EP2523728B1 - Scanning mechanism for lllt or other light source therapy - Google Patents
Scanning mechanism for lllt or other light source therapy Download PDFInfo
- Publication number
- EP2523728B1 EP2523728B1 EP11732715.5A EP11732715A EP2523728B1 EP 2523728 B1 EP2523728 B1 EP 2523728B1 EP 11732715 A EP11732715 A EP 11732715A EP 2523728 B1 EP2523728 B1 EP 2523728B1
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- EP
- European Patent Office
- Prior art keywords
- light source
- light
- source module
- light beam
- treatment area
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 230000007246 mechanism Effects 0.000 title claims description 24
- 238000002560 therapeutic procedure Methods 0.000 title description 2
- 238000011282 treatment Methods 0.000 claims description 51
- 238000009826 distribution Methods 0.000 claims description 33
- 230000001427 coherent effect Effects 0.000 claims description 8
- 239000002131 composite material Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 description 7
- 238000009196 low level laser therapy Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 3
- 238000003491 array Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000009429 electrical wiring Methods 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0616—Skin treatment other than tanning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B2018/2035—Beam shaping or redirecting; Optical components therefor
- A61B2018/20351—Scanning mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B2018/2035—Beam shaping or redirecting; Optical components therefor
- A61B2018/20351—Scanning mechanisms
- A61B2018/20355—Special scanning path or conditions, e.g. spiral, raster or providing spot overlap
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B2018/2065—Multiwave; Wavelength mixing, e.g. using four or more wavelengths
- A61B2018/207—Multiwave; Wavelength mixing, e.g. using four or more wavelengths mixing two wavelengths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0626—Monitoring, verifying, controlling systems and methods
- A61N2005/0629—Sequential activation of light sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
Definitions
- This invention is concerned with apparatus for treatment of body areas with a light beam e.g. to low-level laser therapy and to a mechanical scanning device for use in low-level laser therapy applications.
- the laser which is based on the quantum phenomenon of stimulated emission, provides an excellent source of concentrated light for treating patients.
- the laser allows the use of a selected intensity, monochromatic, and essentially coherent light. This has been found to be effective in treating people for various ailments.
- LLLT Low-level laser therapy
- devices having one light source which covers a small area of the body shower devices which contain two or more light sources and therefore cover a larger body area
- cluster devices which combine a variety of light sources, having different wavelengths and energy distributions.
- the beams generated by the light source have divergent angles and do not remain coherent.
- LLLT devices or other light sources require the treatment of a wide or large area of the human body rather than a small area or specific spot.
- a therapist scans the treatment area by moving the LLLT device or other light source device or probe by hand. The results of scanning in such a way are limited as the treatment does not always cover the desired area properly with the required light and/or energy dose to each treatment area unit.
- WO 2004/033040 (Altshuler et al., Palomar Medical Tech.) is directed to methods and apparatus for performing photobiostimulation of tissue, and more particularly to methods and apparatus for performing temperature controlled photobiostimulation of tissue, also referred to as low-level laser therapy (LLLT).
- the source may be a radiative source of wavelength range 380-2700 nm which may be operated in contact with surface of skin or may project radiation onto surface of skin from a distance.
- Biostimulation may be achieved using sources applied in a conventional small area of irradiation (e.g, a round area having a spot size less than 10 mm 2 in diameter), or a larger area (e.g. a round area having a spot size 1 cm 2 -200 cm 2 or more up to and including the entire human body). Methods of achieving a large area of irradiation are described
- the invention is defined in claim 1. Further aspects and preferred embodiments are defined in the dependent claims. Aspects, embodiments and examples of the present disclosure which do not fall under the scope of the appended claims do not form part of the invention and are merely provided for illustrative purposes.
- the present invention provides an apparatus for treating an area with a low-level laser device so the distribution of the light on the treatment area can be custom designed for a particular treatment procedure and repeated in the same manner for all similar treatments.
- the invention provides an apparatus for the treatment of body areas with a light beam, said apparatus having the features set out in claim 1 of the accompanying claims.
- the apparatus includes a light source and a scanning mechanism attached to the light source and adapted to impart a desired motion to the light source.
- the scanning mechanism may be an electric motor rotating the light beam or beams generated by the light source to provide a desired energy distribution pattern on a treatment area or to cover a wide treatment area, applying different light sources and different wavelengths, each with a different energy distribution on each of a plurality of selected treatment areas.
- the light source may include a laser, such as a laser diode, for example.
- the light source may include two or more light sources, each light source generating a light beam having a different wavelength, thus providing a composite coherent light beam.
- a method of treatment includes generating a light beam and scanning the light beam across a treatment area in a predetermined pattern for providing a desired energy distribution pattern at a treatment area.
- Scanning the light beam may include rotating a light source which generates the light beam or, alternatively, moving the light source in two dimensions to scan the light beam or beams across a wide treatment area.
- the light source may be a cluster of light sources wherein the scanning the light source provides sequential irradiation of a plurality of unit areas of a treatment area with each of the two or more light beams providing an energy distribution corresponding to each of the two or more light beams to each of the plurality of unit areas
- a scanning mechanism 100 to create a circular energy distribution on a treated area is shown.
- a flexible arm 101 is attached to a base 109 at one end thereof.
- a scanning mechanism 103 such as an electric motor, for example, is attached at the opposite end of the flexible arm 101 and is supported by the arm 101.
- the flexible arm 101 comprises a flexible tube wherein electrical wiring and power cables (not shown) may be routed.
- a source 105 is attached to the scanning mechanism 103.
- Scanning mechanism 103 is adapted to impart motion to the light source 105 in a desired manner.
- scanning mechanism 103 rotates the light source 105 about the axis of the light beam 107 thereby rotating the light beam 107 about its axis.
- Light source 105 may be a low-level laser or other suitable light source which generates light beam 107 to illuminate a desired area 111 to be treated.
- Scanning mechanism 103 rotates or otherwise moves the light source 105 such that the treatment area 111 is scanned by the light beam 107 to provide a desired energy distribution over the treatment area.
- the term "light source” is used to designate the source of an energy beam or beams which provide energy to the treatment area during an LLLT procedure.
- light source 105 comprises a low-level laser that provides as output an elongated monochromatic coherent laser beam 107 that is collimated by a lens (not shown) directly from a laser diode embedded in light source 105.
- the effects of LLLT appear to be limited to a specified set of wavelengths of laser emissions.
- the typical wavelength is in the range 600-1000 nm (red to near infrared), although research shows that some wavelengths outside this range may also be useful.
- the typical laser average power used in LLLT treatment is in the range of 1-500 mW. While some high-peak-power lasers in the range of 1-100 W may be used, a short pulse width limits the power at the treatment area.
- the typical average beam irradiance then is 10 mW/cm 2 - 5 W/cm 2 .
- the standard laser diode beam typically has a divergence of about 5-7 degrees along its width and about 30 to 40 degrees along its length.
- a lens is utilized to correct the beam to a narrow beam.
- the resulting elongated beam 107 is essentially coherent having a light beam with an essentially common phase as accepted for laser diode emission for use in LLLT.
- the light source 105 provides a monochromatic laser beam 107 that may be an invisible infrared beam.
- the wavelength of laser beam 107 may be 800 to 900 nanometers (nm). Alternatively, U.S.
- a visible light source for example, an LED, (not shown) may be incorporated with the light source 105 to provide a supplementary visible light beam to accompany the invisible laser beam 107.
- the visible light beam may coincide with the invisible laser beam, or the visible light beam may illuminate an area that surrounds the laser beam 107.
- light source 105 may be a group or cluster of two or more light sources such as lasers, for example. Each such light source is separate and independent of the other light sources in the cluster. Each light source generates a separate beam of light at a different wavelength and may provide a beam of more or less power than each of the other light sources in the cluster.
- the scanning mechanism 103 may be an electric motor which slowly rotates the light source cluster, such as at 2 revolutions per minute, thus irradiating each particular unit area of the treatment area with an energy beam having a different wavelength and power to provide a desired energy distribution at any given time. Each particular unit area of the treatment area is then irradiated with each of the generated energy beams in turn over a given time period as a function of the cluster rotation rate.
- FIG. 2 a graph illustrating a linear energy distribution of an LLLT or other light source device, and the linear energy distribution while the device is being used with a rotating mechanism according to the present disclosure is shown.
- Curve 201 illustrates the energy distribution over a treated area of the light beam along the long dimension of the light beam 107, when it is not rotating.
- curve 203 illustrates the energy distribution created on the treated area 111 by the rotating light beam 107. Rotation of the light beam 107 produces a more uniform energy distribution across treatment area 111.
- a scanning mechanism incorporating two light sources generating light beams having different wavelengths is shown.
- a light source module 303 is attached to a motor 301.
- Motor 301 is adapted to impart motion to the light source module 303 in a regular, desired manner to scan a desired treatment area 315.
- the motor 301 may rotate the light source module 303 about the axis of a light beam 311 to illuminate treatment area 315 with an energy distribution similar to that illustrated by curve 203.
- Two or more light sources 305, 307 of different wavelengths are mounted with the body of light source module 303.
- Light sources 305, 307 may be lasers, such as laser diodes, for example, each generating a laser beam 306, 308, respectively, having a different wavelength.
- the light source module 303 may incorporate one laser 305 that emits a beam having a wavelength of 635 nm, and a second laser 307 that emits a beam having a wavelength of 808 nm. Both such lasers 305, 307 will emit a light beam which is a bright red; however since they are in the near infrared region, their light will be barely visible.
- the two laser beams 306, 308 are directed to an output coupler 309, such as a dichroic beamsplitter, dichroic prism or half-silvered mirror, for example.
- Output coupler 309 combines the two laser beams 306, 308 to provide a beam 311 that includes light of both wavelengths.
- the lasers 305, 307 are alternately pulsed such that the beam 311 will be of only one wavelength at any given time.
- the lasers 305, 307 may be pulsed simultaneously to provide a beam 311 of both wavelengths at any given time.
- An X-Y scanning mechanism 400 includes a base bar or rail 401 and an arm 405 positioned transversely to the base rail 401.
- the arm 405 is moveably mounted to the base rail 401 by a moveable mount 403.
- the arm 405 is moved back and forth along base rail 401, such as by sliding, for example, by a motor or other means (not shown) incorporated within moveable mount 403.
- a light source module 413 is moveably mounted to arm 405 by a moveable mount 407.
- X-Y scanner 400 is similar to an X-Y plotter that operates in two axes of motion ("X" and "Y") in order to define or draw continuous vector graphics.
- the base rail 401 can be treated as the "Y" axis, while the arm 405 is the "X" axis.
- X-Y scanner 400 can be operated automatically by a computer programmed to continuously feed positioning commands to the motor or other means incorporated within moveable mounts 403 and 407 to move the light source module 413 in a desired pattern over the treatment area 411 to illuminate the treatment area at a predetermined distance.
- a frame 409 attached to the base rail 401 defines a treatment area 411.
- light source module 413 may incorporate one or more light sources, such as one or more lasers (not shown) to provide a light beam 415.
- the light source module 415 may incorporate a first laser that emits a beam having a wavelength of 635 nm, and a second laser that emits a beam having a wavelength of 808 nm. Light source module 413 then generates light beam 415 which includes light energy having both wavelengths.
- light source module 413 may incorporate three or more lasers having different wavelengths mounted in a cluster. In other embodiments, the light source module 413 may generate a greater or lesser number of light beams.
- a set of graphs illustrating possible energy distribution patterns according to the present disclosure is shown.
- the light beam 415 can create a wide variety of desired energy distribution patterns at the surface of the treatment area 411, with each one of the wavelengths incorporated in the beam.
- Curve 510 illustrates a distribution that provides approximate equivalent energy to each area unit in the treatment area 411.
- Curve 520 illustrates an energy distribution for treatment of an elongated area such as a long scar or wound.
- Curve 530 illustrates a circular energy distribution at the treatment area 411.
- an apparatus 600 enables a user to design and create desired or custom light source, such as low-level laser, for example, arrays to provide a desired energy distribution pattern on a treatment area (not shown).
- a light source array may be predetermined as a part of a standard LLLT treatment procedure, or the array may be a custom array designed during diagnosis of a patient to treat a specific ailment.
- a support plate 601 such as a flexible, semi-rigid belt or web, for example, includes an array of mounting points 603 to facilitate the mounting of one or more light source modules (not shown) at one or more of the mounting points 603 to form a desired array of light sources.
- Each of the light sources in the array includes optics to provide an array of parallel, coherent light beams to form the desired energy distribution pattern on the surface of a treatment area.
- Mounting points 603 may be slots or circular holes formed in support plate 601 or mounting brackets attached to support plate 601 at the mounting points 603, for example, or other suitable mounting apparatus.
- the frame 605 of mounting plate 601 includes electrical wiring, connections and other supporting circuitry to provide power for and control of the array of light source modules.
- support plate 601 is shown as a flat, rectangular plate, support plate 601 may also take other shapes and configurations, such as circular or square, for example, and may also be curved to attain the desired energy distribution pattern on a treatment area.
- a controller and power supply module 607 provides power and control signals to the array of light source modules via cabling 609.
- the light source modules used to assemble the light source arrays may use lasers, such as diode lasers, for example, to generate the light beam.
- the light source module will provide a monochromatic laser beam.
- the light source module may incorporate two or more lasers, each generating a light beam having a different wavelength.
- each light source module incorporates a pair of lasers, a first laser that emits a beam having a wavelength of 635 nm, and a second laser that emits a beam having a wavelength of 808 nm.
- light source module includes a laser wherein the laser beam generated by the laser is shaped by using a lens to form a collimated elongated beam to cover a larger area, for example an area of 3-6 cm by 0.5 to 1 cm at the surface of the treatment area.
- Support plate 601 may be mounted to a support structure (not shown) which maintains the light source module array positioned relative to a treatment area to provide the desired energy distribution pattern on a treatment area.
- support plate 601 may be mounted in a scanning mechanism such as the scanning mechanism 100 described above.
- the support plate 601 may be mounted to moveable mount 407 in the X-Y scanner mechanism 400 described above.
- support plate 601 includes a light source module mounted at each of the mounting points 603 forming an array of light source modules.
- a controller and power supply module 607 provides power and control signals to the array of light source modules via cabling 609.
- the controller 607 is programmed to switch selected ones of the light sources on and off to provide predetermined energy distribution patterns on a treatment area.
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- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Surgery (AREA)
- Optics & Photonics (AREA)
- Otolaryngology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Electromagnetism (AREA)
- Radiation-Therapy Devices (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL11732715T PL2523728T3 (pl) | 2010-01-14 | 2011-01-14 | Mechanizm skanujący do lllt lub innej terapii źródłem światła |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29505110P | 2010-01-14 | 2010-01-14 | |
PCT/IB2011/000206 WO2011086468A2 (en) | 2010-01-14 | 2011-01-14 | Scanning mechanism and treatment method for lllt or other light source therapy |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2523728A2 EP2523728A2 (en) | 2012-11-21 |
EP2523728A4 EP2523728A4 (en) | 2013-07-24 |
EP2523728B1 true EP2523728B1 (en) | 2019-08-21 |
Family
ID=44278107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11732715.5A Active EP2523728B1 (en) | 2010-01-14 | 2011-01-14 | Scanning mechanism for lllt or other light source therapy |
Country Status (15)
Country | Link |
---|---|
US (2) | US20120323295A1 (es) |
EP (1) | EP2523728B1 (es) |
JP (1) | JP2013517037A (es) |
KR (1) | KR20120112795A (es) |
CN (1) | CN102811768B (es) |
AU (1) | AU2011206330B2 (es) |
BR (1) | BR112012017461B1 (es) |
CA (1) | CA2787118A1 (es) |
EA (1) | EA201270688A1 (es) |
ES (1) | ES2757850T3 (es) |
IL (1) | IL220831A (es) |
MX (1) | MX2012008131A (es) |
PL (1) | PL2523728T3 (es) |
WO (1) | WO2011086468A2 (es) |
ZA (1) | ZA201206048B (es) |
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KR101897295B1 (ko) | 2012-10-11 | 2018-10-22 | 현대자동차주식회사 | 자동화 수동변속기의 동기 제어방법 |
SE538469C2 (sv) * | 2013-10-07 | 2016-07-12 | Johansson Susanne | Anordning för styrning av en laserprob |
TWM481705U (zh) * | 2014-03-03 | 2014-07-11 | Guo-Liang He | 穴位能量增生裝置 |
US10241083B2 (en) * | 2016-03-11 | 2019-03-26 | General Electric Company | Ultrasonic inspection probe assembly |
CN109966657A (zh) * | 2017-12-28 | 2019-07-05 | 重庆半岛医疗科技有限公司 | 一种激光发射头及激光塑身装置 |
CN109173077A (zh) * | 2018-09-29 | 2019-01-11 | 深圳普门科技股份有限公司 | 一种光子治疗仪 |
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WO2004033040A1 (en) * | 2002-10-07 | 2004-04-22 | Palomar Medical Technologies, Inc. | Apparatus for performing photobiostimulation |
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2011
- 2011-01-14 CA CA2787118A patent/CA2787118A1/en not_active Abandoned
- 2011-01-14 US US13/521,754 patent/US20120323295A1/en not_active Abandoned
- 2011-01-14 CN CN201180006235.6A patent/CN102811768B/zh not_active Expired - Fee Related
- 2011-01-14 MX MX2012008131A patent/MX2012008131A/es not_active Application Discontinuation
- 2011-01-14 ES ES11732715T patent/ES2757850T3/es active Active
- 2011-01-14 KR KR1020127021319A patent/KR20120112795A/ko not_active Application Discontinuation
- 2011-01-14 WO PCT/IB2011/000206 patent/WO2011086468A2/en active Application Filing
- 2011-01-14 AU AU2011206330A patent/AU2011206330B2/en not_active Ceased
- 2011-01-14 US US13/006,969 patent/US10898723B2/en active Active
- 2011-01-14 BR BR112012017461-4A patent/BR112012017461B1/pt not_active IP Right Cessation
- 2011-01-14 EP EP11732715.5A patent/EP2523728B1/en active Active
- 2011-01-14 PL PL11732715T patent/PL2523728T3/pl unknown
- 2011-01-14 EA EA201270688A patent/EA201270688A1/ru unknown
- 2011-01-14 JP JP2012548499A patent/JP2013517037A/ja active Pending
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2012
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Also Published As
Publication number | Publication date |
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US20110178583A1 (en) | 2011-07-21 |
ZA201206048B (en) | 2013-05-29 |
AU2011206330A1 (en) | 2012-08-30 |
IL220831A0 (en) | 2012-08-30 |
MX2012008131A (es) | 2012-10-10 |
IL220831A (en) | 2016-07-31 |
US20120323295A1 (en) | 2012-12-20 |
AU2011206330B2 (en) | 2016-03-31 |
CA2787118A1 (en) | 2011-07-21 |
PL2523728T3 (pl) | 2020-03-31 |
EP2523728A4 (en) | 2013-07-24 |
WO2011086468A3 (en) | 2011-11-17 |
WO2011086468A2 (en) | 2011-07-21 |
EP2523728A2 (en) | 2012-11-21 |
EA201270688A1 (ru) | 2012-12-28 |
BR112012017461B1 (pt) | 2021-10-26 |
BR112012017461A2 (pt) | 2017-09-26 |
KR20120112795A (ko) | 2012-10-11 |
CN102811768A (zh) | 2012-12-05 |
JP2013517037A (ja) | 2013-05-16 |
CN102811768B (zh) | 2016-03-09 |
ES2757850T3 (es) | 2020-04-30 |
US10898723B2 (en) | 2021-01-26 |
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