ES2104535T1 - Vacuna que contiene proteina de membrana externa de bordetella pertussis, y metodo para elaborar tal vacuna. - Google Patents
Vacuna que contiene proteina de membrana externa de bordetella pertussis, y metodo para elaborar tal vacuna.Info
- Publication number
- ES2104535T1 ES2104535T1 ES96202627T ES96202627T ES2104535T1 ES 2104535 T1 ES2104535 T1 ES 2104535T1 ES 96202627 T ES96202627 T ES 96202627T ES 96202627 T ES96202627 T ES 96202627T ES 2104535 T1 ES2104535 T1 ES 2104535T1
- Authority
- ES
- Spain
- Prior art keywords
- vaccine
- preparing
- bordetella pertussis
- membrane protein
- pertussis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 241000588832 Bordetella pertussis Species 0.000 title abstract 2
- 108010052285 Membrane Proteins Proteins 0.000 title 1
- 201000005702 Pertussis Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 102000030621 adenylate cyclase Human genes 0.000 abstract 1
- 108060000200 adenylate cyclase Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960003983 diphtheria toxoid Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960000814 tetanus toxoid Drugs 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
UNA VACUNA EN COMPUESTO CONTRA LA ENFERMEDAD CAUSADA POR LA INFECCION POR BORDETELLA PERTUSSIS, QUE SE CARACTERIZA POR: COMO PRIMER COMPONENTE, PERTACTINA PURIFICADA QUE NO TIENE ACTIVIDAD CICLASA DE ADENILATO DETECTABLE; COMO COMPONENTE ADICIONAL AL MENOS OTRO ANTIGENO DE B. PERTUSSIS PURIFICADO QUE ES LA TOXINA PERTUSSIS (TP), HEMAGLUTININA FILAMENTOSA (FHA) Y/O AGLUTINOGENOS; COMO DOS COMPONENTES ADICIONALES, AL MENOS OTROS DOS ANTIGENOS DE NO-BORDETELLA PURIFICADOS QUE SON EL TOXOIDE DE LA DIFTERIA (D) Y EL TOXOIDE DEL TETANOS (T); Y UN VEHICULO ACEPTABLE FARMACEUTICAMENTE DE LO ANTERIOR.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909007657A GB9007657D0 (en) | 1990-04-04 | 1990-04-04 | Purification of a pertussis outer membrane protein(omp69) |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2104535T1 true ES2104535T1 (es) | 1997-10-16 |
Family
ID=10673904
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91906730T Expired - Lifetime ES2088374T5 (es) | 1990-04-04 | 1991-04-03 | Purificacion y uso de pertactina, una proteina de membrana externa de bordetella pertussis. |
ES96202627T Pending ES2104535T1 (es) | 1990-04-04 | 1991-04-03 | Vacuna que contiene proteina de membrana externa de bordetella pertussis, y metodo para elaborar tal vacuna. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91906730T Expired - Lifetime ES2088374T5 (es) | 1990-04-04 | 1991-04-03 | Purificacion y uso de pertactina, una proteina de membrana externa de bordetella pertussis. |
Country Status (11)
Country | Link |
---|---|
US (2) | US5444159A (es) |
EP (2) | EP0527753B2 (es) |
JP (1) | JP2549225B2 (es) |
AT (1) | ATE147754T1 (es) |
CA (1) | CA2079887C (es) |
DE (3) | DE761230T1 (es) |
DK (1) | DK0527753T4 (es) |
ES (2) | ES2088374T5 (es) |
GB (1) | GB9007657D0 (es) |
GR (2) | GR3022769T3 (es) |
WO (1) | WO1991015505A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8412207D0 (en) * | 1984-05-12 | 1984-06-20 | Wellcome Found | Antigenic preparations |
GB8910570D0 (en) | 1989-05-08 | 1989-06-21 | Wellcome Found | Acellular vaccine |
US6197548B1 (en) | 1990-04-02 | 2001-03-06 | Medeva Pharma Limited | Transformed Pichia expressing the pertactin antigen |
NL9002092A (nl) * | 1990-09-25 | 1992-04-16 | Nederlanden Staat | Vaccin, geschikt voor de bestrijding van bordetella pertussis. |
US6444211B2 (en) * | 1991-04-03 | 2002-09-03 | Connaught Laboratories, Inc. | Purification of a pertussis outer membrane protein |
GB9304399D0 (en) * | 1993-03-04 | 1993-04-21 | Smithkline Beecham Biolog | Novel process |
DE69511392T2 (de) * | 1994-04-28 | 2000-03-23 | Takeda Chemical Industries Ltd | Verfahren zur trennung von protektiven verbindungen aus bordetella pertussis |
US5877298A (en) * | 1995-05-04 | 1999-03-02 | Connaught Lab | Acellular pertussis vaccines and methods of preparing thereof |
EP1233022B1 (en) * | 1995-05-04 | 2015-12-09 | Aventis Pasteur Limited | Methods of preparation of components of acellular pertussis vaccines |
JP3745805B2 (ja) * | 1995-10-24 | 2006-02-15 | 日本ケミカルリサーチ株式会社 | トロンボモジュリンの精製方法 |
US5739313A (en) | 1995-11-13 | 1998-04-14 | Regents Of The University Of Minnesota | Radionuclide labeling of vitamin B12 and coenzymes thereof |
AU724743B2 (en) * | 1996-05-31 | 2000-09-28 | Genetics Institute, Llc | IL-12 as an adjuvant for Bordetella Pertussis vaccines |
EP1762246A1 (en) | 1996-07-02 | 2007-03-14 | Sanofi Pasteur Limited | Multivalent DTP-Polio vaccines |
DE60231651D1 (de) * | 2001-12-21 | 2009-04-30 | Immunex Corp | Proteinreinigungsverfahren |
WO2009016651A1 (en) * | 2007-07-31 | 2009-02-05 | Panacea Biotec Limited | Simplified means for obtaining prn from bordetella pertussis |
US8574589B2 (en) | 2009-05-11 | 2013-11-05 | Novartis Ag | Antigen purification process for pertactin antigen |
CN102584958A (zh) * | 2012-02-08 | 2012-07-18 | 北京天坛生物制品股份有限公司 | 百日咳杆菌69kd外膜蛋白的纯化方法 |
DK2863943T3 (en) | 2013-03-08 | 2016-11-07 | Janssen Vaccines & Prevention Bv | acellular pertussis vaccines |
KR102426041B1 (ko) * | 2017-08-01 | 2022-07-29 | 주식회사 녹십자 | 냉동 및 해동 과정을 포함하는 백일해균 유래 단백질 수득 방법 |
CN113151081A (zh) * | 2021-04-21 | 2021-07-23 | 深圳市儿童医院 | 一种百日咳鲍特菌培养基及其制备方法 |
WO2024056508A1 (en) | 2022-09-15 | 2024-03-21 | Cube Biotech Gmbh | In vitro diagnostic method for detecting the presence of a target by using stabilized membrane proteins |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5237052A (en) * | 1984-05-12 | 1993-08-17 | Burroughs Wellcome Company | Antigenic preparations and isolation of such preparations |
GB8412207D0 (en) * | 1984-05-12 | 1984-06-20 | Wellcome Found | Antigenic preparations |
GB8807860D0 (en) * | 1988-04-05 | 1988-05-05 | Connaught Lab | Pertussis vaccine |
US5101014A (en) * | 1989-02-10 | 1992-03-31 | United States Of America | Process for the purification of a 69,000 da outer membrane protein of Bordetella pertussis |
US5276142A (en) * | 1989-12-11 | 1994-01-04 | American Cyanamid Company | Process for purification of a 69000 dalton antigenic protein from Bordetella pertussis |
GB9007416D0 (en) † | 1990-04-02 | 1990-05-30 | Wellcome Found | Expression of heterologous protein in yeast |
-
1990
- 1990-04-04 GB GB909007657A patent/GB9007657D0/en active Pending
-
1991
- 1991-04-03 EP EP91906730A patent/EP0527753B2/en not_active Expired - Lifetime
- 1991-04-03 JP JP3506712A patent/JP2549225B2/ja not_active Expired - Lifetime
- 1991-04-03 DE DE0761230T patent/DE761230T1/de active Pending
- 1991-04-03 WO PCT/CA1991/000110 patent/WO1991015505A1/en active IP Right Grant
- 1991-04-03 DE DE69124235T patent/DE69124235T3/de not_active Expired - Lifetime
- 1991-04-03 EP EP96202627A patent/EP0761230A3/en not_active Withdrawn
- 1991-04-03 DE DE0527753T patent/DE527753T1/de active Pending
- 1991-04-03 CA CA002079887A patent/CA2079887C/en not_active Expired - Lifetime
- 1991-04-03 AT AT91906730T patent/ATE147754T1/de not_active IP Right Cessation
- 1991-04-03 ES ES91906730T patent/ES2088374T5/es not_active Expired - Lifetime
- 1991-04-03 DK DK91906730T patent/DK0527753T4/da active
- 1991-04-03 ES ES96202627T patent/ES2104535T1/es active Pending
-
1992
- 1992-11-06 US US07/930,595 patent/US5444159A/en not_active Expired - Lifetime
-
1995
- 1995-05-04 US US08/433,644 patent/US5667787A/en not_active Expired - Lifetime
-
1997
- 1997-03-07 GR GR970400453T patent/GR3022769T3/el unknown
- 1997-10-31 GR GR970300034T patent/GR970300034T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2088374T3 (es) | 1997-05-16 |
ATE147754T1 (de) | 1997-02-15 |
CA2079887C (en) | 1998-06-23 |
EP0527753B1 (en) | 1997-01-15 |
ES2088374T1 (es) | 1996-08-16 |
DE761230T1 (de) | 1997-09-25 |
US5667787A (en) | 1997-09-16 |
ES2088374T5 (es) | 2004-08-16 |
JPH05506649A (ja) | 1993-09-30 |
GB9007657D0 (en) | 1990-05-30 |
GR3022769T3 (en) | 1997-06-30 |
DE69124235D1 (de) | 1997-02-27 |
EP0527753B2 (en) | 2003-12-17 |
DK0527753T3 (da) | 1997-04-07 |
DE69124235T2 (de) | 1997-05-28 |
DE69124235T3 (de) | 2004-06-03 |
GR970300034T1 (en) | 1997-10-31 |
WO1991015505A1 (en) | 1991-10-17 |
EP0527753A1 (en) | 1993-02-24 |
US5444159A (en) | 1995-08-22 |
DE527753T1 (de) | 1996-11-28 |
JP2549225B2 (ja) | 1996-10-30 |
EP0761230A2 (en) | 1997-03-12 |
EP0761230A3 (en) | 1999-01-20 |
CA2079887A1 (en) | 1991-10-05 |
DK0527753T4 (da) | 2004-03-22 |
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