ES2034893A1 - Procedimiento para la obtencion de nuevos pregna-1,4-diene-3,20-dione-16-17-acetal-21 esteres. - Google Patents
Procedimiento para la obtencion de nuevos pregna-1,4-diene-3,20-dione-16-17-acetal-21 esteres.Info
- Publication number
- ES2034893A1 ES2034893A1 ES919101991A ES9101991A ES2034893A1 ES 2034893 A1 ES2034893 A1 ES 2034893A1 ES 919101991 A ES919101991 A ES 919101991A ES 9101991 A ES9101991 A ES 9101991A ES 2034893 A1 ES2034893 A1 ES 2034893A1
- Authority
- ES
- Spain
- Prior art keywords
- image
- preparation
- diene3
- pregna
- dione
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE NUEVOS PREGNA-1,4-DIENE-3,20-DIONE-16-17-ACETAL-21 ESTERES. ESTOS COMPUESTOS DE LA FORMULA FORMULA ESTAN EN LA FORMA DE UN EPIMERO R, UN EPIMERO S O UNA MEZCLA ESTEREO-ISOMERA DE LOS EPIMEROS R Y S, EN TERMINOS DE LA ORIENTACION DE LOS SUSTITUYENTES SOBRE EL ATOMO DE CARBONO EN LA POSICION 22, CONSISTIENDO EL PROCEDIMIENTO PARA SU OBTENCION EN HIDROLISIS-CETALIZACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57894290A | 1990-09-07 | 1990-09-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2034893A1 true ES2034893A1 (es) | 1993-04-01 |
ES2034893B1 ES2034893B1 (es) | 1994-01-01 |
Family
ID=24314964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9101991A Expired - Fee Related ES2034893B1 (es) | 1990-09-07 | 1991-09-05 | Procedimiento para la obtencion de nuevos pregna-1,4-diene-3,20-dione-16-17-acetal-21 esteres. |
Country Status (19)
Country | Link |
---|---|
US (1) | US5482934A (es) |
JP (1) | JP3292928B2 (es) |
KR (1) | KR100193085B1 (es) |
AT (1) | AT402930B (es) |
AU (1) | AU649472B2 (es) |
BE (1) | BE1005876A5 (es) |
BR (1) | BR1100860A (es) |
CA (1) | CA2050812C (es) |
CH (1) | CH683343A5 (es) |
DE (2) | DE122005000030I2 (es) |
ES (1) | ES2034893B1 (es) |
FR (1) | FR2666585B1 (es) |
GB (1) | GB2247680B (es) |
GR (1) | GR1001529B (es) |
HK (1) | HK1005881A1 (es) |
IT (1) | IT1251376B (es) |
LU (2) | LU88001A1 (es) |
NL (2) | NL194917C (es) |
PT (1) | PT98897B (es) |
Families Citing this family (99)
Publication number | Priority date | Publication date | Assignee | Title |
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MY105368A (en) * | 1990-03-02 | 1994-09-30 | Glaxo Group Ltd | Inhalation device. |
SK280968B6 (sk) | 1990-03-02 | 2000-10-09 | Glaxo Group Limited | Balenie medikamentu na použite v inhalačnom prístroji |
US6536427B2 (en) | 1990-03-02 | 2003-03-25 | Glaxo Group Limited | Inhalation device |
AU683463B2 (en) * | 1993-04-02 | 1997-11-13 | Astrazeneca Ab | New prednisolone derivates |
PT749438E (pt) * | 1994-03-09 | 2001-05-31 | Byk Gulden Lomberg Chem Fab | Novos compostos sililo e sua utilizacao |
DE19635498A1 (de) * | 1996-09-03 | 1998-03-26 | Byk Gulden Lomberg Chem Fab | Verfahren zur Epimerenanreicherung |
SE9604751D0 (sv) * | 1996-12-20 | 1996-12-20 | Astra Ab | New therapy |
US6120752A (en) * | 1997-05-21 | 2000-09-19 | 3M Innovative Properties Company | Medicinal aerosol products containing formulations of ciclesonide and related steroids |
US6264923B1 (en) | 1998-05-13 | 2001-07-24 | 3M Innovative Properties Company | Medicinal aerosol formulation of ciclesonide and related compounds |
US6217895B1 (en) * | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
US20040121014A1 (en) * | 1999-03-22 | 2004-06-24 | Control Delivery Systems, Inc. | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
US6375972B1 (en) | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
AR028948A1 (es) | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
CA2430196C (en) | 2000-11-10 | 2010-01-26 | Altana Pharma Ag | Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-dihydroxy-pregna-1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation |
DE10055820C1 (de) * | 2000-11-10 | 2002-07-25 | Byk Gulden Lomberg Chem Fab | Verfahren zur Herstellung eines Glucocorticoids |
ITMI20020148A1 (it) * | 2002-01-29 | 2003-07-29 | Nicox Sa | Nuovi corticosteroidi |
EP2316468A1 (en) | 2002-02-22 | 2011-05-04 | Shire LLC | Delivery system and methods for protecting and administering dextroamphetamine |
US8871241B2 (en) * | 2002-05-07 | 2014-10-28 | Psivida Us, Inc. | Injectable sustained release delivery devices |
WO2004019955A1 (en) | 2002-08-30 | 2004-03-11 | Altana Pharma Ag | The use of the combination of ciclesonide and antihistamines for the treatment of allergic rhinitis |
US20040235811A1 (en) * | 2002-10-08 | 2004-11-25 | Sepracor Inc. | Fatty acid modified forms of glucocorticoids |
DE60323138D1 (de) | 2002-12-12 | 2008-10-02 | Nycomed Gmbh | Kombinationsarzneimittel aus r,r-formoterol und ciclesonide |
MY143936A (en) | 2003-03-27 | 2011-07-29 | Nycomed Gmbh | Process for preparing crystalline ciclesonide with defined particle size |
CN100404545C (zh) * | 2003-03-27 | 2008-07-23 | 尼科梅德有限责任公司 | 具有规定粒径的结晶环缩松的制备方法 |
GB0312148D0 (en) | 2003-05-28 | 2003-07-02 | Aventis Pharma Ltd | Stabilized pharmaceutical products |
AU2004246819A1 (en) | 2003-06-13 | 2004-12-23 | Nycomed Gmbh | Formoterol and ciclesonide combination |
GB0315889D0 (en) * | 2003-07-08 | 2003-08-13 | Aventis Pharma Ltd | Stable pharmaceutical products |
EP1663999A2 (en) * | 2003-08-29 | 2006-06-07 | Ranbaxy Laboratories, Ltd. | Inhibitors of phosphodiesterase type-iv |
ES2350396T3 (es) * | 2003-09-15 | 2011-01-21 | Nycomed Gmbh | Uso de ciclesonida para el tratamiento de enfermedades intestinales inflamatorias. |
EP1670482B2 (en) * | 2003-09-16 | 2022-06-29 | Covis Pharma B.V. | Use of ciclesonide for the treatment of respiratory diseases |
WO2005051931A2 (en) * | 2003-11-26 | 2005-06-09 | Ranbaxy Laboratories Limited | Phosphodiesterase inhibitors |
PE20050941A1 (es) * | 2003-12-16 | 2005-11-08 | Nycomed Gmbh | Suspensiones acuosas de ciclesonida para nebulizacion |
US20070134165A1 (en) * | 2004-04-20 | 2007-06-14 | Altana Pharma Ag | Use of Ciclesonide for the Treatment of Respiratory Disease in a Smoking Patient |
CN100338089C (zh) * | 2004-08-12 | 2007-09-19 | 重庆医药工业研究院有限责任公司 | 一种哮喘病治疗药物环索奈德的新的制备方法 |
EP1796679A1 (en) * | 2004-09-10 | 2007-06-20 | Altana Pharma AG | Ciclesonide and syk inhibitor combination and methods of use thereof |
CN100345864C (zh) * | 2004-10-29 | 2007-10-31 | 天津药业研究院有限公司 | 一种治疗呼吸道疾病的甾体药物的制备方法及其中间体 |
ES2265276B1 (es) | 2005-05-20 | 2008-02-01 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
US20100209508A1 (en) * | 2005-06-14 | 2010-08-19 | Corus Pharma, Inc. | Substituted Phenylphosphates as Mutual Prodrugs of Steroids and ß-Agonists for the Treatment of Title Pulmonary Inflammation and Bronchoconstriction |
CN1325508C (zh) * | 2005-06-21 | 2007-07-11 | 浙江仙琚制药股份有限公司 | 一锅法制备***龙衍生物 |
TW200738634A (en) | 2005-08-02 | 2007-10-16 | Astrazeneca Ab | New salt |
AU2006286838C1 (en) * | 2005-09-02 | 2013-05-02 | Ferrer Internacional S.A. | Nitrooxy derivatives of glucocorticoids |
US7915286B2 (en) | 2005-09-16 | 2011-03-29 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
AU2006305620A1 (en) * | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Compositions of phosphodiesterase type IV inhibitors |
CA2626612A1 (en) | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of muscarinic receptor antagonists |
CA2622640A1 (en) * | 2005-11-02 | 2007-05-18 | Sicor Inc. | Improved process for the preparation of ciclesonide |
JP2009526068A (ja) * | 2006-02-08 | 2009-07-16 | シコール インコーポレイティド | シクレソニド結晶形 |
US20070232578A1 (en) * | 2006-02-15 | 2007-10-04 | Pierluigi Rossetto | Crystalline forms of ciclesonide |
ES2296516B1 (es) * | 2006-04-27 | 2009-04-01 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
WO2008015696A2 (en) * | 2006-05-23 | 2008-02-07 | Cadila Healthcare Limited | Process for preparing ciclesonide |
EP2069355A4 (en) | 2006-07-19 | 2010-03-24 | Astrazeneca Ab | NOVEL TRICYCLIC SPIROPIPERIDINE COMPOUNDS, THEIR SYNTHESIS AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY |
JO2868B1 (en) | 2006-08-22 | 2015-03-15 | رانبكسي لابوراتوريز ليمتد | Inhibitors of metabolic protein protein enzyme |
WO2008062450A2 (en) * | 2006-09-18 | 2008-05-29 | Cadila Healthcare Limited | Crystalline polymorphs of ciclesonide |
WO2008035066A2 (en) * | 2006-09-19 | 2008-03-27 | Cipla Limited | Processes for the preparation of ciclesonide and its crystal form |
CN101616901A (zh) * | 2006-09-22 | 2009-12-30 | 兰贝克赛实验室有限公司 | Iv型磷酸二酯酶的抑制剂 |
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ES2302447B1 (es) * | 2006-10-20 | 2009-06-12 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
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BRPI0721039A2 (pt) | 2006-12-19 | 2014-07-29 | Astrazeneca Ab | " derivados de quinuclidinol como antagonistas de receptores muscarínicos ". |
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US20080207659A1 (en) * | 2007-02-15 | 2008-08-28 | Asit Kumar Chakraborti | Inhibitors of phosphodiesterase type 4 |
CN103497185A (zh) | 2007-03-14 | 2014-01-08 | 兰贝克赛实验室有限公司 | 用作磷酸二酯酶抑制剂的吡唑并(3,4-b)吡啶衍生物 |
US20110130403A1 (en) * | 2007-03-14 | 2011-06-02 | Ranbaxy Laboratories Limited | Pyrazolo [3, 4-b] pyridine derivatives as phosphodiesterase inhibitors |
EP2022796A1 (en) * | 2007-08-07 | 2009-02-11 | Nycomed GmbH | Amorphous ciclesonide |
US20090075959A1 (en) * | 2007-09-19 | 2009-03-19 | Protia, Llc | Deuterium-enriched ciclesonide |
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WO2010067102A1 (en) | 2008-12-09 | 2010-06-17 | Astrazeneca Ab | Diazaspiro [5.5] undecane derivatives and related compounds as muscarinic-receptor antagonists and beta-adrenoreceptor agonists for the treatment of pulmonary disorders |
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WO2011093814A2 (en) | 2010-01-29 | 2011-08-04 | Mahmut Bilgic | A pharmaceutical combination comprising formoterol and ciclesonide |
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CN102477064B (zh) * | 2010-11-23 | 2014-06-11 | 天津金耀集团有限公司 | 一种制备环索奈德的16,17缩酮中间体 |
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CH608244A5 (en) * | 1974-02-27 | 1978-12-29 | Pierrel Spa | Process for the preparation of steroids |
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NL7412537A (nl) * | 1974-05-17 | 1975-11-19 | Lark Spa | Werkwijze voor het bereiden van 16.17-cyclische acetalen en ketalen van 9-(alpha)-halogeensteroiden. |
US4036831A (en) * | 1975-10-28 | 1977-07-19 | Steroid Development Company Establishment | Trimethyl siloxane steroid intermediates |
DE3012888A1 (de) * | 1980-03-31 | 1981-10-08 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | Neue steroide und verfahren zu ihrer herstellung |
SE8008524L (sv) * | 1980-12-04 | 1982-06-05 | Draco Ab | 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand |
SE8604059D0 (sv) * | 1986-09-25 | 1986-09-25 | Astra Pharma Prod | A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives |
DE3640709A1 (de) * | 1986-11-28 | 1988-06-09 | Schering Ag | Verfahren zur herstellung von 6(alpha),9(alpha)-difluor-11ss,17(alpha)-dihydroxy-16(alpha)-methyl-4-pregnen-3,20-dion und dessen derivate |
-
1991
- 1991-08-13 GR GR910100353A patent/GR1001529B/el not_active IP Right Cessation
- 1991-08-28 IT ITMI912296A patent/IT1251376B/it active IP Right Grant
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- 1991-09-02 BE BE9100816A patent/BE1005876A5/nl not_active IP Right Cessation
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- 1991-09-04 LU LU88001A patent/LU88001A1/fr active Protection Beyond IP Right Term
- 1991-09-05 ES ES9101991A patent/ES2034893B1/es not_active Expired - Fee Related
- 1991-09-05 DE DE200512000030 patent/DE122005000030I2/de active Active
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- 1991-09-06 CA CA002050812A patent/CA2050812C/en not_active Expired - Lifetime
- 1991-09-06 PT PT98897A patent/PT98897B/pt not_active IP Right Cessation
- 1991-09-06 AT AT0176991A patent/AT402930B/de not_active IP Right Cessation
- 1991-09-06 JP JP22741891A patent/JP3292928B2/ja not_active Expired - Lifetime
- 1991-09-06 CH CH2619/91A patent/CH683343A5/de not_active IP Right Cessation
- 1991-09-07 KR KR1019910015617A patent/KR100193085B1/ko not_active IP Right Cessation
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1994
- 1994-07-20 US US08/278,112 patent/US5482934A/en not_active Expired - Lifetime
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1997
- 1997-05-14 BR BR1100860-1A patent/BR1100860A/pt active IP Right Grant
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1998
- 1998-06-08 HK HK98105034A patent/HK1005881A1/xx not_active IP Right Cessation
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2005
- 2005-06-02 NL NL300196C patent/NL300196I2/nl unknown
- 2005-11-09 LU LU91205C patent/LU91205I2/fr unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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EP0164636A2 (en) * | 1984-06-11 | 1985-12-18 | SICOR Società Italiana Corticosteroidi S.p.A. | A process for the preparation of 16,17 acetals of pregnane derivatives and compounds obtained therefrom |
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Title |
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ACTA PHARM. SUEC. Vol.19, 1982, A.ThalÚn:"Epimers of budesonide and related corticosteroids". pag. 327-354. *Todo el documento* * |
ACTA PHARM. SUEC. Vol.21, 1984, A. ThalÚn et al."Synthesis and pharmacological properties of some 16 alpha-hydroxyprednisolone and fluorinated 16 alpha-hydroxyprednisolones". pßg. 109-124. *Todo el documento* * |
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