MX9301505A - Metodo para preparar homo-beta-aminoacidos opticamente activos. - Google Patents
Metodo para preparar homo-beta-aminoacidos opticamente activos.Info
- Publication number
- MX9301505A MX9301505A MX9301505A MX9301505A MX9301505A MX 9301505 A MX9301505 A MX 9301505A MX 9301505 A MX9301505 A MX 9301505A MX 9301505 A MX9301505 A MX 9301505A MX 9301505 A MX9301505 A MX 9301505A
- Authority
- MX
- Mexico
- Prior art keywords
- beta
- amino acids
- homo
- optically active
- preparing optically
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/02—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from isocyanates with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/54—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención está dirigida a la síntesis de homo-beta-aminoácidos de una pureza óptica suficiente para exhibir actividad óptica cuando se efectúa el rearreglo de Curtius de hemiéster ácido de succinato 3-mono-substituido de una pureza óptica suficiente para exhibir actividad óptica y se atrapa el isocianato incipiente con un alcohol primario o secundario. Los homo-beta-aminoésteres protegidos por carbamato resultantes se saponifican después para producir los correspondientes homo-beta-aminoácidos protegidos por carbamato que se desprotegen para producir homo-beta-aminoácidos de una pureza óptica suficiente para exhibir actividad óptica.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85356192A | 1992-03-18 | 1992-03-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9301505A true MX9301505A (es) | 1993-12-01 |
Family
ID=25316357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9301505A MX9301505A (es) | 1992-03-18 | 1993-03-17 | Metodo para preparar homo-beta-aminoacidos opticamente activos. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0561758A3 (es) |
JP (1) | JPH069515A (es) |
CA (1) | CA2091788A1 (es) |
ES (1) | ES2049710T1 (es) |
MX (1) | MX9301505A (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4524015B2 (ja) * | 1999-11-17 | 2010-08-11 | キッセイ薬品工業株式会社 | (2s)−2−ベンジルコハク酸モノエステルの有機アミン塩およびその製造方法 |
US6452041B1 (en) | 2000-10-16 | 2002-09-17 | Pfizer Inc. | Olefination process to itaconate and succinate derivatives |
GB0025310D0 (en) * | 2000-10-16 | 2000-11-29 | Pfizer Ltd | Process |
NI200300043A (es) | 2002-03-28 | 2003-11-05 | Warner Lambert Co | AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA. |
BRPI0414819A (pt) | 2003-09-25 | 2006-11-14 | Warner Lambert Co | pró-fármacos de aminoácidos com afinidade para a proteìna alfa2delta |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02306947A (ja) * | 1989-05-01 | 1990-12-20 | Monsanto Co | キラルβ―アミノ酸の製造方法 |
-
1993
- 1993-03-15 EP EP93870046A patent/EP0561758A3/en not_active Withdrawn
- 1993-03-15 ES ES93870046T patent/ES2049710T1/es active Pending
- 1993-03-17 MX MX9301505A patent/MX9301505A/es unknown
- 1993-03-17 CA CA002091788A patent/CA2091788A1/en not_active Abandoned
- 1993-03-17 JP JP5743793A patent/JPH069515A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ES2049710T1 (es) | 1994-05-01 |
CA2091788A1 (en) | 1993-09-19 |
EP0561758A2 (en) | 1993-09-22 |
JPH069515A (ja) | 1994-01-18 |
EP0561758A3 (en) | 1995-04-05 |
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