EP0684823A4 - Fibrinogen receptor antagonists. - Google Patents

Fibrinogen receptor antagonists.

Info

Publication number: EP0684823A4
Authority: EP; European Patent Office
Prior art keywords: receptor antagonists; fibrinogen receptor; fibrinogen; antagonists; receptor
Prior art date: 1993-02-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP94909745A

Other languages

German (de)

French (fr)

Other versions

EP0684823A1 (en

Inventor

David Alan Claremon

John J Baldwin

Nigel Liverton

Ben Askew

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-22

Filing date

1994-02-22

Publication date

1997-07-09

1994-02-22 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

1995-12-06 Publication of EP0684823A1 publication Critical patent/EP0684823A1/en

1997-07-09 Publication of EP0684823A4 publication Critical patent/EP0684823A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- A61K38/166—Streptokinase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

EP94909745A 1993-02-22 1994-02-22 Fibrinogen receptor antagonists. Withdrawn EP0684823A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US2051793A	1993-02-22	1993-02-22
US20517		1993-02-22
PCT/US1994/001881 WO1994018981A1 (en)	1993-02-22	1994-02-22	Fibrinogen receptor antagonists

Publications (2)

Publication Number	Publication Date
EP0684823A1 EP0684823A1 (en)	1995-12-06
EP0684823A4 true EP0684823A4 (en)	1997-07-09

Family

ID=21799049

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP94909745A Withdrawn EP0684823A4 (en)	1993-02-22	1994-02-22	Fibrinogen receptor antagonists.

Country Status (15)

Country	Link
EP (1)	EP0684823A4 (en)
JP (1)	JP3173792B2 (en)
KR (1)	KR960700722A (en)
CN (1)	CN1118139A (en)
AU (1)	AU680240B2 (en)
BG (1)	BG99863A (en)
CA (1)	CA2155123A1 (en)
CZ (1)	CZ210895A3 (en)
FI (1)	FI953916A0 (en)
HU (1)	HUT71796A (en)
NO (1)	NO953270L (en)
NZ (1)	NZ262664A (en)
PL (1)	PL310386A1 (en)
SK (1)	SK102495A3 (en)
WO (1)	WO1994018981A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5849736A (en) *	1993-11-24	1998-12-15	The Dupont Merck Pharmaceutical Company	Isoxazoline and isoxazole fibrinogen receptor antagonists
US5494921A (en) *	1994-09-16	1996-02-27	Merck & Co., Inc.	Fibrinogen receptor antagonists
ZA963391B (en) *	1995-05-24	1997-10-29	Du Pont Merck Pharma	Isoxazoline fibrinogen receptor antagonists.
US6100423A (en) *	1995-08-30	2000-08-08	G. D. Searle & Co.	Amino benzenepropanoic acid compounds and derivatives thereof
CA2230209A1 (en) *	1995-08-30	1997-03-06	G.D. Searle & Co.	Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid derivatives as integrin antagonists
JPH11512723A (en)	1995-09-29	1999-11-02	イーライリリーアンドカンパニー	Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation
EP0939757A1 (en) *	1995-12-22	1999-09-08	Dupont Pharmaceuticals Company	Novel integrin receptor antagonists
AU2340997A (en) *	1996-03-27	1997-10-17	Merck & Co., Inc.	A method for inhibiting clot formation
KR100504449B1 (en) *	1996-07-25	2005-07-29	바이오겐 아이덱 엠에이 인코포레이티드	Cell adhesion inhibitors
US5900414A (en) *	1996-08-29	1999-05-04	Merck & Co., Inc.	Methods for administering integrin receptor antagonists
DE19653647A1 (en) *	1996-12-20	1998-06-25	Hoechst Ag	Vitronectin receptor antagonists, their preparation and their use
EP1023295A4 (en) *	1997-02-06	2001-01-24	Merck & Co Inc	Fibrinogen receptor antagonist prodrugs
US6214834B1 (en)	1997-03-28	2001-04-10	Dupont Pharmaceuticals Company	Integrin inhibitor prodrugs
US6303625B1 (en) *	1998-07-27	2001-10-16	Ortho-Mcneil Pharmaceutical, Inc.	Triazolopyridines for the treatment of thrombosis disorders
JP4829449B2 (en) *	1999-07-28	2011-12-07	アベンティス・ファーマスーティカルズ・インコーポレイテツド	Substituted oxoazaheterocyclyl compounds
BR0317525A (en) *	2002-12-20	2005-11-16	Pharmacia Corp	Acyclic pyrazole compounds, therapeutic and pharmaceutical composition, kit, as well as their uses
EP2046788A1 (en) *	2006-07-12	2009-04-15	Syngeta Participations AG	Triazolopyridine derivatives as herbicides
BRPI0910987A2 (en) *	2008-04-04	2017-03-21	Gilead Sciences Inc	triazolopyridinone derivatives for use as stearoyl coa desaturase inhibitors
WO2010096722A1 (en) *	2009-02-20	2010-08-26	Takeda Pharmaceutical Company Limited	3-oxo-2, 3-dihydro- [1,2, 4] triazolo [4, 3-a]pyridines as soluble epoxide hydrolase (seh) inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0381033A1 (en) *	1989-01-31	1990-08-08	F. Hoffmann-La Roche Ag	Carboxylic-acid and sulphonic-acid amides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8913011D0 (en) *	1989-06-06	1989-07-26	Wellcome Found	Anticonvulsant pyrazines
US5166154A (en) *	1989-10-17	1992-11-24	Boehringer Ingelheim Pharmaceuticals, Inc.	Imidazo[1,2-a]piperazines
US5278161A (en) *	1990-06-28	1994-01-11	Hoffmann-La Roche Inc.	Amino acid derivatives useful as renin inhibitors

1994
- 1994-02-22 HU HU9502028A patent/HUT71796A/en unknown
- 1994-02-22 CA CA002155123A patent/CA2155123A1/en not_active Abandoned
- 1994-02-22 CN CN94191248A patent/CN1118139A/en active Pending
- 1994-02-22 WO PCT/US1994/001881 patent/WO1994018981A1/en not_active Application Discontinuation
- 1994-02-22 PL PL94310386A patent/PL310386A1/en unknown
- 1994-02-22 NZ NZ262664A patent/NZ262664A/en unknown
- 1994-02-22 AU AU62465/94A patent/AU680240B2/en not_active Ceased
- 1994-02-22 EP EP94909745A patent/EP0684823A4/en not_active Withdrawn
- 1994-02-22 SK SK1024-95A patent/SK102495A3/en unknown
- 1994-02-22 CZ CZ952108A patent/CZ210895A3/en unknown
- 1994-02-22 JP JP51922094A patent/JP3173792B2/en not_active Expired - Fee Related
1995
- 1995-08-15 BG BG99863A patent/BG99863A/en unknown
- 1995-08-21 NO NO953270A patent/NO953270L/en unknown
- 1995-08-21 FI FI953916A patent/FI953916A0/en not_active Application Discontinuation
- 1995-08-21 KR KR1019950703563A patent/KR960700722A/en not_active Application Discontinuation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0381033A1 (en) *	1989-01-31	1990-08-08	F. Hoffmann-La Roche Ag	Carboxylic-acid and sulphonic-acid amides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
B.C. ASKEW ET AL.: "Non-peptide glycoprotein IIb/IIIa inhibitors.", BIOORG. MED. CHEM. LETT., vol. 5, no. 5, 1995, pages 475 - 480, XP000670733 *
See also references of WO9418981A1 *

Also Published As

Publication number	Publication date
JP3173792B2 (en)	2001-06-04
JPH08507072A (en)	1996-07-30
AU680240B2 (en)	1997-07-24
CZ210895A3 (en)	1996-02-14
SK102495A3 (en)	1997-01-08
NO953270L (en)	1995-10-19
HU9502028D0 (en)	1995-09-28
KR960700722A (en)	1996-02-24
FI953916A (en)	1995-08-21
NO953270D0 (en)	1995-08-21
PL310386A1 (en)	1995-12-11
HUT71796A (en)	1996-02-28
CA2155123A1 (en)	1994-09-01
AU6246594A (en)	1994-09-14
EP0684823A1 (en)	1995-12-06
FI953916A0 (en)	1995-08-21
WO1994018981A1 (en)	1994-09-01
CN1118139A (en)	1996-03-06
NZ262664A (en)	1997-04-24
BG99863A (en)	1996-02-29

Legal Events

Date	Code	Title	Description
1995-10-20	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1995-12-06	17P	Request for examination filed	Effective date: 19950922
1995-12-06	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
1997-07-09	A4	Supplementary search report drawn up and despatched	Effective date: 19970522
1997-07-09	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
1998-11-25	17Q	First examination report despatched	Effective date: 19981014
2001-06-19	GRAG	Despatch of communication of intention to grant	Free format text: ORIGINAL CODE: EPIDOS AGRA
2001-10-08	GRAG	Despatch of communication of intention to grant	Free format text: ORIGINAL CODE: EPIDOS AGRA
2001-10-08	GRAH	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOS IGRA
2002-06-28	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2002-08-14	18D	Application deemed to be withdrawn	Effective date: 20020122

Publication	Publication Date	Title
EP0673247A4 (en)	1996-05-01	Fibrinogen receptor antagonists.
EP0667773A4 (en)	1996-09-25	Fibrinogen receptor antagonists.
GB9405317D0 (en)	1994-04-27	Fibrinogen receptor antagonists
AU1441695A (en)	1995-07-10	Fibrinogen receptor antagonists
AU3665793A (en)	1993-09-13	Fibrinogen receptor antagonists
EP0912175A4 (en)	1999-09-08	Fibrinogen receptor antagonists
EP0810994A4 (en)	1998-05-06	Fibrinogen receptor antagonists
EP0676959A4 (en)	1996-01-03	Endothelin receptor antagonists.
IL111431A0 (en)	1994-12-29	Endothelin receptor antagonists
EP0702671A4 (en)	1996-06-19	Bicyclic fibrinogen antagonists
EP0866705A4 (en)	1999-03-03	Fibrinogen receptor antagonists
EP0668075A3 (en)	1996-10-16	Non-peptide tachykinin receptor antagonists.
PH31071A (en)	1998-02-05	Substituted pyrridopyrimidines useful antgiotensinII antagonists.
EP0479481A3 (en)	1993-07-28	Fibrinogen receptor antagonists
EP0885205A4 (en)	2002-11-27	Fibrinogen receptor antagonists
EP0684823A4 (en)	1997-07-09	Fibrinogen receptor antagonists.
EP0885213A4 (en)	1999-04-28	Fibrinogen receptor antagonists
HU9501931D0 (en)	1995-09-28	Endothelin receptor antagonists
EP0796098A4 (en)	1998-04-29	Fibrinogen receptor antagonists
EP0801650A4 (en)	1998-05-06	Fibrinogen receptor antagonists
AU5322994A (en)	1994-05-09	Fibrinogen receptor antagonists
EP0794779A4 (en)	1998-04-29	Fibrinogen receptor antagonists
GB9320799D0 (en)	1993-12-01	Fibrinogen receptor antagonists
GB9515852D0 (en)	1995-10-04	Fibrinogen receptor antagonists
ZA963391B (en)	1997-10-29	Isoxazoline fibrinogen receptor antagonists.