EP1670422A4 - Identifizierung von kinase-inhibitoren - Google Patents
Identifizierung von kinase-inhibitorenInfo
- Publication number
- EP1670422A4 EP1670422A4 EP03752561A EP03752561A EP1670422A4 EP 1670422 A4 EP1670422 A4 EP 1670422A4 EP 03752561 A EP03752561 A EP 03752561A EP 03752561 A EP03752561 A EP 03752561A EP 1670422 A4 EP1670422 A4 EP 1670422A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- identification
- kinase inhibitors
- kinase
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
- G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2003/029870 WO2005034840A2 (en) | 2003-09-17 | 2003-09-17 | Identification of kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1670422A2 EP1670422A2 (de) | 2006-06-21 |
EP1670422A4 true EP1670422A4 (de) | 2007-08-01 |
Family
ID=34434214
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03752561A Withdrawn EP1670422A4 (de) | 2003-09-17 | 2003-09-17 | Identifizierung von kinase-inhibitoren |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1670422A4 (de) |
AU (1) | AU2003270848A1 (de) |
CA (1) | CA2539064A1 (de) |
WO (1) | WO2005034840A2 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7713973B2 (en) | 2004-10-15 | 2010-05-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
JP2010505962A (ja) | 2006-10-09 | 2010-02-25 | 武田薬品工業株式会社 | キナーゼ阻害剤 |
RU2012114902A (ru) * | 2009-09-16 | 2013-10-27 | Авила Терапьютикс, Инк. | Конъюгаты и ингибиторы протеинкиназы |
CA2785738A1 (en) | 2009-12-30 | 2011-07-07 | Avila Therapeutics, Inc. | Ligand-directed covalent modification of protein |
ES2660239T3 (es) * | 2010-06-09 | 2018-03-21 | Dana-Farber Cancer Institute, Inc. | Una mutación de MEK1 que confiere resistencia a inhibidores de RAF y de MEK |
GB201614152D0 (en) | 2016-08-18 | 2016-10-05 | Imp Innovations Ltd | Assay |
WO2020176501A1 (en) * | 2019-02-25 | 2020-09-03 | Albert Einstein College Of Medicine | Compounds useful for inhibiting raf dimers |
CN116434828B (zh) * | 2023-04-17 | 2024-03-26 | 深圳新锐基因科技有限公司 | 基于计算结构生物学的蛋白分子动态二硫键的引入方法及装置 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002042773A2 (en) * | 2000-11-21 | 2002-05-30 | Sunesis Pharmaceuticals, Inc. | An extended tethering approach for rapid identification of ligands |
WO2003014308A2 (en) * | 2001-08-07 | 2003-02-20 | Sunesis Pharmaceuticals, Inc. | Cysteine mutants and methods for detecting ligand binding to biological molecules |
WO2003081210A2 (en) * | 2002-03-21 | 2003-10-02 | Sunesis Pharmaceuticals, Inc. | Identification of kinase inhibitors |
-
2003
- 2003-09-17 AU AU2003270848A patent/AU2003270848A1/en not_active Abandoned
- 2003-09-17 CA CA002539064A patent/CA2539064A1/en not_active Abandoned
- 2003-09-17 WO PCT/US2003/029870 patent/WO2005034840A2/en active Application Filing
- 2003-09-17 EP EP03752561A patent/EP1670422A4/de not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002042773A2 (en) * | 2000-11-21 | 2002-05-30 | Sunesis Pharmaceuticals, Inc. | An extended tethering approach for rapid identification of ligands |
WO2003014308A2 (en) * | 2001-08-07 | 2003-02-20 | Sunesis Pharmaceuticals, Inc. | Cysteine mutants and methods for detecting ligand binding to biological molecules |
WO2003081210A2 (en) * | 2002-03-21 | 2003-10-02 | Sunesis Pharmaceuticals, Inc. | Identification of kinase inhibitors |
Non-Patent Citations (2)
Title |
---|
ERLANSON DANIEL A ET AL: "MAKING DRUGS ON PROTEINS: SITE-DIRECTED LIGAND DISCOVERY FOR FRAGMENT-BASED LEAD ASSEMBLY", CURRENT OPINION IN CHEMICAL BIOLOGY, CURRENT BIOLOGY LTD, LONDON, GB, vol. 8, no. 4, August 2004 (2004-08-01), pages 399 - 406, XP009072514, ISSN: 1367-5931 * |
MALY D J ET AL: "Combinatorial target-guided ligand assembly: Identification of potent subtype-selective c-Src inhibitors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 14 MAR 2000 UNITED STATES, vol. 97, no. 6, 14 March 2000 (2000-03-14), pages 2419 - 2424, XP002199108, ISSN: 0027-8424 * |
Also Published As
Publication number | Publication date |
---|---|
WO2005034840A3 (en) | 2006-10-05 |
WO2005034840A2 (en) | 2005-04-21 |
CA2539064A1 (en) | 2005-04-21 |
WO2005034840A8 (en) | 2006-04-20 |
AU2003270848A1 (en) | 2005-04-27 |
EP1670422A2 (de) | 2006-06-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20060413 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK |
|
PUAK | Availability of information related to the publication of the international search report |
Free format text: ORIGINAL CODE: 0009015 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12Q 1/68 20060101ALI20061115BHEP Ipc: C12N 9/99 20060101AFI20061115BHEP |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20070704 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: G01N 33/566 20060101ALI20070628BHEP Ipc: C12Q 1/48 20060101AFI20070628BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20071003 |