ES2080116T3 - Sal monosodica trihidratada cristalina del acido 4-amino-1-hidroxibutilideno-1,1-bisfosfonico, procedimiento para producirla y composiciones y uso de la misma. - Google Patents

Sal monosodica trihidratada cristalina del acido 4-amino-1-hidroxibutilideno-1,1-bisfosfonico, procedimiento para producirla y composiciones y uso de la misma.

Info

Publication number
ES2080116T3
ES2080116T3 ES90306238T ES90306238T ES2080116T3 ES 2080116 T3 ES2080116 T3 ES 2080116T3 ES 90306238 T ES90306238 T ES 90306238T ES 90306238 T ES90306238 T ES 90306238T ES 2080116 T3 ES2080116 T3 ES 2080116T3
Authority
ES
Spain
Prior art keywords
crystalline
bisphosphonic
amino
acid
hydroxybutylidene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90306238T
Other languages
English (en)
Inventor
Gerald R Kieczykowski
David G Melillo
Ronald B Jobson
Gerald S Brenner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23431886&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2080116(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2080116T3 publication Critical patent/ES2080116T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCESO PARA LA PREPARACION DE ACIDO 4-AMINO-1-HIDROXIBUTILIDENO1,1-BISFOSFONICO O SUS SALES QUE CONSISTE EN: (A) LA REACCION DE ACIDO 4-AMINOBUTIRICO CON UNA COMBINACION DE ACIDO FOSFORICO Y PCI3 CON PRESENCIA DE ACIDO METANOSULFONICO; Y (B) LA RECUPERACION DE DICHO ACIDO 4-AMINO-1-HIDROXIBUTILIDENO-1,1 BISFOSFONICO O SUS SALES.
ES90306238T 1989-06-09 1990-06-08 Sal monosodica trihidratada cristalina del acido 4-amino-1-hidroxibutilideno-1,1-bisfosfonico, procedimiento para producirla y composiciones y uso de la misma. Expired - Lifetime ES2080116T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/363,820 US4922007A (en) 1989-06-09 1989-06-09 Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof

Publications (1)

Publication Number Publication Date
ES2080116T3 true ES2080116T3 (es) 1996-02-01

Family

ID=23431886

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90306238T Expired - Lifetime ES2080116T3 (es) 1989-06-09 1990-06-08 Sal monosodica trihidratada cristalina del acido 4-amino-1-hidroxibutilideno-1,1-bisfosfonico, procedimiento para producirla y composiciones y uso de la misma.

Country Status (23)

Country Link
US (1) US4922007A (es)
EP (1) EP0402152B1 (es)
JP (2) JPH0662651B2 (es)
KR (1) KR0137455B1 (es)
AT (1) ATE129713T1 (es)
AU (1) AU625704C (es)
CA (1) CA2018477C (es)
CH (1) CH0402152H1 (es)
CY (1) CY1894A (es)
DE (1) DE69023280T2 (es)
DK (1) DK0402152T3 (es)
ES (1) ES2080116T3 (es)
FI (1) FI93219C (es)
GR (1) GR3018379T3 (es)
HK (1) HK69596A (es)
HU (1) HU211908A9 (es)
IE (1) IE69564B1 (es)
IL (1) IL94612A (es)
LV (1) LV11472B (es)
NO (2) NO177997C (es)
NZ (1) NZ233972A (es)
PT (1) PT94306B (es)
ZA (1) ZA904446B (es)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
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JPH03101684A (ja) 1991-04-26
CH0402152H1 (fr) 2006-02-28
NO177997B (no) 1995-09-25
NO902559L (no) 1990-12-10
FI93219B (fi) 1994-11-30
JPH0662651B2 (ja) 1994-08-17
NO902559D0 (no) 1990-06-08
NO178228B (no) 1995-11-06
GR3018379T3 (en) 1996-03-31
NZ233972A (en) 1992-05-26
FI902845A0 (fi) 1990-06-07
IL94612A0 (en) 1991-04-15
ZA904446B (en) 1992-06-24
NO941726D0 (no) 1994-05-09
PT94306B (pt) 1997-05-28
FI93219C (fi) 1995-03-10
HK69596A (en) 1996-04-26
AU5701990A (en) 1990-12-13
KR0137455B1 (ko) 1998-05-01
AU625704C (en) 2001-07-26
HU211908A9 (en) 1996-01-29
NO177997C (no) 1996-01-03
CA2018477C (en) 1995-08-01
LV11472B (en) 1996-12-20
CA2018477A1 (en) 1990-12-09
EP0402152A2 (en) 1990-12-12
EP0402152B1 (en) 1995-11-02
LV11472A (lv) 1996-08-20
DE69023280D1 (de) 1995-12-07
JPH0748391A (ja) 1995-02-21
AU625704B2 (en) 1992-07-16
IE69564B1 (en) 1996-10-02
ATE129713T1 (de) 1995-11-15
PT94306A (pt) 1991-02-08
DE69023280T2 (de) 1996-06-20
US4922007A (en) 1990-05-01
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CY1894A (en) 1990-06-08
EP0402152A3 (en) 1991-07-03
IL94612A (en) 1995-03-30
NO178228C (no) 1996-02-14
DK0402152T3 (da) 1995-12-04

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