ES2187171T3 - Derivados de acidos fosfinico y fosfonico en calidad de medicamentos. - Google Patents

Derivados de acidos fosfinico y fosfonico en calidad de medicamentos.

Info

Publication number
ES2187171T3
ES2187171T3 ES99932841T ES99932841T ES2187171T3 ES 2187171 T3 ES2187171 T3 ES 2187171T3 ES 99932841 T ES99932841 T ES 99932841T ES 99932841 T ES99932841 T ES 99932841T ES 2187171 T3 ES2187171 T3 ES 2187171T3
Authority
ES
Spain
Prior art keywords
phosphinic
medicines
derivatives
quality
phosphone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99932841T
Other languages
English (en)
Inventor
Manfred Schudok
Wilfried Schwab
Gerhard Zoller
Eckart Bartnik
Frank Buttner
Klaus-Ulrich Weithmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19831980A external-priority patent/DE19831980A1/de
Priority claimed from DE19921680A external-priority patent/DE19921680A1/de
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Application granted granted Critical
Publication of ES2187171T3 publication Critical patent/ES2187171T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings

Abstract

Compuesto de la fórmula I **(Fórmula)** y/o una forma estereoisómera del compuesto de la fórmula I y/o una sal fisiológicamente tolerable del compuesto de la fórmula I, en donde R1 representa 1. fenilo
ES99932841T 1998-07-16 1999-07-07 Derivados de acidos fosfinico y fosfonico en calidad de medicamentos. Expired - Lifetime ES2187171T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19831980A DE19831980A1 (de) 1998-07-16 1998-07-16 Sulfonylaminophosphin- und phosphonsäurederivate
DE19921680A DE19921680A1 (de) 1999-05-12 1999-05-12 Sulfonylaminophosphin- und phosphonsäurederivate

Publications (1)

Publication Number Publication Date
ES2187171T3 true ES2187171T3 (es) 2003-05-16

Family

ID=26047473

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99932841T Expired - Lifetime ES2187171T3 (es) 1998-07-16 1999-07-07 Derivados de acidos fosfinico y fosfonico en calidad de medicamentos.

Country Status (22)

Country Link
US (2) US6235727B1 (es)
EP (1) EP1097159B1 (es)
JP (1) JP4567886B2 (es)
KR (1) KR100615345B1 (es)
CN (1) CN1194978C (es)
AR (1) AR019390A1 (es)
AT (1) ATE227295T1 (es)
AU (1) AU754050B2 (es)
BR (1) BR9912085A (es)
CA (1) CA2337828C (es)
CZ (1) CZ300780B6 (es)
DE (1) DE59903329D1 (es)
DK (1) DK1097159T3 (es)
ES (1) ES2187171T3 (es)
HK (1) HK1038363A1 (es)
HU (1) HUP0102837A3 (es)
ID (1) ID27133A (es)
PL (1) PL199234B1 (es)
PT (1) PT1097159E (es)
RU (1) RU2224762C2 (es)
TR (1) TR200100084T2 (es)
WO (1) WO2000004030A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02000246A (es) 1999-07-06 2003-08-20 Methylgene Inc Inhibidores de °-lactamasa de sulfonamidometil fosfonato.
MXPA05001544A (es) * 2002-08-08 2005-04-19 Smithkline Beecham Corp Compuestos de tiofeno.
JP4450192B2 (ja) 2004-07-01 2010-04-14 信越化学工業株式会社 珪素複合体及びその製造方法並びに非水電解質二次電池用負極材
JP5562634B2 (ja) * 2006-05-22 2014-07-30 メチルジーン インコーポレイテッド ベータ−ラクタマーゼの新規阻害剤
AU2007268081A1 (en) * 2006-05-22 2007-12-06 Methylgene Inc. Novel sulfonamidomethylphosphonate inhibitors of beta-lactamase
JP5399219B2 (ja) * 2009-11-24 2014-01-29 株式会社ケイティーバイオ 関節リウマチに対するヒト型抗ＴＮＦα抗体薬の薬効予測方法、及び薬効予測装置
CN108676031A (zh) * 2018-05-29 2018-10-19 重庆威鹏药业有限公司 水溶性***类抗真菌膦酸化合物及其制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996040A (en) * 1974-06-28 1976-12-07 Monsanto Company Increasing sucrose content of sugar cane employing N-phenylsulfonamido-N-phosphonomethyl glycine and certain derivatives thereof
JPS6137800A (ja) * 1984-07-31 1986-02-22 Kyowa Hakko Kogyo Co Ltd 含リンペプチド
DE3435156A1 (de) * 1984-09-25 1986-04-03 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-aminoalkylphosphinsaeuren
JPS62148493A (ja) * 1985-12-24 1987-07-02 Teijin Ltd 新規ホスホン酸誘導体および除草剤
DE3770982D1 (de) * 1986-04-24 1991-08-01 Fujisawa Pharmaceutical Co Diphosphonsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel.
JP2764262B2 (ja) 1987-08-28 1998-06-11 持田製薬株式会社 ヒダントイン誘導体及びそれを有効成分とする医薬組成物
TW201303B (es) 1990-07-05 1993-03-01 Hoffmann La Roche
JP2525977B2 (ja) * 1991-10-17 1996-08-21 昭和電工株式会社 Ｎ−アシルアミノメチルホスホン酸の製造法
US5455258A (en) 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
GB2303850B (en) 1994-06-22 1998-06-10 British Biotech Pharm Metalloproteinase inhibitors
US5863949A (en) 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
KR980009238A (ko) * 1995-07-28 1998-04-30 우에노 도시오 설포닐아미노산 유도체
EA001561B1 (ru) * 1996-05-17 2001-04-23 Варнер-Ламберт Компани Бифенилсульфонамидные ингибиторы матричных металлопротеиназ
JP2001509795A (ja) * 1997-01-27 2001-07-24 ニィコメド・オーストリア・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 血液調節作用を有する新規化合物
DE59802394D1 (de) 1997-05-09 2002-01-24 Hoechst Ag Substituierte Diaminocarbonsäuren
AU7294098A (en) * 1997-05-09 1998-11-27 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
DE19719621A1 (de) * 1997-05-09 1998-11-12 Hoechst Ag Sulfonylaminocarbonsäuren

Also Published As

Publication number Publication date
BR9912085A (pt) 2001-04-10
KR100615345B1 (ko) 2006-08-25
PT1097159E (pt) 2003-03-31
TR200100084T2 (tr) 2001-07-23
HK1038363A1 (en) 2002-03-15
DK1097159T3 (da) 2003-03-10
PL199234B1 (pl) 2008-08-29
PL345653A1 (en) 2002-01-02
ID27133A (id) 2001-03-01
EP1097159B1 (de) 2002-11-06
CN1309660A (zh) 2001-08-22
CN1194978C (zh) 2005-03-30
CZ300780B6 (cs) 2009-08-12
AU4908299A (en) 2000-02-07
AR019390A1 (es) 2002-02-20
CZ2001144A3 (en) 2001-05-16
WO2000004030A1 (de) 2000-01-27
CA2337828A1 (en) 2000-01-27
HUP0102837A3 (en) 2002-04-29
JP4567886B2 (ja) 2010-10-20
US20020082246A1 (en) 2002-06-27
US6235727B1 (en) 2001-05-22
KR20010071940A (ko) 2001-07-31
AU754050B2 (en) 2002-10-31
US6500811B2 (en) 2002-12-31
DE59903329D1 (en) 2002-12-12
RU2224762C2 (ru) 2004-02-27
EP1097159A1 (de) 2001-05-09
HUP0102837A2 (hu) 2001-12-28
ATE227295T1 (de) 2002-11-15
CA2337828C (en) 2010-08-17
JP2002520418A (ja) 2002-07-09

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