EP1601357A4 - Heterocyclische kinase-hemmer: verfahren zur verwendung und synthese - Google Patents
Heterocyclische kinase-hemmer: verfahren zur verwendung und syntheseInfo
- Publication number
- EP1601357A4 EP1601357A4 EP04719237A EP04719237A EP1601357A4 EP 1601357 A4 EP1601357 A4 EP 1601357A4 EP 04719237 A EP04719237 A EP 04719237A EP 04719237 A EP04719237 A EP 04719237A EP 1601357 A4 EP1601357 A4 EP 1601357A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- synthesis
- methods
- kinase inhibitors
- heterocyclic kinase
- heterocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45345703P | 2003-03-10 | 2003-03-10 | |
US453457P | 2003-03-10 | ||
US46091003P | 2003-04-07 | 2003-04-07 | |
US460910P | 2003-04-07 | ||
US46302503P | 2003-04-15 | 2003-04-15 | |
US463025P | 2003-04-15 | ||
US50271003P | 2003-09-12 | 2003-09-12 | |
US502710P | 2003-09-12 | ||
PCT/US2004/007286 WO2004080463A1 (en) | 2003-03-10 | 2004-03-10 | Heterocyclic kinase inhibitors: methods of use and synthesis |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1601357A1 EP1601357A1 (de) | 2005-12-07 |
EP1601357A4 true EP1601357A4 (de) | 2007-10-03 |
Family
ID=32996376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04719237A Withdrawn EP1601357A4 (de) | 2003-03-10 | 2004-03-10 | Heterocyclische kinase-hemmer: verfahren zur verwendung und synthese |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1601357A4 (de) |
JP (1) | JP2006519846A (de) |
CA (1) | CA2518398A1 (de) |
MX (1) | MXPA05009722A (de) |
WO (1) | WO2004080463A1 (de) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
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TWI328009B (en) | 2003-05-21 | 2010-08-01 | Glaxo Group Ltd | Quinoline derivatives as phosphodiesterase inhibitors |
MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
WO2007022241A2 (en) | 2005-08-17 | 2007-02-22 | Schering Corporation | Novel high affinity quinoline-based kinase ligands |
EP3719018A1 (de) | 2006-04-25 | 2020-10-07 | Astex Therapeutics Ltd | Purin- und deazapurinderivate als pharmazeutische verbindungen |
US7511063B2 (en) * | 2006-08-16 | 2009-03-31 | Schering Corporation | High affinity quinoline-based kinase ligands |
WO2008059370A2 (en) | 2006-11-17 | 2008-05-22 | Pfizer Japan Inc. | Substituted bicyclocarboxyamide compounds |
EP2099763B1 (de) | 2006-12-07 | 2010-08-11 | F. Hoffmann-La Roche AG | 2-aminochinoline als 5-ht(5a)-rezeptorantagonisten |
EP2124944B1 (de) | 2007-03-14 | 2012-02-15 | Ranbaxy Laboratories Limited | Pyrazolo[3,4-b]pyridin-Derivate als Phosphodiesterasehemmer |
PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
US8030495B2 (en) * | 2007-05-23 | 2011-10-04 | Coleman Paul J | Cyclopropyl pyrrolidine orexin receptor antagonists |
BRPI0816239A2 (pt) * | 2007-08-22 | 2015-02-24 | Allergan Inc | Derivados terapêuticos de quinolina e naftaleno |
AU2008303602A1 (en) * | 2007-09-27 | 2009-04-02 | F. Hoffmann-La Roche Ag | Quinoline derivatives as 5HT5A receptor antagonists |
WO2009047563A1 (en) | 2007-10-11 | 2009-04-16 | Astrazeneca Ab | Pyrrolo [2, 3 -d] pyrimidin derivatives as protein kinase b inhibitors |
US8329691B2 (en) | 2007-10-15 | 2012-12-11 | Takeda Pharmaceutical Company Limited | Amide compounds and use of the same |
KR20100093552A (ko) | 2007-11-02 | 2010-08-25 | 버텍스 파마슈티칼스 인코포레이티드 | 단백질 키나제 c-세타로서의 [1h-피라졸로[3,4-b]피리딘-4-일]-페닐 또는 -피리딘-2-일 유도체 |
WO2009095752A1 (en) * | 2008-01-29 | 2009-08-06 | Glenmark Pharmaceuticals, S.A. | Fused pyrazole derivatives as cannabinoid receptor modulators |
KR20100119825A (ko) * | 2008-03-05 | 2010-11-10 | 에프. 호프만-라 로슈 아게 | 2-아미노퀴놀린 |
EP2252372A1 (de) * | 2008-03-07 | 2010-11-24 | F. Hoffmann-La Roche AG | 2-aminochinoline |
MX2010009403A (es) | 2008-03-07 | 2010-09-24 | Hoffmann La Roche | Derivados de 2-aminoquinolina. |
JP2011513452A (ja) | 2008-03-12 | 2011-04-28 | エフ.ホフマン−ラ ロシュ アーゲー | 5−ht5a受容体アンタゴニストとしての2−アミノキノリン |
GB0812969D0 (en) | 2008-07-15 | 2008-08-20 | Sentinel Oncology Ltd | Pharmaceutical compounds |
KR20110124787A (ko) | 2009-02-27 | 2011-11-17 | 암비트 바이오사이언시즈 코포레이션 | Jak 키나아제 조절 퀴나졸린 유도체 및 이의 사용 방법 |
WO2010101949A1 (en) * | 2009-03-02 | 2010-09-10 | Sirtris Pharmaceuticals, Inc. | 8-substituted quinolines and related analogs as sirtuin modulators |
US10253020B2 (en) | 2009-06-12 | 2019-04-09 | Abivax | Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging |
DK2440545T3 (da) * | 2009-06-12 | 2019-07-22 | Abivax | Forbindelser, der er anvendelige til behandling af cancer |
PL2512243T3 (pl) * | 2009-12-17 | 2016-09-30 | Pozytywne modulatory allosteryczne receptora amidu chinoliny m1 | |
JP5629331B2 (ja) | 2010-01-29 | 2014-11-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換ナフチリジン及びsykキナーゼ阻害剤としてのその使用 |
US8815902B2 (en) | 2010-06-15 | 2014-08-26 | Merck Sharp & Dohme Corp. | Tetrahydroquinoline amide M1 receptor positive allosteric modulators |
US8470852B2 (en) * | 2010-08-27 | 2013-06-25 | Gruenenthal Gmbh | Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators |
WO2012030948A1 (en) | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Quinazoline compounds and methods of use thereof |
EP2489663A1 (de) | 2011-02-16 | 2012-08-22 | Almirall, S.A. | Verbindungen als Syk-Kinasehemmer |
WO2012122370A2 (en) | 2011-03-08 | 2012-09-13 | Eutropics Pharmaceuticals, Inc. | Compositions and methods useful for treating diseases |
KR101851820B1 (ko) | 2011-04-01 | 2018-06-04 | 아스트라제네카 아베 | 치료적 요법 |
AU2012253885A1 (en) | 2011-05-10 | 2013-10-31 | Merck Sharp & Dohme Corp. | Aminopyrimidines as Syk inhibitors |
EP2706852B1 (de) | 2011-05-10 | 2018-08-22 | Merck Sharp & Dohme Corp. | Bipyridylaminopyridine als syk-hemmer |
AU2012253886A1 (en) | 2011-05-10 | 2013-10-31 | Merck Sharp & Dohme Corp. | Pyridyl aminopyridines as Syk inhibitors |
CN103827090B (zh) | 2011-07-26 | 2016-04-20 | 勃林格殷格翰国际有限公司 | 取代的喹啉及其作为药物的用途 |
US8987456B2 (en) | 2011-10-05 | 2015-03-24 | Merck Sharp & Dohme Corp. | 3-pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors |
US9216173B2 (en) | 2011-10-05 | 2015-12-22 | Merck Sharp & Dohme Corp. | 2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors |
WO2013052391A1 (en) | 2011-10-05 | 2013-04-11 | Merck Sharp & Dohme Corp. | PHENYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
WO2013079964A1 (en) | 2011-11-30 | 2013-06-06 | Astrazeneca Ab | Combination treatment of cancer |
AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
WO2013192423A2 (en) | 2012-06-20 | 2013-12-27 | Eutropics Pharmaceuticals, Inc. | Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives |
WO2013192125A1 (en) | 2012-06-20 | 2013-12-27 | Merck Sharp & Dohme Corp. | Pyrazolyl derivatives as syk inhibitors |
US9487504B2 (en) | 2012-06-20 | 2016-11-08 | Merck Sharp & Dohme Corp. | Imidazolyl analogs as syk inhibitors |
WO2013192098A1 (en) | 2012-06-22 | 2013-12-27 | Merck Sharp & Dohme Corp. | SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
WO2013192088A1 (en) | 2012-06-22 | 2013-12-27 | Merck Sharp & Dohme Corp. | SUBSTITUTED DIAZINE AND TRIAZINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
WO2014031438A2 (en) | 2012-08-20 | 2014-02-27 | Merck Sharp & Dohme Corp. | SUBSTITUTED PHENYL SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
EP2900665B1 (de) | 2012-09-28 | 2018-01-03 | Merck Sharp & Dohme Corp. | Triazolylderivate als syk-hemmer |
US20160038503A1 (en) | 2012-11-21 | 2016-02-11 | David Richard | Methods and compositions useful for treating diseases involving bcl-2 family proteins with isoquinoline and quinoline derivatives |
EP2757161A1 (de) | 2013-01-17 | 2014-07-23 | Splicos | miRNA-124 als ein Biomarker für virale Infektion |
WO2015017788A1 (en) | 2013-08-01 | 2015-02-05 | Eutropics Pharmaceuticals, Inc. | Method for predicting cancer sensitivity |
US10640803B2 (en) | 2013-10-30 | 2020-05-05 | Eutropics Pharmaceuticals, Inc. | Methods for determining chemosensitivity and chemotoxicity |
US9822107B2 (en) | 2013-12-20 | 2017-11-21 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors |
US9783531B2 (en) | 2013-12-20 | 2017-10-10 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors |
WO2015095444A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors |
EP3116506B1 (de) | 2014-03-13 | 2019-04-17 | Merck Sharp & Dohme Corp. | 2-pyrazincarboxamide als milz-tyrosinkinase-inhibitoren |
EP2974729A1 (de) | 2014-07-17 | 2016-01-20 | Abivax | Chinolinderivate zur Verwendung bei der Behandlung von Entzündungskrankheiten |
LT3212629T (lt) * | 2014-10-31 | 2019-01-10 | Genoscience Pharma Sas | Pakeistieji 2,4 diamino-chinolinai, kaip nauji priešvėžiniai agentai |
DK3452465T3 (da) * | 2016-05-04 | 2021-02-08 | Genoscience Pharma | Substituerede 2,4-diaminoquinolinderivater til anvendelse til behandling af proliferative sygdomme |
US11091460B2 (en) * | 2017-06-14 | 2021-08-17 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Syk inhibitor and use method therefor |
EP3658560A4 (de) * | 2017-07-25 | 2021-01-06 | Crinetics Pharmaceuticals, Inc. | Somatostatinmodulatoren und verwendungen davon |
EP3620164A1 (de) * | 2018-09-05 | 2020-03-11 | Genoscience Pharma SAS | Substituiertes 2,4-diamino-chinolin als neues medikament erkrankungen im zusammenhang mit fibrose, autophagie und cathepsinen b (ctsb), l (ctsl) und d (ctsd) |
CN113166106B (zh) | 2018-12-14 | 2022-07-08 | 正大天晴药业集团股份有限公司 | 一种Syk抑制剂的盐及其结晶型 |
EP3669873A1 (de) | 2018-12-20 | 2020-06-24 | Abivax | Chinolinderivate zur verwendung bei der behandlung von entzündlichen krankheiten |
US11753413B2 (en) | 2020-06-19 | 2023-09-12 | Incyte Corporation | Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors |
US11691971B2 (en) | 2020-06-19 | 2023-07-04 | Incyte Corporation | Naphthyridinone compounds as JAK2 V617F inhibitors |
AU2021300429A1 (en) | 2020-07-02 | 2023-02-16 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
WO2022006456A1 (en) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Tricyclic pyridone compounds as jak2 v617f inhibitors |
WO2022046989A1 (en) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
WO2022140231A1 (en) | 2020-12-21 | 2022-06-30 | Incyte Corporation | Deazaguaine compounds as jak2 v617f inhibitors |
AR125273A1 (es) | 2021-02-25 | 2023-07-05 | Incyte Corp | Lactamas espirocíclicas como inhibidores de jak2 v617f |
WO2023099589A1 (en) * | 2021-12-01 | 2023-06-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Irap inhibitors for use in the treatment of inflammatory diseases |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE537104C (de) * | 1926-05-04 | 1933-03-17 | Chem Ind Basel | Verfahren zur Darstellung von substituierten Chinolincarbonsaeureamiden |
DE858698C (de) * | 1951-02-09 | 1952-12-08 | Basf Ag | Verfahren zur Herstellung von Pyridin- und Chinolinderivaten |
GB811957A (en) * | 1956-03-01 | 1959-04-15 | Geigy Ag J R | Improvements relating to 2-hydroxy-4-arylamino-quinolines |
WO1998018782A1 (en) * | 1996-10-28 | 1998-05-07 | Celltech Therapeutics Limited | 2-pyrimidineamine derivatives and processes for their preparation |
WO2002014269A2 (en) * | 2000-08-16 | 2002-02-21 | Neurogen Corporation | 2,4-substituted pyridine derivatives |
WO2003078404A1 (en) * | 2002-03-15 | 2003-09-25 | Novartis Ag | Pyrimidine derivatives |
WO2004002960A1 (en) * | 2002-06-27 | 2004-01-08 | Schering Aktiengesellschaft | Substituted quinoline ccr5 receptor antagonists |
WO2004081531A2 (en) * | 2003-03-10 | 2004-09-23 | Schering Corporation | Ligand analysis |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2472066A (en) * | 1949-06-07 | Z-arylamino-x-halogenoqtjinolines | ||
FR6103M (de) * | 1967-02-22 | 1968-06-10 | ||
US3755332A (en) * | 1971-07-01 | 1973-08-28 | Ciba Geigy Corp | Substituted 4 indazolaminoquinolines |
FR2538388B1 (fr) * | 1982-12-24 | 1985-06-21 | Pharmuka Lab | Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments |
JPH05310702A (ja) * | 1992-05-06 | 1993-11-22 | Kyowa Hakko Kogyo Co Ltd | 抗炎症剤、免疫調整剤およびキノリン−2,4−ジカルボン酸ジアミド誘導体 |
EP0975345A1 (de) * | 1997-11-26 | 2000-02-02 | Cerebrus Pharmaceuticals Limited | (-)-mefloquine zur blockierung der purinrezeptoren und zur behandlung von bewegung- oder neurodegenerativen erkrankungen |
US6303593B1 (en) * | 1999-03-02 | 2001-10-16 | Merck & Co., Inc. | 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity |
WO2000076982A1 (en) * | 1999-06-16 | 2000-12-21 | University Of Iowa Research Foundation | Antagonism of immunostimulatory cpg-oligonucleotides by 4-aminoquinolines and other weak bases |
US6593324B2 (en) * | 2000-03-01 | 2003-07-15 | Orion Corporation | Dervatives of quinoline as alpha-2 antagonists |
US6900226B2 (en) * | 2000-09-06 | 2005-05-31 | Hoffman-La Roche Inc. | Neuropeptide Y antagonists |
WO2002094789A1 (en) * | 2001-05-21 | 2002-11-28 | F. Hoffmann-La Roche Ag | Quinoline derivatives as ligands for the neuropeptide y receptor |
GB0118479D0 (en) * | 2001-07-28 | 2001-09-19 | Astrazeneca Ab | Novel compounds |
SE0102858D0 (sv) * | 2001-08-27 | 2001-08-27 | Astrazeneca Ab | N-type calcium channel antagonists for the treatment of pain |
-
2004
- 2004-03-10 WO PCT/US2004/007286 patent/WO2004080463A1/en active Application Filing
- 2004-03-10 CA CA002518398A patent/CA2518398A1/en not_active Abandoned
- 2004-03-10 MX MXPA05009722A patent/MXPA05009722A/es not_active Application Discontinuation
- 2004-03-10 EP EP04719237A patent/EP1601357A4/de not_active Withdrawn
- 2004-03-10 JP JP2006507031A patent/JP2006519846A/ja active Pending
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE537104C (de) * | 1926-05-04 | 1933-03-17 | Chem Ind Basel | Verfahren zur Darstellung von substituierten Chinolincarbonsaeureamiden |
DE858698C (de) * | 1951-02-09 | 1952-12-08 | Basf Ag | Verfahren zur Herstellung von Pyridin- und Chinolinderivaten |
GB811957A (en) * | 1956-03-01 | 1959-04-15 | Geigy Ag J R | Improvements relating to 2-hydroxy-4-arylamino-quinolines |
WO1998018782A1 (en) * | 1996-10-28 | 1998-05-07 | Celltech Therapeutics Limited | 2-pyrimidineamine derivatives and processes for their preparation |
WO2002014269A2 (en) * | 2000-08-16 | 2002-02-21 | Neurogen Corporation | 2,4-substituted pyridine derivatives |
WO2003078404A1 (en) * | 2002-03-15 | 2003-09-25 | Novartis Ag | Pyrimidine derivatives |
WO2004002960A1 (en) * | 2002-06-27 | 2004-01-08 | Schering Aktiengesellschaft | Substituted quinoline ccr5 receptor antagonists |
WO2004081531A2 (en) * | 2003-03-10 | 2004-09-23 | Schering Corporation | Ligand analysis |
Non-Patent Citations (5)
Title |
---|
HASEBE, M.; ET AL., TETRAHEDRON LETTERS, vol. 29, no. 48, 1988, pages 6287 - 6290, XP002445489 * |
ILLUMINATI, G.; GILMAN, H., J. AM. CHEM. SOC., vol. 71, 1949, pages 3349 - 3351, XP002445491 * |
SARGENT, H., J. AM. CHEM. SOC., vol. 68, 1964, pages 2688 - 2692, XP002445490 * |
See also references of WO2004080463A1 * |
WEISS, M.J.; HAUSER, C.R., J. AM. CHEM. SOC., vol. 71, 1949, pages 2026 - 2027, XP002445492 * |
Also Published As
Publication number | Publication date |
---|---|
WO2004080463A1 (en) | 2004-09-23 |
JP2006519846A (ja) | 2006-08-31 |
CA2518398A1 (en) | 2004-09-23 |
EP1601357A1 (de) | 2005-12-07 |
MXPA05009722A (es) | 2006-03-09 |
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