FR2456731A1 - Nouveaux derives substitues d'ary - Google Patents

Nouveaux derives substitues d'ary

Info

Publication number
FR2456731A1
FR2456731A1 FR7912395A FR7912395A FR2456731A1 FR 2456731 A1 FR2456731 A1 FR 2456731A1 FR 7912395 A FR7912395 A FR 7912395A FR 7912395 A FR7912395 A FR 7912395A FR 2456731 A1 FR2456731 A1 FR 2456731A1
Authority
FR
France
Prior art keywords
para
guanidino
substd
meta
cpds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7912395A
Other languages
English (en)
Inventor
Patrick Choay
Dominique Olliero
Edgar Sache
Camille Georges Wermuth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Choay SA
Original Assignee
Choay SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Choay SA filed Critical Choay SA
Priority to FR7912395A priority Critical patent/FR2456731A1/fr
Publication of FR2456731A1 publication Critical patent/FR2456731A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NOUVEAUX DERIVES SUBSTITUES D'ARYLAMINES ET D'ARYLGUANIDINES DE FORMULE GENERALE I DANS LAQUELLE X, Y, R ET R ET Z ONT LES SIGNIFICATIONS DEFINIES DANS LA DEMANDE DE BREVET. PROCEDES DE PREPARATION DE CES NOUVEAUX DERIVES PAR LES VOIES A, B, C OU D, OU LA VOIE E QUI COMBINE LA VOIE A OU B AUX ETAPES I ET J DE LA VOIE C. APPLICATION A LA PREPARATION DE MEDICAMENTS.
FR7912395A 1979-05-16 1979-05-16 Nouveaux derives substitues d'ary Withdrawn FR2456731A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7912395A FR2456731A1 (fr) 1979-05-16 1979-05-16 Nouveaux derives substitues d'ary

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7912395A FR2456731A1 (fr) 1979-05-16 1979-05-16 Nouveaux derives substitues d'ary

Publications (1)

Publication Number Publication Date
FR2456731A1 true FR2456731A1 (fr) 1980-12-12

Family

ID=9225516

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7912395A Withdrawn FR2456731A1 (fr) 1979-05-16 1979-05-16 Nouveaux derives substitues d'ary

Country Status (1)

Country Link
FR (1) FR2456731A1 (fr)

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0222608A2 (fr) * 1985-11-12 1987-05-20 Ono Pharmaceutical Co., Ltd. Dérivés de l'acide p-guanidino-benzoique et compositions pharmaceutiques ayant ces dérivés comme agent actif
JPS62111963A (ja) * 1985-11-12 1987-05-22 Ono Pharmaceut Co Ltd ｐ−グアニジノ安息香酸チオフエニルエステル誘導体及びそれらを含有する医薬品
EP0229370A1 (fr) * 1985-12-27 1987-07-22 Eisai Co., Ltd. Dérivés des esters de l'acide guanidinobenzoique, un procédé pour leur préparation et compositions pharmaceutiques les contenant
US4843094A (en) * 1985-11-12 1989-06-27 Ono Pharmaceutical Co., Ltd. Derivatives of p-guantidinobenzoic acid and pharmaceutical agents containing them as active ingredient
US4937370A (en) * 1987-06-02 1990-06-26 The Procter & Gamble Company Novel chromophores, sunscreen compositions and methods for preventing sunburn
US5138089A (en) * 1986-06-27 1992-08-11 The Procter & Gamble Company Chromophores, sunscreen compositions and methods for preventing sunburn
WO1992016503A1 (fr) * 1991-03-25 1992-10-01 Boehringer Mannheim Gmbh Nouveaux sulfamides, leur procede de preparation et medicaments contenant ces composes
US5229106A (en) * 1986-06-27 1993-07-20 The Procter & Gamble Company Sunscreen agents, sunscreen compositions and method for preventing sunburn
US5229107A (en) * 1986-06-27 1993-07-20 The Procter & Gamble Company Sunscreen agents, sunscreen compositions and methods for preventing sunburn
US5230874A (en) * 1986-06-27 1993-07-27 The Procter & Gamble Company Sunscreen agents, sunscreen compositions and methods for preventing sunburn
US5243064A (en) * 1986-06-27 1993-09-07 The Procter & Gamble Company Chromophores, sunscreen compositions and methods for preventing sunburn
US5247084A (en) * 1985-11-12 1993-09-21 Ono Pharmaceutical Co., Ltd. Derivatives of p-guanidinobenzoic acid
US5352704A (en) * 1989-12-22 1994-10-04 Banyu Pharmaceutical Co., Ltd. Guanidinobenzene derivatives
WO1997036861A1 (fr) * 1996-03-29 1997-10-09 G.D. Searle & Co. Derives meta-substitues du sulphonamide de phenylene
WO1997036858A1 (fr) * 1996-03-29 1997-10-09 G.D. Searle & Co. Derives de l'acide alcanoique de cyclopropyle
FR2761061A1 (fr) * 1997-03-20 1998-09-25 Synthelabo Derives de benzenesulfonamide, leur preparation et leur application en therapeutique
WO2000017159A1 (fr) * 1998-09-23 2000-03-30 Tularik Inc. Arylsulfonanilides urees
WO2002070468A2 (fr) * 2001-02-08 2002-09-12 Rotta Research Laboratorium S.P.A. Nouveaux derives de benzamidine possedant une activite anti-inflammatoire et immunosuppressive
EP1285911A2 (fr) * 1998-09-23 2003-02-26 Tularik Inc. Arylsulfonylanilides-urées
US6822001B2 (en) 2000-11-03 2004-11-23 Tularik Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
WO2007143880A1 (fr) * 2006-06-09 2007-12-21 Shanghai East Best Biopharmaceutical Enterprises Co., Ltd. Composés pour la prévention et le traitement des infections bactériennes, leur préparation et utilisation
US7405227B2 (en) 2005-07-18 2008-07-29 Bipar Sciences, Inc. Treatment of cancer
US7732491B2 (en) 2007-11-12 2010-06-08 Bipar Sciences, Inc. Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
US7994222B2 (en) 2006-09-05 2011-08-09 Bipar Sciences, Inc. Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds
US8048908B2 (en) 2006-07-13 2011-11-01 High Point Pharmaceuticals, Llc 11β-hydroxysteroid dehydrogenase type 1 active compounds
US8053447B2 (en) 2006-04-07 2011-11-08 High Point Pharmaceuticals, Llc 11β-hydroxysteroid dehydrogenase type 1 active compounds
US8053431B2 (en) 2005-11-01 2011-11-08 High Point Pharmaceuticals, Llc Pharmaceutical use of substituted amides
US8138342B2 (en) 2004-10-12 2012-03-20 High Point Pharmacueticals, LLC 11β-hydroxysteroid dehydrogenase type 1 active spiro compounds
US8143447B2 (en) 2006-09-05 2012-03-27 Bipar Sciences, Inc. Treatment of cancer
US8153798B2 (en) 2007-03-09 2012-04-10 High Point Pharmaceuticals, Llc Indole- and benzimidazole amides as hydroxysteroid dehydrogenase inhibitors
US8334305B2 (en) 2007-02-23 2012-12-18 High Point Pharmaceuticals, Llc N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase
US8383683B2 (en) 2007-04-24 2013-02-26 High Point Pharmaceuticals, Llc Pharmaceutical use of substituted amides
US8383820B2 (en) 2007-02-23 2013-02-26 High Point Pharmaceuticals, Llc N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase
GB2533925A (en) * 2014-12-31 2016-07-13 Univ Bath Antimicrobial compounds, compositions and methods
CN114805141A (zh) * 2021-01-27 2022-07-29 中国科学院上海药物研究所 4-胍基苯甲酸芳基酯类化合物及其在抗SARS-CoV-2病毒中的用途
US11666888B2 (en) 2018-02-05 2023-06-06 Bio-Rad Laboratories, Inc. Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand

Cited By (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0222608A2 (fr) * 1985-11-12 1987-05-20 Ono Pharmaceutical Co., Ltd. Dérivés de l'acide p-guanidino-benzoique et compositions pharmaceutiques ayant ces dérivés comme agent actif
JPS62111963A (ja) * 1985-11-12 1987-05-22 Ono Pharmaceut Co Ltd ｐ−グアニジノ安息香酸チオフエニルエステル誘導体及びそれらを含有する医薬品
EP0222608A3 (en) * 1985-11-12 1988-09-07 Ono Pharmaceutical Co., Ltd. Derivatives of p-guanidinobenzoic acid and pharmaceutical agents containing them as active ingredient
US4843094A (en) * 1985-11-12 1989-06-27 Ono Pharmaceutical Co., Ltd. Derivatives of p-guantidinobenzoic acid and pharmaceutical agents containing them as active ingredient
US5376655A (en) * 1985-11-12 1994-12-27 Ono Pharmaceutical Co., Ltd. Derivatives of p-guanidinobenzoic acid and pharmaceutical agents containing them as an active ingredient
US5077428A (en) * 1985-11-12 1991-12-31 Ono Pharmaceutical Co., Ltd. Pharmacologically active derivatives of p-guanidinobenzoic acid
US5247084A (en) * 1985-11-12 1993-09-21 Ono Pharmaceutical Co., Ltd. Derivatives of p-guanidinobenzoic acid
EP0229370A1 (fr) * 1985-12-27 1987-07-22 Eisai Co., Ltd. Dérivés des esters de l'acide guanidinobenzoique, un procédé pour leur préparation et compositions pharmaceutiques les contenant
US4801603A (en) * 1985-12-27 1989-01-31 Eisai Co., Ltd. Guanidinobenzoic ester derivative
US4948808A (en) * 1985-12-27 1990-08-14 Eisai Co., Ltd. Guanidinobenzoic ester derivative
US5229106A (en) * 1986-06-27 1993-07-20 The Procter & Gamble Company Sunscreen agents, sunscreen compositions and method for preventing sunburn
US5210275A (en) * 1986-06-27 1993-05-11 The Procter & Gamble Company Chromophores, sunscreen compositions and methods for preventing sunburn
US5229107A (en) * 1986-06-27 1993-07-20 The Procter & Gamble Company Sunscreen agents, sunscreen compositions and methods for preventing sunburn
US5230874A (en) * 1986-06-27 1993-07-27 The Procter & Gamble Company Sunscreen agents, sunscreen compositions and methods for preventing sunburn
US5243064A (en) * 1986-06-27 1993-09-07 The Procter & Gamble Company Chromophores, sunscreen compositions and methods for preventing sunburn
US5138089A (en) * 1986-06-27 1992-08-11 The Procter & Gamble Company Chromophores, sunscreen compositions and methods for preventing sunburn
US4937370A (en) * 1987-06-02 1990-06-26 The Procter & Gamble Company Novel chromophores, sunscreen compositions and methods for preventing sunburn
US5352704A (en) * 1989-12-22 1994-10-04 Banyu Pharmaceutical Co., Ltd. Guanidinobenzene derivatives
WO1992016503A1 (fr) * 1991-03-25 1992-10-01 Boehringer Mannheim Gmbh Nouveaux sulfamides, leur procede de preparation et medicaments contenant ces composes
WO1997036861A1 (fr) * 1996-03-29 1997-10-09 G.D. Searle & Co. Derives meta-substitues du sulphonamide de phenylene
WO1997036858A1 (fr) * 1996-03-29 1997-10-09 G.D. Searle & Co. Derives de l'acide alcanoique de cyclopropyle
US5843906A (en) * 1996-03-29 1998-12-01 G. D. Searle & Co. Meta-substituted phenylene sulphonamide derivatives
US6677308B1 (en) 1996-03-29 2004-01-13 G. D. Searle & Co. Meta-substituted phenylene sulphonamide derivatives
FR2761061A1 (fr) * 1997-03-20 1998-09-25 Synthelabo Derives de benzenesulfonamide, leur preparation et leur application en therapeutique
WO1998042679A1 (fr) * 1997-03-20 1998-10-01 Sanofi-Synthelabo Derives de benzenesulfonamide, leur preparation et leur application en therapeutique
EP1285911A3 (fr) * 1998-09-23 2003-03-26 Tularik Inc. Arylsulfonylanilides-urées
US7060718B2 (en) 1998-09-23 2006-06-13 Amgen Inc. Arylsulfonanilide ureas
EP1285911A2 (fr) * 1998-09-23 2003-02-26 Tularik Inc. Arylsulfonylanilides-urées
US6214880B1 (en) 1998-09-23 2001-04-10 Tularik Inc. Arylsulfonanilide ureas
US6583165B2 (en) 1998-09-23 2003-06-24 Tularik Inc. Arylsulfonanilide ureas
CN100335461C (zh) * 1998-09-23 2007-09-05 图拉里克公司 芳基磺酰基苯胺脲
WO2000017159A1 (fr) * 1998-09-23 2000-03-30 Tularik Inc. Arylsulfonanilides urees
US6822001B2 (en) 2000-11-03 2004-11-23 Tularik Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
US7202277B2 (en) 2001-02-08 2007-04-10 Rotta Research Laboratorium S.P.A. Benzamidine derivatives having anti-inflammatory and immunosuppressive activity
WO2002070468A3 (fr) * 2001-02-08 2003-09-04 Rotta Research Lab Nouveaux derives de benzamidine possedant une activite anti-inflammatoire et immunosuppressive
US7560591B2 (en) 2001-02-08 2009-07-14 Rotta Research Laboratorium S.P.A. Benzamidine derivatives having anti-inflammatory and immunosuppressive activity
WO2002070468A2 (fr) * 2001-02-08 2002-09-12 Rotta Research Laboratorium S.P.A. Nouveaux derives de benzamidine possedant une activite anti-inflammatoire et immunosuppressive
US8138342B2 (en) 2004-10-12 2012-03-20 High Point Pharmacueticals, LLC 11β-hydroxysteroid dehydrogenase type 1 active spiro compounds
US7405227B2 (en) 2005-07-18 2008-07-29 Bipar Sciences, Inc. Treatment of cancer
US8377985B2 (en) 2005-07-18 2013-02-19 Bipar Sciences, Inc. Treatment of cancer
US8053431B2 (en) 2005-11-01 2011-11-08 High Point Pharmaceuticals, Llc Pharmaceutical use of substituted amides
US8053447B2 (en) 2006-04-07 2011-11-08 High Point Pharmaceuticals, Llc 11β-hydroxysteroid dehydrogenase type 1 active compounds
WO2007143880A1 (fr) * 2006-06-09 2007-12-21 Shanghai East Best Biopharmaceutical Enterprises Co., Ltd. Composés pour la prévention et le traitement des infections bactériennes, leur préparation et utilisation
US8048908B2 (en) 2006-07-13 2011-11-01 High Point Pharmaceuticals, Llc 11β-hydroxysteroid dehydrogenase type 1 active compounds
US7994222B2 (en) 2006-09-05 2011-08-09 Bipar Sciences, Inc. Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds
US8143447B2 (en) 2006-09-05 2012-03-27 Bipar Sciences, Inc. Treatment of cancer
US8334305B2 (en) 2007-02-23 2012-12-18 High Point Pharmaceuticals, Llc N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase
US8383820B2 (en) 2007-02-23 2013-02-26 High Point Pharmaceuticals, Llc N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase
US8809540B2 (en) 2007-02-23 2014-08-19 High Point Pharmaceuticals, Llc N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
US8153798B2 (en) 2007-03-09 2012-04-10 High Point Pharmaceuticals, Llc Indole- and benzimidazole amides as hydroxysteroid dehydrogenase inhibitors
US8383683B2 (en) 2007-04-24 2013-02-26 High Point Pharmaceuticals, Llc Pharmaceutical use of substituted amides
US7732491B2 (en) 2007-11-12 2010-06-08 Bipar Sciences, Inc. Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
GB2533925A (en) * 2014-12-31 2016-07-13 Univ Bath Antimicrobial compounds, compositions and methods
WO2016108045A3 (fr) * 2014-12-31 2016-09-15 Swansea University Composés antimicrobiens, compositions et méthodes associées
US11666888B2 (en) 2018-02-05 2023-06-06 Bio-Rad Laboratories, Inc. Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand
CN114805141A (zh) * 2021-01-27 2022-07-29 中国科学院上海药物研究所 4-胍基苯甲酸芳基酯类化合物及其在抗SARS-CoV-2病毒中的用途

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