ES276648A1 - Procedure for the manufacture of benzodiazepine derivatives (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the manufacture of benzodiazepine derivatives (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES276648A1
ES276648A1 ES276648A ES276648A ES276648A1 ES 276648 A1 ES276648 A1 ES 276648A1 ES 276648 A ES276648 A ES 276648A ES 276648 A ES276648 A ES 276648A ES 276648 A1 ES276648 A1 ES 276648A1
Authority
ES
Spain
Prior art keywords
translation
manufacture
machine
legally binding
*** translate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES276648A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES276648A1 publication Critical patent/ES276648A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Process for the manufacture of benzodiazepine derivatives of the general formula ** (See formula) ** wherein R1 and R2 represent hydrogen or lower alkyl and R3 represents hydrogen, halogen, lower alkyl or nitro, as well as acid addition salts of said derivatives, which process comprises reacting a quinazoline derivative of the general formula ** (See formula) ** in which X represents halogen, R4 represents hydrogen or nitro and R2 and R3 have the meaning expressed before, with ammonia or a lower alkylamine, nitrate the resulting compound, if a quinazoline derivative is used in which R4 is hydrogen, and, if desired, transform the reaction product into an acid addition salt . (Machine-translation by Google Translate, not legally binding)
ES276648A 1961-04-20 1962-04-19 Procedure for the manufacture of benzodiazepine derivatives (Machine-translation by Google Translate, not legally binding) Expired ES276648A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10422761A 1961-04-20 1961-04-20

Publications (1)

Publication Number Publication Date
ES276648A1 true ES276648A1 (en) 1962-10-16

Family

ID=22299329

Family Applications (1)

Application Number Title Priority Date Filing Date
ES276648A Expired ES276648A1 (en) 1961-04-20 1962-04-19 Procedure for the manufacture of benzodiazepine derivatives (Machine-translation by Google Translate, not legally binding)

Country Status (5)

Country Link
BE (1) BE616024A (en)
CH (1) CH411912A (en)
ES (1) ES276648A1 (en)
GB (1) GB986903A (en)
SE (1) SE301976B (en)

Also Published As

Publication number Publication date
BE616024A (en) 1962-10-05
SE301976B (en) 1968-07-01
CH411912A (en) 1966-04-30
GB986903A (en) 1965-03-24

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