DE69522955D1 - Okulares hypotensium - Google Patents

Okulares hypotensium

Info

Publication number
DE69522955D1
DE69522955D1 DE69522955T DE69522955T DE69522955D1 DE 69522955 D1 DE69522955 D1 DE 69522955D1 DE 69522955 T DE69522955 T DE 69522955T DE 69522955 T DE69522955 T DE 69522955T DE 69522955 D1 DE69522955 D1 DE 69522955D1
Authority
DE
Germany
Prior art keywords
group
alkyl
formula
alkenyl
carboxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69522955T
Other languages
English (en)
Other versions
DE69522955T2 (de
Inventor
Tomihisa Yokoyama
Tsunemichi Hosokawa
Hiroaki Yanagisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of DE69522955D1 publication Critical patent/DE69522955D1/de
Publication of DE69522955T2 publication Critical patent/DE69522955T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Steroid Compounds (AREA)
DE69522955T 1994-03-16 1995-03-16 Okulares hypotensium Expired - Fee Related DE69522955T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4540494 1994-03-16
PCT/JP1995/000444 WO1995024902A1 (fr) 1994-03-16 1995-03-16 Reducteur de tension oculaire

Publications (2)

Publication Number Publication Date
DE69522955D1 true DE69522955D1 (de) 2001-10-31
DE69522955T2 DE69522955T2 (de) 2002-05-29

Family

ID=12718322

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69533045T Expired - Fee Related DE69533045T2 (de) 1994-03-16 1995-03-16 Okulares Hypotonikum
DE69522955T Expired - Fee Related DE69522955T2 (de) 1994-03-16 1995-03-16 Okulares hypotensium

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69533045T Expired - Fee Related DE69533045T2 (de) 1994-03-16 1995-03-16 Okulares Hypotonikum

Country Status (20)

Country Link
US (1) US5925664A (de)
EP (2) EP0795326B1 (de)
KR (1) KR100211446B1 (de)
CN (2) CN1104898C (de)
AT (2) ATE206050T1 (de)
AU (1) AU684916B2 (de)
CZ (1) CZ284395B6 (de)
DE (2) DE69533045T2 (de)
DK (2) DK0795326T3 (de)
ES (2) ES2221872T3 (de)
FI (2) FI114897B (de)
GR (1) GR3036989T3 (de)
HK (1) HK1000551A1 (de)
HU (1) HUT74734A (de)
MX (1) MX9604109A (de)
NO (1) NO311068B1 (de)
NZ (1) NZ282485A (de)
PT (2) PT1110551E (de)
RU (1) RU2123847C1 (de)
WO (1) WO1995024902A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200103603T2 (tr) * 1999-06-11 2002-05-21 Sankyo Company Limited Topikal uygulama için göz içi tansiyonu düşüren terkipler
TWI290470B (en) * 1999-12-01 2007-12-01 Sankyo Co The composition for treating glaucoma
GR20000100281A (el) * 2000-08-17 2002-05-24 Ιωαννης Ματσουκας Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων
WO2002045748A1 (fr) * 2000-12-05 2002-06-13 Sankyo Company, Limited Compositions d'abaissement de la tension oculaire pour administration topique
CA2522318C (en) * 2003-04-15 2011-09-13 Sankyo Company Limited Drug for preventing or treating angiogenic eye diseases

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA875052B (en) * 1986-07-11 1989-03-29 Du Pont Angiotensin ii receptor blocking imidazoles
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
WO1991000277A1 (en) * 1989-06-30 1991-01-10 E.I. Du Pont De Nemours And Company Substituted imidazoles
WO1991015206A1 (en) * 1990-04-05 1991-10-17 E.I. Du Pont De Nemours And Company Treatment of glaucoma and ocular hypertension with imidazole angiotensin-ii receptor antagonists
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5126342A (en) * 1990-10-01 1992-06-30 Merck & Co., Inc. Imidazole angiotensin ii antagonists incorporating acidic functional groups
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
IE920540A1 (en) * 1991-02-21 1992-08-26 Sankyo Co 1-biphenylmethylimidazole derivatives, their preparation and¹their therapetuic use
US5219856A (en) * 1992-04-06 1993-06-15 E. I. Du Pont De Nemours And Company Angiotensin-II receptor blocking, heterocycle substituted imidazoles
DE69329982T2 (de) * 1992-06-02 2001-09-27 Sankyo Co 4-Carboxyimidazolderivate als Angiotensin-II-Antagonisten und ihre therapeutische Verwendung
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
RU2109736C1 (ru) * 1992-12-17 1998-04-27 Санкио Компани Лимитед Производные бифенила и способ их получения
CZ154994A3 (en) * 1993-07-02 1995-09-13 Senju Pharma Co Visual hypotensive agent
MX9603259A (es) * 1994-02-08 1997-03-29 Novartis Ag Tratamiento de glaucoma normotensivo con antagonistas de angiotensina ii.

Also Published As

Publication number Publication date
PT795326E (pt) 2002-01-30
AU1960295A (en) 1995-10-03
DE69533045D1 (de) 2004-06-17
CN1202819C (zh) 2005-05-25
ATE266402T1 (de) 2004-05-15
ATE206050T1 (de) 2001-10-15
EP0795326B1 (de) 2001-09-26
FI20041236A (fi) 2004-09-24
FI114897B (fi) 2005-01-31
GR3036989T3 (en) 2002-01-31
KR970701542A (ko) 1997-04-12
ES2221872T3 (es) 2005-01-16
HU9602534D0 (en) 1996-11-28
DK1110551T3 (da) 2004-06-07
ES2163501T3 (es) 2002-02-01
DE69522955T2 (de) 2002-05-29
RU2123847C1 (ru) 1998-12-27
DE69533045T2 (de) 2005-01-27
NO311068B1 (no) 2001-10-08
EP1110551A2 (de) 2001-06-27
DK0795326T3 (da) 2001-11-26
EP0795326A1 (de) 1997-09-17
US5925664A (en) 1999-07-20
HUT74734A (en) 1997-02-28
CN1104898C (zh) 2003-04-09
HK1000551A1 (en) 2002-04-12
FI963645A (fi) 1996-11-14
FI115197B (fi) 2005-03-31
AU684916B2 (en) 1998-01-08
CZ284395B6 (cs) 1998-11-11
CZ269496A3 (en) 1996-12-11
MX9604109A (es) 1997-09-30
KR100211446B1 (ko) 1999-08-02
EP1110551A3 (de) 2001-08-16
FI963645A0 (fi) 1996-09-16
EP1110551B1 (de) 2004-05-12
NO963854D0 (no) 1996-09-13
EP0795326A4 (de) 1997-09-17
NO963854L (no) 1996-11-14
CN1387846A (zh) 2003-01-01
CN1148809A (zh) 1997-04-30
WO1995024902A1 (fr) 1995-09-21
NZ282485A (en) 1997-06-24
PT1110551E (pt) 2004-07-30

Similar Documents

Publication Publication Date Title
ATE216584T1 (de) Xanthine-derivate als antidepressiva
ID29452A (id) 4-okso-1,4-dihidro-3-quinolinkarboksamida sebagai agen-agen antivirus
DK0449216T3 (da) 3,5-Di-tertiærbutyl-4-hydroxyphenylmethylenderivater af 2-substituerede thiazolidinoner, oxazolidinoner og imidazolidinoner som antiinflammatoriske midler
DE69208478D1 (de) Amid derivate von vitamin d
DE69728544D1 (de) Totalsynthese von acylfulvenen mit antitumorwirkung
DE69111816T2 (de) Indolederivate und ihre verwendung als serotonin-antagoniste.
DK0916651T3 (da) Phenylalkylcarboxylsyrederivater
ATE421524T1 (de) 5-ring-heterocyclen, ihre herstellung, ihre verwendung als inhibitoren der leukozytenadhäsion und sie enthaltende pharmazeutische präparate
DE69522955D1 (de) Okulares hypotensium
DK147588A (da) Benzoxazinderivat samt fremgangsmaade til fremstilling deraf
NO893039D0 (no) Bruk av imidazopyrazol-derivater som analgesiske og antiinflammatoriske midler.
EP0878475A3 (de) 5-(4-Piperidinyl)dibenzothiazepine derivate und 5-(4-piperidinyl)dibenzoxazepinderivate, und antiarrhythmische Mittel
TH18321B (th) สารออกฤทธิ์ต้านตัวรับแทคิไคนินชนิดนอนเพปไทด์

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee