DE60117620D1 - Herstellung von cephalosporin - Google Patents

Herstellung von cephalosporin

Info

Publication number
DE60117620D1
DE60117620D1 DE60117620T DE60117620T DE60117620D1 DE 60117620 D1 DE60117620 D1 DE 60117620D1 DE 60117620 T DE60117620 T DE 60117620T DE 60117620 T DE60117620 T DE 60117620T DE 60117620 D1 DE60117620 D1 DE 60117620D1
Authority
DE
Germany
Prior art keywords
cephalosporin
preparation
formula
sodium salt
preparing ceftiofur
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60117620T
Other languages
English (en)
Other versions
DE60117620T2 (de
Inventor
Andres Berger
Martin Decristorforo
Johannes Ludescher
Herbert Schleich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of DE60117620D1 publication Critical patent/DE60117620D1/de
Application granted granted Critical
Publication of DE60117620T2 publication Critical patent/DE60117620T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
DE60117620T 2000-11-22 2001-11-20 Herstellung von cephalosporin Expired - Lifetime DE60117620T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25270700P 2000-11-22 2000-11-22
US252707P 2000-11-22
PCT/EP2001/013443 WO2002042266A2 (en) 2000-11-22 2001-11-20 Process for the production of ceftifur sodium salt

Publications (2)

Publication Number Publication Date
DE60117620D1 true DE60117620D1 (de) 2006-04-27
DE60117620T2 DE60117620T2 (de) 2006-10-12

Family

ID=22957174

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60117620T Expired - Lifetime DE60117620T2 (de) 2000-11-22 2001-11-20 Herstellung von cephalosporin

Country Status (11)

Country Link
US (1) US6504026B2 (de)
EP (1) EP1343790B1 (de)
JP (1) JP4319835B2 (de)
KR (1) KR100870885B1 (de)
AT (1) ATE318825T1 (de)
AU (1) AU2002219127A1 (de)
CA (1) CA2427199C (de)
DE (1) DE60117620T2 (de)
ES (1) ES2258569T3 (de)
TW (1) TWI246513B (de)
WO (1) WO2002042266A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555679B2 (en) 2001-10-03 2003-04-29 Orchid Chemicals & Pharmaceuticals Ltd. Method for preparation of ceftiofur sodium from its hydrohalide salts
JP2006507290A (ja) * 2002-10-29 2006-03-02 ルピン リミティド セフチオフルの製造方法
EP1934231A4 (de) * 2005-10-12 2011-10-26 Orchid Chemicals & Pharm Ltd Kristallines natriumsalz des antibiotikums cephalosporin
US8470809B2 (en) * 2005-10-12 2013-06-25 Orchid Chemicals & Pharmaceuticals Limited Crystalline sodium salt of cephalosporin antibiotic
US8431562B2 (en) * 2008-08-22 2013-04-30 Orchid Chemicals & Pharmaceuticals Limited Crystalline sodium salt of cephalosporin antibiotic
KR101699539B1 (ko) * 2015-12-30 2017-02-13 (주)솔레이어 나노 여과 모듈 및 이를 이용한 농축 방법
CN115772179A (zh) * 2022-12-09 2023-03-10 山东鑫泉医药有限公司 头孢噻呋钠的重结晶方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902683A (en) * 1984-10-25 1990-02-20 The Upjohn Company Crystalline cephalosporin hydrohalide salts
ATE138664T1 (de) * 1985-08-12 1996-06-15 Upjohn Co Umwandlung des cephalosporin-hydrohalid-salzes zu einem alkalimetallsalz
US4877782A (en) * 1988-02-16 1989-10-31 The Upjohn Company Zinc ceftiofur complexes
IL95561A0 (en) 1990-09-02 1991-06-30 Weizmann Kiryat Membrane Prod Method for the purification and concentration of biologically active materials
JP2919112B2 (ja) * 1991-05-13 1999-07-12 武田薬品工業株式会社 セファロスポリン注射剤およびその製造法
TW293821B (en) * 1993-09-27 1996-12-21 Ind Tech Res Inst Process for preparing alkali salts of cephalosporin C
US5491259A (en) 1994-09-13 1996-02-13 The Dow Chemical Company Process to produce aminocarboxylic acids containing low residual salt
ES2105988B1 (es) 1996-03-15 1998-07-01 Antibioticos Sa Procedimiento para purificar 7-sustituido-amino-desacetoxi-cefalosporinas mediante el empleo de membranas de filtracion.
IT1283641B1 (it) 1996-07-30 1998-04-23 Ribbon Srl Procedimento per la preparazione di cefalosporine
RU2247773C2 (ru) 1998-04-14 2005-03-10 ДСМ Ай Пи АССЕТС Б.В. Фильтрование через мембрану
DE19839209A1 (de) 1998-08-28 2000-03-02 Fraunhofer Ges Forschung Verfahren zur Gewinnung von festen Stoffen aus Lösungen
KR100355115B1 (ko) * 1999-01-14 2002-11-22 주식회사 엘지씨아이 세프티오퍼 합성에 유용한 중간체 및 이를 이용한 세프티오퍼의 제조 방법
JP3737642B2 (ja) * 1999-01-18 2006-01-18 武田薬品工業株式会社 セファロスポリン注射剤およびその製造法
US6458949B1 (en) * 2000-08-14 2002-10-01 Aurobindo Pharma Limited Ceftiofur, its intermediate and a process for the preparation of the same

Also Published As

Publication number Publication date
AU2002219127A1 (en) 2002-06-03
EP1343790A2 (de) 2003-09-17
KR100870885B1 (ko) 2008-11-28
JP4319835B2 (ja) 2009-08-26
EP1343790B1 (de) 2006-03-01
CA2427199A1 (en) 2002-05-30
WO2002042266A3 (en) 2002-08-15
ATE318825T1 (de) 2006-03-15
ES2258569T3 (es) 2006-09-01
TWI246513B (en) 2006-01-01
KR20030070014A (ko) 2003-08-27
US20020082248A1 (en) 2002-06-27
JP2004514667A (ja) 2004-05-20
WO2002042266A2 (en) 2002-05-30
CA2427199C (en) 2009-02-10
US6504026B2 (en) 2003-01-07
DE60117620T2 (de) 2006-10-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN