ES2068937T3 - Anticuerpos especificos contra troponina t, su produccion y utilizacion en un reactivo para la determinacion de las necrosis del miocardio. - Google Patents

Anticuerpos especificos contra troponina t, su produccion y utilizacion en un reactivo para la determinacion de las necrosis del miocardio.

Info

Publication number
ES2068937T3
ES2068937T3 ES90107323T ES90107323T ES2068937T3 ES 2068937 T3 ES2068937 T3 ES 2068937T3 ES 90107323 T ES90107323 T ES 90107323T ES 90107323 T ES90107323 T ES 90107323T ES 2068937 T3 ES2068937 T3 ES 2068937T3
Authority
ES
Spain
Prior art keywords
troponin
antibodies against
determination
determined
reagent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90107323T
Other languages
English (en)
Inventor
Hugo Prof Dr Katus
Anneliese Borgya
Klaus Dr Hallermayer
Siegfried Dr Looser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2068937T3 publication Critical patent/ES2068937T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4716—Muscle proteins, e.g. myosin, actin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

DETERMINACION DE LA NECROSIS DE MUSCULOS CARDIACOS UTILIZANDO ANTICUERPOS DE TROPONINA T Y UN AGLUTINANTE B PARA LA TROPONINA T O PARA EL ANTICUEROPO. EL ANTICUERPO O EL AGLUTINANTE B SE MARCAN CON UN GRUPO ANALIZABLE. EL COMPLEJO IMMUNOLOGICO CON EL GRUPO ANALIZABLE SE SEPARA POR SEGREGACION DE FASES Y EN UNA DE LAS FASE SE DETERMINA EL GRUPO ANALIZABLE. TAMBIEN SE DESCRIBEN ANTICUERPOS MONOCLONALES Y POLICLONALES DE LA TROPONINA T.
ES90107323T 1989-04-25 1990-04-18 Anticuerpos especificos contra troponina t, su produccion y utilizacion en un reactivo para la determinacion de las necrosis del miocardio. Expired - Lifetime ES2068937T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3913568 1989-04-25
DE3922873A DE3922873A1 (de) 1989-04-25 1989-07-12 Spezifische antikoerper gegen troponin t, ihre herstellung und verwendung in einem reagenz zur bestimmung von hermuskelnekrosen

Publications (1)

Publication Number Publication Date
ES2068937T3 true ES2068937T3 (es) 1995-05-01

Family

ID=25880249

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90107323T Expired - Lifetime ES2068937T3 (es) 1989-04-25 1990-04-18 Anticuerpos especificos contra troponina t, su produccion y utilizacion en un reactivo para la determinacion de las necrosis del miocardio.

Country Status (9)

Country Link
US (1) US6376206B1 (es)
EP (1) EP0394819B1 (es)
JP (2) JP2564686B2 (es)
AT (1) ATE117435T1 (es)
DE (2) DE3922873A1 (es)
DK (1) DK0394819T3 (es)
ES (1) ES2068937T3 (es)
GR (1) GR3015224T3 (es)
HK (1) HK1002814A1 (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4243648A1 (de) * 1992-12-23 1994-07-07 Boehringer Mannheim Gmbh Verfahren zur Bestimmung von Herzmuskelnekrosen mittels Antikörper gegen das N-terminale Troponin I-Peptid
FR2701954B1 (fr) * 1993-02-23 1995-07-07 Pasteur Sanofi Diagnostics Composition stabilisée de troponine pour immunoessais et procédé de stabilisation de troponine pour immunoessais.
JPH09503050A (ja) * 1993-05-17 1997-03-25 フォートロン バイオサイエンス インク． 心臓トロポニン▲ｉ▼のアッセイ
CA2130280C (en) * 1993-08-24 1999-08-31 Lilian Lee Method for purification of cardiac troponin i
DE4420742A1 (de) * 1993-10-20 1995-04-27 Boehringer Mannheim Gmbh Synthetischer Standard für Immunoassays
US6991907B1 (en) * 1995-04-18 2006-01-31 Biosite, Inc. Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
US6627404B1 (en) 1995-04-18 2003-09-30 Biosite, Inc. Methods for improving the recovery of troponin I and T in membranes, filters and vessels
US6174686B1 (en) 1995-04-18 2001-01-16 Biosite Diagnostics, Inc. Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
US5795725A (en) * 1995-04-18 1998-08-18 Biosite Diagnostics Incorporated Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays
US6072040A (en) * 1996-10-15 2000-06-06 Medical Analysis Systems, Inc. Stabilized conjugates of uncomplexed subunits of multimeric proteins
US6156521A (en) * 1997-12-19 2000-12-05 Biosite Diagnostics, Inc. Methods for the recovery and measurement of troponin complexes
US7384751B1 (en) * 1997-07-16 2008-06-10 Queen's University At Kingston Methods of diagnosing muscle damage
US20040005578A1 (en) * 2000-04-27 2004-01-08 Yoji Yamada Myocardial cell proliferation-associated genes
MXPA03004105A (es) 2002-05-14 2004-10-15 Hoffmann La Roche Elaboracion de una prognosis en casos de enfermedad cardiaca usando una combinacion de marcadores.
WO2004046722A2 (de) 2002-11-16 2004-06-03 Dade Behring Marburg Gmbh Scd40l, papp-a und plazentaler-wachstumsfaktor (pigf) als biochemische markerkombinationen bei kardiovaskulären erkrankungen
DE10351238A1 (de) * 2003-11-03 2005-06-02 Roche Diagnostics Gmbh Diagnosestellung von akuten myokardialen, ischämischen Erkrankungen durch Kombination von Markern
CN101438146B (zh) 2006-04-04 2014-12-10 神谷来克斯公司 高灵敏标志物分析和分子检测的方法和组合物
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
WO2008089994A1 (en) 2007-01-25 2008-07-31 Roche Diagnostics Gmbh Use of igfbp-7 in the assessment of heart failure
WO2008107201A1 (en) 2007-03-08 2008-09-12 Roche Diagnostics Gmbh Use of slim-1 in the assessment of heart failure
US8617820B2 (en) * 2007-08-28 2013-12-31 Ortho-Clinical Diagnostics, Inc. Use of glycosaminoglycans to reduce non-specific binding in immunoassays
JP5524182B2 (ja) 2008-04-30 2014-06-18 エフ．ホフマン−ラ ロシュ アーゲー 心不全の評価におけるｓｆｒｐ−３の使用
EP2133696A1 (en) 2008-06-10 2009-12-16 Eberhardt Spanuth Very low concentrations of troponin I or T for assessing a cardiovascular risk with respect to the administration of anti-inflammatory drugs
CN102187228A (zh) * 2008-10-17 2011-09-14 霍夫曼-拉罗奇有限公司 双糖链蛋白聚糖在心力衰竭评估中的用途
CA2769243C (en) 2009-07-27 2017-08-22 F. Hoffmann-La Roche Ag Use of mimecan in the assessment of heart failure
EP2504466B1 (en) 2009-11-23 2019-11-20 Proxim Diagnostics Corporation Controlled electrochemical activation of carbon-based electrodes
US8652788B2 (en) * 2009-12-02 2014-02-18 Abbott Laboratories Assay for diagnosis of cardiac myocyte damage
US8835120B2 (en) * 2009-12-02 2014-09-16 Abbott Laboratories Assay for cardiac troponin-T (cTnT)
EP2529235B1 (en) 2010-01-29 2019-03-06 Metanomics GmbH Means and methods for diagnosing heart failure in a subject
CA2807213C (en) * 2010-08-26 2022-06-28 F. Hoffman-La Roche Ag Use of biomarkers in the assessment of the early transition from arterial hypertension to heart failure
US9638663B2 (en) 2011-07-25 2017-05-02 Proxim Diagnostics Corporation Cartridge for diagnostic testing
CA2841915A1 (en) 2011-07-28 2013-01-31 Metanomics Gmbh Means and methods for diagnosing and monitoring heart failure in a subject
WO2014121252A1 (en) * 2013-02-04 2014-08-07 The General Hospital Corporation Biomarkers for stroke diagnosis
JP2017500547A (ja) 2013-11-15 2017-01-05 オタゴ イノベーション リミテッド 心臓障害のためのバイオマーカー
CN103940986B (zh) * 2014-03-24 2015-10-21 安徽省煦棠医疗科技有限公司 肌钙蛋白i特定位点抗体制备及其检测试剂盒
WO2017134264A1 (en) 2016-02-04 2017-08-10 Metanomics Gmbh Means and methods for differentiating between heart failure and pulmonary disease in a subject
US20170363620A1 (en) 2016-06-17 2017-12-21 Abbott Laboratories BIOMARKERS TO PREDICT NEW ONSET HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFpEF)
EP3279667A1 (en) 2016-08-02 2018-02-07 Abbott Laboratories Cardiac troponin i and copeptin as biomarkers for short-term mortality in acute exacerbation of chronic obstructive pulmonary disease (aecopd)
BR112020017941A2 (pt) * 2018-03-14 2021-02-17 F. Hoffmann-La Roche Ag anticorpos, moléculas de ácido nucleico, vetor, composição e método de determinação da troponina t cardíaca humana
WO2019175131A1 (en) 2018-03-14 2019-09-19 F. Hoffmann-La Roche Ag Method for affinity maturation of antibodies
WO2020264410A1 (en) * 2019-06-26 2020-12-30 Sensor-Kinesis Corporation Troponin t binding agents and uses thereof
JP2022543863A (ja) * 2019-08-09 2022-10-14 エフ．ホフマン－ラ ロシュ アーゲー 新規抗トロポニンｔ抗体
CN113402608B (zh) * 2021-06-24 2022-02-22 河北省科学院生物研究所 一种杂交瘤细胞株及其分泌的单克隆抗体与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3640412A1 (de) * 1986-11-26 1988-06-09 Boehringer Mannheim Gmbh Verfahren zur bestimmung einer spezifisch bindefaehigen substanz

Also Published As

Publication number Publication date
EP0394819B1 (de) 1995-01-18
HK1002814A1 (en) 1998-09-18
JP2564686B2 (ja) 1996-12-18
US6376206B1 (en) 2002-04-23
JP2818116B2 (ja) 1998-10-30
EP0394819A3 (de) 1991-02-06
JPH07198718A (ja) 1995-08-01
DE3922873A1 (de) 1990-10-31
JPH037597A (ja) 1991-01-14
DE59008278D1 (de) 1995-03-02
DK0394819T3 (da) 1995-06-19
ATE117435T1 (de) 1995-02-15
GR3015224T3 (en) 1995-05-31
EP0394819A2 (de) 1990-10-31

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