NO179551C - Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser

Info

Publication number
NO179551C
NO179551C NO884729A NO884729A NO179551C NO 179551 C NO179551 C NO 179551C NO 884729 A NO884729 A NO 884729A NO 884729 A NO884729 A NO 884729A NO 179551 C NO179551 C NO 179551C
Authority
NO
Norway
Prior art keywords
alkyl
halogen
hydrogen
compounds
substituted
Prior art date
Application number
NO884729A
Other languages
English (en)
Other versions
NO884729L (no
NO884729D0 (no
NO179551B (no
Inventor
Tage Honore
Poul Jacobsen
Flemming Elmelund Nielsen
Lars Naerum
Original Assignee
Novo Nordisk As
Ferrosan As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK586287A external-priority patent/DK586287D0/da
Priority claimed from DK142288A external-priority patent/DK142288D0/da
Application filed by Novo Nordisk As, Ferrosan As filed Critical Novo Nordisk As
Publication of NO884729D0 publication Critical patent/NO884729D0/no
Publication of NO884729L publication Critical patent/NO884729L/no
Publication of NO179551B publication Critical patent/NO179551B/no
Priority to NO963412A priority Critical patent/NO307252B1/no
Publication of NO179551C publication Critical patent/NO179551C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
    • C07D241/52—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO884729A 1987-11-10 1988-10-24 Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser NO179551C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO963412A NO307252B1 (no) 1987-11-10 1996-08-15 Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK586287A DK586287D0 (da) 1987-11-10 1987-11-10 Quinoxalinforbindelser, deres fremstilling og anvendelse
DK142288A DK142288D0 (da) 1988-03-16 1988-03-16 Quinoxalinforbindelser, deres fremstilling og anvendelse

Publications (4)

Publication Number Publication Date
NO884729D0 NO884729D0 (no) 1988-10-24
NO884729L NO884729L (no) 1989-05-11
NO179551B NO179551B (no) 1996-07-22
NO179551C true NO179551C (no) 1996-10-30

Family

ID=26065733

Family Applications (2)

Application Number Title Priority Date Filing Date
NO884729A NO179551C (no) 1987-11-10 1988-10-24 Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser
NO963412A NO307252B1 (no) 1987-11-10 1996-08-15 Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO963412A NO307252B1 (no) 1987-11-10 1996-08-15 Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser

Country Status (16)

Country Link
US (2) US4948794A (no)
EP (1) EP0315959B1 (no)
JP (1) JP2721520B2 (no)
KR (1) KR970011279B1 (no)
AT (1) ATE102192T1 (no)
AU (1) AU618766B2 (no)
CA (1) CA1321587C (no)
DE (1) DE3888093T2 (no)
ES (1) ES2061606T3 (no)
FI (1) FI100181B (no)
IE (1) IE64320B1 (no)
IL (1) IL88155A0 (no)
NO (2) NO179551C (no)
NZ (1) NZ226916A (no)
PH (1) PH25103A (no)
PT (1) PT88964B (no)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO179551C (no) * 1987-11-10 1996-10-30 Novo Nordisk As Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser
DK716188D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Quinoxalinforbindelser, deres fremstilling og anvendelse
DK715888D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Quinoxalinforbindelser, deres fremstilling og anvendelse
DK69790D0 (da) * 1990-03-16 1990-03-16 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling af anvendelse
DK0556393T3 (da) * 1990-11-06 2000-10-16 Yamanouchi Pharma Co Ltd Tilkondenseret pyrazinderivat
PT99864B (pt) 1990-12-21 1999-06-30 Schering Ag Processo para a preparacao de novas composicoes farmaceuticas contendo antagonistas de receptor de quisqualato
DK73091D0 (da) * 1991-04-22 1991-04-22 Novo Nordisk As Quinoxalinforbindelser, deres fremstilling og anvendelse
US5196421A (en) * 1991-06-05 1993-03-23 Eli Lilly And Company Excitatory amino acid receptor antagonists in methods for the use thereof
US5153196A (en) * 1991-06-05 1992-10-06 Eli Lilly And Company Excitatory amino acid receptor antagonists and methods for the use thereof
DK177191D0 (da) * 1991-10-23 1991-10-23 Novo Nordisk As Heterocyclic compounds and their preparation and use
PT101004B (pt) * 1991-10-26 1999-10-29 Schering Ag Derivados da quinoxalina, processo para a sua preparacao e composicoes farmaceuticas que os contem
US6057304A (en) * 1992-10-26 2000-05-02 Schering Aktiengesellschaft Quinoxaline-phosphonic acid derivatives
DE4217952A1 (de) * 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
CA2138026C (en) * 1992-06-22 2003-09-09 Eckard Weber Novel 1,4-dihydroquinoxaline-2,3-diones and uses therefor as glycine receptor antagonists
FR2696466B1 (fr) * 1992-10-02 1994-11-25 Rhone Poulenc Rorer Sa Dérivés de 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant.
DK12293D0 (da) * 1993-02-02 1993-02-02 Novo Nordisk As Heterocykliske forbindelser og deres fremstilling og anvendelse
DE4314592A1 (de) * 1993-04-28 1994-11-03 Schering Ag Benzo(f)chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
IL109397A0 (en) * 1993-04-28 1994-07-31 Schering Ag Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US5631373A (en) * 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
DE4340045A1 (de) * 1993-11-24 1995-06-01 Basf Ag Neue Chinoxaline und Arzneimittel daraus
AU688459B2 (en) * 1994-04-08 1998-03-12 Shionogi & Co., Ltd. Oxopyridinylquinoxaline derivative
DE4428152A1 (de) * 1994-06-22 1996-01-04 Basf Ag Neue Amido-chinoxalindione, ihrer Herstellung und Verwendung
US5597922A (en) * 1994-07-29 1997-01-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Glycine receptor antagonist pharmacophore
DE4436852A1 (de) * 1994-10-14 1996-04-18 Basf Ag Pyrrolyl-tetrahydrobenzochinoxalindione, ihre Herstellung und Verwendung
DE19521058A1 (de) * 1995-06-09 1996-12-12 Basf Ag Verfahren zur Herstellung von Aromaten enthaltenden Polyetherpolyolen
DE19545251A1 (de) * 1995-11-24 1997-05-28 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE19624808A1 (de) 1996-06-21 1998-01-02 Basf Ag Pyrrolylchinoxalindione, ihre Herstellung und Verwendung
JP3908790B2 (ja) * 1996-10-24 2007-04-25 ノバルティス アクチエンゲゼルシャフト 置換アミノアルカンホスホン酸
US5922715A (en) * 1997-02-18 1999-07-13 American Home Products Corporation 5-aminoalkoxy-1, 4-dihydroquinoxaline-2, 3-diones
KR20000071162A (ko) * 1997-02-18 2000-11-25 이곤 이 버그 도파민 효능제인 5-아미노알콕시-1,4-디하이드로퀴녹살린-2,3-디온
JP4707261B2 (ja) * 2001-05-15 2011-06-22 日本エンバイロケミカルズ株式会社 キノキサリン系化合物および工業用殺菌組成物
EP1654221A2 (en) * 2003-06-10 2006-05-10 Smithkline Beecham Corporation Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators
EP2338492A1 (en) 2009-12-24 2011-06-29 Universidad del Pais Vasco Methods and compositions for the treatment of alzheimer
EP2631229B1 (en) 2010-07-29 2014-12-03 Nippon Chemiphar Co., Ltd. P2x4 receptor antagonist
EP3427729A1 (en) 2017-07-13 2019-01-16 Paris Sciences et Lettres - Quartier Latin Probenecid for use in treating epileptic diseases, disorders or conditions
US10890033B1 (en) 2017-12-10 2021-01-12 Watson, Incorporated Kelly bar with locking feature, related system and method

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3431111A (en) * 1963-06-10 1969-03-04 Eastman Kodak Co Cyanine dyes
US3992378A (en) * 1973-12-26 1976-11-16 Eli Lilly And Company Fluoralkyl quinoxadinediones
EP0008864A1 (en) * 1978-08-15 1980-03-19 FISONS plc Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them
EP0030795A3 (en) * 1979-12-06 1981-09-09 Imperial Chemical Industries Plc Quinoxaline derivatives, processes therefor, pharmaceutical compositions, and benzene derivatives
EP0039920B1 (en) * 1980-05-09 1984-07-25 Usv Pharmaceutical Corporation Triazaloquinoxalin-1,4-diones
US4659713A (en) * 1984-10-01 1987-04-21 International Minerals & Chemical Corp. Quinoxalinedione compounds useful for controlling coccidiosis
US4812458A (en) * 1986-09-16 1989-03-14 A/S Ferrosan 6,7-disubstituted-2,3-dihydroxyquinoxaline compounds, pharmaceutical compositions thereof, and their use as neuroleptics
DK146787A (da) * 1987-03-23 1988-09-24 Ferrosan Heterocykliske forbindelser, deres fremstilling og anvendelse
NO179551C (no) * 1987-11-10 1996-10-30 Novo Nordisk As Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser

Also Published As

Publication number Publication date
CA1321587C (en) 1993-08-24
JPH01153680A (ja) 1989-06-15
NO884729L (no) 1989-05-11
NO963412L (no) 1989-05-11
NZ226916A (en) 1991-01-29
AU618766B2 (en) 1992-01-09
PH25103A (en) 1991-02-19
NO884729D0 (no) 1988-10-24
KR890008113A (ko) 1989-07-08
ATE102192T1 (de) 1994-03-15
EP0315959B1 (en) 1994-03-02
IE883209L (en) 1989-05-10
ES2061606T3 (es) 1994-12-16
EP0315959A3 (en) 1989-12-27
IE64320B1 (en) 1995-07-26
AU2494988A (en) 1989-05-11
EP0315959A2 (en) 1989-05-17
PT88964A (pt) 1988-12-01
KR970011279B1 (ko) 1997-07-09
US5026704A (en) 1991-06-25
DE3888093D1 (de) 1994-04-07
NO307252B1 (no) 2000-03-06
PT88964B (pt) 1993-02-26
DE3888093T2 (de) 1994-06-09
NO179551B (no) 1996-07-22
US4948794A (en) 1990-08-14
IL88155A0 (en) 1989-06-30
JP2721520B2 (ja) 1998-03-04
FI885151A (fi) 1989-05-11
FI100181B (fi) 1997-10-15
FI885151A0 (fi) 1988-11-09

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Legal Events

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MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN APRIL 2003