EP1526173A3 - Virus enthaltende zusammensetzungen und Methoden zur Konzentration von Viruspräparaten - Google Patents

Virus enthaltende zusammensetzungen und Methoden zur Konzentration von Viruspräparaten Download PDF

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Publication number
EP1526173A3
EP1526173A3 EP04030394A EP04030394A EP1526173A3 EP 1526173 A3 EP1526173 A3 EP 1526173A3 EP 04030394 A EP04030394 A EP 04030394A EP 04030394 A EP04030394 A EP 04030394A EP 1526173 A3 EP1526173 A3 EP 1526173A3
Authority
EP
European Patent Office
Prior art keywords
methods
viruses
compositions
virus preparations
concentrating virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP04030394A
Other languages
English (en)
French (fr)
Other versions
EP1526173B1 (de
EP1526173A2 (de
Inventor
Andreas Frei
Henry Kwan
Varda E. Sandweiss
Gary J. Vellekamp
Pui-Ho Yuen
Laureano L. Bondoc, Jr.
Frederick William Porter, Iv
John Chu-Tay Tang
Peter Ihnat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of EP1526173A2 publication Critical patent/EP1526173A2/de
Publication of EP1526173A3 publication Critical patent/EP1526173A3/de
Application granted granted Critical
Publication of EP1526173B1 publication Critical patent/EP1526173B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10351—Methods of production or purification of viral material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP04030394A 1998-02-17 1999-02-12 Virus enthaltende zusammensetzungen und Methoden zur Konzentration von Viruspräparaten Expired - Lifetime EP1526173B1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2446298A 1998-02-17 1998-02-17
US24462 1998-02-17
US7964398A 1998-05-15 1998-05-15
US79643 1998-05-15
EP99906690A EP1054955B1 (de) 1998-02-17 1999-02-12 Virus enthaltende zusammensetzungen und methoden zur konzentration von viruspräparaten

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP99906690A Division EP1054955B1 (de) 1998-02-17 1999-02-12 Virus enthaltende zusammensetzungen und methoden zur konzentration von viruspräparaten
EP99906690.5 Division 1999-02-12

Publications (3)

Publication Number Publication Date
EP1526173A2 EP1526173A2 (de) 2005-04-27
EP1526173A3 true EP1526173A3 (de) 2005-08-10
EP1526173B1 EP1526173B1 (de) 2012-11-21

Family

ID=26698472

Family Applications (4)

Application Number Title Priority Date Filing Date
EP99906690A Expired - Lifetime EP1054955B1 (de) 1998-02-17 1999-02-12 Virus enthaltende zusammensetzungen und methoden zur konzentration von viruspräparaten
EP04030394A Expired - Lifetime EP1526173B1 (de) 1998-02-17 1999-02-12 Virus enthaltende zusammensetzungen und Methoden zur Konzentration von Viruspräparaten
EP04030395A Expired - Lifetime EP1526174B1 (de) 1998-02-17 1999-02-12 Virusenthaltende Zusammensetzungen und Methoden zur Konzentration von Viruspräparaten
EP06019642A Expired - Lifetime EP1741777B1 (de) 1998-02-17 1999-02-12 Virus enthaltende Zusammensetzungen und Methoden zur Konzentration von Viruspräparaten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP99906690A Expired - Lifetime EP1054955B1 (de) 1998-02-17 1999-02-12 Virus enthaltende zusammensetzungen und methoden zur konzentration von viruspräparaten

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP04030395A Expired - Lifetime EP1526174B1 (de) 1998-02-17 1999-02-12 Virusenthaltende Zusammensetzungen und Methoden zur Konzentration von Viruspräparaten
EP06019642A Expired - Lifetime EP1741777B1 (de) 1998-02-17 1999-02-12 Virus enthaltende Zusammensetzungen und Methoden zur Konzentration von Viruspräparaten

Country Status (25)

Country Link
EP (4) EP1054955B1 (de)
JP (3) JP4358434B2 (de)
KR (5) KR100912362B1 (de)
CN (2) CN100374551C (de)
AR (3) AR020054A1 (de)
AT (3) ATE478945T1 (de)
AU (1) AU757976B2 (de)
BR (1) BR9908015A (de)
CA (2) CA2723040A1 (de)
CO (1) CO4820440A1 (de)
DE (3) DE69933433T2 (de)
DK (1) DK1054955T3 (de)
ES (2) ES2272053T3 (de)
HK (3) HK1073481A1 (de)
HU (1) HU226015B1 (de)
ID (1) ID28298A (de)
IL (2) IL137510A0 (de)
MY (1) MY141641A (de)
NO (1) NO20004104L (de)
PE (1) PE20000265A1 (de)
PL (1) PL197747B1 (de)
PT (1) PT1054955E (de)
SK (1) SK11842000A3 (de)
TW (1) TWI232107B (de)
WO (1) WO1999041416A2 (de)

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US7732129B1 (en) 1998-12-01 2010-06-08 Crucell Holland B.V. Method for the production and purification of adenoviral vectors
EP1133316B1 (de) * 1998-11-16 2009-01-21 Introgen Therapeutics, Inc. Adenovirus-formulierungen zur gentherapie
US6689600B1 (en) 1998-11-16 2004-02-10 Introgen Therapeutics, Inc. Formulation of adenovirus for gene therapy
AU4346101A (en) * 2000-03-07 2001-09-17 Merck & Co., Inc. Adenovirus formulations
US7456009B2 (en) 2000-03-07 2008-11-25 Merck & Co., Inc. Adenovirus formulations
US20020064860A1 (en) 2000-11-29 2002-05-30 Schering Corporation Method for purifying adenoviruses
WO2002047726A2 (en) * 2000-12-12 2002-06-20 Japan Tobacco Inc. Pharmaceutical composition containing an active with a hemolytic action and a surfactant
EP1453536A4 (de) 2001-12-12 2009-08-26 Mayne Pharma Int Pty Ltd Zusammensetzung zur konservierung von viren
US20030153065A1 (en) * 2002-01-14 2003-08-14 Genvec, Inc. Composition and method for maintaining non-enveloped viral vectors
US20030232018A1 (en) * 2002-01-18 2003-12-18 Berlex Biosciences Stabilized formulations of adenovirus
AU2005214090B2 (en) 2004-02-23 2008-09-11 Crucell Holland B.V. Virus purification methods
CA2586107A1 (en) 2004-11-03 2006-05-18 Introgen Therapeutics Inc. A novel method for the production and purification of adenoviral vectors
JP4621743B2 (ja) 2004-12-13 2011-01-26 カンジ，インコーポレイテッド 複製欠損アデノウイルスの産生のための細胞株
CN101155915B (zh) 2005-04-11 2013-12-04 克鲁塞尔荷兰公司 利用超滤进行病毒纯化
CN1961961B (zh) * 2005-11-11 2010-05-26 深圳市源兴生物医药科技有限公司 一种药物制剂及其制备方法
JP5097714B2 (ja) 2005-12-12 2012-12-12 カンジ，インコーポレイテッド Ｅ１領域内の発現カセットと不活性化されたｅ２ｂポリメラーゼを有するアデノウイルス発現ベクター
AU2007240797B2 (en) * 2006-04-20 2013-05-23 Wyeth Llc Purification processes for isolating purified vesicular stomatitis virus from cell culture
ES2532015T3 (es) 2008-11-03 2015-03-23 Crucell Holland B.V. Método para la producción de vectores adenovíricos
JP5879256B2 (ja) 2009-05-02 2016-03-08 ジェンザイム・コーポレーション 神経変性障害のための遺伝子治療
WO2011098592A1 (en) 2010-02-15 2011-08-18 Crucell Holland B.V. Method for the production of ad26 adenoviral vectors
US8771709B2 (en) 2010-09-20 2014-07-08 Crucell Holland B.V. Therapeutic vaccination against active Tuberculosis
US9168292B2 (en) 2010-09-27 2015-10-27 Crucell Holland B.V. Heterologous prime boost vaccination regimen against malaria
AU2011336410B2 (en) 2010-12-02 2015-01-22 Oncolytics Biotech Inc. Lyophilized viral formulations
WO2012075379A2 (en) 2010-12-02 2012-06-07 Oncolytics Biotech Inc. Liquid viral formulations
EA201391605A1 (ru) * 2011-04-29 2014-02-28 Онколитикс Байотек Инк. Способы очистки вирусов с использованием гельпроникающей хроматографии
US8932607B2 (en) 2012-03-12 2015-01-13 Crucell Holland B.V. Batches of recombinant adenovirus with altered terminal ends
CN104379733B (zh) 2012-03-12 2016-01-20 克鲁塞尔荷兰公司 具改变末端的重组腺病毒群
US9125870B2 (en) 2012-03-22 2015-09-08 Crucell Holland B.V. Vaccine against RSV
MY169352A (en) 2012-03-22 2019-03-25 Janssen Vaccines & Prevention Bv Vaccine against rsv
MX361774B (es) 2013-04-25 2018-12-17 Janssen Vaccines & Prevention Bv Polipéptidos f de prefusión del virus sincicial respiratorio (rsv) solubles y estabilizados.
PE20160045A1 (es) 2013-06-17 2016-02-18 Crucell Holland Bv Polipeptidos f de prefusion del virus sincicial respiratorio (rsv) solubles y estabilizados
KR20170004966A (ko) * 2014-05-28 2017-01-11 에이전시 포 사이언스, 테크놀로지 앤드 리서치 바이러스 감소 방법
US10570417B2 (en) 2015-04-14 2020-02-25 Janssen Vaccines & Prevention B.V. Recombinant adenovirus expressing two transgenes with a bidirectional promoter
JP6840718B2 (ja) 2015-07-07 2021-03-10 ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． 安定化された可溶性融合前ｒｓｖ ｆポリペプチド
WO2017005844A1 (en) 2015-07-07 2017-01-12 Janssen Vaccines & Prevention B.V. Vaccine against rsv
AU2017248021B2 (en) 2016-04-05 2021-08-12 Janssen Vaccines & Prevention B.V. Stabilized soluble pre-fusion RSV F proteins
BR112018070323A2 (pt) 2016-04-05 2019-01-29 Janssen Vaccines & Prevention Bv vacina contra rsv
WO2017207480A1 (en) 2016-05-30 2017-12-07 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion rsv f proteins
US11001858B2 (en) 2016-06-20 2021-05-11 Janssen Vaccines & Prevention B.V. Potent and balanced bidirectional promoter
WO2018011196A1 (en) 2016-07-14 2018-01-18 Janssen Vaccines & Prevention B.V. Hpv vaccines
WO2018210871A1 (en) 2017-05-17 2018-11-22 Janssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against rsv infection
EP3624844A1 (de) 2017-05-17 2020-03-25 Janssen Vaccines & Prevention B.V. Verfahren und zusammensetzungen zur induzierung schützender immunität gegen rsv-infektionen
WO2019021305A1 (en) * 2017-07-24 2019-01-31 Ella Foundation VACCINE AGAINST FOOT AND MOUTH DISEASE
EP3681533A1 (de) 2017-09-15 2020-07-22 Janssen Vaccines & Prevention B.V. Verfahren zur sicheren induktion der immunität gegen rsv
CN114173827A (zh) * 2019-06-28 2022-03-11 武田药品工业株式会社 腺相关病毒纯化方法
JP2023512519A (ja) 2020-01-31 2023-03-27 ベス イスラエル ディーコネス メディカル センター インコーポレイテッド コロナウイルス感染症を予防および処置するための組成物および方法－ｓａｒｓ－ｃｏｖ－２ワクチン
WO2022175477A1 (en) 2021-02-19 2022-08-25 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion rsv fb antigens
WO2023020556A1 (zh) * 2021-08-17 2023-02-23 上海行深生物科技有限公司 病毒制剂、用于配制病毒制剂的溶液及其用途
WO2023020939A1 (en) 2021-08-17 2023-02-23 Janssen Pharmaceuticals, Inc. Sars-cov-2 vaccines
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BE866330A (fr) * 1978-04-25 1978-10-25 Merck & Co Inc Procede de fabrication d'un agent de stabilisation de vaccin
DD295927A5 (de) * 1988-05-06 1991-11-14 Saechsisches Serumwerk Gmbh Dresden, Immobilisiertes immunologisch aktives reagens
WO1997025072A1 (en) * 1996-01-08 1997-07-17 Canji, Inc. Compositions and methods for therapeutic use

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BE866330A (fr) * 1978-04-25 1978-10-25 Merck & Co Inc Procede de fabrication d'un agent de stabilisation de vaccin
DD295927A5 (de) * 1988-05-06 1991-11-14 Saechsisches Serumwerk Gmbh Dresden, Immobilisiertes immunologisch aktives reagens
WO1997025072A1 (en) * 1996-01-08 1997-07-17 Canji, Inc. Compositions and methods for therapeutic use

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Also Published As

Publication number Publication date
ATE341614T1 (de) 2006-10-15
HK1028416A1 (en) 2001-02-16
JP2006166925A (ja) 2006-06-29
KR20010072547A (ko) 2001-07-31
CN100374551C (zh) 2008-03-12
WO1999041416A2 (en) 1999-08-19
KR100912362B1 (ko) 2009-08-19
ATE371020T1 (de) 2007-09-15
KR20090038927A (ko) 2009-04-21
EP1054955A2 (de) 2000-11-29
EP1741777A1 (de) 2007-01-10
EP1526173B1 (de) 2012-11-21
AR020054A1 (es) 2002-04-10
EP1741777B1 (de) 2010-08-25
AU757976B2 (en) 2003-03-13
EP1526173A2 (de) 2005-04-27
DE69936948T2 (de) 2008-05-15
NO20004104D0 (no) 2000-08-16
BR9908015A (pt) 2001-04-24
PE20000265A1 (es) 2000-04-25
KR20080065615A (ko) 2008-07-14
EP1054955B1 (de) 2006-10-04
PL342847A1 (en) 2001-07-16
CA2320419A1 (en) 1999-08-19
JP4358434B2 (ja) 2009-11-04
ES2290613T3 (es) 2008-02-16
AR063315A2 (es) 2009-01-21
CO4820440A1 (es) 1999-07-28
HK1073481A1 (en) 2005-10-07
ID28298A (id) 2001-05-10
PL197747B1 (pl) 2008-04-30
DK1054955T3 (da) 2007-01-15
NO20004104L (no) 2000-10-17
MY141641A (en) 2010-05-31
CN1297478A (zh) 2001-05-30
KR100862169B1 (ko) 2008-10-09
AR063314A2 (es) 2009-01-21
HU226015B1 (en) 2008-02-28
CA2320419C (en) 2011-02-08
DE69933433T2 (de) 2007-08-23
DE69933433D1 (de) 2006-11-16
CN101164623A (zh) 2008-04-23
HUP0100670A3 (en) 2003-10-28
CN101164623B (zh) 2012-11-14
IL137510A (en) 2012-10-31
TWI232107B (en) 2005-05-11
KR20090127947A (ko) 2009-12-14
IL137510A0 (en) 2001-07-24
KR100918187B1 (ko) 2009-09-22
PT1054955E (pt) 2007-01-31
HK1097413A1 (en) 2007-06-22
JP2010213727A (ja) 2010-09-30
EP1526174A2 (de) 2005-04-27
ATE478945T1 (de) 2010-09-15
CA2723040A1 (en) 1999-08-19
DE69942708D1 (de) 2010-10-07
KR100991683B1 (ko) 2010-11-04
WO1999041416A3 (en) 1999-11-18
SK11842000A3 (sk) 2001-05-10
HUP0100670A2 (hu) 2001-06-28
JP2002503484A (ja) 2002-02-05
EP1526174B1 (de) 2007-08-22
DE69936948D1 (de) 2007-10-04
AU2653899A (en) 1999-08-30
KR20080065614A (ko) 2008-07-14
EP1526174A3 (de) 2005-08-31
KR101018992B1 (ko) 2011-03-07
ES2272053T3 (es) 2007-04-16

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