ATE321849T1 - Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren - Google Patents
Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagierenInfo
- Publication number
- ATE321849T1 ATE321849T1 AT98924190T AT98924190T ATE321849T1 AT E321849 T1 ATE321849 T1 AT E321849T1 AT 98924190 T AT98924190 T AT 98924190T AT 98924190 T AT98924190 T AT 98924190T AT E321849 T1 ATE321849 T1 AT E321849T1
- Authority
- AT
- Austria
- Prior art keywords
- peptides
- interact
- poly
- nucleic acid
- acid molecules
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97106753 | 1997-04-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE321849T1 true ATE321849T1 (de) | 2006-04-15 |
Family
ID=8226724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98924190T ATE321849T1 (de) | 1997-04-23 | 1998-04-23 | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
Country Status (7)
Country | Link |
---|---|
US (2) | US6348315B1 (de) |
EP (1) | EP0975748B1 (de) |
JP (1) | JP4086325B2 (de) |
AT (1) | ATE321849T1 (de) |
CA (1) | CA2289691C (de) |
DE (1) | DE69834032T2 (de) |
WO (1) | WO1998048008A1 (de) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE321849T1 (de) * | 1997-04-23 | 2006-04-15 | Univ Zuerich | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
WO1999011777A1 (en) * | 1997-09-03 | 1999-03-11 | Biovation Limited | Methods for protein screening |
US6927025B1 (en) | 1997-09-03 | 2005-08-09 | Biovation Limited | Methods for protein screening |
US20070166741A1 (en) | 1998-12-14 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
CA2373290C (en) * | 1999-05-14 | 2012-04-17 | Enterprise Ireland (Trading As Bioresearch Ireland) | Nucleic acid probe-based diagnostic assays for prokaryotic and eukaryotic organisms |
DE60115405T2 (de) * | 2000-03-31 | 2006-08-03 | Cambridge Antibody Technology Ltd. | Verbesserungen in bezug auf ribosom-komplexe als selektionspartikel |
US7417130B2 (en) | 2000-09-08 | 2008-08-26 | University Of Zurich | Collection of repeat proteins comprising repeat modules |
CA2428732C (en) * | 2000-11-15 | 2018-07-31 | Minerva Biotechnologies Corporation | Methods and kit for simultaneous screening of interactions between a plurality of chemical or biological species and uses thereof |
DE10060959A1 (de) * | 2000-12-06 | 2002-06-20 | Aventis Res & Tech Gmbh & Co | Verfahren zur Isolierung und Identifizierung von Effektoren |
US20040023256A1 (en) * | 2002-01-25 | 2004-02-05 | Puglisi Joseph D. | Translation profiling |
US20050123973A1 (en) * | 2002-02-08 | 2005-06-09 | Shaobing Hua | Methods for generating monoclonal antibody against fusion protein containing peptide fragment derived from membrane protein |
US20040067532A1 (en) | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
CA2505558C (en) * | 2002-11-09 | 2013-07-02 | Avidex Limited | T cell receptor display |
GB0316314D0 (en) * | 2003-07-12 | 2003-08-13 | Univ Belfast | Method |
GB0411771D0 (en) * | 2004-05-26 | 2004-06-30 | Avidex Ltd | Nucleoproteins displaying native T cell receptor libraries |
BRPI0608281B8 (pt) | 2005-04-18 | 2021-05-25 | Amgen Res Munich Gmbh | anticorpo monoclonal humano ou seu fragmento, seu uso no tratamento de doenças inflamatórias, bem como composição farmacêutica que o compreende |
US20070111237A1 (en) * | 2005-09-14 | 2007-05-17 | Maurizio Zanetti | Process for identifying antigenized antibodies using ribosome cell free expression system |
AU2006315347A1 (en) | 2005-11-16 | 2007-05-24 | Ambrx, Inc. | Methods and compositions comprising non-natural amino acids |
US20070166740A1 (en) * | 2006-01-17 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
AR059448A1 (es) | 2006-02-13 | 2008-04-09 | Divergence Inc | Polipeptidos quimericos vegetales de union para el reconocimiento molecular universal |
EP1894939A1 (de) * | 2006-09-01 | 2008-03-05 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Neues Supertag und seine Verwendung |
EP2084528B1 (de) * | 2006-10-20 | 2012-08-29 | Alere Scarborough, Inc. | Tests und vorrichtungen zur identifizierung von krankheitserregern |
US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
WO2009023184A2 (en) * | 2007-08-10 | 2009-02-19 | Protelix, Inc. | Universal fibronectin type iii binding-domain libraries |
US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
EP3753947A1 (de) | 2007-09-14 | 2020-12-23 | Adimab, LLC | Synthetische antikörperbibliotheken mit rationalem design und verwendungen davon |
RU2396336C2 (ru) | 2007-09-27 | 2010-08-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | СПОСОБ ПОЛУЧЕНИЯ АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia |
US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
TWI661833B (zh) | 2007-11-30 | 2019-06-11 | 百慕達商艾伯維生物技術有限責任公司 | 蛋白質調配物及製造其之方法 |
US8865179B2 (en) * | 2008-01-26 | 2014-10-21 | Swey-Shen Alexchen | Aptameric IgE peptides in a protein scaffold as an allergy vaccine |
EP2088432A1 (de) * | 2008-02-11 | 2009-08-12 | MorphoSys AG | Verfahren zur Identifikation eines Antikörpers oder eines Targets |
KR20110036638A (ko) | 2008-07-25 | 2011-04-07 | 리차드 더블유. 와그너 | 단백질 스크리닝 방법 |
KR101698362B1 (ko) | 2008-11-03 | 2017-01-20 | 몰리큘라 파트너스 아게 | Vegf-a 수용체 상호작용을 억제하는 결합 단백질 |
WO2011051333A1 (en) | 2009-10-30 | 2011-05-05 | Novartis Ag | Universal fibronectin type iii bottom-side binding domain libraries |
JP5863045B2 (ja) | 2010-03-11 | 2016-02-16 | 国立研究開発法人理化学研究所 | ポリペプチド配列の選択方法、並びに金属酸化物または含珪素化合物結合ペプチドおよびその利用 |
TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制vegf-a受體交互作用的經修飾結合性蛋白質 |
CN103282560B (zh) | 2010-07-16 | 2016-08-03 | 阿迪马布有限责任公司 | 抗体文库 |
WO2012016245A2 (en) | 2010-07-30 | 2012-02-02 | Novartis Ag | Fibronectin cradle molecules and libraries thereof |
CA2818969C (en) | 2010-11-26 | 2020-04-14 | Molecular Partners Ag | Improved n-terminal capping modules for designed ankyrin repeat proteins |
JP5948673B2 (ja) | 2011-03-10 | 2016-07-06 | ジーンフロンティア株式会社 | リポ多糖混入量を低減した蛋白質合成用組成物、該組成物を用いた蛋白質製造方法 |
EP2686349B1 (de) | 2011-03-15 | 2020-12-09 | X-Body, Inc. | Antikörper-screening-verfahren |
CA2833917C (en) | 2011-04-28 | 2020-04-28 | The Board Of Trustees Of The Leland Stanford Junior University | Identification of polynucleotides associated with a sample. |
EP2702069A4 (de) | 2011-04-29 | 2015-04-29 | Janssen Biotech Inc | Il4/il13-bindende repeat-proteine und verwendungen davon |
US9863936B2 (en) | 2011-05-23 | 2018-01-09 | Riken | Nucleic acid construct, nucleic acid-protein complex, and use thereof |
WO2013085972A1 (en) | 2011-12-05 | 2013-06-13 | X-Body, Inc. | Pdgf receptor beta binding polypeptides |
CN110317259A (zh) | 2012-03-27 | 2019-10-11 | 株式会社绿十字 | 表皮生长因子受体表面抗原的表位及其用途 |
AU2013283296A1 (en) | 2012-06-28 | 2015-02-05 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
EP2738180A1 (de) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Bindeproteine mit mindestens zwei Bindedomänen gegen HER2 |
DK2989239T3 (en) | 2013-04-25 | 2018-09-03 | Sutro Biopharma Inc | Selection of Fab fragments using ribosome display technology |
WO2014176439A1 (en) | 2013-04-25 | 2014-10-30 | Sutro Biopharma, Inc. | The use of lambda-gam protein in ribosomal display technology |
CN105659090B (zh) | 2013-06-28 | 2020-03-06 | X博迪公司 | 用于鉴别靶细胞特异性靶表位的靶抗原发现、表型筛选及其用途 |
WO2015042528A1 (en) | 2013-09-23 | 2015-03-26 | X-Body Biosciences, Inc. | Methods and compositions for generation of binding agents against cell surface antigens |
AU2016245887B2 (en) | 2015-04-10 | 2021-09-23 | Adimab, Llc. | Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69032483T2 (de) * | 1989-10-05 | 1998-11-26 | Optein, Inc., Seattle, Wash. | Zellfreie synthese und isolierung von genen und polypeptiden |
WO1993003172A1 (en) * | 1991-08-01 | 1993-02-18 | University Research Corporation | Systematic polypeptide evolution by reverse translation |
US5466580A (en) * | 1993-09-22 | 1995-11-14 | Xoma Corporation | Method for quantifying BPI in body fluids |
WO1995011922A1 (en) * | 1993-10-29 | 1995-05-04 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
US5922545A (en) * | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
ATE321849T1 (de) * | 1997-04-23 | 2006-04-15 | Univ Zuerich | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
-
1998
- 1998-04-23 AT AT98924190T patent/ATE321849T1/de active
- 1998-04-23 CA CA002289691A patent/CA2289691C/en not_active Expired - Fee Related
- 1998-04-23 JP JP54503898A patent/JP4086325B2/ja not_active Expired - Fee Related
- 1998-04-23 EP EP98924190A patent/EP0975748B1/de not_active Expired - Lifetime
- 1998-04-23 WO PCT/EP1998/002420 patent/WO1998048008A1/en active IP Right Grant
- 1998-04-23 DE DE69834032T patent/DE69834032T2/de not_active Expired - Lifetime
-
1999
- 1999-10-22 US US09/425,585 patent/US6348315B1/en not_active Expired - Lifetime
-
2001
- 2001-09-14 US US09/953,321 patent/US6589741B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1998048008A1 (en) | 1998-10-29 |
JP2001521395A (ja) | 2001-11-06 |
CA2289691C (en) | 2008-01-15 |
JP4086325B2 (ja) | 2008-05-14 |
US20020115083A1 (en) | 2002-08-22 |
US6348315B1 (en) | 2002-02-19 |
US6589741B2 (en) | 2003-07-08 |
CA2289691A1 (en) | 1998-10-29 |
DE69834032D1 (de) | 2006-05-18 |
EP0975748B1 (de) | 2006-03-29 |
DE69834032T2 (de) | 2006-12-07 |
EP0975748A1 (de) | 2000-02-02 |
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