EP0676959A4 - Endothelin receptor antagonists. - Google Patents
Endothelin receptor antagonists.Info
- Publication number
- EP0676959A4 EP0676959A4 EP94904877A EP94904877A EP0676959A4 EP 0676959 A4 EP0676959 A4 EP 0676959A4 EP 94904877 A EP94904877 A EP 94904877A EP 94904877 A EP94904877 A EP 94904877A EP 0676959 A4 EP0676959 A4 EP 0676959A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- receptor antagonists
- endothelin receptor
- endothelin
- antagonists
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99546692A | 1992-12-22 | 1992-12-22 | |
US995466 | 1992-12-22 | ||
PCT/US1993/012435 WO1994014434A1 (en) | 1992-12-22 | 1993-12-21 | Endothelin receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0676959A1 EP0676959A1 (en) | 1995-10-18 |
EP0676959A4 true EP0676959A4 (en) | 1996-01-03 |
Family
ID=25541843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94904877A Withdrawn EP0676959A4 (en) | 1992-12-22 | 1993-12-21 | Endothelin receptor antagonists. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0676959A4 (en) |
JP (1) | JPH08504826A (en) |
CN (1) | CN1096513A (en) |
AU (1) | AU5873594A (en) |
MX (1) | MX9400071A (en) |
WO (1) | WO1994014434A1 (en) |
ZA (1) | ZA939516B (en) |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5767310A (en) * | 1993-03-19 | 1998-06-16 | Merck & Co., Inc. | Phenoxyphenylacetic acid derivatives |
US5686478A (en) * | 1993-07-20 | 1997-11-11 | Merck & Co. Inc. | Endothelin antagonists |
US5767144A (en) * | 1994-08-19 | 1998-06-16 | Abbott Laboratories | Endothelin antagonists |
US6162927A (en) | 1994-08-19 | 2000-12-19 | Abbott Laboratories | Endothelin antagonists |
US7208517B1 (en) | 1994-08-19 | 2007-04-24 | Abbott Labortories | Endothelin antagonists |
US5538991A (en) * | 1994-09-14 | 1996-07-23 | Merck & Co., Inc. | Endothelin antagonists bearing 5-membered heterocyclic amides |
US5559135A (en) * | 1994-09-14 | 1996-09-24 | Merck & Co., Inc. | Endothelin antagonists bearing pyridyl amides |
US5482960A (en) * | 1994-11-14 | 1996-01-09 | Warner-Lambert Company | Nonpeptide endothelin antagonists |
EP0800389A4 (en) * | 1994-12-13 | 1998-04-29 | Smithkline Beecham Corp | Novel compounds |
US5684032A (en) * | 1994-12-13 | 1997-11-04 | Smithkline Beecham Corporation | Compounds |
DE19527568A1 (en) | 1995-07-28 | 1997-01-30 | Merck Patent Gmbh | Endothelin receptor antagonists |
DE19528418A1 (en) * | 1995-08-02 | 1997-02-06 | Merck Patent Gmbh | Endothelin receptor antagonists |
FR2740773B1 (en) * | 1995-11-08 | 1997-12-19 | Roussel Uclaf | NOVEL IMIDAZOLE DERIVATIVES, PREPARATION PROCESS, INTERMEDIATES OBTAINED, APPLICATION AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE |
DE19530032A1 (en) * | 1995-08-16 | 1997-02-20 | Merck Patent Gmbh | Endothelin receptor antagonists |
DE19537548A1 (en) * | 1995-10-09 | 1997-04-10 | Merck Patent Gmbh | Endothelin receptor antagonists |
FR2740774B1 (en) * | 1995-11-08 | 1997-12-19 | Roussel Uclaf | NOVEL IMIDAZOLE N-BENZYLDIOXOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NEW USE |
DE19543639A1 (en) * | 1995-11-23 | 1997-05-28 | Merck Patent Gmbh | Endothelin receptor antagonists |
JP2000507556A (en) * | 1996-03-28 | 2000-06-20 | スミスクライン・ビーチャム・コーポレイション | Chemokine carboxylate indole inhibitors |
GB9609641D0 (en) * | 1996-05-09 | 1996-07-10 | Pfizer Ltd | Compounds useful in therapy |
US6180643B1 (en) | 1996-11-19 | 2001-01-30 | Amgen Inc. | Aryl and heteroaryl substituted fused pyrrole antiinflammatory agents |
US7008950B1 (en) | 1997-06-05 | 2006-03-07 | Takeda Chemical Industries, Ltd. | Benzofurans as suppressors of neurodegeneration |
GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
GB9803226D0 (en) | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
GB9902453D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902452D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902459D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902455D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
US6462032B1 (en) | 1999-05-04 | 2002-10-08 | Wyeth | Cyclic regimens utilizing indoline derivatives |
US6399593B1 (en) | 1999-05-04 | 2002-06-04 | Wyeth | Cyclic regimens using cyclic urea and cyclic amide derivatives |
US6417214B1 (en) * | 1999-05-04 | 2002-07-09 | Wyeth | 3,3-substituted indoline derivatives |
US6380235B1 (en) | 1999-05-04 | 2002-04-30 | American Home Products Corporation | Benzimidazolones and analogues |
US6358948B1 (en) | 1999-05-04 | 2002-03-19 | American Home Products Corporation | Quinazolinone and benzoxazine derivatives as progesterone receptor modulators |
US6306851B1 (en) | 1999-05-04 | 2001-10-23 | American Home Products Corporation | Cyclocarbamate and cyclic amide derivatives |
US6498154B1 (en) | 1999-05-04 | 2002-12-24 | Wyeth | Cyclic regimens using quinazolinone and benzoxazine derivatives |
US6509334B1 (en) | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
US6329416B1 (en) | 1999-05-04 | 2001-12-11 | American Home Products Corporation | Combination regimens using 3,3-substituted indoline derivatives |
US6369056B1 (en) | 1999-05-04 | 2002-04-09 | American Home Products Corporation | Cyclic urea and cyclic amide derivatives |
US6355648B1 (en) | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
US6358947B1 (en) | 1999-05-04 | 2002-03-19 | American Home Products Corporation | Tetracyclic progesterone receptor modulator compounds and methods |
US6319912B1 (en) | 1999-05-04 | 2001-11-20 | American Home Products Corporation | Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides |
US6391907B1 (en) | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
US6380178B1 (en) | 1999-05-04 | 2002-04-30 | American Home Products Corporation | Cyclic regimens using cyclocarbamate and cyclic amide derivatives |
US6444668B1 (en) | 1999-05-04 | 2002-09-03 | Wyeth | Combination regimens using progesterone receptor modulators |
US6423699B1 (en) | 1999-05-04 | 2002-07-23 | American Home Products Corporation | Combination therapies using benzimidazolones |
US6339098B1 (en) | 1999-05-04 | 2002-01-15 | American Home Products Corporation | 2,1-benzisothiazoline 2,2-dioxides |
US6407101B1 (en) | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
GB0000625D0 (en) | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
UA73119C2 (en) | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
GB0016162D0 (en) * | 2000-06-30 | 2000-08-23 | Cancer Res Campaign Tech | Indole-3-acetic acid derivatives |
AU7705601A (en) | 2000-07-25 | 2002-02-05 | Merck & Co Inc | N-substituted indoles useful in the treatment of diabetes |
IL154981A0 (en) * | 2000-10-10 | 2003-10-31 | Smithkline Beecham Corp | Substituted indoles, pharmaceutical compositions containing such indoles and their use as ppay-y-binding agents |
TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
WO2003000253A1 (en) | 2001-06-20 | 2003-01-03 | Wyeth | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
DE10147672A1 (en) * | 2001-09-27 | 2003-04-10 | Bayer Ag | Substituted 2,5-diamidoindoles and their use |
US7605156B2 (en) | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
US7713964B2 (en) | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
MXPA04007414A (en) | 2002-02-01 | 2004-10-11 | Hoffmann La Roche | Substituted indoles as alpha-1 agonists. |
US6716842B2 (en) | 2002-04-05 | 2004-04-06 | Warner-Lambert Company, Llc | Antidiabetic agents |
US7348351B2 (en) | 2002-12-10 | 2008-03-25 | Wyeth | Substituted 3-alkyl and 3-arylalkyl 1H-indol-1yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
WO2004052855A2 (en) | 2002-12-10 | 2004-06-24 | Wyeth | Substituted 3-carbonyl-1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
MXPA05006287A (en) | 2002-12-10 | 2005-09-08 | Wyeth Corp | Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1). |
ATE411288T1 (en) | 2002-12-10 | 2008-10-15 | Wyeth Corp | ARYL-, ARYLOXY- AND ALKYLOXY-SUBSTITUTED 1H-INDOLE-3-YL-GLYOXYLIC ACID DERIVATIVES INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) |
UA80453C2 (en) | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
US7163954B2 (en) | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
US7446201B2 (en) | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
US7534894B2 (en) | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
DE602005009209D1 (en) | 2004-06-18 | 2008-10-02 | Biolipox Ab | INDOORS SUITABLE FOR THE TREATMENT OF IGNITIONS |
CN101044127A (en) | 2004-08-23 | 2007-09-26 | 惠氏公司 | Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1 |
US7186749B2 (en) | 2004-08-23 | 2007-03-06 | Wyeth | Pyrrolo-naphthyl acids and methods for using them |
BRPI0514544A (en) | 2004-08-23 | 2008-06-17 | Wyeth Corp | oxazol-naphthyl acids as modulators of plasminogen activator inhibitor type-1 (pai-1) |
JP2008527029A (en) | 2005-01-19 | 2008-07-24 | バイオリポックス エービー | Indoles useful for the treatment of inflammation |
TW200718687A (en) | 2005-05-27 | 2007-05-16 | Wyeth Corp | Inhibitors of cytosolic phospholipase A2 |
JP2009504762A (en) | 2005-08-17 | 2009-02-05 | ワイス | Substituted indoles and methods for their use |
GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
KR20080114688A (en) | 2006-01-13 | 2008-12-31 | 와이어쓰 | Sulfonyl substituted 1h-indoles as ligands for the 5-hydroxytryptamine receptors |
MX2008015638A (en) * | 2006-06-09 | 2009-01-09 | Icos Corp | Substituted phenyl acetic acids as dp-2 antagonists. |
WO2008082488A1 (en) * | 2006-12-22 | 2008-07-10 | Schering Corporation | 4, 5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections |
EP2285803A4 (en) | 2008-05-23 | 2011-10-05 | Amira Pharmaceuticals Inc | 5-lipoxygenase-activating protein inhibitor |
CN102321074B (en) * | 2011-06-07 | 2013-04-10 | 山东轻工业学院 | Indole ring-substituted pyrazole hydrazide derivative and preparation method and application thereof |
PE20180573A1 (en) | 2015-07-20 | 2018-04-04 | Genzyme Corp | COLONY STIMULATING FACTOR RECEPTOR 1 (CSF-1R) INHIBITORS |
EP4267573A1 (en) | 2020-12-23 | 2023-11-01 | Genzyme Corporation | Deuterated colony stimulating factor-1 receptor (csf-1r) inhibitors |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0449196A2 (en) * | 1990-03-26 | 1991-10-02 | Takeda Chemical Industries, Ltd. | Indole derivatives, their production and use |
EP0460679A2 (en) * | 1990-06-07 | 1991-12-11 | Banyu Pharmaceutical Co., Ltd. | Endothelin antagonistic peptide derivatives |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3131527A1 (en) * | 1981-08-08 | 1983-02-24 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 1-PHENYL-2-AMINOCARBONYLINDOL COMPOUNDS AND METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
US5013732A (en) * | 1984-08-06 | 1991-05-07 | Sterling Drug Inc. | 3-arylcarbonyl- and 3-cycloalkyl-carbonyl-1-aminoalkyl-1H-indoles |
LU86346A1 (en) * | 1986-03-06 | 1987-11-11 | Oreal | TINCTORIAL COMPOSITIONS FOR KERATINIC FIBERS BASED ON INDOLE DERIVATIVES AND NOVEL COMPOUNDS |
-
1993
- 1993-12-20 ZA ZA939516A patent/ZA939516B/en unknown
- 1993-12-21 AU AU58735/94A patent/AU5873594A/en not_active Abandoned
- 1993-12-21 EP EP94904877A patent/EP0676959A4/en not_active Withdrawn
- 1993-12-21 WO PCT/US1993/012435 patent/WO1994014434A1/en not_active Application Discontinuation
- 1993-12-21 JP JP6515386A patent/JPH08504826A/en active Pending
- 1993-12-22 CN CN93119929A patent/CN1096513A/en active Pending
-
1994
- 1994-01-03 MX MX9400071A patent/MX9400071A/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0449196A2 (en) * | 1990-03-26 | 1991-10-02 | Takeda Chemical Industries, Ltd. | Indole derivatives, their production and use |
EP0460679A2 (en) * | 1990-06-07 | 1991-12-11 | Banyu Pharmaceutical Co., Ltd. | Endothelin antagonistic peptide derivatives |
Non-Patent Citations (1)
Title |
---|
See also references of WO9414434A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP0676959A1 (en) | 1995-10-18 |
MX9400071A (en) | 1994-07-29 |
CN1096513A (en) | 1994-12-21 |
WO1994014434A1 (en) | 1994-07-07 |
AU5873594A (en) | 1994-07-19 |
ZA939516B (en) | 1994-06-06 |
JPH08504826A (en) | 1996-05-28 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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17P | Request for examination filed |
Effective date: 19950622 |
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Kind code of ref document: A1 Designated state(s): BE CH DE FR GB IT LI NL |
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AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): BE CH DE FR GB IT LI NL |
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17Q | First examination report despatched |
Effective date: 19991007 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20011228 |