ES2062248T3 - Procedimiento para la obtencion de ureas puras, asimetricamente disubstituidas. - Google Patents
Procedimiento para la obtencion de ureas puras, asimetricamente disubstituidas.Info
- Publication number
- ES2062248T3 ES2062248T3 ES90119673T ES90119673T ES2062248T3 ES 2062248 T3 ES2062248 T3 ES 2062248T3 ES 90119673 T ES90119673 T ES 90119673T ES 90119673 T ES90119673 T ES 90119673T ES 2062248 T3 ES2062248 T3 ES 2062248T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- unsubstituted
- ureas
- procedure
- dialkylurea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1854—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety
Abstract
METODO PARA LA OBTENCION DE UREAS DISUBSTITUIDAS ASIMETRICAMENTE DE LA FORMULA GENERAL EN LA QUE R REPRESENTA UN RESTO DE FENILO NO SUBSTITUIDO O SUBSTITUIDO SIMPLE O MULTIPLEMENTE POR ATOMOS DE HALOGENO O GRUPOS DE ALCOILO, ALCOXI, ARILOXI O TRIFLUORMETILO, UN RESTO DE OXAZOLIL, ISOXAZOLIL, TIAZOLIL, ISOTIAZOLIL, BENZOXAZOLIL O BENZTIAZOLIL UNSUBSTITUIDO O SUBTITUIDO SIMPLE O MULTIPLEMENTE POR ATOMOS DE HALOGENOS O GRUPOS DE ALCOILO, ALCOXI, ARILOXI O TRIFLUORMETILO Y R SUB 1 Y R SUB 2 INDEPENDIENTEMENTE UNA DE OTRA REPRESENTAN UN ATOMO DE HIDROGENO O UN GRUPO ALCOILO, EN EL QUE R SUB 1 Y R SUB 2 NO SON SIMULTANEAMENTE HIDROGENO, O R SUB 1 Y R SUB 2 CONJUNTAMENTE REPRESENTAN UN GRUPO DE BUTILENO O DE PENTILENO, POR LA TRANSFORMACION DE UNA UREA N-ALCOILO O N, N-DIALCOILO CON UNA IGUALMENTE SUSTITUIDA ARILOAMINA O UNA AMINA HETEROCICLICA CON PRESENCIA DE AQUELLA AMINA QUE YA CONTENIA EL PRODUCTO DE PARTIDA, YA FUESE N-ALCOILO O UREA N, N-DIALCOILO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT257589 | 1989-11-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2062248T3 true ES2062248T3 (es) | 1994-12-16 |
Family
ID=3536751
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90119673T Expired - Lifetime ES2062248T3 (es) | 1989-11-10 | 1990-10-15 | Procedimiento para la obtencion de ureas puras, asimetricamente disubstituidas. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5099021A (es) |
EP (1) | EP0427963B1 (es) |
JP (1) | JPH03173860A (es) |
CN (1) | CN1025026C (es) |
AT (1) | ATE103589T1 (es) |
CA (1) | CA2028916A1 (es) |
CZ (1) | CZ282545B6 (es) |
DE (1) | DE59005183D1 (es) |
DK (1) | DK0427963T3 (es) |
ES (1) | ES2062248T3 (es) |
FI (1) | FI905532A0 (es) |
HU (1) | HU209386B (es) |
IL (1) | IL96049A (es) |
PL (1) | PL164621B1 (es) |
SK (1) | SK553590A3 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT394715B (de) * | 1990-08-14 | 1992-06-10 | Chemie Linz Gmbh | Verfahren zur n-alkylierung von harnstoffen |
US5241118A (en) * | 1991-04-04 | 1993-08-31 | Arco Chemical Technology, L.P. | Process for the preparation of trisubstituted ureas by reductive carbonylation |
AT397384B (de) * | 1991-08-16 | 1994-03-25 | Chemie Linz Gmbh | Verfahren zur herstellung reiner n,n'-unsymmetrisch substituierter phenylharnstoffe |
DE4130514A1 (de) * | 1991-09-13 | 1993-03-18 | Chemie Linz Deutschland | Verfahren zur herstellung reiner n,n'-unsymmetrisch substituierter phenylharnstoffe |
WO2000056725A1 (en) | 1999-03-19 | 2000-09-28 | Du Pont Pharmaceuticals Company | N-adamant-1-yl-n'-[4-chlorobenzothiazol-2-yl] urea useful in the treatment of inflammation and as an anticancer radiosensitizing agent |
MXPA02012596A (es) * | 2000-06-21 | 2003-04-10 | Hoffmann La Roche | Derivados de benzotiazol. |
US7087761B2 (en) | 2003-01-07 | 2006-08-08 | Hoffmann-La Roche Inc. | Cyclization process for substituted benzothiazole derivatives |
PT1753760E (pt) | 2004-05-24 | 2008-02-12 | Hoffmann La Roche | '' - metoxi - 7 - morfolin - 4 - il - benzotiazol - 2 - il) - amida do ácido 4 - hidroxi - 4 - metil - piperidina - 1 - carboxílico'' |
DE602005008095D1 (de) | 2004-11-05 | 2008-08-21 | Hoffmann La Roche | Verfahren zur herstellung von isonikotinsäurederivaten |
RU2412943C2 (ru) | 2005-03-23 | 2011-02-27 | Ф. Хоффманн-Ля Рош Аг | ПРОИЗВОДНЫЕ АЦЕТИЛЕНИЛ-ПИРАЗОЛО-ПИРИМИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR2 |
ATE463495T1 (de) | 2005-09-27 | 2010-04-15 | Hoffmann La Roche | Oxadiazolylpyrazolopyrimidine als mglur2- antagonisten |
WO2008077809A1 (en) * | 2006-12-22 | 2008-07-03 | F. Hoffmann-La Roche Ag | Process for the manufacture of 7-oxa-bicyclo derivatives |
HUP1100731A2 (en) | 2011-12-30 | 2013-06-28 | Stratoxer S Kft | Complex forming compounds |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2673877A (en) * | 1951-10-26 | 1954-03-30 | Du Pont | Preparation of chlorphenyldimethyl-ureas |
DE1064051B (de) * | 1958-04-09 | 1959-08-27 | Basf Ag | Verfahren zur Herstellung von substituierten Harnstoffen |
NL277506A (es) * | 1961-04-21 | |||
NL280954A (es) * | 1961-07-14 | |||
NL129423C (es) * | 1964-03-26 | |||
CH493195A (de) * | 1968-01-23 | 1970-07-15 | Ciba Geigy | Schädlingsbekämpfungsmittel |
CH505543A (de) * | 1968-11-01 | 1971-04-15 | Ciba Geigy Ag | Schädlingsbekämpfungsmittel |
DE2436139C3 (de) * | 1973-07-26 | 1983-12-08 | W.H. Dickinson Engineering Ltd., Southampton | Konditioniervorrichtung für Tabak |
US4212981A (en) * | 1973-07-27 | 1980-07-15 | Shionogi & Co., Ltd. | Process for preparing 3-isoxazolylurea derivatives |
JPS5810361B2 (ja) * | 1974-10-04 | 1983-02-25 | 塩野義製薬株式会社 | 3−アルチルイソオキサゾ−ル系除草剤 |
JPS6033109B2 (ja) * | 1977-04-28 | 1985-08-01 | 塩野義製薬株式会社 | 尿素誘導体の合成法 |
DE2742158B2 (de) * | 1977-09-19 | 1979-08-02 | Skw Trostberg Ag, 8223 Trostberg | Verfahren zur Herstellung substituierter Harnstoffe |
EP0002881A1 (en) * | 1977-11-02 | 1979-07-11 | FISONS plc | 5-Isoxazolylurea derivatives, their preparation, their use and compositions containing them |
DE2844962A1 (de) * | 1978-10-16 | 1980-04-30 | Basf Ag | Verfahren zur herstellung von symmetrischen 1,3-disubstituierten harnstoffen |
DE2937331A1 (de) * | 1979-09-14 | 1981-04-02 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von alkylharnstoffen |
BR8106184A (pt) * | 1980-01-25 | 1981-11-24 | Reanal Finomvegyszergyar | Processo para preparacao de derivados de n-aril-n'-(mono-ou dissubstituido)-ureia |
HU185294B (en) * | 1980-12-29 | 1984-12-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing substituted urea derivatives |
US4380641A (en) * | 1981-10-26 | 1983-04-19 | Eli Lilly And Company | Insecticidal oxazolyl ureas |
JPS5939883A (ja) * | 1982-08-27 | 1984-03-05 | Shionogi & Co Ltd | イソオキサゾ−ル系アシル尿素類 |
DE3413755A1 (de) * | 1984-04-12 | 1985-10-24 | Basf Ag, 6700 Ludwigshafen | Thiazolylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses |
FR2577221B1 (fr) * | 1985-02-11 | 1987-02-20 | Rhone Poulenc Agrochimie | Procede de preparation d'une phenyluree substituee |
KR960012208B1 (ko) * | 1987-06-25 | 1996-09-16 | 일라이 릴리 앤드 캄파니 | 우레아, 카바메이트 및 카바메이트 유도체의 제조방법 |
-
1990
- 1990-10-15 AT AT90119673T patent/ATE103589T1/de active
- 1990-10-15 EP EP90119673A patent/EP0427963B1/de not_active Expired - Lifetime
- 1990-10-15 ES ES90119673T patent/ES2062248T3/es not_active Expired - Lifetime
- 1990-10-15 DK DK90119673.3T patent/DK0427963T3/da active
- 1990-10-15 DE DE90119673T patent/DE59005183D1/de not_active Expired - Fee Related
- 1990-10-17 IL IL9604990A patent/IL96049A/en not_active IP Right Cessation
- 1990-10-30 US US07/606,208 patent/US5099021A/en not_active Expired - Fee Related
- 1990-10-30 CA CA002028916A patent/CA2028916A1/en not_active Abandoned
- 1990-11-08 JP JP2301250A patent/JPH03173860A/ja active Pending
- 1990-11-08 FI FI905532A patent/FI905532A0/fi not_active Application Discontinuation
- 1990-11-09 CN CN90109034A patent/CN1025026C/zh not_active Expired - Fee Related
- 1990-11-09 HU HU907086A patent/HU209386B/hu not_active IP Right Cessation
- 1990-11-09 PL PL90287708A patent/PL164621B1/pl unknown
- 1990-11-09 CZ CS905535A patent/CZ282545B6/cs not_active IP Right Cessation
- 1990-11-09 SK SK5535-90A patent/SK553590A3/sk unknown
Also Published As
Publication number | Publication date |
---|---|
CA2028916A1 (en) | 1991-05-11 |
JPH03173860A (ja) | 1991-07-29 |
PL164621B1 (pl) | 1994-08-31 |
DK0427963T3 (da) | 1994-05-02 |
CZ282545B6 (cs) | 1997-08-13 |
CZ553590A3 (en) | 1997-06-11 |
SK279982B6 (sk) | 1999-06-11 |
HUT55748A (en) | 1991-06-28 |
US5099021A (en) | 1992-03-24 |
CN1025026C (zh) | 1994-06-15 |
FI905532A0 (fi) | 1990-11-08 |
EP0427963A1 (de) | 1991-05-22 |
PL287708A1 (en) | 1991-11-04 |
IL96049A0 (en) | 1991-07-18 |
HU209386B (en) | 1994-05-30 |
IL96049A (en) | 1994-10-21 |
EP0427963B1 (de) | 1994-03-30 |
ATE103589T1 (de) | 1994-04-15 |
CN1051726A (zh) | 1991-05-29 |
HU907086D0 (en) | 1991-05-28 |
SK553590A3 (en) | 1999-06-11 |
DE59005183D1 (de) | 1994-05-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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