ES2057568T3 - Metodos para tratar la ansiedad con ligandos de receptores sigma. - Google Patents
Metodos para tratar la ansiedad con ligandos de receptores sigma.Info
- Publication number
- ES2057568T3 ES2057568T3 ES90908385T ES90908385T ES2057568T3 ES 2057568 T3 ES2057568 T3 ES 2057568T3 ES 90908385 T ES90908385 T ES 90908385T ES 90908385 T ES90908385 T ES 90908385T ES 2057568 T3 ES2057568 T3 ES 2057568T3
- Authority
- ES
- Spain
- Prior art keywords
- anxiety
- deal
- methods
- receiver links
- sigma receiver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A UN METODO PARA EL TRATAMIENTO O PROFILAXIS DE LA ANSIEDAD DE ANIMALES QUE CONSISTE EN ADMINISTRAR UNA CANTIDAD ANXIOLITICA DE UNA GUANIDINA N,N''-DISUSTITUIDA QUE TIENE UNA GRAN AFINIDAD CON EL RECEPTOR DE SIGMA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34649489A | 1989-05-02 | 1989-05-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2057568T3 true ES2057568T3 (es) | 1994-10-16 |
Family
ID=23359655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90908385T Expired - Lifetime ES2057568T3 (es) | 1989-05-02 | 1990-05-02 | Metodos para tratar la ansiedad con ligandos de receptores sigma. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0473671B1 (es) |
JP (1) | JPH05500798A (es) |
AT (1) | ATE110265T1 (es) |
AU (1) | AU642881B2 (es) |
CA (1) | CA2054211A1 (es) |
DE (1) | DE69011859T2 (es) |
DK (1) | DK0473671T3 (es) |
ES (1) | ES2057568T3 (es) |
WO (1) | WO1990014067A2 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5312840A (en) * | 1986-07-10 | 1994-05-17 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education | Substituted guanidines having high binding to the sigma receptor and the use thereof |
US5385946A (en) * | 1986-07-10 | 1995-01-31 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Method for treating hypertension with disubstituted granidine compounds |
US5262568A (en) * | 1990-03-02 | 1993-11-16 | State Of Oregon | Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists |
WO1991012797A1 (en) | 1990-03-02 | 1991-09-05 | STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALF SCIENCES UNIVERSITY | Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists |
US5574070A (en) * | 1990-05-25 | 1996-11-12 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Substituted guanidines having high binding to the sigma receptor and the use thereof |
US5847006A (en) * | 1991-02-08 | 1998-12-08 | Cambridge Neuroscience, Inc. | Therapeutic guanidines |
DE69230220T2 (de) * | 1991-02-08 | 2000-06-21 | Cambridge Neuroscience Res | Substituierte guanidine und derivate hiervon als modulatoren der freisetzung von neurotransmittern und neue methode zur identifizierung von inhibitoren der neurotransmitter-freisetzung |
US5741661A (en) * | 1991-02-08 | 1998-04-21 | Cambridge Neuroscience, Inc. | Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers |
NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
DK78692D0 (da) * | 1992-06-12 | 1992-06-12 | Lundbeck & Co As H | Dimere piperidin- og piperazinderivater |
KR20030097618A (ko) * | 1993-05-27 | 2003-12-31 | 캠브리지 뉴로사이언스, 인코포레이티드 | 치료용 치환 구아니딘류 |
CA2177084A1 (en) * | 1993-11-22 | 1995-06-01 | Sharad Magar | Therapeutic guanidines |
JPH09505591A (ja) * | 1993-11-23 | 1997-06-03 | ケンブリッジ・ニューロサイエンス・インコーポレーテッド | 治療用置換グアニジン類 |
US6143791A (en) * | 1994-02-03 | 2000-11-07 | Cambridge Neuroscience, Inc. | Therapeutic guanidines |
KR100423272B1 (ko) | 1994-02-03 | 2004-09-01 | 캠브리지 뉴로사이언스, 인코포레이티드 | 신경전달물질의방출을조절하는화합물,이의약학적으로허용가능한염및이를포함하는약학조성물 |
US7351743B1 (en) | 1994-02-03 | 2008-04-01 | Wyeth | Therapeutic guanidines |
US6787569B1 (en) | 1994-02-03 | 2004-09-07 | Cambridge Neuroscience, Inc. | Therapeutic guanidines |
AU1882395A (en) * | 1994-02-23 | 1995-09-11 | Cambridge Neuroscience, Inc. | Blockers of ion channels and methods of use thereof |
US6875759B1 (en) | 1999-07-21 | 2005-04-05 | Kadmus Pharmaceuticals | Substituted guanidines and the use thereof |
EP1749824A1 (en) | 2005-08-03 | 2007-02-07 | Neuro3D | Benzodiazepine derivatives, their preparation and the therapeutic use thereof |
EP1917244A2 (de) | 2005-08-24 | 2008-05-07 | Abbott GmbH & Co. KG | Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス,インコーポレイティド | Pde阻害による神経新生の調節 |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
JP6397407B2 (ja) * | 2012-07-19 | 2018-09-26 | ドレクセル ユニバーシティ | 細胞タンパク質ホメオスタシスを調節するためのシグマ受容体リガンド |
WO2019089902A1 (en) | 2017-11-01 | 2019-05-09 | Drexel University | Compounds, compositions, and methods for treating diseases |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4709094A (en) * | 1986-07-10 | 1987-11-24 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Sigma brain receptor ligands and their use |
-
1990
- 1990-05-02 ES ES90908385T patent/ES2057568T3/es not_active Expired - Lifetime
- 1990-05-02 AU AU57287/90A patent/AU642881B2/en not_active Ceased
- 1990-05-02 AT AT90908385T patent/ATE110265T1/de not_active IP Right Cessation
- 1990-05-02 EP EP90908385A patent/EP0473671B1/en not_active Expired - Lifetime
- 1990-05-02 JP JP2508151A patent/JPH05500798A/ja active Pending
- 1990-05-02 DE DE69011859T patent/DE69011859T2/de not_active Expired - Fee Related
- 1990-05-02 WO PCT/US1990/002398 patent/WO1990014067A2/en active IP Right Grant
- 1990-05-02 CA CA002054211A patent/CA2054211A1/en not_active Abandoned
- 1990-05-02 DK DK90908385.9T patent/DK0473671T3/da active
Also Published As
Publication number | Publication date |
---|---|
JPH05500798A (ja) | 1993-02-18 |
AU5728790A (en) | 1990-12-18 |
EP0473671A4 (en) | 1992-04-01 |
EP0473671A1 (en) | 1992-03-11 |
DE69011859T2 (de) | 1994-12-15 |
DE69011859D1 (de) | 1994-09-29 |
AU642881B2 (en) | 1993-11-04 |
DK0473671T3 (da) | 1994-09-19 |
WO1990014067A2 (en) | 1990-11-29 |
CA2054211A1 (en) | 1990-11-03 |
WO1990014067A3 (en) | 1991-04-04 |
EP0473671B1 (en) | 1994-08-24 |
ATE110265T1 (de) | 1994-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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