ES285855A1 - A procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES285855A1 ES285855A1 ES285855A ES285855A ES285855A1 ES 285855 A1 ES285855 A1 ES 285855A1 ES 285855 A ES285855 A ES 285855A ES 285855 A ES285855 A ES 285855A ES 285855 A1 ES285855 A1 ES 285855A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- see formula
- formula
- benzophenone
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Process for the manufacture of benzodiazepine derivatives of the general formula ** (See formula) ** where R1 and R2 represent hydrogen or alkyl, R3 represents hydrogen, halogen, alkyl, alkoxy or trifluoromethyl, R4 and R5 individually represent alkyl, and taken together with the nitrogen atom, a monoheterocyclic ring containing at most another heteroatom plus oxygen or nitrogen, and R6 and R7 individually represent hydrogen and, taken together, an additional C-N bond, as well as its salts, process comprising: a) reacting a benzophenone of the general formula ** (See formula) ** with an amino acid of the general formula ** (See formula) ** or one of its esters, or b) reacting said benzophenone with a haloacylamide halide of the general formula ** (See formula) ** and treating 2- (alpha-halo-alkanoyl-amido) -benzophenone formed with ammonia, or c) reductively renting a compound of the general formula ** (See formula) ** where the meaning of the symbols R1, R2, R3, R4, R5, R6 and R7 is the same as stated above, reduce if desired, the 4,5-unsaturated compounds obtained and/or transform the product into a salt obtained. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US178566A US3202665A (en) | 1962-03-09 | 1962-03-09 | 5-piperidino-and 5-diloweralkylamino-2-amino-benzophenones |
Publications (1)
Publication Number | Publication Date |
---|---|
ES285855A1 true ES285855A1 (en) | 1963-08-16 |
Family
ID=22653052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES285855A Expired ES285855A1 (en) | 1962-03-09 | 1963-03-08 | A procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding) |
Country Status (6)
Country | Link |
---|---|
US (1) | US3202665A (en) |
AT (1) | AT242157B (en) |
CH (2) | CH440298A (en) |
ES (1) | ES285855A1 (en) |
GB (1) | GB984707A (en) |
SE (2) | SE318885B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU167950B (en) * | 1973-07-26 | 1976-01-28 | ||
US4064121A (en) * | 1973-07-26 | 1977-12-20 | Richter Gedeon Vegyeszeti Gyar Rt. | Substituted nitrobenzophenone derivatives and a process for the preparation thereof |
EP1812112B1 (en) * | 2004-10-19 | 2011-04-27 | GlaxoSmithKline LLC | Benzodiazepine derivatives as ROCK kinases inhibitors |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2893992A (en) * | 1959-07-07 | I ii i i | ||
US3109843A (en) * | 1963-11-05 | Process for preparing | ||
CH349986A (en) * | 1954-03-03 | 1960-11-15 | Ciba Geigy | Process for the preparation of new basic substituted heterocycles |
US2914563A (en) * | 1957-08-06 | 1959-11-24 | Wm S Merrell Co | Therapeutic composition |
US2926180A (en) * | 1957-06-18 | 1960-02-23 | Universal Oil Prod Co | Condensation of aromatic ketones with carbohydrates and related materials |
US2914564A (en) * | 1957-08-06 | 1959-11-24 | Wm S Merrell Co | Amine derivatives of 1, 1, 2-triphenylethane |
US3045008A (en) * | 1960-02-16 | 1962-07-17 | Pfizer & Co C | Novel 1, 4-diazepines |
-
1962
- 1962-03-09 US US178566A patent/US3202665A/en not_active Expired - Lifetime
-
1963
- 1963-02-07 CH CH149363A patent/CH440298A/en unknown
- 1963-02-12 AT AT115064A patent/AT242157B/en active
- 1963-03-01 GB GB8239/63A patent/GB984707A/en not_active Expired
- 1963-03-07 CH CH1709366A patent/CH457462A/en unknown
- 1963-03-08 ES ES285855A patent/ES285855A1/en not_active Expired
- 1963-03-08 SE SE2567/63A patent/SE318885B/xx unknown
-
1966
- 1966-12-16 SE SE1728266A patent/SE317681B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
SE318885B (en) | 1969-12-22 |
AT242157B (en) | 1965-09-10 |
GB984707A (en) | 1965-03-03 |
CH440298A (en) | 1967-07-31 |
US3202665A (en) | 1965-08-24 |
CH457462A (en) | 1968-06-15 |
DE1445871A1 (en) | 1969-03-13 |
SE317681B (en) | 1969-11-24 |
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