- 1962-03-16 BE BE615194A patent/BE615194A/en unknown
- 1962-03-16 GB GB1012062A patent/GB985657A/en not_active Expired
- 1962-03-16 GB GB1281964A patent/GB985658A/en not_active Expired
- 1962-03-17 ES ES275601A patent/ES275601A1/en not_active Expired
- 1962-03-19 SE SE303062A patent/SE301974B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB985658A (en) | 1965-03-10 |
| CH459239A (en) | 1968-07-15 |
| CH445500A (en) | 1967-10-31 |
| GB985657A (en) | 1965-03-10 |
| SE301974B (en) | 1968-07-01 |
| DE1445858B2 (en) | 1975-07-03 |
| BE615194A (en) | 1962-09-17 |
| DE1445858A1 (en) | 1969-01-16 |
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