ES2082780T3 - Derivados de acido bisfosfonico heterociclicos. - Google Patents
Derivados de acido bisfosfonico heterociclicos.Info
- Publication number
- ES2082780T3 ES2082780T3 ES89308180T ES89308180T ES2082780T3 ES 2082780 T3 ES2082780 T3 ES 2082780T3 ES 89308180 T ES89308180 T ES 89308180T ES 89308180 T ES89308180 T ES 89308180T ES 2082780 T3 ES2082780 T3 ES 2082780T3
- Authority
- ES
- Spain
- Prior art keywords
- chem
- hydrogen atom
- hydroxyl group
- bisphosphonic acid
- hiserociclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Abstract
NUEVOS DERIVADOS DE ACIDO BIFOSFONICO HETEROCICLICO REPRESENTADOS POR LA FORMULA GENERAL (I), EN LA QUE HET SIGNIFICA UNO DE LOS RADICALES DE FORMULA (A) O (B), DONDE UNA LINEA DISCONTINUA EN (A) SIGNIFICA QUE DOS ATOMOS ADYACENTES ESTAN UNIDOS POR UN ENLACE SENCILLO O DOBLE, DONDE R6 Y R7 PUEDEN SER EL MISMO O DIFERENTE, CADA UNO REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO INFERIOR, UN ATOMO DE HALOGENO O UN GRUPO HIDROXILO; R1 REPRESENTA UN ATOMO DE HIDROGENO, O UN GRUPO HIDROXILO; R2, R3, R4 Y R5 PUEDEN SER EL MISMO O DIFERENTE, CADA UNO REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO INFERIOR; N ES 0 O 1, PREVIENDO QUE N ES 1 CUANDO EL ANILLO HET ES (A), Y R1 ES UN GRUPO HIDROXILO CUANDO EL ANILLO HET ES (B), SUS SALES FARMACEUTICAMENTE ACEPTABLES E INHIBIDORES DE RESORCION DE HUESOS QUE CONTIENEN LOS COMPUESTO COMO INGREDIENTE ACTIVO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20153688 | 1988-08-12 | ||
JP20153588 | 1988-08-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2082780T3 true ES2082780T3 (es) | 1996-04-01 |
Family
ID=26512843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89308180T Expired - Lifetime ES2082780T3 (es) | 1988-08-12 | 1989-08-11 | Derivados de acido bisfosfonico heterociclicos. |
Country Status (14)
Country | Link |
---|---|
US (2) | US4990503A (es) |
EP (1) | EP0354806B1 (es) |
KR (1) | KR0156239B1 (es) |
CN (1) | CN1027167C (es) |
AT (1) | ATE129714T1 (es) |
AU (1) | AU624405B2 (es) |
CA (1) | CA1332058C (es) |
DE (1) | DE68924681T2 (es) |
DK (1) | DK170257B1 (es) |
ES (1) | ES2082780T3 (es) |
GR (1) | GR3018086T3 (es) |
HU (2) | HU205766B (es) |
IE (1) | IE71185B1 (es) |
PH (1) | PH26376A (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0521622B1 (en) * | 1991-07-03 | 1997-08-13 | PHARMACIA & UPJOHN COMPANY | Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories |
TW222637B (es) * | 1991-12-12 | 1994-04-21 | Hoechst Ag | |
US5270365A (en) * | 1991-12-17 | 1993-12-14 | Merck & Co., Inc. | Prevention and treatment of periodontal disease with alendronate |
JPH05345791A (ja) * | 1992-03-18 | 1993-12-27 | Hoechst Japan Ltd | 環状アミノメチレンビスホスホン酸誘導体 |
EP0647649B1 (en) * | 1992-06-23 | 1998-11-11 | Yamanouchi Pharmaceutical Co. Ltd. | Novel crystal of monohydrate of heterocyclic bis(phosphonic acid) derivative |
AU4859493A (en) * | 1992-10-09 | 1994-05-09 | Upjohn Company, The | Pyrimidine bisphosphonate esters and (alkoxymethylphosphinyl)alkyl phosphonic acids as anti-inflammatories |
JPH06298779A (ja) * | 1993-04-15 | 1994-10-25 | Hoechst Japan Ltd | ヘテロ環イミノビスメチレンビスホスホン酸誘導体 |
US5728650A (en) * | 1993-10-07 | 1998-03-17 | Zeneca Limited | Herbicidal aza bisphosphonic acids and compositions containing the same |
US5854227A (en) * | 1994-03-04 | 1998-12-29 | Hartmann; John F. | Therapeutic derivatives of diphosphonates |
US5880111A (en) * | 1995-06-07 | 1999-03-09 | Farcasiu; Dan | Therapeutic derivations of diphosphonates |
AU6691798A (en) | 1997-03-07 | 1998-09-22 | Metabasis Therapeutics, Inc. | Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase |
WO1998039344A1 (en) | 1997-03-07 | 1998-09-11 | Metabasis Therapeutics, Inc. | Novel purine inhibitors of fructose-1,6-bisphosphatase |
US7008645B2 (en) * | 1998-07-14 | 2006-03-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of inhibiting restenosis using bisphosphonates |
AU1798700A (en) * | 1998-12-25 | 2000-07-31 | Yamanouchi Pharmaceutical Co., Ltd. | Medicinal compositions for treating osseous lesion in multiple myeloma |
US20030036537A1 (en) * | 2001-07-16 | 2003-02-20 | Marc Lecouvey | Bisphosphonate derivatives, their preparations and uses |
NZ536273A (en) | 2002-12-20 | 2007-08-31 | Hoffmann La Roche | High dose ibandronate formulation |
HUP0300227A2 (hu) * | 2003-01-28 | 2004-09-28 | Richter Gedeon Vegyészeti Gyár Rt. | Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására |
US20060051407A1 (en) * | 2003-06-27 | 2006-03-09 | Yoram Richter | Method of treating ischemia-reperfusion injury |
US10517883B2 (en) * | 2003-06-27 | 2019-12-31 | Zuli Holdings Ltd. | Method of treating acute myocardial infarction |
JPWO2005072746A1 (ja) * | 2004-01-30 | 2007-10-11 | アステラス製薬株式会社 | P2x受容体阻害剤 |
CN101531681B (zh) * | 2008-03-10 | 2013-06-05 | 北京德众万全医药科技有限公司 | 一种高纯度的米诺膦酸及其制备方法 |
KR20110079813A (ko) * | 2008-09-22 | 2011-07-08 | 아이시스 이노베이션 리미티드 | 이미다조〔1,2-α〕피리디닐 비스포스포네이트 |
WO2010033980A2 (en) * | 2008-09-22 | 2010-03-25 | Isis Innovation Ltd. | 4-azaindole bisphosphonates |
WO2011056589A1 (en) | 2009-10-26 | 2011-05-12 | Warner Chilcott Company, Llc | Bisphosphonate compounds for treating bone metabolism disorders |
CN101973993A (zh) * | 2010-11-05 | 2011-02-16 | 天津药物研究院 | 一种制备2-[咪唑并(1,2-a)吡啶-3-基]乙酸的方法 |
CN102153585B (zh) * | 2011-02-24 | 2013-04-17 | 北京欧克兰医药技术开发中心 | 一种米诺膦酸中间体的合成方法及米诺膦酸的合成 |
CN102268042B (zh) * | 2011-06-01 | 2014-06-25 | 广东宏远集团药业有限公司 | 一种米诺膦酸晶型ii及其制备方法 |
US9993427B2 (en) | 2013-03-14 | 2018-06-12 | Biorest Ltd. | Liposome formulation and manufacture |
CN107033187A (zh) * | 2017-04-28 | 2017-08-11 | 江苏笃诚医药科技股份有限公司 | 一种米诺膦酸的制备方法 |
KR20220115062A (ko) | 2021-02-09 | 2022-08-17 | (주)오스티오뉴로젠 | 크로몬 구조의 화합물을 포함하는 골다공증의 예방 및 치료용 약학적 조성물 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3203308A1 (de) * | 1982-01-27 | 1983-07-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate |
DE3428524A1 (de) * | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
DE3626058A1 (de) * | 1986-08-01 | 1988-02-11 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
ATE64397T1 (de) * | 1986-11-21 | 1991-06-15 | Ciba Geigy Ag | Aromatisch substituierte azacycloalkylalkandiphosphons|uren. |
DE3640938A1 (de) * | 1986-11-29 | 1988-06-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel |
EP0317505A1 (de) * | 1987-11-13 | 1989-05-24 | Ciba-Geigy Ag | Neue Azacycloalkylalkandiphosphonsäuren |
-
1989
- 1989-08-07 US US07/390,090 patent/US4990503A/en not_active Expired - Lifetime
- 1989-08-08 AU AU39419/89A patent/AU624405B2/en not_active Ceased
- 1989-08-09 CA CA000607874A patent/CA1332058C/en not_active Expired - Fee Related
- 1989-08-11 DK DK394789A patent/DK170257B1/da not_active IP Right Cessation
- 1989-08-11 ES ES89308180T patent/ES2082780T3/es not_active Expired - Lifetime
- 1989-08-11 EP EP89308180A patent/EP0354806B1/en not_active Expired - Lifetime
- 1989-08-11 AT AT89308180T patent/ATE129714T1/de not_active IP Right Cessation
- 1989-08-11 PH PH39086A patent/PH26376A/en unknown
- 1989-08-11 IE IE260189A patent/IE71185B1/en not_active IP Right Cessation
- 1989-08-11 HU HU894150A patent/HU205766B/hu unknown
- 1989-08-11 KR KR1019890011432A patent/KR0156239B1/ko not_active IP Right Cessation
- 1989-08-11 DE DE68924681T patent/DE68924681T2/de not_active Expired - Fee Related
- 1989-08-12 CN CN89106373A patent/CN1027167C/zh not_active Expired - Fee Related
-
1990
- 1990-08-10 US US07/566,145 patent/US5039669A/en not_active Expired - Fee Related
-
1995
- 1995-06-30 HU HU95P/P00618P patent/HU211949A9/hu unknown
- 1995-11-15 GR GR950403204T patent/GR3018086T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE68924681T2 (de) | 1996-04-04 |
CN1040590A (zh) | 1990-03-21 |
IE71185B1 (en) | 1997-01-29 |
PH26376A (en) | 1992-06-01 |
US5039669A (en) | 1991-08-13 |
US4990503A (en) | 1991-02-05 |
EP0354806B1 (en) | 1995-11-02 |
DK170257B1 (da) | 1995-07-17 |
CN1027167C (zh) | 1994-12-28 |
HU205766B (en) | 1992-06-29 |
AU624405B2 (en) | 1992-06-11 |
EP0354806A3 (en) | 1991-05-02 |
AU3941989A (en) | 1990-02-15 |
EP0354806A2 (en) | 1990-02-14 |
KR900003186A (ko) | 1990-03-26 |
DK394789D0 (da) | 1989-08-11 |
ATE129714T1 (de) | 1995-11-15 |
IE892601L (en) | 1990-02-12 |
HU211949A9 (en) | 1996-01-29 |
HUT51637A (en) | 1990-05-28 |
GR3018086T3 (en) | 1996-02-29 |
CA1332058C (en) | 1994-09-20 |
DE68924681D1 (de) | 1995-12-07 |
KR0156239B1 (ko) | 1998-12-01 |
DK394789A (da) | 1990-02-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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