ES276648A1 - Procedure for the manufacture of benzodiazepine derivatives (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the manufacture of benzodiazepine derivatives (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES276648A1 ES276648A1 ES276648A ES276648A ES276648A1 ES 276648 A1 ES276648 A1 ES 276648A1 ES 276648 A ES276648 A ES 276648A ES 276648 A ES276648 A ES 276648A ES 276648 A1 ES276648 A1 ES 276648A1
- Authority
- ES
- Spain
- Prior art keywords
- translation
- manufacture
- machine
- legally binding
- *** translate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Process for the manufacture of benzodiazepine derivatives of the general formula ** (See formula) ** wherein R1 and R2 represent hydrogen or lower alkyl and R3 represents hydrogen, halogen, lower alkyl or nitro, as well as acid addition salts of said derivatives, which process comprises reacting a quinazoline derivative of the general formula ** (See formula) ** in which X represents halogen, R4 represents hydrogen or nitro and R2 and R3 have the meaning expressed before, with ammonia or a lower alkylamine, nitrate the resulting compound, if a quinazoline derivative is used in which R4 is hydrogen, and, if desired, transform the reaction product into an acid addition salt . (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10422761A | 1961-04-20 | 1961-04-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES276648A1 true ES276648A1 (en) | 1962-10-16 |
Family
ID=22299329
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES276648A Expired ES276648A1 (en) | 1961-04-20 | 1962-04-19 | Procedure for the manufacture of benzodiazepine derivatives (Machine-translation by Google Translate, not legally binding) |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE616024A (en) |
CH (1) | CH411912A (en) |
ES (1) | ES276648A1 (en) |
GB (1) | GB986903A (en) |
SE (1) | SE301976B (en) |
-
1962
- 1962-03-28 CH CH371162A patent/CH411912A/en unknown
- 1962-04-05 GB GB1308862A patent/GB986903A/en not_active Expired
- 1962-04-05 BE BE616024A patent/BE616024A/en unknown
- 1962-04-18 SE SE431862A patent/SE301976B/xx unknown
- 1962-04-19 ES ES276648A patent/ES276648A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
BE616024A (en) | 1962-10-05 |
SE301976B (en) | 1968-07-01 |
CH411912A (en) | 1966-04-30 |
GB986903A (en) | 1965-03-24 |
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