ES2087038A1 - Nuevas piperidinas con actividad antagonista del paf. - Google Patents
Nuevas piperidinas con actividad antagonista del paf.Info
- Publication number
- ES2087038A1 ES2087038A1 ES09402291A ES9402291A ES2087038A1 ES 2087038 A1 ES2087038 A1 ES 2087038A1 ES 09402291 A ES09402291 A ES 09402291A ES 9402291 A ES9402291 A ES 9402291A ES 2087038 A1 ES2087038 A1 ES 2087038A1
- Authority
- ES
- Spain
- Prior art keywords
- antagonist activity
- piperidine derivatives
- paf antagonist
- novel piperidine
- paf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
COMPUESTOS DE FORMULA I, DONDE M REPRESENTA 0,1 O 2; R1 REPRESENTA C1-4 ALQUILO; B REPRESENTA ZCR2R3-X-(CH2)N), CR2R3=CH- O R7N(Y)-CH2-; N REPRESENTA 0 O 1; X REPRESENTA NH O UN ENLACE SENCILLO; UNO DE R2 O R3 REPRESENTA C1-4 ALQUILO, C3-6 CICLOALQUILO O ARILO, Y EL OTRO REPRESENTA HIDROGENO, C1-4 ALQUILO, C1-4 HALOALQUILO, C3-6 CICLOALQUILO O ARILO; Z REPRESENTA HIDROGENO, C1-4 ALQUILO, (CH2-OR4, -COOR4 O -CONR4R5, Y CUANDO X REPRESENTA ENLACE SENCILLO, Z PUEDE SER TAMBIEN HIDROXI, (NR4R5, (NR6C(=O)OR4, -NR6C(=O)R4, -NR6C(=O)NR4R5, -N(OH)C(=O)NR4R5 O -NR6SO2R4; R4 REPRESENTA HIDROGENO, C1-4 ALQUILO, ARILO O ARIL-C1-4 ALQUILO; R5 Y R6 REPRESENTAN HIDROGENO O C1-4 ALQUILO; R7 REPRESENTA C1-4 ALQUILO, C3-6 CICIOALQUILO O ARILO; E Y REPRESENTA HIDROGENO, C1-4 ALQUILO, ARILO, ARIL-C1-4 ALQUILO, -C(=O)OR4, -C(=O)R4, -C(=O)NR4R5, O -SO2R4. ESTOS COMPUESTOS SON ANTAGONISTAS DEL PAF.
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09402291A ES2087038B1 (es) | 1994-11-07 | 1994-11-07 | Nuevas piperidinas con actividad antagonista del paf. |
ES95932668T ES2147616T3 (es) | 1994-11-07 | 1995-09-05 | Derivados de piperidina con actividad antagonista del paf. |
MXPA/A/1996/002559A MXPA96002559A (es) | 1994-11-07 | 1995-09-05 | Nuevos derivados de piperidina con actividadantagonista del paf |
DK95932668T DK0738269T5 (da) | 1994-11-07 | 1995-09-05 | Piperidinderivater med PAF-antagonistaktivitet |
KR1019960703655A KR100514201B1 (ko) | 1994-11-07 | 1995-09-05 | 피에이에프길항활성을갖는피페리딘유도체 |
AU35636/95A AU3563695A (en) | 1994-11-07 | 1995-09-05 | Novel piperidine derivatives with paf antagonist activity |
PCT/EP1995/003487 WO1996014317A1 (en) | 1994-11-07 | 1995-09-05 | Novel piperidine derivatives with paf antagonist activity |
JP51497296A JP4018137B2 (ja) | 1994-11-07 | 1995-09-05 | Pafアンタゴニスト活性を有する新規ピぺリジン誘導体 |
EP95932668A EP0738269B1 (en) | 1994-11-07 | 1995-09-05 | Piperidine derivatives with paf antagonist activity |
DE69516503T DE69516503T2 (de) | 1994-11-07 | 1995-09-05 | Piperidinderivate mit paf antagonistischer wirkung |
PT95932668T PT738269E (pt) | 1994-11-07 | 1995-09-05 | Derivados de piperidina com actividade antagonista de paf |
US08/669,440 US5705504A (en) | 1994-11-07 | 1995-09-05 | Piperidine derivatives with PAF antagonist activity |
CA002180660A CA2180660C (en) | 1994-11-07 | 1995-09-05 | Novel piperidine derivatives with paf antagonist activity |
AT95932668T ATE192152T1 (de) | 1994-11-07 | 1995-09-05 | Piperidinderivate mit paf antagonistischer wirkung |
NO962855A NO306345B1 (no) | 1994-11-07 | 1996-07-05 | Piperidin-derivater med PAF antagonist-aktivitet, anvendelse derav og farmasöytisk blanding |
GR20000401219T GR3033528T3 (en) | 1994-11-07 | 2000-05-29 | Novel piperidine derivatives with paf antagonist activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09402291A ES2087038B1 (es) | 1994-11-07 | 1994-11-07 | Nuevas piperidinas con actividad antagonista del paf. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2087038A1 true ES2087038A1 (es) | 1996-07-01 |
ES2087038B1 ES2087038B1 (es) | 1997-03-16 |
Family
ID=8287905
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09402291A Expired - Fee Related ES2087038B1 (es) | 1994-11-07 | 1994-11-07 | Nuevas piperidinas con actividad antagonista del paf. |
ES95932668T Expired - Lifetime ES2147616T3 (es) | 1994-11-07 | 1995-09-05 | Derivados de piperidina con actividad antagonista del paf. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95932668T Expired - Lifetime ES2147616T3 (es) | 1994-11-07 | 1995-09-05 | Derivados de piperidina con actividad antagonista del paf. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5705504A (es) |
EP (1) | EP0738269B1 (es) |
JP (1) | JP4018137B2 (es) |
KR (1) | KR100514201B1 (es) |
AT (1) | ATE192152T1 (es) |
AU (1) | AU3563695A (es) |
DE (1) | DE69516503T2 (es) |
DK (1) | DK0738269T5 (es) |
ES (2) | ES2087038B1 (es) |
GR (1) | GR3033528T3 (es) |
NO (1) | NO306345B1 (es) |
PT (1) | PT738269E (es) |
WO (1) | WO1996014317A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69611598T2 (de) * | 1995-09-08 | 2001-06-07 | Uriach & Cia Sa J | Azoderivate von 5-aminosalicylsäure zur behandlung von enzündlichen darmerkrankungen |
ES2165803B1 (es) * | 2000-04-10 | 2003-09-16 | Uriach & Cia Sa J | Nueva sal de un derivado azo del acido 5-aminosalicilico |
GB0013060D0 (en) | 2000-05-31 | 2000-07-19 | Astrazeneca Ab | Chemical compounds |
US6638950B2 (en) | 2000-06-21 | 2003-10-28 | Bristol-Myers Squibb Pharma Company | Piperidine amides as modulators of chemokine receptor activity |
CA2774959C (en) * | 2000-08-04 | 2016-05-31 | Dmi Biosciences, Inc. | Method of using diketopiperazines and composition containing them |
GB0021670D0 (en) | 2000-09-04 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
GB0117899D0 (en) | 2001-07-23 | 2001-09-12 | Astrazeneca Ab | Chemical compounds |
JP2007500747A (ja) | 2003-05-15 | 2007-01-18 | ディーエムアイ バイオサイエンシズ インコーポレイテッド | T細胞媒介性疾患の処置 |
FR2860514A1 (fr) * | 2003-10-03 | 2005-04-08 | Sanofi Synthelabo | Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique |
WO2007101270A1 (en) * | 2006-03-02 | 2007-09-07 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
CA2658913C (en) * | 2006-07-24 | 2015-07-21 | Ucb Pharma S.A. | Substituted aniline derivatives |
KR100737397B1 (ko) | 2007-01-31 | 2007-07-09 | 한국교세라정공(주) | 밀링 커터 |
JP5856843B2 (ja) | 2008-05-27 | 2016-02-10 | アンピオ ファーマシューティカルズ,インコーポレイテッド | ジケトピペラジンを用いた医薬組成物 |
FR2962649A1 (fr) | 2010-07-19 | 2012-01-20 | Conservatoire Nat Arts Et Metiers | Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide |
GB201101517D0 (en) * | 2011-01-28 | 2011-03-16 | Proximagen Ltd | Receptor antagonists |
SG10201608087WA (en) | 2011-10-10 | 2016-11-29 | Ampio Pharmaceuticals Inc | Implantable medical devices with increased immune tolerance, and methods for making and implanting |
EP2766029B1 (en) | 2011-10-10 | 2020-03-25 | Ampio Pharmaceuticals, Inc. | Treatment of degenerative joint disease |
MX355446B (es) | 2011-10-28 | 2018-04-18 | Ampio Pharmaceuticals Inc | Tratamiento de rinitis. |
CA2906864A1 (en) | 2013-03-15 | 2014-09-18 | Ampio Pharmaceuticals, Inc. | Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same |
KR20170045274A (ko) | 2014-08-18 | 2017-04-26 | 앰피오 파마슈티컬스 인코퍼레이티드 | 관절 징후의 치료 |
US11389512B2 (en) | 2015-06-22 | 2022-07-19 | Ampio Pharmaceuticals, Inc. | Use of low molecular weight fractions of human serum albumin in treating diseases |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0284359A1 (en) * | 1987-03-24 | 1988-09-28 | Takeda Chemical Industries, Ltd. | 1,4-Disubstituted piperazine compounds, their production and use |
EP0441226A1 (en) * | 1990-01-29 | 1991-08-14 | J. URIACH & CIA. S.A. | (cyanomethyl)pyridines useful as PAF antagonists |
EP0528172A1 (en) * | 1991-08-08 | 1993-02-24 | J. URIACH & CIA. S.A. | (2-Alkyl-3-pyridyl)methylpiperazine derivatives as PAF antagonists |
WO1993005042A1 (en) * | 1991-09-04 | 1993-03-18 | Minnesota Mining And Manufacturing Company | 1-substituted 1h-imidazo(4,5-c)quinolin-4-amines; intermediate and pharmaceutical compositions |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0029707B1 (en) * | 1979-11-21 | 1984-02-01 | Kyowa Hakko Kogyo Co., Ltd | Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them |
GB9102997D0 (en) * | 1991-02-13 | 1991-03-27 | Pfizer Ltd | Therapeutic agents |
US5283242A (en) * | 1991-10-24 | 1994-02-01 | American Home Products Corporation | Substituted benzimidazoles and quinazolines as antihypertensives |
-
1994
- 1994-11-07 ES ES09402291A patent/ES2087038B1/es not_active Expired - Fee Related
-
1995
- 1995-09-05 AU AU35636/95A patent/AU3563695A/en not_active Abandoned
- 1995-09-05 DK DK95932668T patent/DK0738269T5/da active
- 1995-09-05 KR KR1019960703655A patent/KR100514201B1/ko not_active IP Right Cessation
- 1995-09-05 AT AT95932668T patent/ATE192152T1/de not_active IP Right Cessation
- 1995-09-05 DE DE69516503T patent/DE69516503T2/de not_active Expired - Lifetime
- 1995-09-05 ES ES95932668T patent/ES2147616T3/es not_active Expired - Lifetime
- 1995-09-05 EP EP95932668A patent/EP0738269B1/en not_active Expired - Lifetime
- 1995-09-05 WO PCT/EP1995/003487 patent/WO1996014317A1/en active IP Right Grant
- 1995-09-05 JP JP51497296A patent/JP4018137B2/ja not_active Expired - Fee Related
- 1995-09-05 PT PT95932668T patent/PT738269E/pt unknown
- 1995-09-05 US US08/669,440 patent/US5705504A/en not_active Expired - Lifetime
-
1996
- 1996-07-05 NO NO962855A patent/NO306345B1/no not_active IP Right Cessation
-
2000
- 2000-05-29 GR GR20000401219T patent/GR3033528T3/el not_active IP Right Cessation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0284359A1 (en) * | 1987-03-24 | 1988-09-28 | Takeda Chemical Industries, Ltd. | 1,4-Disubstituted piperazine compounds, their production and use |
EP0441226A1 (en) * | 1990-01-29 | 1991-08-14 | J. URIACH & CIA. S.A. | (cyanomethyl)pyridines useful as PAF antagonists |
EP0528172A1 (en) * | 1991-08-08 | 1993-02-24 | J. URIACH & CIA. S.A. | (2-Alkyl-3-pyridyl)methylpiperazine derivatives as PAF antagonists |
WO1993005042A1 (en) * | 1991-09-04 | 1993-03-18 | Minnesota Mining And Manufacturing Company | 1-substituted 1h-imidazo(4,5-c)quinolin-4-amines; intermediate and pharmaceutical compositions |
Also Published As
Publication number | Publication date |
---|---|
PT738269E (pt) | 2000-08-31 |
ES2147616T3 (es) | 2000-09-16 |
MX9602559A (es) | 1997-07-31 |
DE69516503T2 (de) | 2001-03-15 |
ATE192152T1 (de) | 2000-05-15 |
DE69516503D1 (de) | 2000-05-31 |
AU3563695A (en) | 1996-05-31 |
NO962855L (no) | 1996-07-05 |
NO962855D0 (no) | 1996-07-05 |
GR3033528T3 (en) | 2000-09-29 |
DK0738269T3 (da) | 2000-08-28 |
JPH09507862A (ja) | 1997-08-12 |
EP0738269A1 (en) | 1996-10-23 |
DK0738269T5 (da) | 2000-12-18 |
NO306345B1 (no) | 1999-10-25 |
WO1996014317A1 (en) | 1996-05-17 |
EP0738269B1 (en) | 2000-04-26 |
JP4018137B2 (ja) | 2007-12-05 |
US5705504A (en) | 1998-01-06 |
ES2087038B1 (es) | 1997-03-16 |
KR100514201B1 (ko) | 2005-12-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2087038A1 (es) | Nuevas piperidinas con actividad antagonista del paf. | |
NZ333801A (en) | Piperidine and piperazine derivatives and their use as muscarinic antagonists | |
MY112102A (en) | Therapeutic heterocycles. | |
PL308217A1 (en) | Derivatives of 1-(oxo-acetyl)-piperidine-2-carboxylic as agents sensibilising multiple-drug-resistant cancer cells | |
IL123002A0 (en) | 1-Phenyl-2- phenylacetoxy- ethanone derivatives | |
IL114894A (en) | Pyrrolidine derivatives as endothelin antagonists, pharmaceutical compositions containing them, and their use in the preparation of medicaments | |
IL117149A0 (en) | Muscarinic antagonists | |
ATE427936T1 (de) | Substituierte piperidin-verbindungen als modulatoren der chemokine receptor aktivitat | |
DE69715865D1 (de) | Muscarin-antagonisten | |
MX9702382A (es) | Nuevos derivados de pirimidona con actividad antifungica. | |
EP0896533A4 (en) | PENTAFLUOROBENZEN SULPHONAMIDES AND ANALOGS | |
MX9704777A (es) | Compuestos espiro tetraciclicos, procedimiento para su preparacion y composiciones que los contienen. | |
ATE201671T1 (de) | Chinolon und acridinon derivate zur behandlung der harninkontinenz | |
IL117093A0 (en) | Heterocyclic derivatives | |
GR3031215T3 (en) | Bicyclic heterocycles as neurokinin a antagonists | |
HK1018265A1 (en) | Piperazino derivatives as neurokinin antagonists | |
MX9708416A (es) | Derivados de piperazino como antagonistas de neuroquininas. | |
GR3032950T3 (en) | Substituted fused and bridged bicyclic compounds as therapeutic agents | |
BG105923A (en) | Novel morpholine derivatives, method for the production thereof and pharmaceutical preparations containing said derivatives | |
GB9116056D0 (en) | Compounds | |
CA2180660A1 (en) | Novel piperidine derivatives with paf antagonist activity | |
MX9703610A (es) | Nuevas (5,6)-heteroaril condensado-pirimidin-4-onas 2,3 disustituidas. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19941107 Kind code of ref document: A1 Effective date: 19941107 |
|
FD1A | Patent lapsed |
Effective date: 20051108 |