EP0684823A4 - Antagonistes des recepteurs de fibrinogene. - Google Patents

Antagonistes des recepteurs de fibrinogene.

Info

Publication number: EP0684823A4
Authority: EP; European Patent Office
Prior art keywords: receptor antagonists; fibrinogen receptor; fibrinogen; antagonists; receptor
Prior art date: 1993-02-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP94909745A

Other languages

German (de)

English (en)

Other versions

EP0684823A1 (fr

Inventor

David Alan Claremon

John J Baldwin

Nigel Liverton

Ben Askew

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-22

Filing date

1994-02-22

Publication date

1997-07-09

1994-02-22 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

1995-12-06 Publication of EP0684823A1 publication Critical patent/EP0684823A1/fr

1997-07-09 Publication of EP0684823A4 publication Critical patent/EP0684823A4/fr

Status Withdrawn legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- A61K38/166—Streptokinase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

EP94909745A 1993-02-22 1994-02-22 Antagonistes des recepteurs de fibrinogene. Withdrawn EP0684823A4 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US2051793A	1993-02-22	1993-02-22
PCT/US1994/001881 WO1994018981A1 (fr)	1993-02-22	1994-02-22	Antagonistes des recepteurs de fibrinogene
US20517		1996-06-28

Publications (2)

Publication Number	Publication Date
EP0684823A1 EP0684823A1 (fr)	1995-12-06
EP0684823A4 true EP0684823A4 (fr)	1997-07-09

Family

ID=21799049

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP94909745A Withdrawn EP0684823A4 (fr)	1993-02-22	1994-02-22	Antagonistes des recepteurs de fibrinogene.

Country Status (15)

Country	Link
EP (1)	EP0684823A4 (fr)
JP (1)	JP3173792B2 (fr)
KR (1)	KR960700722A (fr)
CN (1)	CN1118139A (fr)
AU (1)	AU680240B2 (fr)
BG (1)	BG99863A (fr)
CA (1)	CA2155123A1 (fr)
CZ (1)	CZ210895A3 (fr)
FI (1)	FI953916A (fr)
HU (1)	HUT71796A (fr)
NO (1)	NO953270L (fr)
NZ (1)	NZ262664A (fr)
PL (1)	PL310386A1 (fr)
SK (1)	SK102495A3 (fr)
WO (1)	WO1994018981A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5849736A (en) *	1993-11-24	1998-12-15	The Dupont Merck Pharmaceutical Company	Isoxazoline and isoxazole fibrinogen receptor antagonists
US5494921A (en) *	1994-09-16	1996-02-27	Merck & Co., Inc.	Fibrinogen receptor antagonists
ZA963391B (en) *	1995-05-24	1997-10-29	Du Pont Merck Pharma	Isoxazoline fibrinogen receptor antagonists.
US6100423A (en) *	1995-08-30	2000-08-08	G. D. Searle & Co.	Amino benzenepropanoic acid compounds and derivatives thereof
KR100481285B1 (ko) *	1995-08-30	2005-08-08	지.디. 썰 엘엘씨	인테그린길항제로서의메타-구아니딘,우레아,티오우레아또는아자고리아미노벤조산유도체
CA2233204A1 (fr)	1995-09-29	1997-04-03	Joseph A. Jakubowski	Composes spiro comme inhibiteurs de l'agregation de plaquettes dependante du fibrinogene
AU1345697A (en) *	1995-12-22	1997-07-17	Du Pont Merck Pharmaceutical Company, The	Novel integrin receptor antagonists
WO1997035579A1 (fr) *	1996-03-27	1997-10-02	Merck & Co., Inc.	Procede d'inhibition de la formation de caillots
PL190866B1 (pl) *	1996-07-25	2006-02-28	Biogen	Inhibitor adhezji komórek, sposób jego wytwarzania i jego zastosowanie oraz kompozycja farmaceutyczna i sposób jej wytwarzania
US5900414A (en) *	1996-08-29	1999-05-04	Merck & Co., Inc.	Methods for administering integrin receptor antagonists
DE19653647A1 (de) *	1996-12-20	1998-06-25	Hoechst Ag	Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
CA2279927A1 (fr) *	1997-02-06	1998-08-13	Merck & Co., Inc.	Promedicaments antagonistes de recepteur de fibrinogene
US6214834B1 (en)	1997-03-28	2001-04-10	Dupont Pharmaceuticals Company	Integrin inhibitor prodrugs
US6303625B1 (en) *	1998-07-27	2001-10-16	Ortho-Mcneil Pharmaceutical, Inc.	Triazolopyridines for the treatment of thrombosis disorders
PL354998A1 (en) *	1999-07-28	2004-03-22	Aventis Pharmaceuticals Products Inc.	Substituted oxoazaheterocyclyl compounds
BR0317525A (pt) *	2002-12-20	2005-11-16	Pharmacia Corp	Compostos pirazol acìclico, composição terapêutica e farmacêutica, kit, bem como respectivos usos
AU2007272009A1 (en) *	2006-07-12	2008-01-17	Syngenta Limited	Triazolopyridine derivatives as herbicides
US8088792B2 (en)	2008-04-04	2012-01-03	Gilead Sciences, Inc.	Triazolopyridinone derivatives for use as stearoyl CoA desaturase inhibitors
WO2010096722A1 (fr) *	2009-02-20	2010-08-26	Takeda Pharmaceutical Company Limited	3-oxo-2,3-dihydro-[1,2,4]triazolo[4, 3-a]pyridines utilisées comme inhibiteurs de l'époxyde hydrolase soluble (eh soluble)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0381033A1 (fr) *	1989-01-31	1990-08-08	F. Hoffmann-La Roche Ag	Amides d'acides carboxyliques et amides sulfoniques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8913011D0 (en) *	1989-06-06	1989-07-26	Wellcome Found	Anticonvulsant pyrazines
US5166154A (en) *	1989-10-17	1992-11-24	Boehringer Ingelheim Pharmaceuticals, Inc.	Imidazo[1,2-a]piperazines
US5278161A (en) *	1990-06-28	1994-01-11	Hoffmann-La Roche Inc.	Amino acid derivatives useful as renin inhibitors

1994
- 1994-02-22 AU AU62465/94A patent/AU680240B2/en not_active Ceased
- 1994-02-22 NZ NZ262664A patent/NZ262664A/en unknown
- 1994-02-22 HU HU9502028A patent/HUT71796A/hu unknown
- 1994-02-22 WO PCT/US1994/001881 patent/WO1994018981A1/fr not_active Application Discontinuation
- 1994-02-22 CZ CZ952108A patent/CZ210895A3/cs unknown
- 1994-02-22 PL PL94310386A patent/PL310386A1/xx unknown
- 1994-02-22 SK SK1024-95A patent/SK102495A3/sk unknown
- 1994-02-22 CA CA002155123A patent/CA2155123A1/fr not_active Abandoned
- 1994-02-22 EP EP94909745A patent/EP0684823A4/fr not_active Withdrawn
- 1994-02-22 JP JP51922094A patent/JP3173792B2/ja not_active Expired - Fee Related
- 1994-02-22 CN CN94191248A patent/CN1118139A/zh active Pending
1995
- 1995-08-15 BG BG99863A patent/BG99863A/xx unknown
- 1995-08-21 FI FI953916A patent/FI953916A/fi not_active Application Discontinuation
- 1995-08-21 NO NO953270A patent/NO953270L/no unknown
- 1995-08-21 KR KR1019950703563A patent/KR960700722A/ko not_active Application Discontinuation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0381033A1 (fr) *	1989-01-31	1990-08-08	F. Hoffmann-La Roche Ag	Amides d'acides carboxyliques et amides sulfoniques

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
B.C. ASKEW ET AL.: "Non-peptide glycoprotein IIb/IIIa inhibitors.", BIOORG. MED. CHEM. LETT., vol. 5, no. 5, 1995, pages 475 - 480, XP000670733 *
See also references of WO9418981A1 *

Also Published As

Publication number	Publication date
JP3173792B2 (ja)	2001-06-04
WO1994018981A1 (fr)	1994-09-01
HU9502028D0 (en)	1995-09-28
NO953270L (no)	1995-10-19
FI953916A0 (fi)	1995-08-21
SK102495A3 (en)	1997-01-08
NO953270D0 (no)	1995-08-21
HUT71796A (en)	1996-02-28
AU6246594A (en)	1994-09-14
PL310386A1 (en)	1995-12-11
KR960700722A (ko)	1996-02-24
FI953916A (fi)	1995-08-21
JPH08507072A (ja)	1996-07-30
CN1118139A (zh)	1996-03-06
EP0684823A1 (fr)	1995-12-06
NZ262664A (en)	1997-04-24
CZ210895A3 (en)	1996-02-14
CA2155123A1 (fr)	1994-09-01
AU680240B2 (en)	1997-07-24
BG99863A (en)	1996-02-29

Legal Events

Date	Code	Title	Description
1995-10-20	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1995-12-06	17P	Request for examination filed	Effective date: 19950922
1995-12-06	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
1997-07-09	A4	Supplementary search report drawn up and despatched	Effective date: 19970522
1997-07-09	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
1998-11-25	17Q	First examination report despatched	Effective date: 19981014
2001-06-19	GRAG	Despatch of communication of intention to grant	Free format text: ORIGINAL CODE: EPIDOS AGRA
2001-10-08	GRAG	Despatch of communication of intention to grant	Free format text: ORIGINAL CODE: EPIDOS AGRA
2001-10-08	GRAH	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOS IGRA
2002-06-28	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2002-08-14	18D	Application deemed to be withdrawn	Effective date: 20020122

Publication	Publication Date	Title
EP0673247A4 (fr)	1996-05-01	Antagonistes des recepteurs du fibrinogene.
EP0667773A4 (fr)	1996-09-25	Antagonistes des recepteurs du fibrinogene.
GB9405317D0 (en)	1994-04-27	Fibrinogen receptor antagonists
AU1441695A (en)	1995-07-10	Fibrinogen receptor antagonists
AU3665793A (en)	1993-09-13	Fibrinogen receptor antagonists
EP0912175A4 (fr)	1999-09-08	Antagonistes du recepteur de fibrinogene
EP0810994A4 (fr)	1998-05-06	Antagonistes des recepteurs de fibrinogene
EP0676959A4 (fr)	1996-01-03	Antagonistes des recepteurs de l'endotheline.
ZA948541B (en)	1995-05-02	Endothelin receptor antagonists
EP0866705A4 (fr)	1999-03-03	Antagonistes du recepteur de fibrinogene
EP0668075A3 (fr)	1996-10-16	Antagonistes de récepteurs tachykiniques de nature non-peptidiques.
AU8477891A (en)	1992-04-02	Fibrinogen receptor antagonists
PH31071A (en)	1998-02-05	Substituted pyrridopyrimidines useful antgiotensinII antagonists.
EP0885205A4 (fr)	2002-11-27	Antagonistes des recepteurs de fibrinogenes
EP0684823A4 (fr)	1997-07-09	Antagonistes des recepteurs de fibrinogene.
EP0885213A4 (fr)	1999-04-28	Antagonistes du recepteur du fibrinogene
SG49667A1 (en)	1998-06-15	Endothelin receptor antagonists
EP0796098A4 (fr)	1998-04-29	Antagonistes des recepteurs du fibrinogene
EP0801650A4 (fr)	1998-05-06	Antagonistes des recepteurs du fibrinogene
AU5322994A (en)	1994-05-09	Fibrinogen receptor antagonists
EP0794779A4 (fr)	1998-04-29	Antagonistes des recepteurs du fibrinogene
GB9320799D0 (en)	1993-12-01	Fibrinogen receptor antagonists
GB9515852D0 (en)	1995-10-04	Fibrinogen receptor antagonists
ZA963391B (en)	1997-10-29	Isoxazoline fibrinogen receptor antagonists.
EP0800395A4 (fr)	1998-04-29	Antagonistes des recepteurs du fibrinogene