ES2058644T3 - Nuevo proceso para la sintesis de la n-metil-3,4-dimetoxifeniletilamina. - Google Patents

Nuevo proceso para la sintesis de la n-metil-3,4-dimetoxifeniletilamina.

Info

Publication number
ES2058644T3
ES2058644T3 ES90104931T ES90104931T ES2058644T3 ES 2058644 T3 ES2058644 T3 ES 2058644T3 ES 90104931 T ES90104931 T ES 90104931T ES 90104931 T ES90104931 T ES 90104931T ES 2058644 T3 ES2058644 T3 ES 2058644T3
Authority
ES
Spain
Prior art keywords
synthesis
methyl
gives
new process
dimetoxifeniletilamina
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90104931T
Other languages
English (en)
Inventor
Vincenzo Cannata
Giancarlo Tamerlani
Graziano Zagnoni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Chemicals Italiana SpA
Original Assignee
Alfa Chemicals Italiana SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Chemicals Italiana SpA filed Critical Alfa Chemicals Italiana SpA
Application granted granted Critical
Publication of ES2058644T3 publication Critical patent/ES2058644T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/50—Ethers of hydroxy amines of undetermined structure, e.g. obtained by reactions of epoxides with hydroxy amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NUEVO PROCESO PARA LA SINTESIS DEL N-METIL-3,4-DIMETOXIFENILETILAMINO DE LA FORMULA INTERMEDIARIO EN LA SINTESIS DE LA GROGA INTERNACIONALMENTE CONOCIDA COMO VERAPAMIL. EL PROCESO COMIENZA DEL 3,4-DIMETOXIBENZALDEHIDO QUE, POR MEDIO DE UNA CONDENSACION DARZENS, DA UN EPOXIESTER QUE, POR HIDROLISIS ALCALINA Y LA SUBSECUENTE DECARBOXILACION, DA EL 3,4-DIMETOXIFENILACETALDEHIDO. ESTE ALDEHIDO DA EL AMINO DE LA FORMULA I POR REACCION CON MONOMETILAMINO SEGUIDO POR LA REDUCCION CON BOROHIDRURO DE SODIO.
ES90104931T 1989-03-31 1990-03-15 Nuevo proceso para la sintesis de la n-metil-3,4-dimetoxifeniletilamina. Expired - Lifetime ES2058644T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8919959A IT1229214B (it) 1989-03-31 1989-03-31 Processo per la sintesi della n metil 3,4 dimetossifeniletilamina

Publications (1)

Publication Number Publication Date
ES2058644T3 true ES2058644T3 (es) 1994-11-01

Family

ID=11162654

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90104931T Expired - Lifetime ES2058644T3 (es) 1989-03-31 1990-03-15 Nuevo proceso para la sintesis de la n-metil-3,4-dimetoxifeniletilamina.

Country Status (25)

Country Link
US (1) US5057624A (es)
EP (1) EP0389876B1 (es)
JP (1) JPH06102636B2 (es)
KR (1) KR940011899B1 (es)
AR (1) AR245930A1 (es)
AT (1) ATE92467T1 (es)
AU (1) AU627561B2 (es)
CA (1) CA2013080C (es)
DD (1) DD293109A5 (es)
DE (1) DE69002500T2 (es)
DK (1) DK0389876T3 (es)
ES (1) ES2058644T3 (es)
FI (1) FI102370B (es)
HR (1) HRP940599B1 (es)
HU (1) HU209947B (es)
IE (1) IE63954B1 (es)
IL (1) IL93762A (es)
IT (1) IT1229214B (es)
NO (1) NO170149C (es)
NZ (1) NZ232975A (es)
PL (1) PL162349B1 (es)
PT (1) PT93598B (es)
SI (1) SI9010634B (es)
YU (1) YU48167B (es)
ZA (1) ZA902003B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990014830A (ko) * 1995-05-17 1999-02-25 카르크 Ｎ-메틸-2-(3,4-디메톡시페닐)에틸아민의 제조 방법
CN101580460B (zh) * 2009-05-26 2012-05-23 台州市知青化工有限公司 一种3，4-二羟基苯乙醇的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3894051A (en) * 1973-07-05 1975-07-08 Colgate Palmolive Co N-methylenedioxyphenylalkyl)-{62 -(alkyl)-disubstituted phenethylamines
US3997608A (en) * 1973-07-05 1976-12-14 Richardson-Merrell Inc. N-substituted-dihydroxyphenethylamines
DE3338681A1 (de) * 1983-10-25 1985-05-09 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von n-methylhomoveratrylamin
GB8603765D0 (en) * 1986-02-15 1986-03-19 Beecham Wuelfung Gmbh & Co Kg Compounds
IT1215409B (it) * 1987-04-08 1990-02-08 Alfa Chem Ital Processo per la sintesi dell'alfa-(1-metiletil)-3,4-dimetossibenzeneacetonitrile.

Also Published As

Publication number Publication date
DE69002500T2 (de) 1994-01-13
JPH06102636B2 (ja) 1994-12-14
KR900014310A (ko) 1990-10-23
HRP940599B1 (en) 1998-04-30
NO901454D0 (no) 1990-03-30
NO170149C (no) 1992-09-16
AR245930A1 (es) 1994-03-30
EP0389876B1 (en) 1993-08-04
HUT53865A (en) 1990-12-28
EP0389876A1 (en) 1990-10-03
PT93598A (pt) 1990-11-20
FI102370B1 (fi) 1998-11-30
NZ232975A (en) 1991-11-26
ATE92467T1 (de) 1993-08-15
IT8919959A0 (it) 1989-03-31
CA2013080C (en) 1997-07-22
HU902025D0 (en) 1990-07-28
YU63490A (en) 1991-10-31
CA2013080A1 (en) 1990-09-30
SI9010634A (en) 1997-08-31
IE901171L (en) 1990-09-30
NO901454L (no) 1990-10-01
HU209947B (en) 1994-12-28
PL162349B1 (pl) 1993-10-30
SI9010634B (sl) 1998-06-30
AU627561B2 (en) 1992-08-27
DD293109A5 (de) 1991-08-22
NO170149B (no) 1992-06-09
DE69002500D1 (de) 1993-09-09
JPH02289539A (ja) 1990-11-29
ZA902003B (en) 1990-12-28
PT93598B (pt) 1996-03-29
FI901611A0 (fi) 1990-03-30
US5057624A (en) 1991-10-15
HRP940599A2 (en) 1997-06-30
DK0389876T3 (da) 1993-09-27
KR940011899B1 (ko) 1994-12-27
IL93762A (en) 1994-07-31
IT1229214B (it) 1991-07-25
AU5247090A (en) 1990-10-04
IE63954B1 (en) 1995-06-28
IL93762A0 (en) 1990-12-23
YU48167B (sh) 1997-07-31
FI102370B (fi) 1998-11-30

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