BG99863A - Antagonists of fibrogenous receptor - Google Patents

Antagonists of fibrogenous receptor

Info

Publication number
BG99863A
BG99863A BG99863A BG9986395A BG99863A BG 99863 A BG99863 A BG 99863A BG 99863 A BG99863 A BG 99863A BG 9986395 A BG9986395 A BG 9986395A BG 99863 A BG99863 A BG 99863A
Authority
BG
Bulgaria
Prior art keywords
receptor
fibrogenous
antagonists
compounds
formula
Prior art date
Application number
BG99863A
Other languages
Bulgarian (bg)
Inventor
David Claremon
John Baldwin
Nigel Liverton
Ben Askew
Original Assignee
John Baldwin
Nigel Liverton
Ben Askew
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Baldwin, Nigel Liverton, Ben Askew, Merck & Co. Inc. filed Critical John Baldwin
Publication of BG99863A publication Critical patent/BG99863A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A61K38/166—Streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Съединенията притежават антагонистична активност по отношение на фибриногеновия рецептор. Те имат формула или напримерThe compounds have antagonistic activity with respect to the fibrinogen receptor. They have a formula or for example

BG99863A 1993-02-22 1995-08-15 Antagonists of fibrogenous receptor BG99863A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2051793A 1993-02-22 1993-02-22
PCT/US1994/001881 WO1994018981A1 (en) 1993-02-22 1994-02-22 Fibrinogen receptor antagonists

Publications (1)

Publication Number Publication Date
BG99863A true BG99863A (en) 1996-02-29

Family

ID=21799049

Family Applications (1)

Application Number Title Priority Date Filing Date
BG99863A BG99863A (en) 1993-02-22 1995-08-15 Antagonists of fibrogenous receptor

Country Status (15)

Country Link
EP (1) EP0684823A4 (en)
JP (1) JP3173792B2 (en)
KR (1) KR960700722A (en)
CN (1) CN1118139A (en)
AU (1) AU680240B2 (en)
BG (1) BG99863A (en)
CA (1) CA2155123A1 (en)
CZ (1) CZ210895A3 (en)
FI (1) FI953916A0 (en)
HU (1) HUT71796A (en)
NO (1) NO953270L (en)
NZ (1) NZ262664A (en)
PL (1) PL310386A1 (en)
SK (1) SK102495A3 (en)
WO (1) WO1994018981A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849736A (en) * 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
US5494921A (en) * 1994-09-16 1996-02-27 Merck & Co., Inc. Fibrinogen receptor antagonists
ZA963391B (en) * 1995-05-24 1997-10-29 Du Pont Merck Pharma Isoxazoline fibrinogen receptor antagonists.
CZ293323B6 (en) * 1995-08-30 2004-04-14 G. D. Searle & Co. Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid derivatives as integrin antagonists
US6100423A (en) * 1995-08-30 2000-08-08 G. D. Searle & Co. Amino benzenepropanoic acid compounds and derivatives thereof
AU713235B2 (en) 1995-09-29 1999-11-25 Cor Therapeutics, Inc. Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation
EP0939757A1 (en) * 1995-12-22 1999-09-08 Dupont Pharmaceuticals Company Novel integrin receptor antagonists
WO1997035579A1 (en) * 1996-03-27 1997-10-02 Merck & Co., Inc. A method for inhibiting clot formation
SK8199A3 (en) * 1996-07-25 2000-04-10 Biogen Inc Cell adhesion inhibitors, preparation method thereof and pharmaceutical composition with their content
US5900414A (en) * 1996-08-29 1999-05-04 Merck & Co., Inc. Methods for administering integrin receptor antagonists
DE19653647A1 (en) * 1996-12-20 1998-06-25 Hoechst Ag Vitronectin receptor antagonists, their preparation and their use
CA2279927A1 (en) * 1997-02-06 1998-08-13 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
WO1998043962A1 (en) * 1997-03-28 1998-10-08 Du Pont Pharmaceuticals Company Heterocyclic integrin inhibitor prodrugs
US6303625B1 (en) * 1998-07-27 2001-10-16 Ortho-Mcneil Pharmaceutical, Inc. Triazolopyridines for the treatment of thrombosis disorders
JP4829449B2 (en) * 1999-07-28 2011-12-07 アベンティス・ファーマスーティカルズ・インコーポレイテツド Substituted oxoazaheterocyclyl compounds
JP2006514043A (en) * 2002-12-20 2006-04-27 ファルマシア・コーポレーション Mitogen-activated protein kinase-compound that inhibits activated protein kinase-2
US20100035756A1 (en) * 2006-07-12 2010-02-11 Syngenta Limited Triazolophyridine derivatives as herbicides
BRPI0910987A2 (en) * 2008-04-04 2017-03-21 Gilead Sciences Inc triazolopyridinone derivatives for use as stearoyl coa desaturase inhibitors
WO2010096722A1 (en) * 2009-02-20 2010-08-26 Takeda Pharmaceutical Company Limited 3-oxo-2, 3-dihydro- [1,2, 4] triazolo [4, 3-a]pyridines as soluble epoxide hydrolase (seh) inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084466A (en) * 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
GB8913011D0 (en) * 1989-06-06 1989-07-26 Wellcome Found Anticonvulsant pyrazines
US5166154A (en) * 1989-10-17 1992-11-24 Boehringer Ingelheim Pharmaceuticals, Inc. Imidazo[1,2-a]piperazines
US5278161A (en) * 1990-06-28 1994-01-11 Hoffmann-La Roche Inc. Amino acid derivatives useful as renin inhibitors

Also Published As

Publication number Publication date
KR960700722A (en) 1996-02-24
FI953916A (en) 1995-08-21
AU680240B2 (en) 1997-07-24
JP3173792B2 (en) 2001-06-04
CZ210895A3 (en) 1996-02-14
PL310386A1 (en) 1995-12-11
HUT71796A (en) 1996-02-28
EP0684823A1 (en) 1995-12-06
CN1118139A (en) 1996-03-06
SK102495A3 (en) 1997-01-08
EP0684823A4 (en) 1997-07-09
HU9502028D0 (en) 1995-09-28
WO1994018981A1 (en) 1994-09-01
NO953270D0 (en) 1995-08-21
JPH08507072A (en) 1996-07-30
CA2155123A1 (en) 1994-09-01
AU6246594A (en) 1994-09-14
NZ262664A (en) 1997-04-24
FI953916A0 (en) 1995-08-21
NO953270L (en) 1995-10-19

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