ES2084069T3 - Reactivos de inmunoensayo y metodo para la determinacion de ciclosporina. - Google Patents
Reactivos de inmunoensayo y metodo para la determinacion de ciclosporina.Info
- Publication number
- ES2084069T3 ES2084069T3 ES91113328T ES91113328T ES2084069T3 ES 2084069 T3 ES2084069 T3 ES 2084069T3 ES 91113328 T ES91113328 T ES 91113328T ES 91113328 T ES91113328 T ES 91113328T ES 2084069 T3 ES2084069 T3 ES 2084069T3
- Authority
- ES
- Spain
- Prior art keywords
- cyclosporine
- determination
- assay reagents
- immuno assay
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
SE EXPONEN LOS DERIVADOS DE LA CICLOSPORINA UTILES COMO COMPUESTOS TRAZADORES DETECTABLES PARA LA DETERMINACION DE LAS PRUEBAS DE INMUNIDAD DE LA CICLOSPORINA. LOS DERIVADOS COMPRENDEN UNA MITAD DETECTABLE ACOPLADA AL AMINOACIDO EN LA PRIMERA POSICION (MEBMT), LA SEGUNDA POSICION (ABU) EN LA CICLOSPORINA, LA TERCERA POSICION (SAR), LA OCTAVA POSICION (D-ALA) O LA DECIMA POSICION (MELEU) EN LA CICLOSPORINA. UN DERIVADO DE LA CICLOSPORINA PREFERENTE COMPRENDE UNA MITAD FLUORESCENTE ACOPLADA AL GRUPO HIDROXILO DEL AMINOACIDO EN LA PRIMERA POSICION EN LA CICLOSPORINA, Y ES UTILIZADO ESPECIALMENTE PARA LA DETERMINACION DE LA PRUEBA DE INMUNIDAD DE POLARIZACION FLUORESCENTE DE LA CICLOSPORINA. SE EXPONEN TAMBIEN UN METODO PARA LA PRUEBA DE INMUNIDAD DE POLARIZACION FLUORESCENTE Y UN JUEGO DE PRUEBAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56784290A | 1990-08-15 | 1990-08-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2084069T3 true ES2084069T3 (es) | 1996-05-01 |
Family
ID=24268868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91113328T Expired - Lifetime ES2084069T3 (es) | 1990-08-15 | 1991-08-08 | Reactivos de inmunoensayo y metodo para la determinacion de ciclosporina. |
Country Status (10)
Country | Link |
---|---|
US (2) | US5489668A (es) |
EP (1) | EP0473961B1 (es) |
JP (1) | JP3171460B2 (es) |
AT (1) | ATE132504T1 (es) |
AU (1) | AU642035B2 (es) |
CA (1) | CA2049089C (es) |
DE (1) | DE69116034T2 (es) |
DK (1) | DK0473961T3 (es) |
ES (1) | ES2084069T3 (es) |
GR (1) | GR3019512T3 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69133095T2 (de) * | 1990-11-20 | 2003-03-27 | Dade Behring Marburg Gmbh | Cyclosporin-Immunoassay |
US5352803A (en) * | 1992-03-30 | 1994-10-04 | Abbott Laboratories | 5(6)-methyl substituted fluorescein derivatives |
ES2148225T3 (es) * | 1992-03-30 | 2000-10-16 | Abbott Lab | Reactivos y procedimientos que permiten la deteccion y la cuantificacion de la tiroxina en muestras de fluido. |
GB9307491D0 (en) * | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
USRE40596E1 (en) * | 1993-04-08 | 2008-12-02 | Novartis Ag | Rapamycin assay |
US5504091A (en) * | 1993-04-23 | 1996-04-02 | American Home Products Corporation | Biotin esters of rapamycin |
EP0710110B1 (en) | 1993-04-23 | 2002-03-06 | Abbott Laboratories | Antibodies of ring opened rapamycins |
US7279561B1 (en) | 1993-04-23 | 2007-10-09 | Wyeth | Anti-rapamycin monoclonal antibodies |
US5393891A (en) * | 1993-06-08 | 1995-02-28 | The Du Pont Merck Pharmaceutical Company | Immunoassay reagents and methods for detecting brequinar and analogs |
US5650288A (en) * | 1995-07-14 | 1997-07-22 | Macfarlane; Gordon D. | Immunophilin-bound immunosuppressant assay |
DE69832984T2 (de) | 1997-10-08 | 2006-09-21 | Isotechnika, Inc., Edmonton | DEUTERIERtE und undeuterierte CYCLOSPORIN-ANALOGA UND IHRE VERWENDUNG ALS IMMUNMODULIERENDE AGENtIEN |
US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
US5990274A (en) * | 1997-11-25 | 1999-11-23 | Dade Behring Inc. | Cyclosporine derivatives and uses thereof |
US8569516B2 (en) | 2001-09-07 | 2013-10-29 | Elitech Holding B.V. | Compounds and methods for fluorescent labeling |
US6972339B2 (en) | 2001-09-07 | 2005-12-06 | Epoch Biosciences, Inc. | Compounds and methods for fluorescent labeling |
PL210795B1 (pl) * | 2001-10-19 | 2012-03-30 | Isotechnika Inc | Sposób wytwarzania mieszaniny ISATX247 wzbogaconej w izomer (E), sposób wytwarzania mieszaniny ISATX247 wzbogaconej w izomer (Z), sposób stereoselektywnej syntezy izomeru (E) ISATX247, sposób stereoselektywnej syntezy izomeru (Z) ISATX247 i sposób wytwarzania mieszaniny izomerów ISATX247 |
KR100444698B1 (ko) * | 2001-11-08 | 2004-08-21 | 한국과학기술연구원 | 면역복합체 단일검출시약, 그의 제조방법 및 그를 이용한농약의 검출방법 |
US8022188B2 (en) * | 2006-04-24 | 2011-09-20 | Abbott Laboratories | Immunosuppressant binding antibodies and methods of obtaining and using same |
US7883855B2 (en) * | 2006-07-21 | 2011-02-08 | Abbott Laboratories | Immunosuppressant drug extraction reagent for immunoassays |
US7576057B2 (en) | 2006-11-20 | 2009-08-18 | Scynexis, Inc. | Cyclic peptides |
US7914999B2 (en) * | 2006-12-29 | 2011-03-29 | Abbott Laboratories | Non-denaturing lysis reagent |
ES2405364T3 (es) * | 2006-12-29 | 2013-05-30 | Abbott Laboratories | Ensayo diagnóstico para la detección de una molécula o fármaco en sangre entera |
CA2673314C (en) * | 2006-12-29 | 2014-03-11 | Abbott Laboratories | Non-denaturing lysis reagent for use with capture-in-solution immunoassay |
EP2118656B1 (en) * | 2006-12-29 | 2012-08-29 | Abbott Laboratories | Improved assay for immunosuppressant drugs |
JP5174898B2 (ja) | 2007-05-24 | 2013-04-03 | アボット・ラボラトリーズ | 疎水性薬物検体代謝産物との交差反応性が低下している免疫アッセイ |
ES2559311T3 (es) * | 2007-12-19 | 2016-02-11 | Abbott Laboratories | Reactivo de extracción de fármacos inmunosupresores para inmunoanálisis |
US20090170218A1 (en) * | 2008-01-02 | 2009-07-02 | Dade Behring Inc. | Methods for detection of cyclosporin a |
CN110320364B (zh) * | 2018-03-30 | 2023-03-31 | 洛阳普泰生物技术有限公司 | 一种双抗夹心胶体金检测试剂盒、及其制备方法与应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1023287A (en) * | 1972-12-08 | 1977-12-27 | Boehringer Mannheim G.M.B.H. | Process for the preparation of carrier-bound proteins |
US4117118A (en) * | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
DE2819094A1 (de) * | 1977-05-10 | 1978-11-23 | Sandoz Ag | Cyclosporin-derivate, ihre verwendung und herstellung |
DE3587342T2 (de) * | 1984-10-04 | 1993-12-02 | Sandoz Ag | Cyclosporine. |
US5169773A (en) * | 1984-10-04 | 1992-12-08 | Sandoz Ltd. | Monoclonal antibodies to cyclosporins |
US4727035A (en) * | 1984-11-14 | 1988-02-23 | Mahoney Walter C | Immunoassay for cyclosporin |
US5124457A (en) * | 1986-05-21 | 1992-06-23 | Abbott Laboratories | Phencyclidine and phencyclidine metabolites assay, tracers, immunogens and antibodies |
US4939264A (en) * | 1986-07-14 | 1990-07-03 | Abbott Laboratories | Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies |
EP0283801A3 (en) * | 1987-03-27 | 1990-05-30 | Abbott Laboratories | Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies |
US5427960A (en) * | 1987-03-27 | 1995-06-27 | Abbott Laboratories | Fluorescence polarization assay for cyclosporin A and metabolites and related immunogens and antibodies |
US5239057A (en) * | 1987-03-27 | 1993-08-24 | Abbott Laboratories | Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies |
EP0329184A3 (en) * | 1988-02-19 | 1990-05-23 | Neorx Corporation | Antimers and antimeric conjugation |
-
1991
- 1991-08-08 ES ES91113328T patent/ES2084069T3/es not_active Expired - Lifetime
- 1991-08-08 DK DK91113328.8T patent/DK0473961T3/da active
- 1991-08-08 DE DE69116034T patent/DE69116034T2/de not_active Expired - Fee Related
- 1991-08-08 AT AT91113328T patent/ATE132504T1/de not_active IP Right Cessation
- 1991-08-08 EP EP91113328A patent/EP0473961B1/en not_active Expired - Lifetime
- 1991-08-13 CA CA002049089A patent/CA2049089C/en not_active Expired - Fee Related
- 1991-08-14 AU AU82471/91A patent/AU642035B2/en not_active Ceased
- 1991-08-15 JP JP20523391A patent/JP3171460B2/ja not_active Expired - Fee Related
-
1993
- 1993-11-04 US US08/148,164 patent/US5489668A/en not_active Expired - Lifetime
-
1995
- 1995-05-04 US US08/433,104 patent/US5750413A/en not_active Expired - Lifetime
-
1996
- 1996-04-02 GR GR960400900T patent/GR3019512T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2049089A1 (en) | 1992-02-16 |
US5750413A (en) | 1998-05-12 |
EP0473961A3 (en) | 1993-04-14 |
DE69116034T2 (de) | 1996-06-20 |
JP3171460B2 (ja) | 2001-05-28 |
DK0473961T3 (da) | 1996-07-01 |
AU642035B2 (en) | 1993-10-07 |
ATE132504T1 (de) | 1996-01-15 |
CA2049089C (en) | 2002-09-03 |
EP0473961A2 (en) | 1992-03-11 |
EP0473961B1 (en) | 1996-01-03 |
DE69116034D1 (de) | 1996-02-15 |
GR3019512T3 (en) | 1996-07-31 |
JPH04253999A (ja) | 1992-09-09 |
US5489668A (en) | 1996-02-06 |
AU8247191A (en) | 1992-02-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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