ES2135722T3 - 1,5-benzodiacepinas 5-heterociclicas moduladoras de la cck o de la gastrina. - Google Patents

1,5-benzodiacepinas 5-heterociclicas moduladoras de la cck o de la gastrina.

Info

Publication number
ES2135722T3
ES2135722T3 ES95915540T ES95915540T ES2135722T3 ES 2135722 T3 ES2135722 T3 ES 2135722T3 ES 95915540 T ES95915540 T ES 95915540T ES 95915540 T ES95915540 T ES 95915540T ES 2135722 T3 ES2135722 T3 ES 2135722T3
Authority
ES
Spain
Prior art keywords
cck
moduladoras
heterociclicas
gastrina
benzodiacepines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95915540T
Other languages
English (en)
Inventor
Christopher Joseph Aquino
Elizabeth Ellen Sugg
Jerzy Ryszard Szewczyk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
Glaxo Wellcome Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9407433A external-priority patent/GB9407433D0/en
Priority claimed from GB9420783A external-priority patent/GB9420783D0/en
Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc
Application granted granted Critical
Publication of ES2135722T3 publication Critical patent/ES2135722T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPUESTOS DE FORMULA GENERAL (I) Y SALES FISIOLOGICAS DEL MISMO, PROCESOS PARA SU PREPARACION Y SU USO COMO MODULADORES DE LOS EFECTOS DE LA GASTRINA Y EL CCK
ES95915540T 1994-04-14 1995-04-12 1,5-benzodiacepinas 5-heterociclicas moduladoras de la cck o de la gastrina. Expired - Lifetime ES2135722T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9407433A GB9407433D0 (en) 1994-04-14 1994-04-14 Heterocyclic derivatives
GB9420783A GB9420783D0 (en) 1994-10-14 1994-10-14 Heterocyclic derivatives

Publications (1)

Publication Number Publication Date
ES2135722T3 true ES2135722T3 (es) 1999-11-01

Family

ID=26304703

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95915540T Expired - Lifetime ES2135722T3 (es) 1994-04-14 1995-04-12 1,5-benzodiacepinas 5-heterociclicas moduladoras de la cck o de la gastrina.

Country Status (25)

Country Link
EP (1) EP0756602B1 (es)
JP (1) JPH09511223A (es)
KR (1) KR970702274A (es)
CN (1) CN1176646A (es)
AT (1) ATE181737T1 (es)
AU (1) AU697349B2 (es)
BR (1) BR9507381A (es)
CA (1) CA2186900A1 (es)
CZ (1) CZ286764B6 (es)
DE (1) DE69510545T2 (es)
DK (1) DK0756602T3 (es)
ES (1) ES2135722T3 (es)
FI (1) FI964045A0 (es)
GR (1) GR3031335T3 (es)
HU (1) HUT76135A (es)
IL (1) IL113365A (es)
IS (1) IS4367A (es)
MX (1) MX9604765A (es)
NO (1) NO964348L (es)
NZ (1) NZ283929A (es)
PL (1) PL180026B1 (es)
RU (1) RU2152939C1 (es)
SK (1) SK281433B6 (es)
TW (1) TW369529B (es)
WO (1) WO1995028419A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9307833D0 (en) * 1993-04-15 1993-06-02 Glaxo Inc Modulators of cholecystokinin and gastrin
PE27497A1 (es) * 1994-04-15 1997-08-07 Glaxo Inc Derivados de 1,5 benzodiazepina
AU721081B2 (en) * 1996-12-10 2000-06-22 Zeria Pharmaceutical Co., Ltd. 1,5-benzodiazepine derivatives
US7910548B2 (en) * 1997-06-06 2011-03-22 Amylin Pharmaceuticals, Inc. Methods for treating obesity
WO2000023428A1 (fr) * 1998-10-20 2000-04-27 Takeda Chemical Industries, Ltd. Composes de 1,5-benzodiazepine, procede de production de ces composes, et medicament
JP4535350B2 (ja) * 1998-11-17 2010-09-01 クミアイ化学工業株式会社 ピリミジニルベンズイミダゾール誘導体及び農園芸用殺菌剤
ES2311120T3 (es) * 2002-08-27 2009-02-01 Merck Patent Gmbh Derivados de glicinamida como inhibidores de quinasa-raf.
AU2005247693A1 (en) 2004-05-25 2005-12-08 Pfizer Products Inc. Tetraazabenzo[E]azulene derivatives and analogs thereof
CN108863959B (zh) * 2012-01-13 2021-11-30 日本化学药品株式会社 P2x4受体拮抗剂
CR20180413A (es) 2016-02-05 2018-12-04 Denali Therapeutics Inc Inhibidores de la proteína quinasa 1 que interactua con el receptor
WO2018107060A1 (en) 2016-12-09 2018-06-14 Denali Therapeutics Inc. Compounds, compositions and methods
WO2021071837A1 (en) 2019-10-07 2021-04-15 Kallyope, Inc. Gpr119 agonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2641280B1 (fr) * 1988-12-29 1994-01-21 Roussel Uclaf Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
GEP20001968B (en) * 1992-01-21 2000-03-05 Glaxo Spa Arilthio Compounds as Antibacterial and Antiviral Agents
GB9307833D0 (en) * 1993-04-15 1993-06-02 Glaxo Inc Modulators of cholecystokinin and gastrin

Also Published As

Publication number Publication date
WO1995028419A1 (en) 1995-10-26
NO964348L (no) 1996-12-02
DE69510545D1 (de) 1999-08-05
JPH09511223A (ja) 1997-11-11
IL113365A (en) 1999-11-30
BR9507381A (pt) 1997-09-23
RU2152939C1 (ru) 2000-07-20
CZ297296A3 (en) 1997-09-17
NZ283929A (en) 1998-02-26
FI964045A (fi) 1996-10-09
SK130096A3 (en) 1997-08-06
EP0756602B1 (en) 1999-06-30
EP0756602A1 (en) 1997-02-05
CN1176646A (zh) 1998-03-18
NO964348D0 (no) 1996-10-11
FI964045A0 (fi) 1996-10-09
SK281433B6 (sk) 2001-03-12
IL113365A0 (en) 1995-07-31
CA2186900A1 (en) 1995-10-26
PL180026B1 (pl) 2000-12-29
KR970702274A (ko) 1997-05-13
IS4367A (is) 1996-09-30
PL316870A1 (en) 1997-02-17
CZ286764B6 (en) 2000-06-14
AU697349B2 (en) 1998-10-01
DE69510545T2 (de) 2000-01-13
DK0756602T3 (da) 2000-01-31
TW369529B (en) 1999-09-11
MX9604765A (es) 1998-05-31
GR3031335T3 (en) 1999-12-31
ATE181737T1 (de) 1999-07-15
HUT76135A (en) 1997-06-30
AU2239095A (en) 1995-11-10
HU9602835D0 (en) 1996-12-30

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