ES2194547T3 - Arilsulfonanilida-ureas. - Google Patents
Arilsulfonanilida-ureas.Info
- Publication number
- ES2194547T3 ES2194547T3 ES99969408T ES99969408T ES2194547T3 ES 2194547 T3 ES2194547 T3 ES 2194547T3 ES 99969408 T ES99969408 T ES 99969408T ES 99969408 T ES99969408 T ES 99969408T ES 2194547 T3 ES2194547 T3 ES 2194547T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- heteroalkyl
- hydrogen
- aryl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 150000002431 hydrogen Chemical group 0.000 abstract 5
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 3
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Furan Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
Un compuesto que tiene la fórmula: **(Fórmula)** o una de sus sales farmacéuticamente aceptable en la que: - X es O, S o NH; - R1 y R2 son cada uno independientemente hidrógeno, un alquilo de C1-C6 o un heteroalquilo de C1-C6; - R3 es hidrógeno, un alquilo de C1-C6 o un heteroalquilo de C1-C6, o está combinado con Y y el átomo de nitrógeno al que está unido cada uno para formar un anillo heterocíclico de 5, 6 o 7 miembros; - R4 es hidrógeno, un halógeno, un alquilo de C1-C8, un heteroalquilo de C1-C8, -OR11, -SR11, o NR11R12, en las que R11 y R12 son cada uno independientemente hidrógeno, un alquilo de C1-C8, o un heteroalquilo de C1-C8; - Y es hidrógeno, un anillo heterocíclico, un alquilo de C1-C8, un heteroalquilo de C1-C8, un arilo, un aril-alquilo de C1-C4, un aril-heteroalquilo de C1-C4; un heterociclil-alquilo de C1-C4, o un heterociclilheteroalquilo de C1-C4, o está opcionalmente unido conjuntamente con R3 para formar un anillo heterocíclico de 5, 6 o 7 miembros; y - Ar es **(Fórmula)**
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10088898P | 1998-09-23 | 1998-09-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2194547T3 true ES2194547T3 (es) | 2003-11-16 |
Family
ID=22282047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99969408T Expired - Lifetime ES2194547T3 (es) | 1998-09-23 | 1999-09-21 | Arilsulfonanilida-ureas. |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US6214880B1 (es) |
| EP (1) | EP1115701B1 (es) |
| JP (1) | JP3926983B2 (es) |
| KR (1) | KR100642184B1 (es) |
| CN (1) | CN100335461C (es) |
| AT (1) | ATE240940T1 (es) |
| AU (1) | AU747663B2 (es) |
| BR (1) | BR9913903A (es) |
| CA (1) | CA2343204C (es) |
| CZ (1) | CZ2001934A3 (es) |
| DE (1) | DE69908156T2 (es) |
| DK (1) | DK1115701T3 (es) |
| EA (1) | EA003924B1 (es) |
| ES (1) | ES2194547T3 (es) |
| HK (1) | HK1038913A1 (es) |
| HU (1) | HUP0103884A3 (es) |
| IL (2) | IL142066A0 (es) |
| NO (1) | NO20011453L (es) |
| NZ (1) | NZ510435A (es) |
| PL (1) | PL198394B1 (es) |
| PT (1) | PT1115701E (es) |
| SK (1) | SK284757B6 (es) |
| WO (1) | WO2000017159A1 (es) |
| ZA (1) | ZA200102033B (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9508644D0 (en) * | 1995-04-28 | 1995-06-14 | Exxon Chemical Patents Inc | Fuel compositions |
| KR100642184B1 (ko) * | 1998-09-23 | 2006-11-10 | 암젠 인크 | 아릴술폰아닐리드 우레아 |
| US6316503B1 (en) * | 1999-03-15 | 2001-11-13 | Tularik Inc. | LXR modulators |
| ES2241639T3 (es) * | 1999-07-29 | 2005-11-01 | Amgen, Inc. | Terapia de combinacion que usa un compuesto de pentafluorobencensulfonamidas y platino. |
| CO5280089A1 (es) * | 2000-03-16 | 2003-05-30 | Smithkline Beecham Corp | Antagonistas del receptor il-8 |
| US6664259B2 (en) | 2000-03-16 | 2003-12-16 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| UY26627A1 (es) * | 2000-03-24 | 2001-09-28 | Smithkline Beecham Corp | Antagonistas de receptores de il-8 |
| WO2002020463A2 (en) * | 2000-09-05 | 2002-03-14 | Tularik Inc. | Fxr modulators |
| US20050250854A1 (en) * | 2000-11-03 | 2005-11-10 | Amgen Inc. | Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents |
| US6822001B2 (en) | 2000-11-03 | 2004-11-23 | Tularik Inc. | Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents |
| ATE479657T1 (de) | 2001-02-28 | 2010-09-15 | Univ Temple | N-(aryl)-2-arylethensulfonamide und ihre therapeutischen anwendungen |
| AUPR738301A0 (en) * | 2001-08-30 | 2001-09-20 | Starpharma Limited | Chemotherapeutic agents |
| ES2314212T3 (es) * | 2002-01-30 | 2009-03-16 | Amgen Inc. | Compuestos arilsulfonamidobencilicos. |
| JP4434745B2 (ja) * | 2002-01-30 | 2010-03-17 | アムジェン インコーポレイテッド | 複素環式アリールスルホンアミドベンジル化合物 |
| JP4538233B2 (ja) | 2002-02-28 | 2010-09-08 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 増殖性障害治療用の、アミノ置換されたスルホンアニリド及びその誘導体 |
| MY143477A (en) * | 2002-10-29 | 2011-05-31 | Smithkline Beecham Corp | Il-8 receptor antagonists |
| US20060264424A1 (en) * | 2003-08-12 | 2006-11-23 | Tularik Inc | Arylsulfonamidobenzylic compounds |
| US20050124664A1 (en) * | 2003-10-30 | 2005-06-09 | Eric Sartori | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 |
| US20050154455A1 (en) * | 2003-12-18 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
| US20050261762A1 (en) * | 2004-05-21 | 2005-11-24 | Medtronic Vascular, Inc. | Medical devices to prevent or inhibit restenosis |
| US20060062822A1 (en) * | 2004-09-21 | 2006-03-23 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
| US20070027530A1 (en) * | 2005-07-26 | 2007-02-01 | Medtronic Vascular, Inc. | Intraluminal device, catheter assembly, and method of use thereof |
| FI20055498A0 (fi) * | 2005-09-16 | 2005-09-16 | Biotie Therapies Corp | Sulfonamidijohdannaisia |
| US20070067020A1 (en) * | 2005-09-22 | 2007-03-22 | Medtronic Vasular, Inc. | Intraluminal stent, delivery system, and a method of treating a vascular condition |
| WO2007124423A2 (en) * | 2006-04-21 | 2007-11-01 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| CL2007001142A1 (es) * | 2006-04-21 | 2008-01-25 | Smithkline Beecham Corp | Compuestos derivados de sulfona, antagonistas del receptor il-8; procedimiento de preparacion;compuestos intermediarios;composicion farmaceutica; combinacion farmaceutica; y uso en el tratamiento de asma, enfermedad pulmonar obstructiva cronica, dermatitis, psoriasis, alzheimer, aterosclerosis, osteoporosis. |
| MX2008014953A (es) * | 2006-05-26 | 2009-03-05 | Bayer Healthcare Llc | Combinaciones de medicamentos con diarilureas sustituidas para el tratamiento de cancer. |
| AR061571A1 (es) * | 2006-06-23 | 2008-09-03 | Smithkline Beecham Corp | Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un |
| AU2008347024A1 (en) * | 2007-10-19 | 2009-07-16 | Omm Scientific, Inc. | Methods of inhibiting bacterial virulence and compounds relating thereto |
| EP2385831A4 (en) * | 2009-01-09 | 2014-03-26 | Uab Research Foundation | SMALL MOLECULAR HEMMER OF NADS, NAMNAT AND NMNAT |
| US9444712B2 (en) | 2012-11-21 | 2016-09-13 | Cisco Technology, Inc. | Bandwidth on-demand services in multiple layer networks |
| JP5887423B2 (ja) * | 2012-11-21 | 2016-03-16 | 日本曹達株式会社 | 非フェノール系化合物を用いた記録材料 |
| EP3438091A4 (en) * | 2016-03-30 | 2019-11-27 | Ajinomoto Co., Inc. | CONNECTION WITH INCREASING ACTIVITY FOR ACTION OF GLUCAGON LIKE PEPTIDE-1 RECEPTOR |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1955207A (en) | 1931-09-16 | 1934-04-17 | Ig Farbenindustrie Ag | Mothproofing agent |
| DE622494C (de) | 1932-01-03 | 1935-11-29 | I G Farbenindustrie Akt Ges | Verfahren zur Darstellung von Mono- bzw. Polynitropolysulfonen und deren Reduktionsprodukten |
| US2358365A (en) | 1940-08-03 | 1944-09-19 | Parke Davis & Co | Sulphonamide derivatives and process for obtaining the same |
| US2402623A (en) | 1943-06-24 | 1946-06-25 | Rohm & Haas | Nu-nitroaryl haloarylsulphonamides |
| CH361275A (de) | 1957-09-10 | 1962-04-15 | Geigy Ag J R | Verfahren zur Herstellung von neuen Arylsulfonarylamiden |
| GB938890A (en) | 1961-02-03 | 1963-10-09 | Boots Pure Drug Co Ltd | New fungicidal compositions and compounds |
| CH504416A (de) | 1966-12-05 | 1971-03-15 | Ciba Geigy Ag | Verfahren zur Herstellung von aromatischen Sulfamoylverbindungen |
| GB1242057A (en) | 1968-07-04 | 1971-08-11 | Ici Ltd | Derivatives of 4-hydroxytetrafluoropyridine and the use thereof as plant growth regulators |
| NL174644C (nl) | 1970-04-13 | 1984-07-16 | Minnesota Mining & Mfg | Werkwijze ter bereiding van een herbicide verbinding; tevens werkwijze voor de bereiding van een preparaat met herbicide werking. |
| FR2456731A1 (fr) * | 1979-05-16 | 1980-12-12 | Choay Sa | Nouveaux derives substitues d'ary |
| DE3623184A1 (de) | 1986-07-10 | 1988-01-14 | Kali Chemie Ag | Verfahren zur herstellung von n-fluorsulfonamiden |
| US4883914A (en) | 1987-08-17 | 1989-11-28 | American Cyanamid Company | Benzenesulfonyl carboxamide compounds useful as herbicidal agents |
| DE3804990A1 (de) | 1988-02-18 | 1989-08-31 | Basf Ag | Herbizid wirksame, heterocyclisch substituierte sulfonamide |
| DE3905075A1 (de) | 1989-02-18 | 1990-08-30 | Hoechst Ag | Benzolsulfonamide und verfahren zu ihrer herstellung |
| FR2645537B1 (fr) | 1989-04-05 | 1994-03-04 | Fabre Medicament Pierre | Nouveaux sulfonamides derives d'acides benzocycliques ou benzoheterocycliques, leur preparation et leur application en therapeutique |
| FR2665440B1 (fr) | 1990-07-31 | 1994-02-04 | Lipha | Nouveaux cycloalkylsulfonamides substitues, procedes de preparation et medicaments les contenant. |
| US5189211A (en) | 1990-08-01 | 1993-02-23 | Taisho Pharmaceutical Co., Ltd. | Sulfonamide derivatives |
| EP0472053B1 (en) * | 1990-08-20 | 1998-06-17 | Eisai Co., Ltd. | Sulfonamide derivatives |
| US5780483A (en) * | 1995-02-17 | 1998-07-14 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| DE69724777T2 (de) * | 1996-02-22 | 2004-07-15 | Tularik, Inc., South San Francisco | Pentafluorobenzensulfonamiden und analoge |
| US6482860B1 (en) * | 1996-07-19 | 2002-11-19 | Tularik Inc. | Pentafluorobenzenesulfonamides and analogs |
| WO1999024407A1 (en) | 1997-11-10 | 1999-05-20 | Array Biopharma, Inc. | Compounds which inhibit tryptase activity |
| US6268387B1 (en) | 1997-12-23 | 2001-07-31 | Warner-Lambert Company | Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis |
| KR100642184B1 (ko) * | 1998-09-23 | 2006-11-10 | 암젠 인크 | 아릴술폰아닐리드 우레아 |
| ES2241639T3 (es) * | 1999-07-29 | 2005-11-01 | Amgen, Inc. | Terapia de combinacion que usa un compuesto de pentafluorobencensulfonamidas y platino. |
-
1999
- 1999-09-21 KR KR1020017003646A patent/KR100642184B1/ko not_active IP Right Cessation
- 1999-09-21 HU HU0103884A patent/HUP0103884A3/hu unknown
- 1999-09-21 ZA ZA200102033A patent/ZA200102033B/en unknown
- 1999-09-21 CN CNB99811233XA patent/CN100335461C/zh not_active Expired - Fee Related
- 1999-09-21 JP JP2000574069A patent/JP3926983B2/ja not_active Expired - Fee Related
- 1999-09-21 EA EA200100376A patent/EA003924B1/ru not_active IP Right Cessation
- 1999-09-21 PL PL346797A patent/PL198394B1/pl not_active IP Right Cessation
- 1999-09-21 PT PT99969408T patent/PT1115701E/pt unknown
- 1999-09-21 US US09/399,907 patent/US6214880B1/en not_active Expired - Fee Related
- 1999-09-21 ES ES99969408T patent/ES2194547T3/es not_active Expired - Lifetime
- 1999-09-21 EP EP99969408A patent/EP1115701B1/en not_active Expired - Lifetime
- 1999-09-21 DE DE69908156T patent/DE69908156T2/de not_active Expired - Fee Related
- 1999-09-21 CZ CZ2001934A patent/CZ2001934A3/cs unknown
- 1999-09-21 SK SK400-2001A patent/SK284757B6/sk not_active IP Right Cessation
- 1999-09-21 WO PCT/US1999/022013 patent/WO2000017159A1/en active IP Right Grant
- 1999-09-21 CA CA002343204A patent/CA2343204C/en not_active Expired - Fee Related
- 1999-09-21 AT AT99969408T patent/ATE240940T1/de not_active IP Right Cessation
- 1999-09-21 AU AU60580/99A patent/AU747663B2/en not_active Ceased
- 1999-09-21 NZ NZ510435A patent/NZ510435A/xx unknown
- 1999-09-21 IL IL14206699A patent/IL142066A0/xx active IP Right Grant
- 1999-09-21 DK DK99969408T patent/DK1115701T3/da active
- 1999-09-21 BR BR9913903-0A patent/BR9913903A/pt not_active Application Discontinuation
-
2001
- 2001-02-21 US US09/792,669 patent/US6583165B2/en not_active Expired - Fee Related
- 2001-03-18 IL IL142066A patent/IL142066A/en not_active IP Right Cessation
- 2001-03-22 NO NO20011453A patent/NO20011453L/no not_active Application Discontinuation
-
2002
- 2002-01-17 HK HK02100388A patent/HK1038913A1/xx not_active IP Right Cessation
-
2003
- 2003-03-11 US US10/387,217 patent/US7060718B2/en not_active Expired - Fee Related
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