ES2062319T3 - 3-(1,2,5,6-tetrahidropiridil) pirrolopiridinas. - Google Patents

3-(1,2,5,6-tetrahidropiridil) pirrolopiridinas.

Info

Publication number
ES2062319T3
ES2062319T3 ES90300361T ES90300361T ES2062319T3 ES 2062319 T3 ES2062319 T3 ES 2062319T3 ES 90300361 T ES90300361 T ES 90300361T ES 90300361 T ES90300361 T ES 90300361T ES 2062319 T3 ES2062319 T3 ES 2062319T3
Authority
ES
Spain
Prior art keywords
hydrogen
selected independently
alkyl
alcoxi
rent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90300361T
Other languages
English (en)
Inventor
John Eugene Macor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2062319T3 publication Critical patent/ES2062319T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LOS COMPONENTES DE LA FORMULA (I) DONDE A,B,D Y E SON NITROGENO Y LOS 3 ATOMOS RESTANTES SON CARBONOS. R1 Y R2 ESTAN SELECCIONADOS INDEPENDIENTEMENTE DEL HIDROGENO Y DE LOS ALQUILES C1 A C6, Y R3, R4, R5 Y R6 ESTAN SELECCIONADOS INDEPENDIENTEMENTE DEL HIDROGENO, HALOGENO, HIDROXIL, ALQUIL C1-C6, ALCOXI, C1-C8, FENIL-C1-C6 ALCOXI, FENOXI, -NR7R8, DONDE R7 Y R8 ESTAN SELECCIONADOS INDEPENDIENTEMENTE DEL HIDROGENO, ALQUIL C1-C8, ALCANOL C1-C6, Y COOR9 DONDE R9 UN HIDROGENO O UN ALQUIL C1-C6; CIANO, COOR10, DONDE R10 ES UN HIDROGENO O UN ALQUIL C1-C6 Y CONR11R12, DONDE R10 Y R11 ESTAN SELECCIONADOS INDEPENDIENTEMENTE DEL HIDROGENO Y DEL ALQUIL C1-C6 Y DE LAS SALES FARMACEUTICAMENTE ACEPTABLES. EL COMPUESTO ES UTIL EN LA PSICOTERAPIA Y PUEDE SER USADO EN EL TRATAMIENTO DE LA OBESIDAD, DEPRESION Y DESORDENES DONDE LA AGRESION ES UNO DE LOS SINTOMAS.
ES90300361T 1989-01-20 1990-01-12 3-(1,2,5,6-tetrahidropiridil) pirrolopiridinas. Expired - Lifetime ES2062319T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/000231 WO1990007926A1 (en) 1989-01-20 1989-01-20 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

Publications (1)

Publication Number Publication Date
ES2062319T3 true ES2062319T3 (es) 1994-12-16

Family

ID=22214793

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90300361T Expired - Lifetime ES2062319T3 (es) 1989-01-20 1990-01-12 3-(1,2,5,6-tetrahidropiridil) pirrolopiridinas.

Country Status (26)

Country Link
US (2) US5051412A (es)
EP (1) EP0379314B1 (es)
JP (1) JPH0751576B2 (es)
KR (1) KR920010642B1 (es)
CN (1) CN1025998C (es)
AT (1) ATE103282T1 (es)
CA (1) CA2008016A1 (es)
CS (1) CS277611B6 (es)
DD (2) DD291559A5 (es)
DE (1) DE69007501T2 (es)
DK (1) DK0379314T3 (es)
EG (1) EG18945A (es)
ES (1) ES2062319T3 (es)
FI (1) FI94641C (es)
HU (1) HU206349B (es)
IE (1) IE62757B1 (es)
IL (1) IL93041A (es)
MX (1) MX19185A (es)
MY (1) MY106305A (es)
NO (1) NO912860D0 (es)
NZ (1) NZ232166A (es)
PL (2) PL287840A1 (es)
PT (1) PT92889A (es)
WO (1) WO1990007926A1 (es)
YU (1) YU47553B (es)
ZA (1) ZA90393B (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007926A1 (en) * 1989-01-20 1990-07-26 Pfizer Inc. 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines
US5451566A (en) * 1993-11-17 1995-09-19 Zeneca Limited Herbicidal pyrrolopyridine compounds
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
ZA979961B (en) * 1996-11-15 1999-05-05 Lilly Co Eli 5-HT1F agonists
EP1082958A3 (en) * 1996-11-15 2002-12-11 Eli Lilly And Company 5-HT1F agonists in chronic pain
EP0875513A1 (en) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituted heteroaromatic 5-HT 1F agonists
ZA989389B (en) * 1997-11-14 2000-04-14 Lilly Co Eli Pyrrolo [3,2-b] pyridine processes and intermediates.
US5905084A (en) * 1997-11-14 1999-05-18 Eli Lilly And Company 5-HTIF -agonists effective in treating migraine
US6476034B2 (en) 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
US7332183B2 (en) 2002-12-26 2008-02-19 Pozen Inc. Multilayer dosage forms containing NSAIDs and triptans
NZ547327A (en) * 2003-11-21 2009-08-28 Array Biopharma Inc AKT protein kinase inhibitors
US7452993B2 (en) 2004-07-27 2008-11-18 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
MX2007001127A (es) * 2004-07-27 2007-07-11 Sgx Pharmaceuticals Inc Moduladores de pirrolo-piridina cinasa.
US7626021B2 (en) * 2004-07-27 2009-12-01 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US7361764B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
WO2008006032A1 (en) 2006-07-06 2008-01-10 Array Biopharma Inc. Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
ATE532789T1 (de) 2006-07-06 2011-11-15 Array Biopharma Inc Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8329701B2 (en) 2006-07-06 2012-12-11 Array Biopharma Inc. Dihydrofuro pyrimidines as AKT protein kinase inhibitors
ES2404668T3 (es) 2006-12-29 2013-05-28 Rigel Pharmaceuticals, Inc. Triazoles sustituidos con arilo bicíclico puenteado y heteroarilo bicíclico puenteado, útiles como agentes inhibidores del axl
RU2486181C2 (ru) 2007-07-05 2013-06-27 Эррэй Биофарма Инк. Пиримидилциклопентаны как ингибиторы акт-протеинкиназ
EP2173723B3 (en) * 2007-07-05 2014-11-19 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
AU2009204019B2 (en) * 2008-01-09 2014-02-20 Array Biopharma Inc. Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor
ES2422733T3 (es) * 2008-01-09 2013-09-13 Array Biopharma Inc Pirimidilciclopentanos hidroxilados como inhibidores de proteínas cinasas AKT
US8546433B2 (en) 2009-01-16 2013-10-01 Rigel Pharmaceuticals, Inc. Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer
HUE031048T2 (en) 2009-06-17 2017-06-28 Vertex Pharma Influenza virus replication inhibitors
CN103492381A (zh) 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
CN103857395A (zh) 2011-04-01 2014-06-11 基因泰克公司 Akt抑制剂化合物和阿比特龙的组合及使用方法
JP6147246B2 (ja) 2011-04-01 2017-06-14 ジェネンテック， インコーポレイテッド Ａｋｔ及びｍｅｋ阻害剤化合物の組み合わせ、及び使用方法
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
RS57541B1 (sr) 2013-11-13 2018-10-31 Vertex Pharma Postupci za pripremu inhibitora replikacije virusa gripa
CN105849100B (zh) 2013-11-13 2019-07-16 沃泰克斯药物股份有限公司 流感病毒复制抑制剂
EP3209663B1 (en) 2014-10-23 2018-12-12 Janssen Pharmaceutica N.V. New pyrazolopyrimidine derivatives as nik inhibitors
ES2704738T3 (es) 2014-10-23 2019-03-19 Janssen Pharmaceutica Nv Nuevos derivados de tienopirimidina en calidad de inhibidores de nik
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3272804A (en) * 1963-12-23 1966-09-13 Sterling Drug Inc Process and intermediates for preparing indoles
GB1141949A (en) * 1966-02-23 1969-02-05 Sterling Drug Inc 7-azaindole derivatives
IL48508A (en) * 1974-12-09 1979-10-31 Roussel Uclaf Pharmaceutical compositions comprising piperidylindole derivatives
FR2362628A1 (fr) * 1976-08-26 1978-03-24 Roussel Uclaf Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments
FR2421899A1 (fr) * 1978-01-16 1979-11-02 Roussel Uclaf Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
FR2444678A2 (fr) * 1978-12-22 1980-07-18 Roussel Uclaf Nouveau procede de preparation de derives du piperidyl-indole et de leurs sels
US5025096A (en) * 1985-08-22 1991-06-18 Mine Safety Appliances Company Preparation of indole and indole derivatives
WO1990007926A1 (en) * 1989-01-20 1990-07-26 Pfizer Inc. 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

Also Published As

Publication number Publication date
DD298398A5 (de) 1992-02-20
DD291559A5 (de) 1991-07-04
CN1025998C (zh) 1994-09-28
FI913509A0 (fi) 1991-07-22
IE900210L (en) 1990-07-23
HU206349B (en) 1992-10-28
DK0379314T3 (da) 1994-05-09
NO912860L (no) 1991-07-22
DE69007501D1 (de) 1994-04-28
IL93041A0 (en) 1990-11-05
KR900011772A (ko) 1990-08-02
AU4867390A (en) 1990-07-26
NZ232166A (en) 1992-10-28
DE69007501T2 (de) 1994-06-30
YU47553B (sh) 1995-10-03
MX19185A (es) 1993-12-01
NO912860D0 (no) 1991-07-22
FI94641C (fi) 1995-10-10
EP0379314B1 (en) 1994-03-23
ZA90393B (en) 1991-08-28
MY106305A (en) 1995-04-29
CA2008016A1 (en) 1990-07-20
EP0379314A1 (en) 1990-07-25
IE62757B1 (en) 1995-02-22
YU9990A (en) 1992-05-28
IL93041A (en) 1994-02-27
US5051412A (en) 1991-09-24
AU613259B2 (en) 1991-07-25
CS277611B6 (en) 1993-03-17
JPH0751576B2 (ja) 1995-06-05
KR920010642B1 (ko) 1992-12-12
ATE103282T1 (de) 1994-04-15
PL287840A1 (en) 1991-07-15
PL163626B1 (pl) 1994-04-29
CN1044465A (zh) 1990-08-08
US5169947A (en) 1992-12-08
CS26090A3 (en) 1992-02-19
JPH02247175A (ja) 1990-10-02
PL283354A1 (en) 1991-08-12
PT92889A (pt) 1990-07-31
HUT57762A (en) 1991-12-30
EG18945A (en) 1994-09-29
WO1990007926A1 (en) 1990-07-26
FI94641B (fi) 1995-06-30

Similar Documents

Publication Publication Date Title
ES2062319T3 (es) 3-(1,2,5,6-tetrahidropiridil) pirrolopiridinas.
MX9205242A (es) Compuestos heterociclicos que contienen nitrogeno triciclico fusionado.
ATE106245T1 (de) Anwendung von monoaminakridinen bei mangelerscheinungen des cholinergen nervensystems.
TW369526B (en) Diazabicyclic neurokinin antagonists
KR950010888A (ko) 평활근세포 증식 및 재발협착증을 억제하는 방법
CO4810230A1 (es) Nuevos derivados del 19-nor-pregneno
TW222636B (es)
MXPA03001073A (es) Compuestos que actuan como ligandos receptores de melanocortina.
ATE115581T1 (de) 1-azabicyclo(3.2.2>nonan-3-aminderivate.
FI935701A0 (fi) Fluoralkoxibensylaminoderivat av kvaeve-innehaollande heterocykliska foereningar
ATE196140T1 (de) Substituierte benzylaminoquinuclidine als substanz p antagonisten
DE69805361D1 (de) Azindolethylaminderivate als Nikotin-acetylcholin-Rezeptor Bindung Verbindungen
DK0632036T3 (da) Amidderivater med antipypercholesteræmisk aktivitet, deres fremstilling og deres terapeutiske anvendelser
PE34297A1 (es) Ligandos especificos del neuropeptido y1
CO4370018A1 (es) Derivados de naftaleno, metodo de preparacion y uso
ES2052917T3 (es) Derivados de piperidina.
HK1049487A1 (zh) 用於治療或預防心血管疾病的植物甾醇和/或植物甾烷醇的芳族和雜環衍生物
GEP19991779B (en) Use of Aminoadamantane Compounds as Immunoregulators
IL108387A (en) Optically active beta-aminoalkoxyborane complex and its use in organic synthesis
DE69013672D1 (de) Halogensubstituierte aminotetraline.
TW328957B (en) Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation
NO922945L (no) Pyrazolderivater
DK0900082T3 (da) Anvendelse af pyridyl- og pyrimidyl-piperaziner til fremstilling af et lægemiddel til behandling af rusgiftbetingede lidelser
US3736323A (en) 1-aminoalkyl-2,6-diaryl-4,5,6,7-tetrahydroindoles
NO920619L (no) Oxazinobenzazolforbindelser

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 379314

Country of ref document: ES