EP1651341A2 - Fond d'un reacteur - Google Patents
Fond d'un reacteurInfo
- Publication number
- EP1651341A2 EP1651341A2 EP04741243A EP04741243A EP1651341A2 EP 1651341 A2 EP1651341 A2 EP 1651341A2 EP 04741243 A EP04741243 A EP 04741243A EP 04741243 A EP04741243 A EP 04741243A EP 1651341 A2 EP1651341 A2 EP 1651341A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- reactor
- closure part
- opening
- reactor base
- collecting funnel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002775 capsule Substances 0.000 claims abstract description 40
- 238000000034 method Methods 0.000 claims abstract description 24
- 239000000203 mixture Substances 0.000 claims abstract description 19
- 238000004062 sedimentation Methods 0.000 claims abstract description 4
- 239000012071 phase Substances 0.000 claims description 41
- 238000003306 harvesting Methods 0.000 claims description 37
- 239000007788 liquid Substances 0.000 claims description 5
- 239000007791 liquid phase Substances 0.000 claims description 5
- 239000007790 solid phase Substances 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 238000011010 flushing procedure Methods 0.000 claims description 2
- 238000005191 phase separation Methods 0.000 claims description 2
- 238000007599 discharging Methods 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 11
- 239000011521 glass Substances 0.000 description 5
- 238000005538 encapsulation Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 239000002245 particle Substances 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 239000004810 polytetrafluoroethylene Substances 0.000 description 3
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 210000004102 animal cell Anatomy 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 239000003094 microcapsule Substances 0.000 description 2
- 229920000371 poly(diallyldimethylammonium chloride) polymer Polymers 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 229910021653 sulphate ion Inorganic materials 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000011942 biocatalyst Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 210000001821 langerhans cell Anatomy 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000010327 methods by industry Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
Definitions
- the invention relates to a reactor base of a reactor, which is used in particular when encapsulating cells, and a method for separating a phase from a phase mixture in a reactor with such a reactor base.
- DD 217 821 A1 describes the mixing of Langerhans cells with NaCS and the dropping of the mixture into a precipitation bath which contains PDMDAAC.
- DD 217 821 A1 describes a method for producing a NaCS-PDMDAAC microcapsule system which contains hormone-producing cells.
- Microcapsules made of NaCS and PDADMAC are also known, inter alia, from DD 160 393 A, DD 219 795 A1, DD 217 821 A1 and DD 274 051 A1.
- An improved apparatus for the production of NaCS capsules is in Cho (process engineering design of an apparatus for the production of microencapsulated biocatalysts with separate supply of catalyst solution and capsule base substance, progress reports VDI, series 17, no.
- the reactor or the reactor vessel In a known device for encapsulating cells (Encapsulator AP 'medical' from Inotech), the reactor or the reactor vessel must be removed from the device in order to harvest the capsules. By shaking and tilting the reactor vessel, the capsules are rinsed through a drain opening, which is located about 3 cm above a reactor base in the wall of the reactor vessel, into a collecting vessel or harvesting flask. This procedure is not very user-friendly and leads to an unusable residue of capsules in the reactor vessel.
- the reactor base of the reactor is formed as a collecting funnel
- the phase of the phase mixture contained in the reactor or the capsules formed at the bottom or center of the funnel can Meltrichter formed harvest opening and the outlet channel are removed or harvested.
- a simple handling and operation results from the fact that a closure part is provided for the harvest opening, which is movably arranged on the reactor floor and between a closed position in which it closes the harvest opening of the collecting funnel and a removal position in which it is lowered into the reactor floor and releases a connection between the harvest opening and the outlet channel is adjustable.
- the harvest opening can be released by adjusting the closure part and the phase to be separated or the capsules can be withdrawn through the outlet channel essentially without residues due to the collecting funnel. Dismantling of the reactor or reactor vessel for manual pouring out or pouring out the phase to be separated or the capsules is not necessary.
- the surface or top of the closure part is preferably used as a diverting device for diverting the reactor! of? Phase mixture or the capsules formed from the harvest opening in the outlet channel.
- the Abieit thus supports the almost or completely loss-free draining.
- the surface or top of the closure part has a collection area with a low level, the collection area being assigned to the outlet channel in the lowered removal position of the closure part.
- the collection area is in particular part of the drainage device and it can e.g. B. be formed approximately punctiform or linear.
- a circular or ring-shaped and thus approximately linear collecting area is formed on the periphery of the closure part, for example, in the case of a concavely curved upper side of the closure part.
- the harvest opening is expediently arranged in the region of the center of the collecting funnel in order to enable the phase or the capsules located above the harvest opening to be removed completely.
- the crop opening can be arranged both centrally and eccentrically to the central axis or to the center of the collecting funnel, which is formed symmetrically or asymmetrically. It is particularly preferred if the edge of the harvest opening runs through or touches the central axis of the collecting funnel and the surface of the closure part is inclined at the location of the harvest opening in accordance with the inclination of the funnel surface or has the corresponding funnel shape. Due to this shape of the surface, no particles or capsules remain on the lowered closure part, which opens the harvest opening.
- the surface of the closure part In its closed position, the surface of the closure part is then expediently arranged flush with the surface of the collecting funnel. When the closure part is open, the collecting funnel can be emptied without residue.
- the surface of the closure part can be beveled or spherical with respect to the central axis, so that no residues of particles or capsules can remain on the surface when they flow or flow out of the reactor ,
- An outlet recess which extends from the harvest opening in the reactor base and in particular parallel to the central axis of the collecting funnel, is preferably provided, which receives the closure part in a displaceable manner and into which the at least one outlet channel opens.
- the outlet recess can be a hole with a round cross-section or a non-circular one such as B. elliptical or rectangular cross section.
- the outlet recess can also run at an acute angle to the central axis.
- an annular groove and / or a plurality of openings is or are formed in the wall of the outlet recess, the Communicate with the outlet channel, the draining or harvesting of the capsules can be done faster due to the larger drain cross-sections.
- At least one drain channel covered by a sieve opens into the collecting funnel.
- a second liquid phase in particular a liquid phase, can be drained or sucked out of the reactor via the discharge channel.
- a washing or rinsing liquid which has previously been fed to the reactor in order to rinse the capsules or generally the product formed in the reactor can also be drained off via the discharge channel. Such a rinsing process can be carried out once or several times.
- the reactor base can be formed in one piece with the reactor or the reactor wall. On the other hand, it can be provided that the reactor and the reactor wall to the reactor bottom and is detachably connected to the top of the actuator bottom Re- the Samme! R trichte surrounding reactor wall can be fixed.
- the reactor floor is made of plastic such as. B. PTFE manufactured.
- the collecting funnel can also be attached to the reactor base as a separate sheet metal or plastic part.
- the closure part can be adjustable both manually and by means of a drive device arranged on the reactor base.
- the funnel angle of the collecting funnel is preferably essentially 130 ° to 170 ° and in particular 153 °. Otherwise, the funnel angle is selected as a function of the capsules or phases to be separated and their flow properties and can therefore have any suitable angle.
- the phase mixture is introduced into the reactor, the phases are separated and the desired phase is removed by moving the closure part arranged in its closed position into its removal position and thereby releasing a connection between the harvest opening and the outlet channel, via the harvest opening and the outlet channel from the reactor.
- the phase mixture is a mixture of solid and liquid phases and the phases are separated by sedimentation of the solid phase, capsules in particular forming the solid phase.
- the phase separation by means of sedimentation is particularly expedient if the phase mixture is a hardening bath with capsules contained in the hardening bath as the phase to be separated and the capsules settle at the bottom of the collecting funnel, where they can be removed.
- the capsules are, for example, ⁇ aCS capsules and they preferably contain biological cells, in particular animal, human or plant cells.
- the hardening bath is drained via the drain channel and flushing liquid is fed into the reactor and drained again via the drain channel, this process step being carried out one or more times can.
- the desired phase which in the reactor z. B. forms a lower layer, can be removed through the harvesting opening and the outlet channel and the middle or the upper layer-like phase can, depending on the arrangement of the phase or layer, through the outlet channel or subsequently hd to the lower phase through the harvest opening and the outlet channel.
- Figure 1 is a vertical sectional view of a reactor floor according to the invention with an outlet device.
- FIG. 2 shows a plan view in a reduced representation of the reactor floor shown in FIG. 1;
- Fig. 3 in a vertical sectional view in an enlarged view an embodiment of the reactor floor with a modified outlet device.
- a reactor 1 of a device for encapsulating cells, in particular microbial, plant or animal cells, or of biological and chemical substances contains a reactor base 2, which, for. B. is made of a circular or square plate made of PTFE and has on its underside 3 a support device with, for example, four feet 4, which are firmly attached to the underside 3 of the reactor base 2.
- the support device can be, for example, a support frame on which the reactor base 2 rests.
- the reactor base 2 is formed on its top 5 as a collecting funnel 7 having a central axis 6, which is surrounded by an edge region 8 of the top 5 and has a funnel angle of, for example, 153 °.
- the edge area 8 preferably contains a flat shoulder 9 for receiving a sealing ring 10 on which a reactor vessel, for. B. a glass cylinder 11 is arranged liquid-tight.
- a holding device is preferably attached to the reactor base 2, which, for example, four distributed over the circumference of the reactor base 2 and on the Actuator floor 2 attached rods 12.
- the rods 12 preferably extend to the upper section of the glass cylinder 11 and fix a reactor head part (not shown) to the glass cylinder 11 by means of a releasable holding device and this to the reactor base 2.
- the reactor base 2 also contains an outlet or harvest recess 13 which extends downward from the collecting funnel 7 into the reactor base 2 and is formed, for example, as a through-opening which connects the collecting funnel 7 to the underside 3 of the reactor base 2.
- the z. B. formed as a cylindrical bore outlet recess 13 or through opening is arranged eccentrically and in particular parallel to the central axis 6 that its wall 14, for example, touches the central axis 6 and thus runs through the deepest central point of the collecting funnel 7.
- a harvest opening 15 is thus formed in the inclined surface of the collecting funnel 7 by the outlet recess 13.
- a closure member 16 which, for. B.
- the sealing of the closure part 16 takes place either due to the play-free fit of a plastic such as. B. PTFE manufactured closure member 16 in the outlet recess 13 and / or by a seal (not shown), for. B. an O-ring which is arranged on the circumference of the closure part 16 and bears sealingly on the wall 14 of the outlet recess 13 or alternatively is arranged in an annular groove formed in the wall 14.
- the closure part 16 is preferably received and guided in the outlet recess 13 in such a way that it cannot twist.
- This protection against rotation is provided, for example, by a non-round cross-sectional shape of the closure part 16 or the outlet recess 13 or by a corresponding guide which prevents the closure part 16, which is round in cross section, from rotating in the cylindrical outlet recess 13.
- the top or surface 17 of the closure part 16 is inclined and in particular is formed in accordance with the inclined surface of the collecting funnel 7 adjoining the upper harvest opening 15 of the outlet recess 13, so that the closure part 16 is arranged flush in the surface of the collecting funnel 7 when it is in it upper closed position.
- the reactor base 2 also contains an outlet channel 18 which, for example, on the one hand in the wall 14 of the outlet recess 13 below the center or on the central axis 6 of the collecting funnel 7 and on the other hand on the underside 3 of the reactor base 2 z. B. opens into an outlet pipe or connector 19.
- the closure part 16 is preferably movable or displaceable in the outlet recess 13 by means of a drive device.
- the drive device contains, for example, an electrically attached to the underside 3 of the reactor base plate 2.
- a manual stroke actuation or a manual displacement of the closure part 16 is provided.
- the shape or shape of the top or surface 17 of the closure oil 16 forms a drainage device with a collecting area 26 at a low level, so that the reactor contents, e.g. B. a liquid or solids such as capsules or the like, is discharged from the surface 17 in the removal direction or in the direction of the outlet channel 18 substantially without residue.
- the collecting area 26 extends around the lowest point of the surface 17 on the peripheral edge of the closure part 16.
- the reactor base 2 also contains an additional drain channel 23, which preferably leads from the surface of the collecting funnel 7 to the underside 3 of the reactor base 2.
- the outlet recess or through hole is preferably arranged centrally to the central axis 6 of the collecting funnel 7.
- a groove 25 is preferably formed as an annular channel into which the at least one outlet channel 18 opens.
- the surface 17 of the closure part 16 is preferably spherical or convex, so that in the lowered removal position of the closure part 16 (shown in broken lines in FIG. 3) the desired phase, in particular capsules formed, can be removed with little loss or without loss.
- the discharge device here forms an annular collecting area 26, which is lowered on the edge side, on the surface 17 of the closure part 16, in order to B. derive the capsules to the groove 25 or the ring channel.
- the reactor is e.g. B. used in the encapsulation of cells.
- a suspension of sodium cellulose sulphate and cells is dripped through a nozzle. The drops fall into a hardness bath made of PDADMAC contained in the reactor 1 or the reactor vessel 11.
- the closure part 16 is arranged in its upper closing division flush with the surface of the collecting funnel 7 and the drain channel 23 is blocked off.
- the hardening bath is drained or pumped out via the drain channel 23, the sieve 24 holding back the encapsulated substances or capsules.
- a rinsing or washing liquid can then be filled into the reactor and, after washing the capsules, drained off via the drain channel 23. This washing process can be carried out once or several times.
- the closure member 16 is moved downward until the opening of the outlet channel 18 in the wall 14 of the outlet recess 13 is exposed and thus the capsules can flow through the harvest opening 15 and the outlet channel 18 with little loss or loss-free, since no corners are present on the flow path in which capsules may remain.
- the upper side or surface 17 of the closure part 16 enables and thus supports the loss-free drainage of the capsules from the reactor 1.
- the reactor 1 with the described reactor bottom can be used very generally to separate a phase from a phase mixture with at least two phases, the phase located above the surface of the collecting funnel 7 through the harvest opening 15 with little loss or can even be deducted without loss.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10334371A DE10334371A1 (de) | 2003-07-25 | 2003-07-25 | Reaktorboden eines Reaktors |
PCT/EP2004/008260 WO2005011857A2 (fr) | 2003-07-25 | 2004-07-23 | Fond d'un reacteur |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1651341A2 true EP1651341A2 (fr) | 2006-05-03 |
Family
ID=34071952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04741243A Withdrawn EP1651341A2 (fr) | 2003-07-25 | 2004-07-23 | Fond d'un reacteur |
Country Status (6)
Country | Link |
---|---|
US (1) | US20060207682A1 (fr) |
EP (1) | EP1651341A2 (fr) |
JP (1) | JP2006528545A (fr) |
CA (1) | CA2533487A1 (fr) |
DE (1) | DE10334371A1 (fr) |
WO (1) | WO2005011857A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3501550A1 (fr) | 2012-04-02 | 2019-06-26 | Moderna Therapeutics, Inc. | Polynucléotides modifiés pour la production de protéines associées à une maladie humaine |
DE102016014457A1 (de) * | 2016-12-05 | 2018-06-07 | Pva Tepla Ag | Probengefäß zur Aufnahme kleinvolumiger flüssiger Proben |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD38062A (fr) * | ||||
GB685371A (en) * | 1949-06-07 | 1953-01-07 | North Thames Gas Board | Means embodying a gas-tight valve for use in removing flowable solids from or introducing flowable solids into gas-solid reaction vessels |
US3690842A (en) * | 1970-10-05 | 1972-09-12 | Universal Oil Prod Co | Reactor for fluidized particles with adjustable level weir to particle outlet |
DD217821A1 (de) * | 1983-08-08 | 1985-01-23 | Adw Inst Polymerenchemie | Verfahren zur herstellung eines hormonproduzierenden mikrokapselsystems |
JPS6251957A (ja) * | 1985-08-30 | 1987-03-06 | Hitachi Ltd | 海藻ゲル包括菌体粒子ゲル製造装置及び方法 |
JPS63248381A (ja) * | 1987-04-03 | 1988-10-14 | Hitachi Ltd | 無菌式吐出弁 |
DE4316944C2 (de) * | 1993-05-21 | 2000-10-12 | Puth Hans Edgar | Verfahren und Vorrichtung zur semikontinuierlichen Herstellung von Milchsäure aus Würze |
US5733776A (en) * | 1993-11-09 | 1998-03-31 | Genzyme Corporation | Continuous settling apparatus |
US5925563A (en) * | 1997-07-21 | 1999-07-20 | Redford; Steven G. | Multi-stage column continuous fermentation system |
JP3329709B2 (ja) * | 1997-10-27 | 2002-09-30 | 株式会社総合開発 | 反応器 |
IT1307234B1 (it) * | 1999-04-01 | 2001-10-30 | Gimar Tecno S R L | Vasca di fermentazione, particolarmente per la vinificazione in rosso. |
DE19923628C2 (de) * | 1999-05-22 | 2002-03-07 | Herbert Huettlin | Verfahren und Vorrichtung zum Herstellen von partikelförmigen Teilchen |
US6780507B2 (en) * | 2000-02-09 | 2004-08-24 | Analytical Research Systems, Inc. | Hydrocapsules and method of preparation thereof |
DE10024154A1 (de) * | 2000-05-19 | 2001-11-22 | Inotech Encapsulation Ag Dotti | Verfahren und Vorrichtung zur Verkapselung von Zellen |
-
2003
- 2003-07-25 DE DE10334371A patent/DE10334371A1/de not_active Ceased
-
2004
- 2004-07-23 WO PCT/EP2004/008260 patent/WO2005011857A2/fr not_active Application Discontinuation
- 2004-07-23 CA CA002533487A patent/CA2533487A1/fr not_active Abandoned
- 2004-07-23 US US10/565,421 patent/US20060207682A1/en not_active Abandoned
- 2004-07-23 JP JP2006520803A patent/JP2006528545A/ja active Pending
- 2004-07-23 EP EP04741243A patent/EP1651341A2/fr not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
See references of WO2005011857A3 * |
Also Published As
Publication number | Publication date |
---|---|
WO2005011857A3 (fr) | 2005-04-07 |
WO2005011857A2 (fr) | 2005-02-10 |
US20060207682A1 (en) | 2006-09-21 |
DE10334371A1 (de) | 2005-02-17 |
JP2006528545A (ja) | 2006-12-21 |
CA2533487A1 (fr) | 2005-02-10 |
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