JPS57183738A - Aromatic carboxylic acid derivative - Google Patents
Aromatic carboxylic acid derivativeInfo
- Publication number
- JPS57183738A JPS57183738A JP6777881A JP6777881A JPS57183738A JP S57183738 A JPS57183738 A JP S57183738A JP 6777881 A JP6777881 A JP 6777881A JP 6777881 A JP6777881 A JP 6777881A JP S57183738 A JPS57183738 A JP S57183738A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- formula
- carboxylic acid
- acid derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A compound of formulaI[R1 is formula II(R3,R4 are H, lower alkyl, CF3), 6W10C alkyl, mono- or di-lower alkylaminolower alkyl, pyridyl; R2 is hydroxyl, lower alkoxy, which may be substituted with, e.g., OH, CN, morpholino), lower alkylamino, aromatic amino; A is CH, N; B is N (R5) (R5 is H, lower alkyl, aromatic group, which may be substituted), O; where when R2 is hydroxyl or lower alkoxy and B is NH, BR1 and OR2 are not in the ortho- position]or its salt.
EXAMPLE: N-(m-Trifluoromethylphenyl)anthranylic 3-morpholinopropyl ester.
USE: An adenolytic accelerator used as a thrombolytic agent.
PREPARATION: The acid component of formulaIb and the alcohol component of formula IV (R6 is lower alkyl, which may be substituted with, e.g., a morpholino group) are esterified by a usual method to give the compound of formula Ic.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6777881A JPS57183738A (en) | 1981-05-06 | 1981-05-06 | Aromatic carboxylic acid derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6777881A JPS57183738A (en) | 1981-05-06 | 1981-05-06 | Aromatic carboxylic acid derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS57183738A true JPS57183738A (en) | 1982-11-12 |
Family
ID=13354747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6777881A Pending JPS57183738A (en) | 1981-05-06 | 1981-05-06 | Aromatic carboxylic acid derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57183738A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994022835A2 (en) * | 1993-03-29 | 1994-10-13 | Zeneca Limited | Heterocyclic compounds as platelet aggregation inhibitors |
| EP0825184A1 (en) * | 1993-03-29 | 1998-02-25 | Zeneca Limited | Heterocyclic derivatives as platelet aggregation inhibitors |
| WO2008029199A1 (en) * | 2006-09-03 | 2008-03-13 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate |
| JP2015120703A (en) * | 2015-01-05 | 2015-07-02 | テックフィールズ インコーポレイテッド | Nsaia prodrug having very fast skin- and film-infiltration rate, and new use thereof as medicine |
| US9371284B2 (en) | 2007-06-04 | 2016-06-21 | Techfields Pharma Co., Ltd. | Pro-drugs of NSAIAS with very high skin and membranes penetration rates and their new medicinal uses |
| JP2017105853A (en) * | 2017-03-22 | 2017-06-15 | テックフィールズ インコーポレイテッド | Nsaia prodrug having very fast skin- and film-infiltration rate, and new use thereof as medicine |
| US9872846B2 (en) | 2006-07-09 | 2018-01-23 | Techfields Pharma Co., Ltd. | High penetration compositions and uses thereof |
| JP2020147604A (en) * | 2020-06-17 | 2020-09-17 | テックフィールズ インコーポレイテッド | Nsaia prodrug having very fast skin- and film-infiltration rate, and new use thereof as medicine |
| US11135153B2 (en) | 2006-07-09 | 2021-10-05 | Techfields Pharma Co., Ltd. | High penetration composition and uses thereof |
| US11541029B2 (en) | 2008-12-04 | 2023-01-03 | Techfields Pharma Co., Ltd. | High penetration compositions and their applications |
| US11813256B2 (en) | 2012-05-16 | 2023-11-14 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions and pharmaceutical compositon thereof for treatment of pulmonary conditions |
-
1981
- 1981-05-06 JP JP6777881A patent/JPS57183738A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994022835A2 (en) * | 1993-03-29 | 1994-10-13 | Zeneca Limited | Heterocyclic compounds as platelet aggregation inhibitors |
| EP0825184A1 (en) * | 1993-03-29 | 1998-02-25 | Zeneca Limited | Heterocyclic derivatives as platelet aggregation inhibitors |
| US11135153B2 (en) | 2006-07-09 | 2021-10-05 | Techfields Pharma Co., Ltd. | High penetration composition and uses thereof |
| US9872846B2 (en) | 2006-07-09 | 2018-01-23 | Techfields Pharma Co., Ltd. | High penetration compositions and uses thereof |
| WO2008029199A1 (en) * | 2006-09-03 | 2008-03-13 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate |
| US9371284B2 (en) | 2007-06-04 | 2016-06-21 | Techfields Pharma Co., Ltd. | Pro-drugs of NSAIAS with very high skin and membranes penetration rates and their new medicinal uses |
| US10233198B2 (en) | 2007-06-04 | 2019-03-19 | Techfields Pharma Co., Ltd. | Pro-drugs of NSAIAs with very high skin and membranes penetration rates and their new medicinal uses |
| US11541029B2 (en) | 2008-12-04 | 2023-01-03 | Techfields Pharma Co., Ltd. | High penetration compositions and their applications |
| US11813256B2 (en) | 2012-05-16 | 2023-11-14 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions and pharmaceutical compositon thereof for treatment of pulmonary conditions |
| US11857545B2 (en) | 2012-05-16 | 2024-01-02 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions |
| JP2015120703A (en) * | 2015-01-05 | 2015-07-02 | テックフィールズ インコーポレイテッド | Nsaia prodrug having very fast skin- and film-infiltration rate, and new use thereof as medicine |
| JP2017105853A (en) * | 2017-03-22 | 2017-06-15 | テックフィールズ インコーポレイテッド | Nsaia prodrug having very fast skin- and film-infiltration rate, and new use thereof as medicine |
| JP2020147604A (en) * | 2020-06-17 | 2020-09-17 | テックフィールズ インコーポレイテッド | Nsaia prodrug having very fast skin- and film-infiltration rate, and new use thereof as medicine |
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