AR054831A1 - Derivados de heptaazafenaleno, procedimientos para su obtencion, asi como utilizacion de los mismos como agentes protectores contra la radiacion uv - Google Patents
Derivados de heptaazafenaleno, procedimientos para su obtencion, asi como utilizacion de los mismos como agentes protectores contra la radiacion uvInfo
- Publication number
- AR054831A1 AR054831A1 ARP060102991A ARP060102991A AR054831A1 AR 054831 A1 AR054831 A1 AR 054831A1 AR P060102991 A ARP060102991 A AR P060102991A AR P060102991 A ARP060102991 A AR P060102991A AR 054831 A1 AR054831 A1 AR 054831A1
- Authority
- AR
- Argentina
- Prior art keywords
- radical
- optionally substituted
- different
- proviso
- equal
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000003223 protective agent Substances 0.000 title 1
- 230000005855 radiation Effects 0.000 title 1
- -1 polycyclic aryl radical Chemical class 0.000 abstract 18
- 150000003254 radicals Chemical class 0.000 abstract 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 7
- 229920006395 saturated elastomer Polymers 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000004429 atom Chemical group 0.000 abstract 4
- 125000005842 heteroatom Chemical group 0.000 abstract 4
- 125000002950 monocyclic group Chemical group 0.000 abstract 4
- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 3
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 2
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Formulaciones que los contienen, método para prepararlos y usos como agentes anti-UV. Reivindicacion 1: Derivado de heptaazafenaleno de formula general (1), donde: R1, R2, y R3 son iguales o diferentes entre sí y representan un radical arilo mono o policíclico opcionalmente sustituido; un radical heterocíclico opcionalmente sustituido de 5 a 10 átomos, saturado, insaturado o aromático, que puede contener 1, 2 o 3 heteroátomos seleccionados de entre O, N y S; un radical -OR4; o un radical - NR5R6; R4 representa -H, un radical alquilo opcionalmente sustituido, lineal o ramificado, saturado o insaturado, que contiene C1-18; un radical cicloalquilo C3-12 opcionalmente sustituido; un radical arilo mono o policíclico opcionalmente sustituido; un radical heterocíclico opcionalmente sustituido de 5 a 14 átomos, saturado, insaturado o aromático, que puede contener 1, 2 o 3 heteroátomos seleccionados de entre O, N y S; con la condicion de que cuando R1, R2 y R3 sean iguales entre sí, R4 sea diferente de -H; con la condicion de que cuando R1, R2 y R3 sean iguales entre sí, R4 sea diferente de butilo, etilo, fenilo, bencilo, 2,6-dimetilfenilo, 3,5-dimetilfenilo, 2,2,3,3,4,4,4-heptafluorobutilo, 2,2,3,3,3-pentafluoropropilo, 2,2,2-trifluoroetilo e hidroximetilo; y con la condicion de que cuando R4 sea etilo para dos de los radicales R1, R2, y R3, R4 sea diferente de -H para el tercer radical; R5 y R6 son iguales o diferentes entre sí y representan -H; un radical alquilo C1-18, de cadena lineal o ramificada, saturada o insaturada, opcionalmente sustituido; un radical cicloalquilo C3-12 opcionalmente sustituido; un radical arilo mono o policíclico opcionalmente sustituido; un radical heteroarilo de 5 a 10 átomos opcionalmente sustituido, saturado, insaturado o aromático, que puede contener 1, 2 o 3 heteroátomos seleccionados de entre O, N y S; o bien R5 y R6 están fusionados formando junto con el nitrogeno un sistema anular mono o policíclico, saturado, insaturado o aromático de 4 a 10 átomos que puede contener opcionalmente 1 o 2 heteroátomos seleccionados de entre N, O y S; o una sal, tautomero, isomero o solvato farmacéuticamente, dermatologicamente o cosméticamente aceptable del mismo; con la condicion de que cuando R1, R2 y R3 sean iguales entre sí, R5 y R6, siendo iguales entre sí, sean diferentes de hidrogeno, etilo, n-butilo, bencilo, n-heptilo, fenilo, ciclohexilo, 2-piridilo o hidroximetilo; con la condicion de que cuando R1, R2 y R3 sean iguales entre sí, si R5 o R6 es -H, el otro radical R5 o R6 es diferente de butilo, fenilo, hidroximetilo, 4-metoxi-9,10-dihidro-9,10-dioxoantraceno-1-ilo, 9,10-dihidro-9,10-dioxoantraceno-1-ilo, 9,10-dihidro-9,10-dioxoantraceno-2-ilo, o 5- benzoilamino-9,10-dihidro-9,10-dioxoantraceno-1-ilo; con la condicion de que cuando R1, R2 y R3 sean iguales entre sí, si R5 o R6 es fenilo, el otro radical R5 o R6 es deferente de metilo; con la condicion de que cuando R5 y R6 sean iguales entre sí para dos de los radicales R1, R2, R3 y representen n-heptilo, para el tercer radical de R1, R2,R3, R5 o R6 es fenilo y el otro R5 o R6 es diferente de fenilo; y con la condicion de que cuando R5 y R6 sean iguales entre sí para dos de los radicales R1, R2, y R3, y representen fenilo, para el tercer radical de R1, R2, y R3, R5 o R6 es n-heptilo y el otro R5 o R6 es diferente de n-heptilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200501746A ES2264904B1 (es) | 2005-07-13 | 2005-07-13 | Nuevos derivados de heptaazafenaleno, procedimientos para su obtencion, asi como utilizacion de estos como agentes protectores contra la radiacion uv. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054831A1 true AR054831A1 (es) | 2007-07-18 |
Family
ID=37036766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060102991A AR054831A1 (es) | 2005-07-13 | 2006-07-12 | Derivados de heptaazafenaleno, procedimientos para su obtencion, asi como utilizacion de los mismos como agentes protectores contra la radiacion uv |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20080193398A1 (es) |
| EP (1) | EP1904500A1 (es) |
| JP (1) | JP2009501194A (es) |
| KR (1) | KR20080031388A (es) |
| CN (1) | CN101223174A (es) |
| AR (1) | AR054831A1 (es) |
| AU (1) | AU2006268582A1 (es) |
| BR (1) | BRPI0613434A2 (es) |
| CA (1) | CA2614582A1 (es) |
| ES (1) | ES2264904B1 (es) |
| IL (1) | IL188736A0 (es) |
| MX (1) | MX2008000567A (es) |
| NZ (1) | NZ565882A (es) |
| PE (1) | PE20070177A1 (es) |
| RU (1) | RU2008105077A (es) |
| TW (1) | TW200740824A (es) |
| UY (1) | UY29668A1 (es) |
| WO (1) | WO2007006807A1 (es) |
| ZA (1) | ZA200800252B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008083975A1 (en) * | 2007-01-12 | 2008-07-17 | Isdin S.A. | Light-stabilized composition |
| CL2008000096A1 (es) * | 2007-01-12 | 2008-05-16 | Isdin | Combinacion farmaceutica que comprende dos compuestos uv-absorventes derivados de heptaazafenaleno; y su uso para tratar querotosis actinica, dermatitis, cronica, fotoenvejecimiento, urticaria solar, entre otras. |
| EP2153815A1 (en) | 2008-08-05 | 2010-02-17 | Isdin S.A. | Use of urea containing compositions |
| EP2153814A1 (en) | 2008-08-05 | 2010-02-17 | Isdin S.A. | Use of compositions comprising urea |
| DE102008045192A1 (de) * | 2008-08-30 | 2010-03-04 | Durferrit Gmbh | Sprengstoff |
| DE102009009277B4 (de) | 2009-02-17 | 2023-12-07 | Merck Patent Gmbh | Organische elektronische Vorrichtung, Verfahren zu deren Herstellung und Verwendung von Verbindungen |
| US20120091884A1 (en) * | 2009-05-22 | 2012-04-19 | Commonwealth Scientific And Industrial Research Organisation | Heptaazaphenalene derivatives and use thereof in organic electroluminescent device |
| EP2824159A4 (en) * | 2012-03-09 | 2015-12-09 | Univ Kyushu Nat Univ Corp | ELECTROLUMINESCENT MATERIAL AND ORGANIC ELECTROLUMINESCENT ELEMENT |
| CN103755711B (zh) * | 2013-12-23 | 2016-08-17 | 中节能万润股份有限公司 | 一种多氮杂环化合物及其制备方法和应用 |
| KR101796390B1 (ko) * | 2015-07-24 | 2017-11-09 | 동국대학교 산학협력단 | Blt 저해 활성을 갖는 신규 화합물 및 이를 유효성분으로 포함하는 염증성 질환 예방 또는 치료용 조성물 |
| CN106866683A (zh) * | 2017-01-07 | 2017-06-20 | 青岛科技大学 | 一种溴代均草怕津的制备方法 |
| WO2021256446A1 (ja) * | 2020-06-15 | 2021-12-23 | 国立研究開発法人理化学研究所 | 有機化合物及び有機発光デバイス |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3089875A (en) * | 1961-02-23 | 1963-05-14 | Olin Mathieson | Alkyl, aryl substituted melems |
| IT1283295B1 (it) * | 1996-03-22 | 1998-04-16 | 3V Sigma Spa | Filtri solari |
| DE59709127D1 (de) * | 1996-07-08 | 2003-02-20 | Ciba Sc Holding Ag | Triazinderivate als UV-Filter in Sonnenschutzmitteln |
| EP0863145B1 (de) * | 1997-03-03 | 2003-10-01 | F. Hoffmann-La Roche Ag | Lichtschutzmittel |
| US6090370A (en) * | 1997-06-27 | 2000-07-18 | Ciba Specialty Chemicals Corporation | Use of selected benzotriazole and triazine derivatives for protecting human hair from the harmful effects of UV radiation |
-
2005
- 2005-07-13 ES ES200501746A patent/ES2264904B1/es not_active Expired - Fee Related
-
2006
- 2006-07-12 AR ARP060102991A patent/AR054831A1/es not_active Application Discontinuation
- 2006-07-12 UY UY29668A patent/UY29668A1/es unknown
- 2006-07-12 PE PE2006000826A patent/PE20070177A1/es not_active Application Discontinuation
- 2006-07-13 KR KR1020087003185A patent/KR20080031388A/ko not_active Application Discontinuation
- 2006-07-13 CN CNA2006800256774A patent/CN101223174A/zh active Pending
- 2006-07-13 NZ NZ565882A patent/NZ565882A/en not_active IP Right Cessation
- 2006-07-13 EP EP06764155A patent/EP1904500A1/en not_active Withdrawn
- 2006-07-13 MX MX2008000567A patent/MX2008000567A/es active IP Right Grant
- 2006-07-13 ZA ZA200800252A patent/ZA200800252B/xx unknown
- 2006-07-13 CA CA002614582A patent/CA2614582A1/en not_active Abandoned
- 2006-07-13 US US11/995,489 patent/US20080193398A1/en not_active Abandoned
- 2006-07-13 AU AU2006268582A patent/AU2006268582A1/en not_active Abandoned
- 2006-07-13 WO PCT/EP2006/064201 patent/WO2007006807A1/en active Application Filing
- 2006-07-13 TW TW095125572A patent/TW200740824A/zh unknown
- 2006-07-13 BR BRPI0613434-3A patent/BRPI0613434A2/pt not_active IP Right Cessation
- 2006-07-13 JP JP2008520884A patent/JP2009501194A/ja not_active Withdrawn
- 2006-07-13 RU RU2008105077/04A patent/RU2008105077A/ru not_active Application Discontinuation
-
2008
- 2008-01-13 IL IL188736A patent/IL188736A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20080193398A1 (en) | 2008-08-14 |
| AU2006268582A1 (en) | 2007-01-18 |
| NZ565882A (en) | 2011-03-31 |
| MX2008000567A (es) | 2008-03-14 |
| UY29668A1 (es) | 2007-01-31 |
| ES2264904A1 (es) | 2007-01-16 |
| EP1904500A1 (en) | 2008-04-02 |
| KR20080031388A (ko) | 2008-04-08 |
| ZA200800252B (en) | 2009-08-26 |
| TW200740824A (en) | 2007-11-01 |
| PE20070177A1 (es) | 2007-04-14 |
| BRPI0613434A2 (pt) | 2011-01-11 |
| IL188736A0 (en) | 2008-08-07 |
| ES2264904B1 (es) | 2007-12-01 |
| RU2008105077A (ru) | 2009-08-20 |
| JP2009501194A (ja) | 2009-01-15 |
| CA2614582A1 (en) | 2007-01-18 |
| CN101223174A (zh) | 2008-07-16 |
| WO2007006807A1 (en) | 2007-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |