ES2087950T3 - Derivados de benzofenona oxima, composicion farmaceutica y su utilizacion. - Google Patents

Derivados de benzofenona oxima, composicion farmaceutica y su utilizacion.

Info

Publication number
ES2087950T3
ES2087950T3 ES91119345T ES91119345T ES2087950T3 ES 2087950 T3 ES2087950 T3 ES 2087950T3 ES 91119345 T ES91119345 T ES 91119345T ES 91119345 T ES91119345 T ES 91119345T ES 2087950 T3 ES2087950 T3 ES 2087950T3
Authority
ES
Spain
Prior art keywords
lower alkyl
benzofenona
oxima
derivatives
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91119345T
Other languages
English (en)
Inventor
Youji Yamagishi
Kozo Akasaka
Takeshi Suzuki
Mitsuaki Miyamoto
Kouji Nakamoto
Kazuo Okano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP61065963A external-priority patent/JPH07103082B2/ja
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ES2087950T3 publication Critical patent/ES2087950T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/14—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/40—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/52—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/60—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/62—Carboxylic acid nitriles containing cyano groups and oxygen atoms being part of oxyimino groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/04—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers
    • C07C257/06—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers having carbon atoms of imino-carboxyl groups bound to hydrogen atoms, to acyclic carbon atoms, or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/58—Derivatives of thiocarboxylic acids, the doubly-bound oxygen atoms being replaced by nitrogen atoms, e.g. imino-thio ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

UN NUEVO DERIVADO DE DIFENIL-METANO ES UTIL PARA INHIBIR LA AGLOMERACION DE SANGRE Y ESTA DEFINIDO POR LA FORMULA, INCLUYENDO UN DERIVADO DE DIFENILETILENO Y UN DERIVADO DE ETER DE OXIMA DE BENZOFENONA. DONDE R1 Y R2 SON CADA UNO HIDROGENO, HIDROXILO O UN ALCOXI INFERIOR, V ES = CXY O = N -OW, X ES HIDROGENO, CIANO O -COR6, SIENDO R6 HIDROXILO O UN AMINO, Y ES -R10-COOR3, SIENDO R3 HIDROGENO O UN ALCOXI INFERIOR, R10 ES UN ALQUILENO CON 1 A 3 ATOMOS DE CARBONO, EN LINEA O RAMIFICADO, -CO-XR4, R5, R4 Y R5 SON CADA UNO HIDROGENO, UN ALQUILO INFERIOR O UN ARILALQUILO INFERIOR, -CH2 -NHSO2 -C6HS O -C(R8)R7 ES UN ALCOXI INFERIOR O UN ARILO, R8 ES -VR9, SIENDO V OXIGENO, AZUFRE O NITROGENO, R9 ES UN ALQUILO O UN ARILO, W ES -CH2-CO-CH2-COOR13, SIENDO R13 HIDROGENO O UN ALQUILO INFERIOR, -CH2-C(=NOR14)-CH2-COOR15, R15 ES HIDROGENO O UN ALQUILO INFERIOR, SIENDO R14 UN ALQUILO INFERIOR, -CH(CN)-(CH2)Q-COOR16, R16 ES HIDROGENO O UN ALQUILO INFERIOR, SIENDO Q UN NUMERO ENTERO DE 1 A 3, O -(CH2)P-Z, SIENDO Z-SH, -SCN O UN GRUPO MONOVALENTE DERIVADO DE UN ANILLO DE CINCO O SEIS ELEMENTOS QUE PUEDE SUSTITUIRSE POR UN ANILLO CON UNO O MAS ATOMOS DE AZUFRE EN EL ANILLO, SIENDO P 1 O 2. TAMBIEN SE DESCRIBE UNA COMPOSICION FARMACEUTICA QUE CONTIENE COMPUESTOS DE FORMULA (XX) O SUS SALES FARMACEUTICAMENTE ACTIVAS COMO INGREDIENTES ACTIVOS, Y EL USO DE COMPUESTOS DE FORMULA (XX) O SUS SALES FARMACEUTICAMENTE ACEPTABLES EN LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO DE ENFERMEDADES CAUSADAS POR TRASTORNOS EN EL RIEGO SANGUINEO.
ES91119345T 1986-03-17 1987-03-17 Derivados de benzofenona oxima, composicion farmaceutica y su utilizacion. Expired - Lifetime ES2087950T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP5706186 1986-03-17
JP61065963A JPH07103082B2 (ja) 1986-03-26 1986-03-26 置換ベンゾフエノンオキシムエ−テル誘導体

Publications (1)

Publication Number Publication Date
ES2087950T3 true ES2087950T3 (es) 1996-08-01

Family

ID=26398063

Family Applications (4)

Application Number Title Priority Date Filing Date
ES87103834T Expired - Lifetime ES2052504T3 (es) 1986-03-17 1987-03-17 Derivado de difenilmetano, compuesto farmaceutico y su utilizacion.
ES91119345T Expired - Lifetime ES2087950T3 (es) 1986-03-17 1987-03-17 Derivados de benzofenona oxima, composicion farmaceutica y su utilizacion.
ES89114183T Expired - Lifetime ES2043982T3 (es) 1986-03-17 1987-03-17 Derivado de difenil-metano, compuesto farmaceutico y utilizacion del mismo.
ES91119344T Expired - Lifetime ES2073648T3 (es) 1986-03-17 1987-03-17 Derivado de difenil-metano, composicion farmaceutica y su utilizacion.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES87103834T Expired - Lifetime ES2052504T3 (es) 1986-03-17 1987-03-17 Derivado de difenilmetano, compuesto farmaceutico y su utilizacion.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES89114183T Expired - Lifetime ES2043982T3 (es) 1986-03-17 1987-03-17 Derivado de difenil-metano, compuesto farmaceutico y utilizacion del mismo.
ES91119344T Expired - Lifetime ES2073648T3 (es) 1986-03-17 1987-03-17 Derivado de difenil-metano, composicion farmaceutica y su utilizacion.

Country Status (18)

Country Link
US (6) US4886834A (es)
EP (4) EP0346943B1 (es)
KR (1) KR920007233B1 (es)
CN (1) CN1014889B (es)
AT (2) ATE139225T1 (es)
AU (1) AU593334B2 (es)
CA (1) CA1296338C (es)
DE (4) DE3751367T2 (es)
DK (1) DK133487A (es)
ES (4) ES2052504T3 (es)
FI (1) FI92189C (es)
GR (2) GR3006448T3 (es)
HU (1) HU196589B (es)
IE (2) IE930935L (es)
MX (1) MX172622B (es)
NO (1) NO168577C (es)
NZ (1) NZ219630A (es)
PH (1) PH23358A (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2639942B1 (fr) * 1988-12-02 1991-03-29 Sanofi Sa Ethers oximes de propenone, procede pour leur preparation et compositions pharmaceutiques les contenant
CA2100918C (en) * 1992-07-21 1997-01-21 Nobuyuki Hamanaka Oxime derivative
DE4415871A1 (de) * 1994-05-05 1995-11-09 Basf Ag O-(Oxyimino)ethyl-Cyclohexenonoximether und deren Verwendung als Herbizide
FR2802930B1 (fr) * 1999-12-23 2003-10-10 Fournier Ind & Sante Benzophenone glycopyranosides, preparation et utilisation en therapeutique
FR2802929B1 (fr) * 1999-12-23 2003-06-06 Fournier Ind & Sante Benzophenone alpha-d-glycopyranosides, preparation et utilisation en therapeutique
US7097645B2 (en) * 2001-06-04 2006-08-29 Sdgi Holdings, Inc. Dynamic single-lock anterior cervical plate system having non-detachably fastened and moveable segments
JP4283665B2 (ja) * 2001-06-04 2009-06-24 ウォーソー・オーソペディック・インコーポレーテッド 可動セグメントを有する前方頸椎用動的平板
US7186256B2 (en) * 2001-06-04 2007-03-06 Warsaw Orthopedic, Inc. Dynamic, modular, single-lock anterior cervical plate system having assembleable and movable segments
US7041105B2 (en) * 2001-06-06 2006-05-09 Sdgi Holdings, Inc. Dynamic, modular, multilock anterior cervical plate system having detachably fastened assembleable and moveable segments
US7044952B2 (en) * 2001-06-06 2006-05-16 Sdgi Holdings, Inc. Dynamic multilock anterior cervical plate system having non-detachably fastened and moveable segments
US8563279B2 (en) * 2007-12-24 2013-10-22 Dsm Ip Assets B.V. Convergent synthesis of renin inhibitors and intermediates useful therein
CA2740772A1 (en) 2008-10-09 2010-04-15 Asahi Kasei Pharma Corporation Indazole compounds
AU2009301797B2 (en) 2008-10-09 2012-03-01 Asahi Kasei Pharma Corporation Indazole derivative
EP2749300A1 (en) * 2012-12-26 2014-07-02 Universidad Del Pais Vasco-Euskal Herriko Unibertsitatea Modified polyaryletherketone polymer (PAEK) and process to obtain it
CN106883141B (zh) * 2017-03-15 2018-08-10 何黎琴 一种丹皮酚肟醚类化合物、其制备方法及医药用途
CN107602414A (zh) * 2017-10-29 2018-01-19 合肥祥晨化工有限公司 一种二苯甲酮肟二聚体晶体化合物的合成方法及用途
CN108658084B (zh) * 2018-04-23 2021-12-03 上海大学 表面改性二氧化硅微球、其复合纳米微球及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB999613A (es) *
NL126306C (es) * 1960-03-09
US3215725A (en) * 1961-11-02 1965-11-02 Gen Aniline & Film Corp Bis-alpha-cyano-beta, beta-diphenylacrylic acid derivatives
US3215724A (en) * 1961-09-18 1965-11-02 Gen Aniline & Film Corp alpha-cyano-beta, beta-diphenyl acrylic acid esters
US3272810A (en) * 1962-05-01 1966-09-13 Gen Aniline & Film Corp Alpha-cyano-beta, beta-diphenylacrylamide compounds
US3149148A (en) * 1962-01-02 1964-09-15 Gen Aniline & Film Corp Process for condensation reactions
US3644466A (en) * 1966-05-06 1972-02-22 Gaf Corp Alpha-cyano-beta beta-diphenylacrylic acid esters
BE754469A (fr) * 1969-08-05 1971-02-05 Beecham Group Ltd Derives d'acides alkenoiques
GB1488003A (en) * 1973-10-23 1977-10-05 Lilly Industries Ltd 1,2-benzisoxazole derivatives processes for their preparation and their use as pharmaceuticals
GB1599181A (en) * 1977-04-01 1981-09-30 Ici Ltd Oxyalkanoic acid derivatives
GB2058057A (en) * 1979-08-31 1981-04-08 Boots Co Ltd Pesticidal substituted benzophenone hydrazones
CA1142540A (en) * 1979-12-12 1983-03-08 Georg Frater Propionic acid esters
DE3340265A1 (de) * 1983-11-08 1985-05-15 Basf Ag, 6700 Ludwigshafen Cyclohexan-1,3-dionderivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
CS244440B2 (en) * 1983-02-28 1986-07-17 Celamerck Gmbh & Co Kg Method of acrylic acids' new amides production
US4603145A (en) * 1983-05-06 1986-07-29 American Cyanamid Company Antiatherosclerotic diphenyl alkanamides
US4536346A (en) * 1983-05-06 1985-08-20 American Cyanamid Company Aralkanamidophenyl compounds

Also Published As

Publication number Publication date
AU7008587A (en) 1987-09-24
KR870008836A (ko) 1987-10-21
EP0346943B1 (en) 1993-02-17
DE3784253T2 (de) 1993-08-12
US4954523A (en) 1990-09-04
ES2052504T3 (es) 1994-07-16
NO168577C (no) 1992-03-11
FI871022A0 (fi) 1987-03-09
DE3751838D1 (de) 1996-07-18
US5034418A (en) 1991-07-23
EP0238973B1 (en) 1992-12-02
GR3006448T3 (es) 1993-06-21
MX172622B (es) 1994-01-04
PH23358A (en) 1989-07-14
AU593334B2 (en) 1990-02-08
HUT44007A (en) 1988-01-28
DE3782837T2 (de) 1993-04-29
NO871072L (no) 1987-09-18
ATE139225T1 (de) 1996-06-15
US4886834A (en) 1989-12-12
DE3784253D1 (de) 1993-03-25
EP0238973A2 (en) 1987-09-30
CA1296338C (en) 1992-02-25
US5064848A (en) 1991-11-12
KR920007233B1 (ko) 1992-08-28
IE930935L (en) 1987-09-17
FI871022A (fi) 1987-09-18
DE3751367D1 (de) 1995-07-27
HU196589B (en) 1988-12-28
EP0478001A1 (en) 1992-04-01
EP0479332A3 (en) 1992-04-15
GR3007103T3 (es) 1993-07-30
EP0238973A3 (en) 1989-10-04
EP0479332A2 (en) 1992-04-08
EP0479332B1 (en) 1995-06-21
DE3751838T2 (de) 1996-11-28
US4978767A (en) 1990-12-18
EP0346943A1 (en) 1989-12-20
US5103010A (en) 1992-04-07
IE63993B1 (en) 1995-06-28
CN1014889B (zh) 1991-11-27
NO168577B (no) 1991-12-02
NO871072D0 (no) 1987-03-16
CN87101979A (zh) 1987-10-28
DK133487A (da) 1987-09-18
ES2043982T3 (es) 1994-01-01
DE3751367T2 (de) 1996-01-25
DE3782837D1 (de) 1993-01-14
NZ219630A (en) 1990-08-28
EP0478001B1 (en) 1996-06-12
FI92189B (fi) 1994-06-30
FI92189C (fi) 1994-10-10
ES2073648T3 (es) 1995-08-16
DK133487D0 (da) 1987-03-16
ATE124032T1 (de) 1995-07-15
IE870690L (en) 1987-09-17

Similar Documents

Publication Publication Date Title
ES2087950T3 (es) Derivados de benzofenona oxima, composicion farmaceutica y su utilizacion.
NZ331319A (en) Cyclic amine derivatives that are CCR-3 receptor (chemokine receptor) antagonists, compositions containing them and methods for their use (to combat eosinophil induced diseases).
FR2651122B1 (fr) Compositions destinees a etre utilisees pour freiner la chute des cheveux et pour induire et stimuler leur croissance, contenant des derives de l'amino-2 pyrimidine oxyde-3 et nouveaux composes derives de l'amino-2 pyrimidine oxyde-3.
FR2673532B1 (fr) Procede de teinture des fibres keratiniques associant l'isatine ou ses derives a une aminopyridine ou aminopyrimidine, et agents de teinture.
ATE137749T1 (de) Benzomorphane und ihre verwendung als arzneimittel
FR2659653B1 (fr) Derives de l'uree, leur preparation et les medicaments les contenant.
IT1200450B (it) Stabilizzanti per polimeri sintetici
IE41462L (en) Piperidyl-methylenedioxybenzene derivatives.
FI20021652A (fi) Tratsodonin alkyylijohdannaisten valmistuksessa käyttökelpoisia välituotteita
DE69522955D1 (de) Okulares hypotensium
ES2090901T3 (es) Composiciones de tincion de fibras queratinicas a base de 4-monoindolil-1,2-naftoquinonas y nuevos compuestos de 4-monoindolil-1,2-naftoquinonas.
CA2070120A1 (en) Thioxanthenone antitumor agents
FR2315256A1 (fr) Coupleurs nitres utilisables en teintures directes, teintures d'oxydation et teintures mixtes
FR2330673A1 (fr) Coupleurs nitres utilisables en teintures directes, teintures d'oxydation et teintures mixtes
KR790000401B1 (en) Tricyclic compounds
NL7604231A (en) Bi- and tricyclic pyridine thio-amides - for use as antiulcer agents
BE810256A (en) Pyrazolinebenzenesulphonamide derivs. - useful as anionic optical brightene-rs, esp. for polyamide fibres

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 478001

Country of ref document: ES