ES2536438T3 - Métodos y composiciones basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón - Google Patents

Métodos y composiciones basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón Download PDF

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ES2536438T3
ES2536438T3 ES12165748.0T ES12165748T ES2536438T3 ES 2536438 T3 ES2536438 T3 ES 2536438T3 ES 12165748 T ES12165748 T ES 12165748T ES 2536438 T3 ES2536438 T3 ES 2536438T3
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mir
level
lung cancer
prognosis
mir gene
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Carlo Croce
Nozomu Yanaihara
Curtis Harris
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Ohio State University Research Foundation
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Ohio State University Research Foundation
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Abstract

Un método para determinar el pronóstico de un sujeto con cáncer de pulmón, que comprende la medición del nivel de productos génicos de miR en una muestra de ensayo de dicho sujeto, en el que: la firma de los productos génicos de miR está asociada con un pronóstico adverso en cáncer de pulmón; y una alteración del nivel de los productos génicos de miR en la muestra de ensayo de pulmón, con respecto al nivel de los productos génicos correspondientes de miR en una muestra de control, es indicativa de un pronóstico adverso, en donde el cáncer de pulmón es un adenocarcinoma de pulmón, y los productos génicos de miR consisten en miR-155 y let-7a-2; y en donde el nivel del producto génico de miR-155 en la muestra de ensayo es mayor que el nivel del producto génico correspondiente de miR en la muestra de control, y en donde el nivel del producto génico de let-7a-2 en la muestra de ensayo es menor que el nivel del producto génico correspondiente de miR en la muestra de control.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
E12165748
07-05-2015
Las Tablas 1a y 1b describen las secuencias de nucleótidos de microARN humanos precursores y maduros. Tabla 1a-Secuencias de precursores de microARN humano
Nombre del Precursor
Secuencia (de 5’ a 3’)* SEC ID Nº
let-7A-1
1
let-7a-2
2
let-7a-3
3
let-7a-4
imagen6 4
let-7b
imagen7 5
let-7c
6
let-7d
7
let-7d-v1
8
let-7d-v2
9
let-7e
10
let-7f-1
11
let-7f-2-1
12
let-7f-2-2
13
let-7g
14
E12165748
07-05-2015 E12165748
let-7i
15
miR-1b-1-1
imagen8 16
miR-1b-1-2
17
miR-1b-2
18
miR-1b
19
miR-1d
imagen9 20
miR-7-1a
21
miR-7-1b
22
miR-7-2
23
miR-7-3
24
miR-9-1
25
miR-9-2
26
miR-9-3
27
miR-10a
28
07-05-2015 E12165748
miR-10b
29
miR-15a-2
30
miR-15a
31
miR-15b-1
32
miR-15b-2
33
miR-16-1
imagen10 34
miR-16-2
35
miR-16-13
36
miR-17
imagen11 37
miR-18
38
miR-18-13
39
miR-19a
40
miR-19a-13
41
miR-19b-1
imagen12 42
miR-19b-2
43
07-05-2015 E12165748
miR-19b-13
44
miR-19b-X
imagen13 45
miR-20 (miR-20a)
46
miR-21
47
miR-21-17
imagen14 48
miR-22
49
miR-23a
50
miR-23b
51
miR-23-19
52
miR-24-1
imagen15 53
miR-24-2
imagen16 54
miR-24-19
55
miR-24-9
56
miR-25
57
miR-26a
58
miR-26a-1
imagen17 59
07-05-2015 E12165748
miR-26a-2
60
miR-26b
imagen18 61
miR-27a
62
miR-27b-1
63
miR-27b-2
imagen19 64
miR-27-19
65
miR-28
imagen20 66
miR-29a-2
67
miR-29a
68
miR-29b-1
69
miR-29b-2
70
miR-29c
71
miR-30a
72
miR-30b-1
73
miR-30b-2
74
miR-30c
75
07-05-2015 E12165748
miR-30d
76
miR-30e
77
miR-31
imagen21 78
miR-32
79
miR-33b
80
miR-33b-2
81
miR-33
82
miR-34-a
83
miR-34-b
84
miR-34-c
85
miR-91-13
86
miR-92-1
87
miR-92 -2
imagen22 88
miR-93-1 (miR93-2)
89
miR-95-4
90
07-05-2015 E12165748
miR-96-7
91
miR-97-6 (miR30*)
92
miR-98
93
miR-99b
imagen23 94
miR-99a
95
miR-100-1/2
96
miR-100-11
97
miR-101-1/2
98
miR-101
99
miR-101-1
100
miR-101-2
101
miR-101-9
102
miR-102-1
103
miR-102-7.1 (miR-102-7.2)
104
miR-103-2
105
07-05-2015 E12165748
miR-103-1
106
miR-104-17
107
miR-105-1
imagen24 108
miR-105-2
109
miR-106-a
110
miR-106-b
111
miR-107
imagen25 112
miR-108-1pequeño
113
miR-108-2pequeño
imagen26 114
miR-122a-1
115
miR-122a-2
116
miR-123
imagen27 117
miR-124a-1
118
miR-124a-2
119
miR-124a-3
120
miR-124a
121
miR-124b
122
07-05-2015 E12165748
miR-125a-1
123
miR-125a-2
124
miR-125b-1
imagen28 125
miR-125b-2
126
miR-126-1
127
miR-126-2
imagen29 128
miR-127-1
129
miR-127-2
130
miR-128a
131
miR-128b
132
miR-128
133
miR-129-1
134
miR-129-2
135
miR-130a
136
miR-131-1
137
07-05-2015 E12165748
miR-131-3
138
miR-131
139
miR-132-1
140
miR-132-2
imagen30 141
miR-133a-1
imagen31 142
miR-133a-2
143
miR-133
144
miR-133b
145
miR-133bpequeño
146
miR-134-1
147
miR-134-2
148
miR-135a-1
149
miR-135a-2 (miR135-2)
150
miR-135
imagen32 151
miR-135b
152
miR-136-1
imagen33 153
07-05-2015 E12165748
miR-136-2
154
miR-137
155
miR-138-1
imagen34 156
miR-138-2
imagen35 157
miR-138
158
miR-139
159
miR-140
160
miR-140as
imagen36 161
miR-140s
162
miR-141-1
163
miR-141-2
imagen37 164
miR-142
imagen38 165
miR-143-1
166
miR-143-2
167
miR-144-1
168
miR-144-2
169
miR-145-1
170
07-05-2015 E12165748
miR-1 45-2
171
miR-146-1
172
miR-146-2
imagen39 173
miR-147
174
miR-148a (miR148)
175
miR-148b
imagen40 176
miR-148bpequeño
177
miR-149-1
178
miR-149-2
179
miR-150-1
180
miR-150-2
181
miR-151
imagen41 182
miR-151-2
183
miR-152-1
184
miR-152-2
185
miR-153-1-1
186
miR-153-1-2
imagen42 187
07-05-2015 E12165748
miR-153-2-1
188
miR-153-2-2
189
miR-154-1
imagen43 190
miR-154-2
imagen44 191
miR-155
imagen45 192
miR-156 = miR157=solapamiento miR-141
imagen46 193
miR-158pequeño = miR192
imagen47 194
miR-159-1pequeño
imagen48 195
miR-161pequeño
imagen49 196
miR-163-1bpequeño
197
miR-163-3pequeño
198
miR-162
199
miR-175pequeño =miR224
200
miR-177pequeño
201
miR-180pequeño
202
07-05-2015 E12165748
miR-181a
203
miR-181b-1
204
miR-181b-2
imagen50 205
miR-181c
206
miR-182-as
imagen51 207
miR-182
208
miR-183
209
miR-184-1
210
miR-184-2
imagen52 211
miR-185-1
212
miR-185-2
213
miR-186-1
214
miR-186-2
215
miR-187
216
miR-188-1
217
07-05-2015 E12165748
miR-188-2
218
miR-189-1
219
miR-189-2
imagen53 220
miR-190-1
221
miR-190-2
imagen54 222
miR-191-1
223
miR-191-2
224
miR-192-2/3
225
miR-192
226
miR-193-1
227
miR-193-2
228
miR-194-1
imagen55 229
miR-194-2
230
miR-195-1
imagen56 231
miR-195-2
232
miR-196-1
233
miR-196a-1
234
07-05-2015 E12165748
miR-196a-2 (miR196-2)
235
miR-196
imagen57 236
miR-196b
237
miR-197
238
miR-197-2
239
miR-198
240
miR-199a-1
241
miR-199a-2
242
miR-199b
243
miR-199s
244
miR-200a
245
miR-200b
246
miR-200c
imagen58 247
miR-202
248
miR-203
imagen59 249
07-05-2015 E12165748
miR-204
250
miR-205
251
miR-206-1
252
miR-206-2
253
miR-208
254
miR-210
255
miR-211
256
miR-212
imagen60 257
miR-213-2
258
miR-213
259
miR-95-4
260
miR-215
261
miR-216
262
07-05-2015 E12165748
miR-217
263
miR-218-1
imagen61 264
miR-218-2
265
miR-219
266
miR-219-1
267
miR-219-2
268
miR-220
269
miR-221
270
miR-222
271
miR-223
272
miR-95-4
imagen62 273
miR-294-1 (chr16)
274
miR-296
275
miR-299
276
07-05-2015 E12165748
miR-301
277
miR-302a
278
miR-302b
imagen63 279
miR-302c
280
miR-302d
281
miR-320
imagen64 282
miR-321
283
miR-323
imagen65 284
miR-324
imagen66 285
miR-325
286
miR-326
287
miR-328
288
miR-330
289
miR-331
290
miR-335
291
miR-337
292
miR-338
293
miR-339
294
07-05-2015
miR-340
295
miR-342
296
miR-345
297
miR-346
298
miR-367
imagen67 299
miR-368
300
miR-369
301
miR-370
302
miR-371
303
miR-372
304
miR-373
305
miR-374
306
miR-hes1
307
miR-hes2
308
miR-hes3
309
* Una secuencia subrayada dentro de una secuencia de precursor corresponde a un transcrito de miR procesado maduro (véase la Tabla 1b). Algunas secuencias de precursor tienen dos secuencias subrayadas que indican dos miR maduros diferentes que se obtienen a partir del mismo precursor. Todas las secuencias son humanas.
Tabla 1b -Secuencias de microRNA Maduro Humano.
Nombre de miRNA Maduro
Secuencia de miRNA Maduro (5’ a 3’) SEC ID Nº microRNA precursor correspondiente(s); véase la Tabla 1a
let-7a
ugagguaguagguuguauaguu 310 let-7a-1; let-7a-2; let-7a-3; let-7a-4
let-7b
ugagguaguagguugugugguu 311
let-7b
let-7c
ugagguaguagguuguaugguu 312
let-7c
let-7d
agagguaguagguugcauagu 313 let-7d; let-7d-v1
let-7e
ugagguaggagguuguauagu 314
let-7e
let-7f
ugagguaguagauuguauaguu 315 let-7f-1; let-7f-2-1; let-7f-2-2
E12165748
07-05-2015 E12165748
let-7g
ugagguaguaguuuguacagu 316
let-7g
let-7i
ugagguaguaguuugugcu 317
let-7i
miR-1
uggaauguaaagaaguaugua 318 miR-1b; miR-1b-1; miR-1b-2
miR-7
uggaagacuagugauuuuguu 319 miR-7-1; miR-7-1a; miR-7-2; miR-7-3
miR-9
ucuuugguuaucuagcuguauga 320 miR-9-1; miR-9-2; miR-9-3
miR-9*
uaaagcuagauaaccgaaagu 321 miR-9-1; miR-9-2; miR-9-3
miR-10a
uacccuguagauccgaauuugug 322
miR-10a
miR-10b
uacccuguagaaccgaauuugu 323
miR-10b
miR-15a
uagcagcacauaaugguuugug 324 miR-15a; miR-15a-2
miR-15b
uagcagcacaucaugguuuaca 325
miR-15b
miR-16
uagcagcacguaaauauuggcg 326 miR-16-1; miR-16-2; miR-16-13
miR-17-5p
caaagugcuuacagugcagguagu 327 miR-17
miR-17-3p
acugcagugaaggcacuugu 328 miR-17
miR-18
uaaggugcaucuagugcagaua 329 miR-18; miR-18-13
miR-19a
ugugcaaaucuaugcaaaacuga 330 miR-19a; miR-19a-13
miR-19b
ugugcaaauccaugcaaaacuga 331 miR-19b-1; miR-19b-2
miR-20
uaaagugcuuauagugcaggua 332 miR-20 (miR-20a)
miR-21
uagcuuaucagacugauguuga 333 miR-21; miR-21-17
miR-22
aagcugccaguugaagaacugu 334
miR-22
miR-23a
aucacauugccagggauuucc 335
miR-23a
miR-23b
aucacauugccagggauuaccac 336
miR-23b
miR-95-4
uggcucaguucagcaggaacag 337 miR-24-1; miR-24-2; miR-24-19; miR24-9
miR-25
cauugcacuugucucggucuga 338
miR-25
miR-26a
uucaaguaauccaggauaggcu 339 miR-26a; miR-26a-1; miR-26a-2
miR-26b
uucaaguaauucaggauaggu 340
miR-26b
miR-27a
uucacaguggcuaaguuccgcc 341
miR-27a
miR-27b
uucacaguggcuaaguucug 342 miR-27b-1; miR-27b-2
miR-28
aaggagcucacagucuauugag 343
miR-28
miR-29a
cuagcaccaucugaaaucgguu 344 miR-29a-2; miR-29a
miR-29b
uagcaccauuugaaaucagu 345 miR-29b-1; miR-29b-2
miR-29c
uagcaccauuugaaaucgguua 346
miR-29c
miR-30a-5p
uguaaacauccucgacuggaagc 347 miR-30a
miR-30a-3p
cuuucagucggauguuugcagc 348 miR-30a
miR-30b
uguaaacauccuacacucagc 349 miR-30b-1; miR-30b-2
miR-30c
uguaaacauccuacacucucagc 350
miR-30c
miR-30d
uguaaacauccccgacuggaag 351
miR-30d
miR-30e
uguaaacauccuugacugga 352
miR-30e
miR-31
ggcaagaugcuggcauagcug 353
miR-31
miR-32
uauugcacauuacuaaguugc 354
miR-32
miR-33
gugcauuguaguugcauug 355 miR-33; miR-33b
miR-34a
uggcagugucuuagcugguugu 356
miR-34a
miR-34b
aggcagugucauuagcugauug 357
miR-34b
miR-34c
aggcaguguaguuagcugauug 358
miR-34c
miR-92
uauugcacuugucccggccugu 359 miR-92-2; miR-92-1
miR-93
aaagugcuguucgugcagguag 360 miR-93-1; miR-93-2
miR-95
uucaacggguauuuauugagca 361
miR-95
miR-96
uuuggcacuagcacauuuuugc 362
miR-96
miR-98
ugagguaguaaguuguauuguu 363
miR-98
miR-99a
aacccguagauccgaucuugug 364
miR-99a
miR-99b
cacccguagaaccgaccuugcg 365
miR-99b
miR-100
uacaguacugugauaacugaag 366
miR-100
miR-101
uacaguacugugauaacugaag 367 miR-101-1; miR-101-2
miR-103
agcagcauuguacagggcuauga 368 miR-103-1
miR-105
ucaaaugcucagacuccugu 369
miR-105
miR-106-a
aaaagugcuuacagugcagguagc 370
miR-106-a
miR-106-b
uaaagugcugacagugcagau 371
miR-106-b
miR-107
agcagcauuguacagggcuauca 372
miR-107
miR-122a
uggagugugacaaugguguuugu 373 miR-122a-1; miR-122a-2
miR-124a
uuaaggcacgcggugaaugcca 374 miR-124a-1; miR-124a-2; miR-124a-3
miR-125a
ucccugagacccuuuaaccugug 375 miR-125a-1; miR-125a-2
07-05-2015 E12165748
miR-125b
ucccugagacccuaacuuguga 376 miR-125b-1; miR-125b-2
miR-126*
cauuauuacuuuugguacgcg 377 miR-126-1; miR-126-2
miR-126
ucguaccgugaguaauaaugc 378 miR-126-1; miR-126-2
miR-127
ucggauccgucugagcuuggcu 379 miR-127-1; miR-127-2
miR-128a
ucacagugaaccggucucuuuu 380 miR-128; miR-128a
miR-128b
ucacagugaaccggucucuuuc 381
miR-128b
miR-129
cuuuuugcggucugggcuugc 382 miR-129-1; miR-129-2
miR-130a
cagugcaauguuaaaagggc 383
miR-130a
miR-130b
cagugcaaugaugaaagggcau 384
miR-130b
miR-132
uaacagucuacagccauggucg 385 miR-132-1
miR-133a
uugguccccuucaaccagcugu 386 miR-133a-1; miR-133a-2
miR-133b
uugguccccuucaaccagcua 387
miR-133b
miR-95-4
ugugacugguugaccagaggg 388 miR-134-1; miR-134-2
miR-135a
uauggcuuuuuauuccuauguga 389 miR-135a; miR-135a-2 (miR-135-2)
miR-135b
uauggcuuuucauuccuaugug 390
miR-135b
miR-136
acuccauuuguuuugaugaugga 391 miR-136-1; miR-136-2
miR-137
uauugcuuaagaauacgcguag 392
miR-137
miR-138
agcugguguugugaauc 393 miR-138-1; miR-138-2
miR-139
ucuacagugcacgugucu 394
miR-139
miR-140
agugguuuuacccuaugguag 395 miR-140; miR-140as; miR-140s
miR-141
aacacugucugguaaagaugg 396 miR-141-1; miR-141-2
miR-142-3p
uguaguguuuccuacuuuaugga 397 miR-142
miR-142-5p
cauaaaguagaaagcacuac 398 miR-142
miR-143
ugagaugaagcacuguagcuca 399 miR-143-1
miR-144
uacaguauagaugauguacuag 400 miR-144-1; miR-144-2
miR-145
guccaguuuucccaggaaucccuu 401 miR-145-1; miR-145-2
miR-146
ugagaacugaauuccauggguu 402 miR-146-1; miR-146-2
miR-147
guguguggaaaugcuucugc 403
miR-147
miR-148a
ucagugcacuacagaacuuugu 404 miR-148a (miR-148)
miR-148b
ucagugcaucacagaacuuugu 405
miR-148b
miR-149
ucuggcuccgugucuucacucc 406
miR-149
miR-150
ucucccaacccuuguaccagug 407 miR-150-1; miR-150-2
miR-151
acuagacugaagcuccuugagg 408
miR-151
miR-152
ucagugcaugacagaacuugg 409 miR-152-1; miR-152-2
miR-153
uugcauagucacaaaaguga 410 miR-153-1-1; miR-153-1-2; miR-1532-1; m iR-153-2-2
miR-154
uagguuauccguguugccuucg 411 miR-154-1; miR-154-2
miR-154*
aaucauacacgguugaccuauu 412 miR-154-1; miR-154-2
miR-155
uuaaugcuaaucgugauagggg 413
miR-155
miR-181a
aacauucaacgcugucggugagu 414
miR-181a
miR-181b
aacauucauugcugucgguggguu 415 miR-181b-1; miR-181b-2
miR-181c
aacauucaaccugucggugagu 416
miR-181c
miR-182
uuuggcaaugguagaacucaca 417 miR-182; miR-182as
miR-182*
ugguucuagacuugccaacua 418 miR-182; miR-182as
miR-183
uauggcacugguagaauucacug 419
miR-183
miR-95-4
uggacggagaacugauaagggu 420 miR-184-1; miR-184-2
miR-185
uggagagaaaggcaguuc 421 miR-185-1; miR-185-2
miR-186
caaagaauucuccuuuugggcuu 422 miR-186-1; miR-186-2
miR-187
ucgugucuuguguugcagccg 423
miR-187
miR-188
caucccuugcaugguggagggu 424
miR-188
miR-189
gugccuacugagcugauaucagu 425 miR-189-1; miR-189-2
miR-190
ugauauguuugauauauuaggu 426 miR-190-1; miR-190-2
miR-191
caacggaaucccaaaagcagcu 427 miR-191-1; miR-191-2
miR-192
cugaccuaugaauugacagcc 428
miR-192
miR-193
aacuggccuacaaagucccag 429 miR-193-1; miR-193-2
miR-95-4
uguaacagcaacuccaugugga 430 miR-194-1; miR-194-2
miR-195
uagcagcacagaaauauuggc 431 miR-195-1; miR-195-2
miR-196a
uagguaguuucauguuguugg 432 miR-196a; miR-196a-2 (miR19
miR-196b
uagguaguuuccuguuguugg 433
miR-196b
miR-197
uucaccaccuucuccacccagc 434
miR-197
miR-198
gguccagaggggagauagg 435
miR-198
07-05-2015
miR-199a
cccaguguucagacuaccuguuc 436 miR-199a-1; miR-199a-2
miR-199a*
uacaguagucugcacauugguu 437 miR-199a-1; miR-199a-2; miR-199s; miR-199b
miR-199b
cccaguguuuagacuaucuguuc 438
miR-199b
miR-200a
uaacacugucugguaacgaugu 439
miR-200a
miR-200b
cucuaauacugccugguaaugaug 440
miR-200b
miR-200c
aauacugccggguaaugaugga 441
miR-200c
miR-202
agagguauagggcaugggaaga 442
miR-202
miR-203
gugaaauguuuaggaccacuag 443
miR-203
miR-204
uucccuuugucauccuaugccu 444
miR-204
miR-205
uccuucauuccaccggagucug 445
miR-205
miR-206
uggaauguaaggaagugugugg 446 miR-206-1; miR-206-2
miR-208
auaagacgagcaaaaagcuugu 447
miR-208
miR-210
cugugcgugugacagcggcug 448
miR-210
miR-211
uucccuuugucauccuucgccu 449
miR-211
miR-212
uaacagucuccagucacggcc 450
miR-212
miR-213
accaucgaccguugauuguacc 451
miR-213
miR-214
acagcaggcacagacaggcag 452 miR-95-4
miR-215
augaccuaugaauugacagac 453
miR-215
miR-216
uaaucucagcuggcaacugug 454
miR-216
miR-217
uacugcaucaggaacugauuggau 455
miR-217
miR-218
uugugcuugaucuaaccaugu 456 miR-218-1; miR-218-2
miR-219
ugauuguccaaacgcaauucu 457 miR-219; miR-219-1; miR-219-2
miR-220
ccacaccguaucugacacuuu 458
miR-220
miR-221
agcuacauugucugcuggguuuc 459
miR-221
miR-222
agcuacaucuggcuacugggucuc 460
miR-222
miR-223
ugucaguuugucaaauacccc 461
miR-223
miR-224
caagucacuagugguuccguuua 462
miR-224
miR-296
agggcccccccucaauccugu 463
miR-296
miR-299
ugguuuaccgucccacauacau 464
miR-299
miR-301
cagugcaauaguauugucaaagc 465
miR-301
miR-302a
uaagugcuuccauguuuugguga 466
miR-302a
miR-302b*
acuuuaacauggaagugcuuucu 467 miR-302b
miR-302b
uaagugcuuccauguuuuaguag 468
miR-302b
miR-302c*
uuuaacauggggguaccugcug 469 miR-302c
miR-302c
uaagugcuuccauguuucagugg 470
miR-302c
miR-302d
uaagugcuuccauguuugagugu 471
miR-302d
miR-320
aaaagcuggguugagagggcgaa 472
miR-320
miR-321
uaagccagggauuguggguuc 473
miR-321
miR-323
gcacauuacacggucgaccucu 474
miR-323
miR-324-5p
cgcauccccuagggcauuggugu 475 miR-324
miR-324-3p
ccacugccccaggugcugcugg 476 miR-324
miR-325
ccuaguagguguccaguaagu 477
miR-325
miR-326
ccucugggcccuuccuccag 478
miR-326
miR-328
cuggcccucucugcccuuccgu 479
miR-328
miR-330
gcaaagcacacggccugcagaga 480
miR-330
miR-331
gccccugggccuauccuagaa 481
miR-331
miR-335
ucaagagcaauaacgaaaaaugu 482
miR-335
miR-337
uccagcuccuauaugaugccuuu 483
miR-337
miR-338
uccagcaucagugauuuuguuga 484
miR-338
miR-339
ucccuguccuccaggagcuca 485
miR-339
miR-340
uccgucucaguuacuuuauagcc 486
miR-340
miR-342
ucucacacagaaaucgcacccguc 487
miR-342
miR-345
ugcugacuccuaguccagggc 488
miR-345
miR-346
ugucugcccgcaugccugccucu 489
miR-346
miR-367
aauugcacuuuagcaaugguga 490
miR-367
miR-368
acauagaggaaauuccacguuu 491
miR-368
miR-369
aauaauacaugguugaucuuu 492
miR-369
miR-370
gccugcugggguggaaccugg 493
miR-370
miR-371
gugccgccaucuuuugagugu 494
miR-371
miR-372
aaagugcugcgacauuugagcgu 495
miR-372
imagen68
imagen69
imagen70
imagen71
imagen72
imagen73
imagen74
imagen75
imagen76
imagen77
imagen78
imagen79
imagen80
imagen81
imagen82
imagen83
imagen84
imagen85
imagen86
imagen87
imagen88

Claims (1)

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ES12165748.0T 2006-01-05 2007-01-03 Métodos y composiciones basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón Active ES2536438T3 (es)

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