ES2155045T1 - Inhibicion de la quinasa raf utilizando ureas heterociclicas sustituidas con arilo y heteroarilo. - Google Patents
Inhibicion de la quinasa raf utilizando ureas heterociclicas sustituidas con arilo y heteroarilo.Info
- Publication number
- ES2155045T1 ES2155045T1 ES98963810T ES98963810T ES2155045T1 ES 2155045 T1 ES2155045 T1 ES 2155045T1 ES 98963810 T ES98963810 T ES 98963810T ES 98963810 T ES98963810 T ES 98963810T ES 2155045 T1 ES2155045 T1 ES 2155045T1
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- group
- heteroaryl
- nr5r5
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000005764 inhibitory process Effects 0.000 title 1
- 150000003672 ureas Chemical class 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 10
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 9
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 8
- 125000005915 C6-C14 aryl group Chemical group 0.000 abstract 7
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 125000001424 substituent group Chemical group 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- 101100533874 Hypocrea jecorina (strain QM6a) sor5 gene Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Un compuesto de fórmula (I) y sus sales farmacéuticamente aceptables **fórmula** en cuya fórmula A es un heteroarilo seleccionado del grupo constituido por **fórmula** en cuyas fórmulas R1 se selecciona del grupo constituido por alquilo C3-C10, Cicloalquilo C3-C10, alquilo C1-C10 hasta per-halosustituido y cicloalquilo C3-C10 hasta per-halosustituido; B es un resto arilo o heteroarilo sustituido o insustituido, hasta tricíclico, de hasta 30 átomos de carbono con al menos una estructura aromática de 5 ó 6 miembros que contiene 0-4 miembros del grupo constituido por nitrógeno, oxígeno y azufre, en el cual si B es un grupo sustituido, está sustituido con uno o más sustituyentes seleccionados independientemente del grupo constituido por halógeno, hasta per-halosustitución, y Xn, en cuya fórmula n es 0-3 y cada X se selecciona independientemente del grupo constituido por -CN, -CO2R5, -C(O)NR5R5'', -C(O)R5, -NO2, -OR5, -SR5, -NR5R5'', -NR5 C(O)OR5'', -NR5 C(O)R5'', alquilo C1-C10, alquenilo C2-C10, alcoxi C1-C10, cicloalquilo C3-C10, rilo C6-C14, alcarilo C7-C24, heteroarilo C3-C13, alc-heteroarilo C4-C23, alquilo C1-C10 sustituido, alquenilo C2-C10 Sustituido, alcoxilo C1-C10 sustituido, cicloalquilo C3-C10 sustituido, alc-heteroarilo C4-C23 sustituido e -Y-Ar; donde X es un grupo sustituido, estásustituido conuno o más sustituyentes seleccionados independientemente del grupo constituido por -CN, -CO2R5, -C(O)R5, -C(O)NR5R5'', -OR5, -SR5, -NR5R5'', -NO2, -NR5 C(O)R5'', -NR5 C(O)OR5'' y halógeno hasta per-halosustitución; en cuyas fórmulas R5 y R5'' se seleccionan independientemente de H, alquilo C1-C10, alquenilo C2-C10, cicloalquilo C3-C10, arilo C6-C14, heteroarilo C3-C13, alcarilo C7-C24, alc-heteroarilo C4-C23, alquilo C1-C10 hasta per-halosustituido, alquenilo C2-C10 hasta per-halosustituido, cicloalquilo C3-C10 hasta per-halosustituido, arilo C6-C14 hasta per-halosustituido y heteroarilo C3-C13 hasta per-halosustituido, en cuyas fórmulas Y es -O-, -S-, -N(R5)-, -(CH2)m-, -C(O)-, -CH(OH)-, -(CH2)mO-, -NR5 C(O)NR5R5''-,-NR5C(O)-, -C(O)NR5a-O(CH2)m-, -(CH2)mS-, -(CH2)mN(R5)-, -O(CH2)m-, -CHXa -, -CXa2-, -S-(CH2)m- y -N(R5 )(CH2)m-, m = 1-3, y X a es halógeno; y Ar es una estructura aromática de 5-10 miembros que contiene 0-2 miembros del grupo constituido por nitrógeno, oxígeno y azufre que está insustituida o sustituida con halógeno hasta per-halosustitución y sustituida opcionalmente con Zn1, encuyafórmula n1 es 0 a 3 y cada Z se selecciona independientemente del grupo constituido por -CN, -CO2R5, -C(O)NR5R5'', -C(O)NR5 , -NO2, -OR5, -SR5, -NR5R5'', -NR5C(O)OR5'', -C(O)R5 , NR5 C(O)R5'', alquilo C1-C10, cicloalquilo C3-C10, arilo C6-C14, heteroarilo C3-C13, alcarilo C7-C24, alc-heteroarilo C4-C23, alquilo C1-C10 sustituido, cicloalquilo C3-C10 sustituido, alcarilo C7-C24 sustituido y alc-heteroarilo C4-C23 sustituido; en cuyas fórmulas, si Z es un grupo sustituido, estásustituido conlosuno o más sustituyentes seleccionados independientemente del grupo constituido por -CN, -CO2R5, -C(O)NR5R5'', -OR5, -SR5, -NO2, -NR5R5'' , -NR5C(O)R5'' y -NR5C(O)OR5'', y en cuyas fórmulas R2 es arilo C6-C14, heteroarilo C3-C14, arilo C6-C14 sustituido o heteroarilo C3-C14 sustituido, en cuyas fórmulas, si R2 es un grupo sustituido, está sustituido conuno o más sustituyentes seleccionados independientemente del grupo constituido por halógeno, hasta per-halosustitución, y Vn, en cuya fórmula n = 0-3 y cada V se selecciona independientemente del grupo constituido por -CN, -CO2R5, -C(O)NR5R5'', -OR5 , -SR5, -NR5R5'', -C(O)R5, -OC(O)NR5R5'', -NR5 C(O)OR5'', -SO2R5, SOR5, -NR5C(O)R5'', -NO2, alquilo C1-C10, cicloalquilo C3-C10, arilo C6-C14, heteroarilo C3-C13, alcarilo C7-C24, alc-heteroarilo C4-C24, alquilo C1-C10 sustituido, cicloalquilo C3-C10 sustituido, arilo C6-C14 sustituido, heteroarilo C3-C13 sustituido, alcarilo C7-C24 sustituido y alc-heteroarilo C4-C24 sustituido, donde, si V es un grupo sustituido, está sustituido con uno o más sustituyentes seleccionados independientemente delgrupo constituido por halógeno, hasta per-halosustitución, -CN, -CO2R5, -C(O)R5, -C(O)NR5R5'', -NR5 R5'', -OR5, -SR5, -NR5C(O)R5'', -NR5 C(O)OR5'' y -NO2; en cuyas fórmulas R5 y R5'' son cada uno independientemente como se define con anterioridad.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99618197A | 1997-12-22 | 1997-12-22 | |
US996181 | 1997-12-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2155045T1 true ES2155045T1 (es) | 2001-05-01 |
ES2155045T3 ES2155045T3 (es) | 2007-02-01 |
Family
ID=25542594
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98963810T Expired - Lifetime ES2155045T3 (es) | 1997-12-22 | 1998-12-22 | Inhibicion de la quinasa raf utilizando ureas heterociclicas sustituidas con arilo y heteroarilo. |
Country Status (29)
Country | Link |
---|---|
EP (1) | EP1056725B1 (es) |
JP (1) | JP4395823B2 (es) |
KR (1) | KR100622138B1 (es) |
CN (1) | CN1117081C (es) |
AT (1) | ATE328873T1 (es) |
AU (1) | AU765412B2 (es) |
BG (1) | BG65207B1 (es) |
BR (1) | BR9814361A (es) |
CA (1) | CA2315713C (es) |
CU (1) | CU23127A3 (es) |
CY (1) | CY1105395T1 (es) |
CZ (1) | CZ299836B6 (es) |
DE (2) | DE69834842T2 (es) |
DK (1) | DK1056725T3 (es) |
ES (1) | ES2155045T3 (es) |
GR (1) | GR20010300010T1 (es) |
HK (1) | HK1029989A1 (es) |
HU (1) | HUP0004426A3 (es) |
ID (1) | ID26328A (es) |
IL (2) | IL136773A0 (es) |
NO (1) | NO319209B1 (es) |
NZ (1) | NZ505845A (es) |
PL (1) | PL341356A1 (es) |
PT (1) | PT1056725E (es) |
RU (1) | RU2265597C2 (es) |
SK (1) | SK285371B6 (es) |
TR (3) | TR200002617T2 (es) |
UA (1) | UA67763C2 (es) |
WO (1) | WO1999032455A1 (es) |
Families Citing this family (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1473292A1 (en) * | 1997-11-03 | 2004-11-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
ES2155817T3 (es) * | 1997-12-22 | 2007-06-16 | Bayer Pharmaceuticals Corp. | Inhibicion de la actividad de la quinasa p38 utilizando ureas heterociclicas sustituidas con arilo y heteroarilo. |
WO1999032111A1 (en) * | 1997-12-22 | 1999-07-01 | Bayer Corporation | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS |
CZ299156B6 (cs) * | 1997-12-22 | 2008-05-07 | Bayer Corporation | Substituované heterocyklické mocoviny, farmaceutické prípravky je obsahující a jejich použití |
AU2006201959B2 (en) * | 1997-12-22 | 2008-09-04 | Bayer Healthcare Llc | Inhibition of Raf Kinase using Substituted Heterocyclic Ureas |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
US7928239B2 (en) * | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
JP2002534468A (ja) | 1999-01-13 | 2002-10-15 | バイエル コーポレイション | p38キナーゼ阻害剤としてのω−カルボキシアリール置換ジフェニル尿素 |
UA73492C2 (en) * | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
EP1157026A1 (en) | 1999-02-22 | 2001-11-28 | Boehringer Ingelheim Pharmaceuticals Inc. | Polycyclo heterocyclic derivatives as antiinflammatory agents |
CA2360740A1 (en) | 1999-03-02 | 2000-09-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cathepsin s |
DE60014603T2 (de) | 1999-03-12 | 2006-02-16 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | Heterocyklischer harnstoff und verwandte verbindungen als entzündungshemmende mittel |
DE60023853T2 (de) | 1999-03-12 | 2006-05-24 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | Aromatische heterozyklische verbindungen als antientzündungwirkstoffe |
DE60024830T2 (de) | 1999-07-09 | 2006-06-14 | Boehringer Ingelheim Pharma | Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen |
YU9602A (sh) * | 1999-08-12 | 2004-11-25 | Pharmacia Italia S.P.A. | Derivati 3(5)-amino-pirazola, postupak za njihovu izradu i njihova upotreba kao antitumornih agenasa |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
AU1623601A (en) | 1999-11-22 | 2001-06-04 | Smithkline Beecham Plc | Novel compounds |
US6525046B1 (en) | 2000-01-18 | 2003-02-25 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as antiinflammatory agents |
US6608052B2 (en) | 2000-02-16 | 2003-08-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as anti-inflammatory agents |
EA006381B1 (ru) | 2000-08-10 | 2005-12-29 | Фармация Италия С.П.А. | Бициклопиразолы, активные в качестве ингибиторов киназы, способ их получения и включающие их фармацевтические композиции |
US6645990B2 (en) | 2000-08-15 | 2003-11-11 | Amgen Inc. | Thiazolyl urea compounds and methods of uses |
WO2002044156A2 (en) | 2000-11-29 | 2002-06-06 | Glaxo Group Limited | Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors |
EP1392661A1 (en) | 2001-05-16 | 2004-03-03 | Boehringer Ingelheim Pharmaceuticals Inc. | Diarylurea derivatives useful as anti-inflammatory agents |
JP2004531571A (ja) | 2001-05-25 | 2004-10-14 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | サイトカイン生産のインヒビターとしてのカルバメート及びオキサミド化合物 |
EP1709965A3 (en) * | 2001-07-11 | 2006-12-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Methods of treating cytokine mediate diseases |
WO2003022838A1 (en) * | 2001-09-05 | 2003-03-20 | Smithkline Beecham Plc | Pyridine substituted furan derivatives as raf kinase inhibitors |
ES2393900T3 (es) * | 2001-12-03 | 2012-12-28 | Bayer Healthcare Llc | Compuestos de aril-urea en combinación con otros agentes citostáticos o citotóxicos para tratamiento de cánceres humanos |
EP2324825A1 (en) | 2002-02-11 | 2011-05-25 | Bayer Healthcare LLC | Aryl ureas with angiogenesis inhibiting activity |
PT1580188E (pt) | 2002-02-11 | 2012-01-25 | Bayer Healthcare Llc | Aril-ureias como inibidores de cinases |
US10653684B2 (en) | 2002-02-11 | 2020-05-19 | Bayer Healthcare Llc | Aryl ureas with angiogenisis inhibiting activity |
US20040023961A1 (en) * | 2002-02-11 | 2004-02-05 | Bayer Corporation | Aryl ureas with raf kinase and angiogenisis inhibiting activity |
ATE386030T1 (de) | 2002-02-25 | 2008-03-15 | Boehringer Ingelheim Pharma | 1,4-disubstituierte benzokondensierte cycloalkyl- harnstoffverbindungen zur behandlung von zytokinvermittelten erkrankungen |
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US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
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