ES2159798T3 - Derivados heterociclicos como inhibidores de la agregacion plaquetaria. - Google Patents

Derivados heterociclicos como inhibidores de la agregacion plaquetaria.

Info

Publication number
ES2159798T3
ES2159798T3 ES97117909T ES97117909T ES2159798T3 ES 2159798 T3 ES2159798 T3 ES 2159798T3 ES 97117909 T ES97117909 T ES 97117909T ES 97117909 T ES97117909 T ES 97117909T ES 2159798 T3 ES2159798 T3 ES 2159798T3
Authority
ES
Spain
Prior art keywords
plaquetary
agregation
inhibitors
heterociclic
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97117909T
Other languages
English (en)
Inventor
Stuart Dennett Mills
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939306453A external-priority patent/GB9306453D0/en
Priority claimed from GB939325605A external-priority patent/GB9325605D0/en
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of ES2159798T3 publication Critical patent/ES2159798T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Electroluminescent Light Sources (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE DESCRIBE EL ACIDO RS )PIPERAZIN BOLICAMENTE LABILES DEL MISMO, Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DEL MISMO, COMO UN INHIBIDOR DE LA UNION DEL FIBRINOGENO A LA GLUCOPROTEINA IIB/IIIA.
ES97117909T 1993-03-29 1994-03-28 Derivados heterociclicos como inhibidores de la agregacion plaquetaria. Expired - Lifetime ES2159798T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939306453A GB9306453D0 (en) 1993-03-29 1993-03-29 Heterocyclic derivatives
GB939325605A GB9325605D0 (en) 1993-12-15 1993-12-15 Heterocyclic derivatives

Publications (1)

Publication Number Publication Date
ES2159798T3 true ES2159798T3 (es) 2001-10-16

Family

ID=26302668

Family Applications (2)

Application Number Title Priority Date Filing Date
ES97117909T Expired - Lifetime ES2159798T3 (es) 1993-03-29 1994-03-28 Derivados heterociclicos como inhibidores de la agregacion plaquetaria.
ES94910494T Expired - Lifetime ES2119184T3 (es) 1993-03-29 1994-03-28 Derivados heterociclicos como inhibidores de la agregacion de plaquetas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES94910494T Expired - Lifetime ES2119184T3 (es) 1993-03-29 1994-03-28 Derivados heterociclicos como inhibidores de la agregacion de plaquetas.

Country Status (26)

Country Link
US (1) US5556977A (es)
EP (2) EP0691959B1 (es)
JP (1) JPH08508291A (es)
KR (1) KR100231089B1 (es)
CN (1) CN1120334A (es)
AT (2) ATE168678T1 (es)
AU (1) AU692438B2 (es)
BR (1) BR9406613A (es)
CA (1) CA2156070A1 (es)
CZ (1) CZ250995A3 (es)
DE (2) DE69427548T2 (es)
DK (2) DK0691959T3 (es)
ES (2) ES2159798T3 (es)
FI (1) FI954616A0 (es)
GB (1) GB9406143D0 (es)
GR (2) GR3027751T3 (es)
HU (2) HUT72088A (es)
IL (1) IL109144A (es)
NO (1) NO305244B1 (es)
NZ (1) NZ262941A (es)
PL (1) PL310889A1 (es)
PT (1) PT825184E (es)
SK (1) SK120895A3 (es)
TW (1) TW276254B (es)
WO (1) WO1994022834A1 (es)
ZW (1) ZW4294A1 (es)

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JP2001511799A (ja) 1997-02-13 2001-08-14 ゼネカ・リミテッド オキシド−スクアレンシクラーゼ阻害剤として有用なヘテロ環式化合物
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
WO1999061410A1 (en) 1998-05-12 1999-12-02 American Home Products Corporation 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
US6110963A (en) * 1998-05-12 2000-08-29 American Home Products Corporation Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6451827B2 (en) 1998-05-12 2002-09-17 Wyeth 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
US6166069A (en) * 1998-05-12 2000-12-26 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6221902B1 (en) 1998-05-12 2001-04-24 American Home Products Corporation Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
US6699896B1 (en) 1998-05-12 2004-03-02 Wyeth Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
US6232322B1 (en) 1998-05-12 2001-05-15 American Home Products Corporation Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
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GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
CA2370742A1 (en) * 1999-04-19 2000-10-26 Coelacanth Corporation Ppar-(gamma) agonists as agents for the treatment of type ii diabetes
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ATE502928T1 (de) 2000-11-01 2011-04-15 Millennium Pharm Inc Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung
DE202011000090U1 (de) 2011-01-14 2011-04-21 E-LEAD ELECTRONIC CO., LTD., Shengang Shiang Fahrzeug-Audiosystem mit auswechselbarem Plug-In-Computer
WO2019058393A1 (en) 2017-09-22 2019-03-28 Jubilant Biosys Limited HETEROCYCLIC COMPOUNDS AS INHIBITORS OF PAD
KR20200071752A (ko) 2017-10-18 2020-06-19 주빌런트 에피파드 엘엘씨 Pad 억제제로서의 이미다조-피리딘 화합물
AU2018362046B2 (en) 2017-11-06 2023-04-13 Jubilant Prodel LLC Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
IL274762B2 (en) 2017-11-24 2023-10-01 Jubilant Episcribe Llc Novel heterocyclic compounds as PRMT5 inhibitors
CA3093527A1 (en) 2018-03-13 2019-09-19 Jubilant Prodel LLC Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation

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Also Published As

Publication number Publication date
HU211336A9 (en) 1995-11-28
NO953837L (no) 1995-09-28
IL109144A0 (en) 1994-06-24
GR3027751T3 (en) 1998-11-30
NO953837D0 (no) 1995-09-28
NO305244B1 (no) 1999-04-26
JPH08508291A (ja) 1996-09-03
SK120895A3 (en) 1996-06-05
EP0691959A1 (en) 1996-01-17
DE69411900D1 (de) 1998-08-27
CZ250995A3 (en) 1996-01-17
WO1994022834A1 (en) 1994-10-13
IL109144A (en) 2000-02-29
PL310889A1 (en) 1996-01-08
ATE202345T1 (de) 2001-07-15
HUT72088A (en) 1996-03-28
AU6288994A (en) 1994-10-24
FI954616A (fi) 1995-09-28
FI954616A0 (fi) 1995-09-28
KR100231089B1 (ko) 1999-11-15
CN1120334A (zh) 1996-04-10
EP0825184A1 (en) 1998-02-25
PT825184E (pt) 2001-11-30
EP0691959B1 (en) 1998-07-22
ATE168678T1 (de) 1998-08-15
GB9406143D0 (en) 1994-05-18
BR9406613A (pt) 1996-02-06
CA2156070A1 (en) 1994-10-13
US5556977A (en) 1996-09-17
GR3036640T3 (en) 2001-12-31
ZW4294A1 (en) 1994-12-21
DK0825184T3 (da) 2001-09-10
DE69411900T2 (de) 1998-12-10
AU692438B2 (en) 1998-06-11
HU9502290D0 (en) 1995-10-30
DK0691959T3 (da) 1999-04-26
DE69427548T2 (de) 2002-04-18
TW276254B (es) 1996-05-21
NZ262941A (en) 1997-07-27
EP0825184B1 (en) 2001-06-20
DE69427548D1 (de) 2001-07-26
ES2119184T3 (es) 1998-10-01

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