ATE216584T1 - Xanthine-derivate als antidepressiva - Google Patents

Xanthine-derivate als antidepressiva

Info

Publication number: ATE216584T1
Authority: AT; Austria
Prior art keywords: optionally substituted; different; same; group; integer
Prior art date: 1992-07-08

Application number

AT93914963T

Other languages

English (en)

Inventor

Fumio Suzuki

Junichi Shimada

Akio Ishii

Joji Nakamura

Shunji Ichikawa

Shigeto Kitamura

Nobuaki Koike

Original Assignee

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-08

Filing date

1993-07-07

Publication date

2002-05-15

1993-07-07 Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk

2002-05-15 Application granted granted Critical

2002-05-15 Publication of ATE216584T1 publication Critical patent/ATE216584T1/de

Links

LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 title abstract 2
239000000935 antidepressant agent Substances 0.000 title abstract 2
229940005513 antidepressants Drugs 0.000 title abstract 2
229940083747 low-ceiling diuretics xanthine derivative Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000003107 substituted aryl group Chemical group 0.000 abstract 2
125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
- F16B37/00—Nuts or like thread-engaging members
- F16B37/04—Devices for fastening nuts to surfaces, e.g. sheets, plates
- F16B37/048—Non-releasable devices

AT93914963T 1992-07-08 1993-07-07 Xanthine-derivate als antidepressiva ATE216584T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP18102592		1992-07-08
PCT/JP1993/000931 WO1994001114A1 (en)	1992-07-08	1993-07-07	Antidepressant

Publications (1)

Publication Number	Publication Date
ATE216584T1 true ATE216584T1 (de)	2002-05-15

Family

ID=16093453

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93914963T ATE216584T1 (de)	1992-07-08	1993-07-07	Xanthine-derivate als antidepressiva

Country Status (11)

Country	Link
US (1)	US5543415A (de)
EP (1)	EP0628311B1 (de)
JP (1)	JP2928386B2 (de)
AT (1)	ATE216584T1 (de)
CA (1)	CA2116967C (de)
DE (1)	DE69331843T2 (de)
DK (1)	DK0628311T3 (de)
ES (1)	ES2176204T3 (de)
NO (1)	NO306237B1 (de)
PT (1)	PT628311E (de)
WO (1)	WO1994001114A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994025462A1 (en) *	1993-05-03	1994-11-10	The United States Of America, Represented By The	8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists
ATE218139T1 (de) *	1994-02-23	2002-06-15	Kyowa Hakko Kogyo Kk	Xanthin-derivate
US5620676A (en) *	1994-03-08	1997-04-15	The United States Of America As Represented By The Department Of Health And Human Services	Biologically active ATP analogs
US5786360A (en)	1996-11-19	1998-07-28	Link Technology Incorporated	A1 adenosine receptor antagonists
WO1999012546A1 (fr)	1997-09-05	1999-03-18	Kyowa Hakko Kogyo Co., Ltd.	Remede contre la degenerescence neurale
ATE319452T1 (de) *	1999-10-29	2006-03-15	Kyowa Hakko Kogyo Kk	Arzneimittel gegen essstörungen
KR100701455B1 (ko) *	2001-02-15	2007-03-29	그레이트 레이크스 케미칼 코포레이션	하이드록시아릴 포스핀 옥사이드의 혼합물 및 이의 제조방법, 및 이로부터 유도된 에폭시 올리고머 생성물, 난연성 에폭시 조성물, 수지-함침된 복합물 및 적층물
US20020172732A1 (en) *	2001-03-21	2002-11-21	Wies Ter Laak	Composition comprising cocoa
EP2942082B1 (de) *	2002-01-28	2019-03-06	Kyowa Hakko Kogyo Co., Ltd	A2a rezeptor antagonisten zur verwendung in der behandlung von bewegungsstörungen
US20060106040A1 (en) *	2002-12-19	2006-05-18	Michael Grzelak	Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
US20060128694A1 (en) *	2002-12-19	2006-06-15	Michael Grzelak	Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
JP2006518390A (ja) *	2003-02-19	2006-08-10	エンダシア，インコーポレイテッド	Ａ１アデノシンレセプターアンタゴニスト
EP1626049B1 (de) *	2003-05-09	2012-02-22	Kyowa Hakko Kirin Co., Ltd.	Microkristall of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione
US7247639B2 (en) *	2003-06-06	2007-07-24	Endacea, Inc.	A1 adenosine receptor antagonists
CA2528367A1 (en) *	2003-06-09	2004-12-23	Endacea, Inc.	A1 adenosine receptor antagonists
BRPI0411120A (pt) *	2003-06-10	2006-07-18	Kyowa Hakko Kogyo Kk	método para tratar de um distúrbio de ansiedade, composição, agente para tratar de um distúrbio de ansiedade, e, usos de um composto e de um derivado de xantina
TW200507850A (en)	2003-07-25	2005-03-01	Kyowa Hakko Kogyo Kk	Pharmaceutical composition
ES2532479T3 (es)	2004-01-28	2015-03-27	Kyowa Hakko Kirin Co., Ltd.	Agentes para el tratamiento de la migraña
ES2273599B1 (es)	2005-10-14	2008-06-01	Universidad De Barcelona	Compuestos para el tratamiento de la fibrilacion auricular.
GB0719544D0 (en) *	2007-10-08	2007-11-14	Barry Callebaut Ag	Cocoa extract and use thereof
GB0719545D0 (en) *	2007-10-08	2007-11-14	Barry Callebaut Ag	Novel use of cocoa extract
GB0719542D0 (en) *	2007-10-08	2007-11-14	Barry Callebaut Ag	Use of cocoa extract
TWI473614B (zh)	2008-05-29	2015-02-21	Kyowa Hakko Kirin Co Ltd	Anti-analgesic inhibitors
UA113383C2 (xx)	2009-09-02	2017-01-25		Терапевтичний агент для лікування тривожних розладів
UA110097C2 (uk)	2009-09-02	2015-11-25		Терапевтичний агент для лікування розладів настрою
RU2477726C1 (ru) *	2011-10-18	2013-03-20	Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак")	Замещенные феноксиуксусные кислоты, их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент, - антагонисты аденозинового a2a рецептора и их применение
CN104744464B (zh) *	2013-11-15	2016-09-21	南京华威医药科技开发有限公司	伊曲茶碱晶型
CN104262342B (zh) *	2014-08-26	2019-01-29	南京恒道医药科技有限公司	一种伊曲茶碱中间体的制备方法
CN105884776A (zh) *	2014-11-05	2016-08-24	南京瑞天医药科技有限公司	一种伊曲茶碱的新晶型及其制备方法
CN110981876B (zh) *	2018-12-21	2021-10-01	广东东阳光药业有限公司	8-取代的苯乙烯基黄嘌呤衍生物及其用途
CN111333648B (zh) *	2019-04-24	2021-05-11	东莞市东阳光新药研发有限公司	8-取代的芳香环乙烯基黄嘌呤衍生物及其用途
CN110041331B (zh) *	2019-05-17	2020-08-07	广东东阳光药业有限公司	苯乙烯基黄嘌呤衍生物及其用途
CN111018856B (zh) *	2019-12-12	2021-10-01	广东东阳光药业有限公司	8-取代的苯乙烯基黄嘌呤衍生物及其用途
CN111072663B (zh) *	2019-12-12	2021-10-01	广东东阳光药业有限公司	8-取代的苯乙烯基黄嘌呤衍生物及其用途
CN113248505B (zh) *	2021-06-09	2021-09-21	南京安杰新生物医药有限公司	伊曲茶碱去甲基杂质的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3641010A (en) *	1970-06-11	1972-02-08	Parke Davis & Co	Novel xanthine compounds and means for obtaining the same
FR2512672A1 (fr) *	1981-09-16	1983-03-18	Panmedica	Nouvelles compositions a base de 5-hydroxytryptophane, leur procede de preparation et medicaments les contenant
FR2531713A2 (fr) *	1981-09-16	1984-02-17	Panmedica Sa	Nouvelles compositions a base de 5-hydroxytryptophane, leur procede de preparation et medicaments les contenant
DE3224100A1 (de) *	1982-06-29	1983-12-29	Michael 6950 Schriesheim Long	Depotmedikament zur behandlung von psychologischen aberrationen, erkrankungen und dergleichen
US4769377A (en) *	1983-02-18	1988-09-06	The Johns Hopkins University	Adenosine receptor antagonists
JPH0256428A (ja) *	1988-08-19	1990-02-26	Rohto Pharmaceut Co Ltd	肥満症治療剤
US5047534A (en) *	1990-03-26	1991-09-10	Merrell Dow Pharmaceuticals Inc.	Selective adenosine receptor agents
DE69130869T2 (de) *	1990-10-18	1999-06-10	Kyowa Hakko Kogyo Kk	Xanthinderivate
IT1260444B (it) *	1992-01-24	1996-04-09	Mario Brufani	Derivati della 8-(1-amminocicloalchil)1,3-dialchilxantina, procedimenbto di preparazione e loro composizioni farmaceutiche antidepressive, nootropiche e psicostimolanti
CA2093403C (en) *	1992-04-08	1999-08-10	Fumio Suzuki	Therapeutic agent for parkinson's disease

1993
- 1993-07-07 JP JP6502746A patent/JP2928386B2/ja not_active Expired - Fee Related
- 1993-07-07 AT AT93914963T patent/ATE216584T1/de not_active IP Right Cessation
- 1993-07-07 EP EP93914963A patent/EP0628311B1/de not_active Expired - Lifetime
- 1993-07-07 PT PT93914963T patent/PT628311E/pt unknown
- 1993-07-07 WO PCT/JP1993/000931 patent/WO1994001114A1/ja active IP Right Grant
- 1993-07-07 DE DE69331843T patent/DE69331843T2/de not_active Expired - Fee Related
- 1993-07-07 US US08/199,142 patent/US5543415A/en not_active Expired - Lifetime
- 1993-07-07 DK DK93914963T patent/DK0628311T3/da active
- 1993-07-07 ES ES93914963T patent/ES2176204T3/es not_active Expired - Lifetime
- 1993-07-07 CA CA002116967A patent/CA2116967C/en not_active Expired - Fee Related
1994
- 1994-03-03 NO NO940737A patent/NO306237B1/no unknown

Also Published As

Publication number	Publication date
DE69331843T2 (de)	2002-09-26
CA2116967A1 (en)	1994-01-20
WO1994001114A1 (en)	1994-01-20
JP2928386B2 (ja)	1999-08-03
NO940737D0 (no)	1994-03-03
DK0628311T3 (da)	2002-07-22
US5543415A (en)	1996-08-06
CA2116967C (en)	2003-08-19
NO306237B1 (no)	1999-10-11
EP0628311B1 (de)	2002-04-24
EP0628311A4 (de)	1999-03-10
PT628311E (pt)	2002-09-30
ES2176204T3 (es)	2002-12-01
NO940737L (de)	1994-05-03
DE69331843D1 (de)	2002-05-29
EP0628311A1 (de)	1994-12-14
JPH09502006A (ja)	1997-02-25

Legal Events

Date	Code	Title	Description
2009-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE216584T1 (de)	2002-05-15	Xanthine-derivate als antidepressiva
NO933452L (no)	1994-03-29	Et terapeutisk middel for Parkinson's sykdom
ATE206412T1 (de)	2001-10-15	Heterocyclische verbindungen als bradykinin antagonisten
MX9202142A (es)	1993-06-01	Nuevos derivados de urea, proceso para su preparacion, y composicion farmaceutica que los comprende.
ATE180468T1 (de)	1999-06-15	Anthranilsäure derivate
KR920700204A (ko)	1992-02-19	트리아진유도체 및 그것을 유효성분으로 하는 제초제
MX9306831A (es)	1995-01-31	Nuevos compuestos heterociclicos.
DE69613139D1 (de)	2001-07-05	Heterozyclische fungizide
ATE173256T1 (de)	1998-11-15	Azolidindion-derivate und ihre anwendung als antihyperglykämika
ATE218132T1 (de)	2002-06-15	Azol-derivate
DK0565377T3 (da)	1998-03-16	Terapeutiske midler til behandling af Parkinsons sygdom
DE69111816D1 (de)	1995-09-07	Indolederivate und ihre verwendung als serotonin-antagoniste.
ATE170851T1 (de)	1998-09-15	Guanidinothiazolederivate und ihre anwendung als h2-rezeptor-antagonisten
DK0466662T3 (da)	1995-11-27	6,7-Disubstituerede-2-aminotetraliner, der er aktive som immunmodulatorer, samt farmaceutiske præparater indeholdende sådanne forbindelser
HU9602534D0 (en)	1996-11-28	Use of biphenyl methyl imidazole derivatives for producing pharmaceutical compositions having ocular tension derpessant activity
EA199800720A1 (ru)	1999-02-25	Гетероциклические производные эрголина в качестве лигандов 5-htia рецептора
HUP0202237A2 (hu)	2002-11-28	Amin, módosított pszeudomicin vegyületek, azokat tartalmazó gyógyászati készítmény és alkalmazásuk