YU48167B - Nov postupak za sintezu n-metil-3,4-dimetoksifeniletilamina - Google Patents
Nov postupak za sintezu n-metil-3,4-dimetoksifeniletilaminaInfo
- Publication number
- YU48167B YU48167B YU63490A YU63490A YU48167B YU 48167 B YU48167 B YU 48167B YU 63490 A YU63490 A YU 63490A YU 63490 A YU63490 A YU 63490A YU 48167 B YU48167 B YU 48167B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- formula
- hours
- temperature
- methyl
- straight
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/50—Ethers of hydroxy amines of undetermined structure, e.g. obtained by reactions of epoxides with hydroxy amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NOV POSTUPAK ZA SINTEZU N-METIL-3,4-DIMETOKSIFENILETILAMINA, formule naznacen time, sto a) 3,4-dimetoksibenzaldehid, formule reaguje sa a-halogenestrom, formule X-CH2-COOR VI u kojoj X predstavlja atom halogena, a R predstavlja alkil-radikal, sa pravim ili razgranatim nizom, koji sadrzi od 1 do 6 atoma ugljenika, u prisustvu alkalnog sredstva, odabranog izmedju alkoholata alkalnog metala, formule R1O-Me+ VII u kojoj Me+ predstavlja katjon alkalnog metala, a R1 predstavlja alkil-radikal, sa pravim ili razgranatim nizom, koji sadrzi od 1 do 6 atoma ugljenika, natrijum-amida ili natrijum-hidrida, eventualno u prisustvu rastvaraca, odabranog izmedju aromatskog ugljovodonika i nekog alkohola, sa pravim ili razgranatim nizom, koji sadrzi 1 do 6 atoma ugljenika, ili njihove smese, za vreme od izmedju oko 1 do oko 6 sati, na tempeaturi izmedju oko 0°C i oko 40°C, b) dobijeni estar glicidne kiseline, formule u kome R ima gore pomenuto znacenje, biva alkalno hidrolizovan, na temperaturi izmedju oko 10°C i oko 40°C u toku, izmedju oko 6 i oko 24 sata, da bi se dobila alkalna so epoksi kiseline, formule u kojoj Me+ ima gore pomenuto znacenje, c) jedinjenje formule IV, biva dekarboksilovano u kiseloj sredini, na temperaturi izmedju oko 10°C i oko 40°C, u toku, izmedju oko 1 i oko 8 casova, da bi se dobio 3,4-dimetoksiben-zenacetaldehid, formule d) tretiranjem tog aldehida, formule V, prvo sa monometilaminom, na temperaturi izmedju oko -10°C, u toku, izmedju oko 1 i oko 6 sati, a zatim sa natrijum-borohidridom, na temperaturi izmedju, oko -10°C i oko 80°C, u toku, izmedju oko 2 i oko 8 sati, nastaje N-metil-3,4-dimetoksifeniletilamin, formule 1. Prijava sadrzi jos 6 zavisnih zahteva.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9010634A SI9010634B (sl) | 1989-03-31 | 1990-03-29 | Nov postopek za sintezo N-metil-3,4-dimetoksifeniletilamina |
HRP-634/90A HRP940599B1 (en) | 1989-03-31 | 1994-09-26 | New process for the synthesis of the n-methyl-3,4-dimethoxyphenylethylamine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8919959A IT1229214B (it) | 1989-03-31 | 1989-03-31 | Processo per la sintesi della n metil 3,4 dimetossifeniletilamina |
Publications (2)
Publication Number | Publication Date |
---|---|
YU63490A YU63490A (en) | 1991-10-31 |
YU48167B true YU48167B (sh) | 1997-07-31 |
Family
ID=11162654
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU63490A YU48167B (sh) | 1989-03-31 | 1990-03-29 | Nov postupak za sintezu n-metil-3,4-dimetoksifeniletilamina |
Country Status (25)
Country | Link |
---|---|
US (1) | US5057624A (sh) |
EP (1) | EP0389876B1 (sh) |
JP (1) | JPH06102636B2 (sh) |
KR (1) | KR940011899B1 (sh) |
AR (1) | AR245930A1 (sh) |
AT (1) | ATE92467T1 (sh) |
AU (1) | AU627561B2 (sh) |
CA (1) | CA2013080C (sh) |
DD (1) | DD293109A5 (sh) |
DE (1) | DE69002500T2 (sh) |
DK (1) | DK0389876T3 (sh) |
ES (1) | ES2058644T3 (sh) |
FI (1) | FI102370B (sh) |
HR (1) | HRP940599B1 (sh) |
HU (1) | HU209947B (sh) |
IE (1) | IE63954B1 (sh) |
IL (1) | IL93762A (sh) |
IT (1) | IT1229214B (sh) |
NO (1) | NO170149C (sh) |
NZ (1) | NZ232975A (sh) |
PL (1) | PL162349B1 (sh) |
PT (1) | PT93598B (sh) |
SI (1) | SI9010634B (sh) |
YU (1) | YU48167B (sh) |
ZA (1) | ZA902003B (sh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR19990014830A (ko) * | 1995-05-17 | 1999-02-25 | 카르크 | N-메틸-2-(3,4-디메톡시페닐)에틸아민의 제조 방법 |
CN101580460B (zh) * | 2009-05-26 | 2012-05-23 | 台州市知青化工有限公司 | 一种3,4-二羟基苯乙醇的合成方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3894051A (en) * | 1973-07-05 | 1975-07-08 | Colgate Palmolive Co | N-methylenedioxyphenylalkyl)-{62 -(alkyl)-disubstituted phenethylamines |
US3997608A (en) * | 1973-07-05 | 1976-12-14 | Richardson-Merrell Inc. | N-substituted-dihydroxyphenethylamines |
DE3338681A1 (de) * | 1983-10-25 | 1985-05-09 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von n-methylhomoveratrylamin |
GB8603765D0 (en) * | 1986-02-15 | 1986-03-19 | Beecham Wuelfung Gmbh & Co Kg | Compounds |
IT1215409B (it) * | 1987-04-08 | 1990-02-08 | Alfa Chem Ital | Processo per la sintesi dell'alfa-(1-metiletil)-3,4-dimetossibenzeneacetonitrile. |
-
1989
- 1989-03-31 IT IT8919959A patent/IT1229214B/it active
-
1990
- 1990-03-15 EP EP90104931A patent/EP0389876B1/en not_active Expired - Lifetime
- 1990-03-15 ES ES90104931T patent/ES2058644T3/es not_active Expired - Lifetime
- 1990-03-15 DE DE90104931T patent/DE69002500T2/de not_active Expired - Fee Related
- 1990-03-15 ZA ZA902003A patent/ZA902003B/xx unknown
- 1990-03-15 AT AT90104931T patent/ATE92467T1/de not_active IP Right Cessation
- 1990-03-15 DK DK90104931.2T patent/DK0389876T3/da active
- 1990-03-15 KR KR1019900003444A patent/KR940011899B1/ko not_active IP Right Cessation
- 1990-03-16 IL IL9376290A patent/IL93762A/en unknown
- 1990-03-19 NZ NZ232975A patent/NZ232975A/xx unknown
- 1990-03-26 CA CA002013080A patent/CA2013080C/en not_active Expired - Fee Related
- 1990-03-27 AR AR90316461A patent/AR245930A1/es active
- 1990-03-27 DD DD90339109A patent/DD293109A5/de unknown
- 1990-03-28 PL PL28450790A patent/PL162349B1/pl unknown
- 1990-03-29 PT PT93598A patent/PT93598B/pt not_active IP Right Cessation
- 1990-03-29 YU YU63490A patent/YU48167B/sh unknown
- 1990-03-29 JP JP2082896A patent/JPH06102636B2/ja not_active Expired - Fee Related
- 1990-03-29 SI SI9010634A patent/SI9010634B/sl unknown
- 1990-03-30 FI FI901611A patent/FI102370B/fi not_active IP Right Cessation
- 1990-03-30 AU AU52470/90A patent/AU627561B2/en not_active Ceased
- 1990-03-30 HU HU902025A patent/HU209947B/hu not_active IP Right Cessation
- 1990-03-30 IE IE117190A patent/IE63954B1/en not_active IP Right Cessation
- 1990-03-30 US US07/502,038 patent/US5057624A/en not_active Expired - Lifetime
- 1990-03-30 NO NO901454A patent/NO170149C/no not_active IP Right Cessation
-
1994
- 1994-09-26 HR HRP-634/90A patent/HRP940599B1/xx not_active IP Right Cessation
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