ES2049710T1 - Procedimiento de preparacion de homo-beta-aminoacidos opticamente activos. - Google Patents
Procedimiento de preparacion de homo-beta-aminoacidos opticamente activos.Info
- Publication number
- ES2049710T1 ES2049710T1 ES93870046T ES93870046T ES2049710T1 ES 2049710 T1 ES2049710 T1 ES 2049710T1 ES 93870046 T ES93870046 T ES 93870046T ES 93870046 T ES93870046 T ES 93870046T ES 2049710 T1 ES2049710 T1 ES 2049710T1
- Authority
- ES
- Spain
- Prior art keywords
- beta
- homo
- amino acids
- optic
- preparation procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/02—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from isocyanates with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/54—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA INVENCION SE REFIERE A LA SINTESIS DE HOMO-(BETA)-AMINOACIDOS DE UNA PUREZA OPTICA SUFICIENTE PARA EXHIBIR ACTIVIDAD OPTICA. EN DICHA SINTESIS SE AFECTA LA REORDENACION "CURTIUS" DE UN SEMIESTER ACIDO DE SUCCIANATO 3-MONO-SUSTITUIDO DE UNA PUREZA OPTICA SUFICIENTE PARA EXHIBIR ACTIVIDAD OPTICA Y EL ISOCIANATO INCIPIENTE QUE SE ATRAPA CON UN ALCOHOL PRIMARIO O SECUNDARIO. LOS HOMO-(BETA)-AMINOESTERES PROTEGIDOS CON CARBAMATO RESULTANTES SE SAPONIFICAN PARA PRODUCIR LOS CORRESPONDIENTES HOMO-(BETA)-AMINOACIDOS PROTEGIDOS CON CARBAMATO QUE SE DESPROTEGEN PARA DAR COMO RESULTADO HOMO-(BETA)-AMINOACIDOS DE UNA PUREZA SUFICIENTE PARA EXHIBIR ACTIVIDAD OPTICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85356192A | 1992-03-18 | 1992-03-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2049710T1 true ES2049710T1 (es) | 1994-05-01 |
Family
ID=25316357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93870046T Pending ES2049710T1 (es) | 1992-03-18 | 1993-03-15 | Procedimiento de preparacion de homo-beta-aminoacidos opticamente activos. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0561758A3 (es) |
JP (1) | JPH069515A (es) |
CA (1) | CA2091788A1 (es) |
ES (1) | ES2049710T1 (es) |
MX (1) | MX9301505A (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4524015B2 (ja) * | 1999-11-17 | 2010-08-11 | キッセイ薬品工業株式会社 | (2s)−2−ベンジルコハク酸モノエステルの有機アミン塩およびその製造方法 |
GB0025310D0 (en) * | 2000-10-16 | 2000-11-29 | Pfizer Ltd | Process |
US6452041B1 (en) | 2000-10-16 | 2002-09-17 | Pfizer Inc. | Olefination process to itaconate and succinate derivatives |
NI200300043A (es) | 2002-03-28 | 2003-11-05 | Warner Lambert Co | AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA. |
JP2007506729A (ja) | 2003-09-25 | 2007-03-22 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | α2δタンパク質に親和性を有するアミノ酸のプロドラッグ |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02306947A (ja) * | 1989-05-01 | 1990-12-20 | Monsanto Co | キラルβ―アミノ酸の製造方法 |
-
1993
- 1993-03-15 ES ES93870046T patent/ES2049710T1/es active Pending
- 1993-03-15 EP EP93870046A patent/EP0561758A3/en not_active Withdrawn
- 1993-03-17 CA CA002091788A patent/CA2091788A1/en not_active Abandoned
- 1993-03-17 JP JP5743793A patent/JPH069515A/ja active Pending
- 1993-03-17 MX MX9301505A patent/MX9301505A/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP0561758A3 (en) | 1995-04-05 |
JPH069515A (ja) | 1994-01-18 |
CA2091788A1 (en) | 1993-09-19 |
MX9301505A (es) | 1993-12-01 |
EP0561758A2 (en) | 1993-09-22 |
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