EP2531164B1 - Vorrichtung zum entnehmen eines fluids aus einem behälter - Google Patents

Vorrichtung zum entnehmen eines fluids aus einem behälter Download PDF

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Publication number
EP2531164B1
EP2531164B1 EP10747394.4A EP10747394A EP2531164B1 EP 2531164 B1 EP2531164 B1 EP 2531164B1 EP 10747394 A EP10747394 A EP 10747394A EP 2531164 B1 EP2531164 B1 EP 2531164B1
Authority
EP
European Patent Office
Prior art keywords
container
accordance
catch structure
applicator
jacket wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP10747394.4A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2531164A1 (de
Inventor
William Brem
Ralph Egon Kayser
Andy Greter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medmix Systems AG
Original Assignee
Medmix Systems AG
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Filing date
Publication date
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Publication of EP2531164A1 publication Critical patent/EP2531164A1/de
Application granted granted Critical
Publication of EP2531164B1 publication Critical patent/EP2531164B1/de
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2058—Connecting means having multiple connecting ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents

Definitions

  • the present invention relates to an apparatus for withdrawing a fluid from at least one container closed by a pierceable closure, e.g. a vial with septum closure.
  • a pierceable closure e.g. a vial with septum closure.
  • the present invention relates to a device for filling an applicator with at least one fluid reservoir of one or more vials.
  • Applicators such as syringes, are often used, in particular in medicine, but also in other technical fields, to discharge and apply fluent substances in a controlled and metered manner.
  • the substances may be, for example, medicaments or adhesives for medical or technical applications.
  • a conventional syringe has at least one reservoir, in which a flowable substance is received. This substance can be discharged through a distal outlet by means of a piston which is inserted into an open, proximal end of the reservoir.
  • these syringes may include an injection needle that is in fluid communication with the distal outlet.
  • a so-called vial in particular in a glass vial with septum closure, i. in a sterilizable glass vial, which is closed at one end by a pierceable, self-sealing membrane (a so-called septum), to absorb the substance stored therein only shortly before application from the vial into the reservoir.
  • septum a so-called septum
  • the septum can be pierced directly with the injection needle of the syringe and the substance stored in the vial can be drawn up into the syringe.
  • hypodermic needle poses a potential hazard to the user in terms of injury and, in addition, sterility of the hypodermic needle must be ensured during administration, any manipulation with the hypodermic needle prior to actual administration should be avoided.
  • many pharmaceutical products are known, which are stored and sold in lyophilized form, for example as a powder and must be dissolved in water before use.
  • the lyophilisates are usually stored in a closed container with a septum, which must therefore be injected before use water. This injection can for example be done by machine or performed by hand, for example, again by means of a syringe. Any devices of the prior art are conceivable for this purpose.
  • US 6,358,236 discloses such a device having a piercing member for piercing the septum of a vial upon placement of the device on the vial.
  • the device also has a connection to which a syringe can be connected.
  • the substance stored in the vial can be drawn into the syringe through a channel extending through the connection and the piercing member.
  • the simultaneous placement of the device on the vial and piercing of the septum can lead to mishandling and in particular to it connected accidental spills of liquid contained in the vial.
  • the vial For most devices used to withdraw a substance from a vial closed with a septum, the vial is simply inserted into the device to puncture the septum. In some of these devices, the vial is then fixed to the device by a snap-in connection after it has been fully inserted into the device and after piercing the septum.
  • known devices are generally not suitable for storing the vial directly on the device since it can not be ruled out that the septum of a vial will be accidentally punctured during transport or handling.
  • US 2002/0079285 describes a device which is already placed on a vial before piercing the septum.
  • a displaceably arranged piercing member is displaced toward the septum in such a way that it punctures it and establishes a fluid connection between the vial and the reservoir of the syringe.
  • US 6,258,078 The device shown is designed so that the septum can not be pierced until the device is correctly placed on the vial. By turning a screw cap connected to the piercing member, the piercing member is displaced toward the vial, piercing the septum.
  • these devices have a relatively complicated, multi-part construction and are correspondingly expensive to manufacture.
  • WO 88/01881 A1 discloses a device according to the preamble of claim 1. Further devices for fluid removal from vials are in DE 10 2006 031 712 B3 . EP 0 335 378 A2 . US 2004/0249235 A1 and DE 35 03 460 A1 specified.
  • the present invention provides an adapter-like device for withdrawing a fluid from at least one container closed by a pierceable closure, which makes it possible to store the container on the device without unintentionally opening the container.
  • the container receptacle has a first latching structure to move the container to a storage position where the container is farther from the base body than in the removal position (And in the thereby the closure is not pierced) to fix by a releasable locking connection to the container receptacle.
  • the container is also fixed in the removal position, and the container receptacle then also has a second latching structure for this purpose in order to fix the container in the removal position by a latching connection to the container receptacle.
  • the latching structures can interact directly or indirectly with the container.
  • the container can be inserted directly into the container receptacle, wherein the latching structures directly to a corresponding retention structure, such as a taper, attack the container, or the container may be held on a separate holder which is inserted into the container receptacle or pushed onto this, wherein the latching structures of the container receptacle cooperate with a corresponding retention structure of the holder.
  • the container receptacle has only a single latching structure, while the container or the holder has two retention structures, wherein in the storage position, the first of these retention structures with the (single) latching structure cooperates, while in the removal position, the second of these retention structures the latching structure cooperates.
  • the container receptacle has a preferably at least partially cylindrical jacket wall.
  • the first latching structure and the second latching structure each comprise a spring arm formed in the casing wall, at the free end of which a latching nose extending into the interior of the casing wall is formed. This allows a very simple and inexpensive production.
  • the latching structures are preferably arranged offset with respect to the circumferential direction of the jacket wall, in particular ⁇ m offset approximately 180 °, i. diametrically opposite one another in order to take up as little space as possible with the greatest possible stability of the container receptacle.
  • first latching structure and the second latching structure can also be arranged directly next to each other with respect to the circumferential direction of the casing wall.
  • the two latching structures are then separated from one another in the circumferential direction of the jacket wall only by an air gap.
  • the locking lugs each have an inclined surface, the surface normal on the one hand, in the opposite direction to the insertion direction of the container in the container receptacle and on the other hand is inclined to a defined by the casing wall longitudinal axis.
  • the container receptacle can in particular be constructed as follows: It has a bottom, from which a pin extends into the inlet opening of the base body. Through the pin and bottom through a passage opening is formed, and the piercing member is held in the passage opening.
  • the device can be used in particular as a filling device or adapter for filling at least one reservoir of an applicator from at least one container, in particular a vial, are used.
  • the applicator can be a syringe-like applicator in which the reservoir is delimited by a movable piston, so that the reservoir can be filled by retracting the piston from a distal end position into a proximal direction.
  • the device preferably has an applicator connection in order to connect the reservoir of the applicator to the outlet opening.
  • the applicator connection can be equipped with a holding device, in particular with a detachable latching connection, for the applicator. It can be made in one piece with the base body or separately from it.
  • the applicator connection is preferably formed, for example, by a female luer cone. However, it may also have a special configuration in which the loss volume is lower than in a normal standardized luer connection.
  • the device can be configured for the simultaneous removal of fluids from at least two containers.
  • the above features are present at least twice.
  • the device then has two or more piercing members and just as many container receptacles to hold two or more containers on the device, each of these container receptacles each having a first latching structure, and also a second latching structure.
  • the latching structures can be designed so that they fix the two or more containers simultaneously in the storage position or in the removal position.
  • the base body, the container receptacle and the applicator connection are preferably made of a thermoplastic material by injection molding.
  • FIG. 2 illustrates a filling device 200 not according to the invention, the container receptacle of which is designed according to a conventional manner to remove fluid substances from two containers closed by a pierceable closure.
  • the filling device 200 has a base body 210 of elongate, substantially disk-shaped basic shape. On the base body 210, a central, cylindrical thickening 211 is formed, to which the two halves of a flat support plate 212 connect.
  • the thickening 211 defines with its cylinder axis a longitudinal direction.
  • each of the two ends of the cylindrical thickening 211 forth a blind hole-like longitudinal bore is formed, which ends in each case shortly before the center of the thickening ( FIGS. 3 and 4 ).
  • Each of these holes widens slightly conically towards its open end to form a fluid channel.
  • the two holes are collinear with each other, ie they lie on the same axis one behind the other.
  • an inlet opening 213 is formed in the region of the thickening for each of the holes ( Fig. 4 ).
  • This inlet opening 213 connects the respective bore, each with a cup-like container receptacle 220.
  • the container receptacle 220 has a circumferential cylindrical jacket wall which is formed multiple slotted from its upper edge, so that each of the interrupted by a slot portions of the jacket wall forms a spring arm. Retaining lugs protrude inwardly at the free ends of these resilient arm portions to latch a container 300 in a picking position on the container receptacle.
  • the containers 300 are present here in the form of so-called vials with septum closure.
  • Each container comprises a Be Strukturerköper 310, which is preferably made of glass, but may also consist of special plastic.
  • a circumferential cylindrical jacket wall 312 which has a taper 313 near the bottom distal end.
  • the mantle wall widens slightly again and delimits a container opening.
  • the associated closure 320 comprises a septum 321 (a pierceable, self-sealing membrane, see Fig. 4 ) held by a crimped metal cover leaving a central part of the septum on the container opening.
  • a piercing member 230 of relatively hard plastic is inserted into the inlet opening 213, terminating in a tip 231 at its upper end. Laterally at the tip 231, a removal opening 232 is formed, which is connected to a central withdrawal channel 233, which in turn opens into the inlet opening 213 of the base body 210.
  • an outlet opening 214 is formed which leads to an applicator connection 240.
  • the applicator port 240 is formed integrally with the base body 210, but may be separately formed in front of the base body 210 and connected to the base body 210 in a suitable manner, e.g. glued or welded, be.
  • a double-syringe-like applicator 100 can be attached and detachably fastened.
  • the applicator has an applicator body 110 with two cylindrical, parallel, proximally open reservoirs 111, 112 of equal or (here) different volume.
  • the reservoirs open at their distal ends into outlets 116, 117.
  • a piston 121, 122 is inserted in the open proximal ends of the reservoirs in each case a piston 121, 122 is inserted.
  • the two pistons are connected together at their proximal ends to form a piston unit.
  • an actuating surface 123 is formed for a user's thumb.
  • a retaining flange 113 serves to hold the applicator by means of index and middle fingers.
  • the applicator can be handled in this respect as a commercial double syringe.
  • the present connection between the applicator 100 and the filling device 200 functionally corresponds substantially to the in WO 2007/109915 described connection between a syringe / cartridge and an accessory.
  • the applicator 100 and the filling device 200 comprise retention means configured according to this document.
  • the applicator connection is designed as follows: Each of the outlet openings 214 of the two fluid channels opens into a conically widening insertion region for the outlets 116, 117 of the applicator 100. These outlets are correspondingly complementary to the insertion regions and can be inserted into this insertion region.
  • the applicator connection 240 has a cylindrical receiving region 241, which radially surrounds the insertion regions and the webs with the latching noses and on which two opposite snap-in openings are formed.
  • the latching noses 115 snap when inserting the applicator in the Snap-in openings of the receiving area 241 a.
  • the receiving region 241 is designed elastically deformable such that the latching connection between the latching noses 115 and the corresponding snap-in openings by pressure on a relative to the cylinder axis of the receiving area by about 90 degrees from the Einschnappötechnisch offset wall portion of the receiving area 241 is releasable again.
  • the receiving area 241 is deformed such that the snap-in openings are pressed radially outward away from the latching noses 115 and thereby get out of engagement with the latching noses.
  • two opposite pressure wings 243 are formed on the support plate 212.
  • a lateral compression of the two pressure vanes 243 is transferred offset to the Einschnappö réelleen on the cylindrical receiving portion 241 of the applicator 240 and thereby leads to release the locking connection between the applicator 100 and the filling device 200th
  • a Codiereriel 114 on the applicator 100 and a corresponding Codiereriel 242 on the filling device 200 indicate the correct orientation of the applicator 100 when connecting to the filling device 200 at.
  • the terminals themselves are formed differently to ensure that the applicator 100 can be connected to the filling device 200 only in the correct orientation.
  • each of the two longitudinally extending bores of the base body 210 is inserted in each case a pin-shaped or needle-shaped insert element 250, which in the Fig. 5 is shown alone.
  • the insert member 250 serves to reduce the cross section of the fluid passage formed by the bore between the inlet port 213 and the outlet port 214.
  • the insert element 250 is formed substantially complementary to the bore in the base body 210 and in particular also widens slightly to the free end the bore down, so that it rests with its peripheral surface substantially sealingly against the boundary wall of the bore.
  • a first annular groove 251 is formed in the peripheral surface of the insert element 250, while a second annular groove 252 is formed in the region of the outlet opening 214.
  • These annular grooves are interconnected by a longitudinally extending connecting groove.
  • the annular grooves 251, 252 and the connecting groove 253 establish a fluid communication between the inlet port 213 and the outlet port 214, which is commonly defined by the grooves and the boundary wall of the fluid channel.
  • a straight connecting groove and a different shape can be selected.
  • a flattening may also be provided on the circumferential surface, or the connecting groove may be replaced by a fine, eg diagonal, bore connecting the annular grooves.
  • the insert element 250 can be easily slid into the open end of the bore in any orientation along the longitudinal direction with the open end of the bore forming an insertion opening 216 for the insert element. Because of the circumferential annular grooves 251, 252, it does not depend on the exact orientation of the insert element with respect to a rotation of the insert element about the longitudinal axis. In order to secure the insert element 250 in the bore, it has in the region of the insertion opening an annular bead 254 which engages in an annular groove 215 of the base body 210. This allows a further securing of the insert element 250 in the base body 210, e.g. a bonding or welding, omitted.
  • the applicator 100 For filling the two reservoirs 111, 112, the applicator 100 is fastened to the filling device 200 with pistons 121, 122 completely inserted.
  • the containers 300 are inserted into the corresponding container receptacles until they reach the removal position in which the septa of the container 300 are pierced and the containers are latched to the container receptacles.
  • the piston unit 120 is withdrawn to separately and simultaneously remove the fluids from the two containers and to transfer them into the reservoirs 111, 112. Only a small amount of the respective fluid is lost in the filling device.
  • the applicator 100 By pressure on the pressure wings 243, the applicator 100 is now released from the filling device 200.
  • an accessory such as a mixer or a sprayer, on the applicator can be connected, and the fluids can be discharged through the accessory from the applicator.
  • FIGS. 6 to 8 a first embodiment of a device according to the invention is illustrated, which is designed to remove a fluid from at least one container closed by a pierceable closure.
  • This inventive embodiment differs from the filling of the FIGS. 1 to 5 by the design of the container receptacles. In particular, the way in which the vials are held in the container receptacle is different.
  • the container receptacles 260 are formed here as a chimney-like, cylindrical structures which have a sufficiently large length to accommodate the respective container in full length. While in the FIGS. 1 to 4 The container receptacles 260 of the embodiment shown in FIG. 1 have been formed integrally with the base body 210, as shown in FIGS. 6 to 8 formed separately from the base body 210 and with this via a suitable connection, for. B. a welding connection connected.
  • the respective inlet opening 213 in the base body 210 has in the embodiment of the FIGS. 6 to 8 a larger diameter than in the filling of the FIGS. 1 to 5 on.
  • the container receptacle 260 has a bottom 264, from which a pin 265 extends into the inlet opening 213.
  • a passage opening 266 through bottom 264 and pin 265 connects between the withdrawal channel of the piercing member 230 and the fluid channel in the base body 210, the piercing member 230 being inserted into a region of the enlarged diameter passage opening 266 and having a lower edge on a stop edge 267 is seated.
  • a cylindrical shell wall 261 extends upward. In addition, extends from the bottom 264 of a part-cylindrical apron-like cover down, which partially surrounds the base body 210 laterally and in particular covers the insertion opening 216 for the insert element 250.
  • each case a latching structure 262, 263 is formed on two opposite sides.
  • the first latching structure 262 lies further away from the base body 210 than the second latching structure 263.
  • Each of the latching structures comprises a spring arm, at the free end of a latching lug is formed, which extends into the interior of the container receptacle 260 inside.
  • the second latching structure 263 is arranged so that it fixes the container 300 in a completely inserted removal position in which the piercing member 230 has pierced the closure 220 by a latching connection.
  • the latching lug of the second latching structure 263 engages in the region of the taper 313 of the container body and thus prevents retraction of the container from the container receptacle.
  • the first latching structure 262 fixes the container to the container receptacle when the container is in a storage position in which the closure 320 is arranged at a certain distance from the tip of the piercing member 230.
  • the first latching structure 262 on the one hand prevents the container 300 from being pulled out, on the other hand this latching structure also impedes further movement of the container 300 in the direction of the piercing member 230.
  • FIGS. 9 to 11b a second embodiment of a filling device 270 according to the invention is illustrated.
  • the filling device 270 has in this embodiment, a base body 271 with only one container receptacle 272 and serves to a.
  • Applicator 280 to fill with a fluid from a container 300.
  • the applicator 280 is embodied here in the form of a single syringe, which has an applicator body 281 with a reservoir 282 and a piston 283 displaceable therein.
  • the container receptacle 272 in which a container 300 in the form of a vial can be used here, has a circular bottom 276, from which a jacket wall 273 extends upwards over an angular range of approximately 270 °.
  • the jacket wall 273 is thus formed partially cylindrical in its region facing the bottom 276 and thereby defines a longitudinal axis of the filling device 270.
  • the jacket wall 273 In an end region arranged at a distance from the bottom 276, however, the jacket wall 273 is circumferential, ie cylindrical, in the circumferential direction.
  • the jacket wall 273 thus has a substantially rectangular window opening which is bounded from the bottom 276 downwards and from the cylindrical area of the jacket wall 273 at the top.
  • the length of the jacket wall 273 corresponds approximately to the total length of the container 300.
  • two latching structures 274 and 275 are provided, which are offset in the circumferential direction of the jacket wall 273 to each other.
  • the two latching structures 274 and 275 are each designed as spring arms, which extend from the circumferentially formed end region of the casing wall 273 in the longitudinal direction adjacent and extending parallel to each other downwards.
  • the spring arm of the latching structure 275 extends in comparison to the spring arm of the latching structure 274 further towards the bottom 246 and is formed longer in the longitudinal direction. Both spring arms are also slightly flexible in each case in the radial direction.
  • the two latching structures instead of side by side, however, could also be arranged diametrically opposite one another in order to claim as little space as possible with the greatest possible stability of the container receptacle.
  • each latching noses extend in the radial direction inwards.
  • the locking lugs are each slightly inclined downward to the bottom 276. In particular, they have an oblique surface whose surface normal points away from the bottom 276 substantially in the longitudinal direction and is inclined towards the axis of the axis.
  • the bottom 276 has a central passage opening, which opens upwards in a hollow needle-like piercing member 277, which projects into the container receptacle 272. Towards the bottom, the central passage opening opens into a Applicator connection 278, which is arranged on the piercing member 277 opposite side of the bottom 276. Through the applicator 278, the piercing member 277 and the bottom 276 therethrough, a continuous fluid channel 279 is formed.
  • the applicator port 278 serves to connect an applicator 280 and is here designed in the form of a Luer connection with a female Luer cone and a locking structure formed around it.
  • FIGS. 10a to 10c is a container 300 from above (arrow in Fig. 9 ) is inserted into the container receptacle 272 of the filling device 270.
  • the container 300 strikes with its closure 320 in the longitudinal direction of the latching lug of the second latching structure 275.
  • the septum 321 is located near the piercing member 277 but spaced therefrom. Further advancement of the container 300 to the piercing member 277 is prevented by the second latching structure 275.
  • the second latching structure 275 thus secures the container 300 from further insertion into the container receptacle 272. Inadvertent piercing of the septum 321 by the piercing member 277 is thereby prevented.
  • the first latching structure 274 protrudes into the taper 313 of the container 300 in such a way that it prevents movement of the container 300 away from the piercing member 277 and out of the container receptacle 272. Due to the latching nose of the first latching structure 274, which is inclined towards the bottom 276, forcible pulling out of the container 300 from the container receptacle 272 would lead to an irreversible destruction of the first latching structure 274.
  • the first latching structure 274 thus fixes the container 300, which is snapped in between the first and the second latching structure, in the container receptacle 272.
  • the container 300 is in a storage position and can thus be stored, distributed or sold together with the filling device 270.
  • the fact that the container 300 is surrounded by the jacket wall 273, it is optimally protected.
  • the applicator 280 may already be connected at the point of sale by means of a Luer connection 284 on the applicator connection 278.
  • the user presses the container 300 from this storage position with increased force further in the direction of the piercing member 277.
  • the two spring arms of the locking structures 274 and 275 are thereby pressed due to the oblique surfaces of their locking lugs in the radial direction to the outside, whereby the container 300th along the longitudinal axis (or in the direction of arrow in Fig. 11a ) until it stops of the closure 320 on the floor 276 can be advanced.
  • the piercing member 277 pierces the septum 321 of the container 300, creating fluid communication between the interior of the container 300 and the reservoir 282 of the applicator 280.
  • the container closure 320 When the container closure 320 is advanced to the bottom 276, snaps the second locking structure 275 with its latch into the taper 313 of the container 300 a.
  • the container 300 is thereby fixed in its position relative to the filling device 270 and is in the removal position, which in the Figures 11a and 11b is shown.
  • the substance stored in the container 300 can be removed by pulling the piston 283 out of the applicator body 281 (arrow direction in FIG Fig. 11a ) are transferred to the applicator 280. Removal of the container 300 from the container receptacle 272 is prevented by the second latching structure 275.
  • the filling device 270 is made in the present embodiment as a whole in one piece by injection molding of a plastic.
  • the container receptacle can also be formed in a different manner than in the manner shown here.
  • a single container receptacle receives two containers together, for. B. in the manner of a common hood for two containers.
  • the container or containers are held in a holding structure, and that the holding structure with the containers inserted therein is completely inserted into a corresponding container receptacle, as for example in some embodiments of the already mentioned US 6,488,650 the case is.
  • a latching does not take place directly between the container receptacle and the respective container, but that such a latching takes place between the container receptacle and the holding structure inserted therein.
  • applicator of the type specified here, of course, other types of applicators can be used, in particular applicators, as in WO 2009/144085 or WO 2007/109915 are illustrated. Conventional double syringes or unit-connected individual syringes can also be used. Accordingly, it is also possible, the applicator connection accordingly differently embody.
  • Such a filling device can also be used for filling different types of reservoirs from containers with a pierceable closure.
  • cartridges containers with septum closure and displaceable piston
  • another type of accessory may be connected, e.g. a mixer to mix the contents of two cartridges.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
EP10747394.4A 2010-02-01 2010-08-24 Vorrichtung zum entnehmen eines fluids aus einem behälter Active EP2531164B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1152010 2010-02-01
PCT/CH2010/000206 WO2011091542A1 (de) 2010-02-01 2010-08-24 Vorrichtung zum entnehmen eines fluids aus einem vial

Publications (2)

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EP2531164A1 EP2531164A1 (de) 2012-12-12
EP2531164B1 true EP2531164B1 (de) 2014-05-21

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EP10747394.4A Active EP2531164B1 (de) 2010-02-01 2010-08-24 Vorrichtung zum entnehmen eines fluids aus einem behälter
EP10801102.4A Not-in-force EP2531165B1 (de) 2010-02-01 2010-12-16 Vorrichtung zum entnehmen von fluiden aus vials

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EP (2) EP2531164B1 (zh)
CN (2) CN102791241B (zh)
WO (2) WO2011091542A1 (zh)

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Also Published As

Publication number Publication date
US20120302986A1 (en) 2012-11-29
EP2531164A1 (de) 2012-12-12
CN102770110A (zh) 2012-11-07
WO2011091543A3 (de) 2012-08-16
US9402787B2 (en) 2016-08-02
WO2011091542A1 (de) 2011-08-04
EP2531165B1 (de) 2013-11-20
CN102770110B (zh) 2015-09-16
CN102791241A (zh) 2012-11-21
US20120298254A1 (en) 2012-11-29
EP2531165A2 (de) 2012-12-12
WO2011091543A2 (de) 2011-08-04
CN102791241B (zh) 2015-04-08

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