ATE321849T1 - Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren - Google Patents

Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren

Info

Publication number
ATE321849T1
ATE321849T1 AT98924190T AT98924190T ATE321849T1 AT E321849 T1 ATE321849 T1 AT E321849T1 AT 98924190 T AT98924190 T AT 98924190T AT 98924190 T AT98924190 T AT 98924190T AT E321849 T1 ATE321849 T1 AT E321849T1
Authority
AT
Austria
Prior art keywords
peptides
interact
poly
nucleic acid
acid molecules
Prior art date
Application number
AT98924190T
Other languages
English (en)
Inventor
Andreas Plueckthun
Jozef Hanes
Lutz Jermutus
Original Assignee
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Zuerich filed Critical Univ Zuerich
Application granted granted Critical
Publication of ATE321849T1 publication Critical patent/ATE321849T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT98924190T 1997-04-23 1998-04-23 Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren ATE321849T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97106753 1997-04-23

Publications (1)

Publication Number Publication Date
ATE321849T1 true ATE321849T1 (de) 2006-04-15

Family

ID=8226724

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98924190T ATE321849T1 (de) 1997-04-23 1998-04-23 Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren

Country Status (7)

Country Link
US (2) US6348315B1 (de)
EP (1) EP0975748B1 (de)
JP (1) JP4086325B2 (de)
AT (1) ATE321849T1 (de)
CA (1) CA2289691C (de)
DE (1) DE69834032T2 (de)
WO (1) WO1998048008A1 (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE321849T1 (de) * 1997-04-23 2006-04-15 Univ Zuerich Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren
WO1999011777A1 (en) * 1997-09-03 1999-03-11 Biovation Limited Methods for protein screening
US6927025B1 (en) 1997-09-03 2005-08-09 Biovation Limited Methods for protein screening
US20070166741A1 (en) 1998-12-14 2007-07-19 Somalogic, Incorporated Multiplexed analyses of test samples
CA2373290C (en) * 1999-05-14 2012-04-17 Enterprise Ireland (Trading As Bioresearch Ireland) Nucleic acid probe-based diagnostic assays for prokaryotic and eukaryotic organisms
DE60115405T2 (de) * 2000-03-31 2006-08-03 Cambridge Antibody Technology Ltd. Verbesserungen in bezug auf ribosom-komplexe als selektionspartikel
US7417130B2 (en) 2000-09-08 2008-08-26 University Of Zurich Collection of repeat proteins comprising repeat modules
CA2428732C (en) * 2000-11-15 2018-07-31 Minerva Biotechnologies Corporation Methods and kit for simultaneous screening of interactions between a plurality of chemical or biological species and uses thereof
DE10060959A1 (de) * 2000-12-06 2002-06-20 Aventis Res & Tech Gmbh & Co Verfahren zur Isolierung und Identifizierung von Effektoren
US20040023256A1 (en) * 2002-01-25 2004-02-05 Puglisi Joseph D. Translation profiling
US20050123973A1 (en) * 2002-02-08 2005-06-09 Shaobing Hua Methods for generating monoclonal antibody against fusion protein containing peptide fragment derived from membrane protein
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
CA2505558C (en) * 2002-11-09 2013-07-02 Avidex Limited T cell receptor display
GB0316314D0 (en) * 2003-07-12 2003-08-13 Univ Belfast Method
GB0411771D0 (en) * 2004-05-26 2004-06-30 Avidex Ltd Nucleoproteins displaying native T cell receptor libraries
BRPI0608281B8 (pt) 2005-04-18 2021-05-25 Amgen Res Munich Gmbh anticorpo monoclonal humano ou seu fragmento, seu uso no tratamento de doenças inflamatórias, bem como composição farmacêutica que o compreende
US20070111237A1 (en) * 2005-09-14 2007-05-17 Maurizio Zanetti Process for identifying antigenized antibodies using ribosome cell free expression system
AU2006315347A1 (en) 2005-11-16 2007-05-24 Ambrx, Inc. Methods and compositions comprising non-natural amino acids
US20070166740A1 (en) * 2006-01-17 2007-07-19 Somalogic, Incorporated Multiplexed analyses of test samples
AR059448A1 (es) 2006-02-13 2008-04-09 Divergence Inc Polipeptidos quimericos vegetales de union para el reconocimiento molecular universal
EP1894939A1 (de) * 2006-09-01 2008-03-05 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Neues Supertag und seine Verwendung
EP2084528B1 (de) * 2006-10-20 2012-08-29 Alere Scarborough, Inc. Tests und vorrichtungen zur identifizierung von krankheitserregern
US8470966B2 (en) 2007-08-10 2013-06-25 Protelica, Inc. Universal fibronectin type III binding-domain libraries
US8680019B2 (en) * 2007-08-10 2014-03-25 Protelica, Inc. Universal fibronectin Type III binding-domain libraries
WO2009023184A2 (en) * 2007-08-10 2009-02-19 Protelix, Inc. Universal fibronectin type iii binding-domain libraries
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
EP3753947A1 (de) 2007-09-14 2020-12-23 Adimab, LLC Synthetische antikörperbibliotheken mit rationalem design und verwendungen davon
RU2396336C2 (ru) 2007-09-27 2010-08-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
TWI661833B (zh) 2007-11-30 2019-06-11 百慕達商艾伯維生物技術有限責任公司 蛋白質調配物及製造其之方法
US8865179B2 (en) * 2008-01-26 2014-10-21 Swey-Shen Alexchen Aptameric IgE peptides in a protein scaffold as an allergy vaccine
EP2088432A1 (de) * 2008-02-11 2009-08-12 MorphoSys AG Verfahren zur Identifikation eines Antikörpers oder eines Targets
KR20110036638A (ko) 2008-07-25 2011-04-07 리차드 더블유. 와그너 단백질 스크리닝 방법
KR101698362B1 (ko) 2008-11-03 2017-01-20 몰리큘라 파트너스 아게 Ｖｅｇｆ－ａ 수용체 상호작용을 억제하는 결합 단백질
WO2011051333A1 (en) 2009-10-30 2011-05-05 Novartis Ag Universal fibronectin type iii bottom-side binding domain libraries
JP5863045B2 (ja) 2010-03-11 2016-02-16 国立研究開発法人理化学研究所 ポリペプチド配列の選択方法、並びに金属酸化物または含珪素化合物結合ペプチドおよびその利用
TWI510246B (zh) 2010-04-30 2015-12-01 Molecular Partners Ag 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質
CN103282560B (zh) 2010-07-16 2016-08-03 阿迪马布有限责任公司 抗体文库
WO2012016245A2 (en) 2010-07-30 2012-02-02 Novartis Ag Fibronectin cradle molecules and libraries thereof
CA2818969C (en) 2010-11-26 2020-04-14 Molecular Partners Ag Improved n-terminal capping modules for designed ankyrin repeat proteins
JP5948673B2 (ja) 2011-03-10 2016-07-06 ジーンフロンティア株式会社 リポ多糖混入量を低減した蛋白質合成用組成物、該組成物を用いた蛋白質製造方法
EP2686349B1 (de) 2011-03-15 2020-12-09 X-Body, Inc. Antikörper-screening-verfahren
CA2833917C (en) 2011-04-28 2020-04-28 The Board Of Trustees Of The Leland Stanford Junior University Identification of polynucleotides associated with a sample.
EP2702069A4 (de) 2011-04-29 2015-04-29 Janssen Biotech Inc Il4/il13-bindende repeat-proteine und verwendungen davon
US9863936B2 (en) 2011-05-23 2018-01-09 Riken Nucleic acid construct, nucleic acid-protein complex, and use thereof
WO2013085972A1 (en) 2011-12-05 2013-06-13 X-Body, Inc. Pdgf receptor beta binding polypeptides
CN110317259A (zh) 2012-03-27 2019-10-11 株式会社绿十字 表皮生长因子受体表面抗原的表位及其用途
AU2013283296A1 (en) 2012-06-28 2015-02-05 Molecular Partners Ag Designed ankyrin repeat proteins binding to platelet-derived growth factor
EP2738180A1 (de) 2012-11-30 2014-06-04 Molecular Partners AG Bindeproteine mit mindestens zwei Bindedomänen gegen HER2
DK2989239T3 (en) 2013-04-25 2018-09-03 Sutro Biopharma Inc Selection of Fab fragments using ribosome display technology
WO2014176439A1 (en) 2013-04-25 2014-10-30 Sutro Biopharma, Inc. The use of lambda-gam protein in ribosomal display technology
CN105659090B (zh) 2013-06-28 2020-03-06 X博迪公司 用于鉴别靶细胞特异性靶表位的靶抗原发现、表型筛选及其用途
WO2015042528A1 (en) 2013-09-23 2015-03-26 X-Body Biosciences, Inc. Methods and compositions for generation of binding agents against cell surface antigens
AU2016245887B2 (en) 2015-04-10 2021-09-23 Adimab, Llc. Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69032483T2 (de) * 1989-10-05 1998-11-26 Optein, Inc., Seattle, Wash. Zellfreie synthese und isolierung von genen und polypeptiden
WO1993003172A1 (en) * 1991-08-01 1993-02-18 University Research Corporation Systematic polypeptide evolution by reverse translation
US5466580A (en) * 1993-09-22 1995-11-14 Xoma Corporation Method for quantifying BPI in body fluids
WO1995011922A1 (en) * 1993-10-29 1995-05-04 Affymax Technologies N.V. In vitro peptide and antibody display libraries
US5922545A (en) * 1993-10-29 1999-07-13 Affymax Technologies N.V. In vitro peptide and antibody display libraries
ATE321849T1 (de) * 1997-04-23 2006-04-15 Univ Zuerich Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren

Also Published As

Publication number Publication date
WO1998048008A1 (en) 1998-10-29
JP2001521395A (ja) 2001-11-06
CA2289691C (en) 2008-01-15
JP4086325B2 (ja) 2008-05-14
US20020115083A1 (en) 2002-08-22
US6348315B1 (en) 2002-02-19
US6589741B2 (en) 2003-07-08
CA2289691A1 (en) 1998-10-29
DE69834032D1 (de) 2006-05-18
EP0975748B1 (de) 2006-03-29
DE69834032T2 (de) 2006-12-07
EP0975748A1 (de) 2000-02-02

Similar Documents

Publication Publication Date Title
ATE321849T1 (de) Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren
DE69939896D1 (de) Methoden zur detektion von nukleinsäuren unter verwendung von zymogenen und dazugehörige kits
PT1482040E (pt) Homologos nl3 de ligandos do receptor tirosina-quinase tie
ATE310090T1 (de) Gereinigte coprinus laccasen und nukleinsäuren welche dafür kodieren
DE59804008D1 (de) Verfahren zur identifikation von nucleinsäuren durch matrix-assistierte laser desorptions/ionisations massenspektrometrie
WO2002004523A3 (en) Artificial antibody polypeptides
WO1998022589A3 (en) Survivin, a protein that inhibits cellular apoptosis, and its modulation
ATE470712T1 (de) Nukleinsäureliganden mit hoher affinität zu dem c5-protein des komplementsystems
DE50012831D1 (de) Verfahren zur verbindung von molekularen substanzen
ATE319814T1 (de) Luciferase, fluoreszenzproteine, für luciferase und fluoreszenzproteine kodierend nukleinsaüre und ihre verwendung in der diagnose, hoch- durchsatz screeningsverfahren
DE60238449D1 (de) Nukleinsäuren, polypeptide und verfahren zur apoptosemodulation
ATE516351T1 (de) Verfahren zur molekularen evolution der proteinfunktion in vitro
DE60319369D1 (de) Nukleinsäuren, polypeptide und verfahren zur modulierung von apoptosis
AU6177101A (en) In vitro evolution of nucleic acids and encoded polypeptide
DE69902796D1 (de) Verfahren zur reinigung von biomolekül- oder proteinkomplexen
ATE214430T1 (de) Verfahren zur erkennung von lebenden mikrobiologischen verunreinigungen in einer lebensmittelprobe
WO2002042458A3 (en) G protein coupled receptors
DE69927593D1 (de) Verfahren zur abtrennung von hydroxymethylthiobuttersäure
ATE346165T1 (de) Verfahren zur trennung und/oder erkennung von dns-molekülen
WO2003070768A3 (en) Cd40 splice variants,method of detection thereof, compositions comprising said variant(s) or nucleic acid encoding the same and use thereof
ATE468396T1 (de) Nukleinsäureliganden mit hoher affinität für das c1q protein des komplementsystems
ATE351909T1 (de) Neue peptidfragmente zur reinigung von proteinen
DE69634297D1 (de) Verfahren zur verlängerung der expression eines interessierenden gens unter verwendung von löslichen ctla4 molekülen
ATE377092T1 (de) Verfahren zur isolierung und charakterisierung potentieller funktionen ausgehend von einer biologischen probe, welche nukleinsäuren enthält
EA200100440A1 (ru) Ген prv-1 и его применение

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0975748

Country of ref document: EP