EE200300547A - Laiaspektrilised 2-aminobensoksasoolsulfoonamiidid kui HIV proteaasi inhibiitorid, nende kasutamine, farmatseutiline kompositsioon ja meetod retroviiruse replikatsiooni inhibeerimiseks - Google Patents
Laiaspektrilised 2-aminobensoksasoolsulfoonamiidid kui HIV proteaasi inhibiitorid, nende kasutamine, farmatseutiline kompositsioon ja meetod retroviiruse replikatsiooni inhibeerimiseksInfo
- Publication number
- EE200300547A EE200300547A EEP200300547A EEP200300547A EE200300547A EE 200300547 A EE200300547 A EE 200300547A EE P200300547 A EEP200300547 A EE P200300547A EE P200300547 A EEP200300547 A EE P200300547A EE 200300547 A EE200300547 A EE 200300547A
- Authority
- EE
- Estonia
- Prior art keywords
- broad
- spectrum
- pharmaceutical composition
- protease inhibitors
- hiv protease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01201732 | 2001-05-11 | ||
PCT/EP2002/005212 WO2002092595A1 (en) | 2001-05-11 | 2002-05-10 | Broadspectrum 2-amino-benzoxazole sulfonamide hiv protease inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EE200300547A true EE200300547A (et) | 2004-02-16 |
EE05307B1 EE05307B1 (et) | 2010-06-15 |
Family
ID=8180286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200300547A EE05307B1 (et) | 2001-05-11 | 2002-05-10 | Laiaspektrilised 2-aminobensoksasoolsulfoonamiidid kui HIV proteaasi inhibiitorid, nende kasutamine, farmatseutiline kompositsioon ja meetod retroviiruse replikatsiooni inhibeerimiseks |
Country Status (32)
Country | Link |
---|---|
US (2) | US7622490B2 (et) |
EP (1) | EP1387842B1 (et) |
JP (1) | JP4467889B2 (et) |
KR (1) | KR100878853B1 (et) |
CN (1) | CN100549007C (et) |
AP (1) | AP1652A (et) |
AR (1) | AR035970A1 (et) |
AT (1) | ATE429431T1 (et) |
AU (1) | AU2002310818B2 (et) |
BG (1) | BG66350B1 (et) |
BR (1) | BR0209594A (et) |
CA (1) | CA2444895C (et) |
CY (1) | CY1109247T1 (et) |
CZ (1) | CZ304524B6 (et) |
DE (1) | DE60232067D1 (et) |
DK (1) | DK1387842T3 (et) |
EA (1) | EA009590B1 (et) |
EE (1) | EE05307B1 (et) |
ES (1) | ES2325809T3 (et) |
HK (1) | HK1062912A1 (et) |
HR (1) | HRP20031026B1 (et) |
HU (1) | HUP0400438A3 (et) |
IL (1) | IL158093A0 (et) |
MX (1) | MXPA03010258A (et) |
NO (1) | NO326883B1 (et) |
NZ (1) | NZ529250A (et) |
OA (1) | OA13134A (et) |
PL (1) | PL209029B1 (et) |
PT (1) | PT1387842E (et) |
SK (1) | SK287952B6 (et) |
WO (1) | WO2002092595A1 (et) |
ZA (1) | ZA200307799B (et) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5767429B2 (ja) | 1999-11-12 | 2015-08-19 | アッヴィ・インコーポレイテッド | 固体分散剤中の結晶化阻害剤 |
DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
WO2003064406A1 (en) | 2002-01-07 | 2003-08-07 | Sequoia Pharmaceuticals | Resistance-repellent retroviral protease inhibitors |
US7157489B2 (en) | 2002-03-12 | 2007-01-02 | The Board Of Trustees Of The University Of Illinois | HIV protease inhibitors |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
SI1670773T1 (sl) * | 2003-09-30 | 2007-06-30 | Tibotec Pharm Ltd | Postopki za pripravo benzoksazol sulfonamidnih spojin in njihovih intermediatov |
US8193227B2 (en) | 2003-12-11 | 2012-06-05 | Abbott Laboratories | HIV protease inhibiting compounds |
US20050131042A1 (en) * | 2003-12-11 | 2005-06-16 | Flentge Charles A. | HIV protease inhibiting compounds |
EP1725566B1 (en) | 2003-12-23 | 2009-06-17 | Tibotec Pharmaceuticals Ltd. | Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate |
ME01059B (me) | 2003-12-23 | 2012-10-20 | Janssen Sciences Ireland Uc | Proces za pripremanje (3r,3as,6ar)-heksahidrofuro [2,3-b] furan-3-il (1s,2r)-3-[[(4-aminofenil) sulfonil] (izobutil) amino]-1-benzil-2- hidroksipropilkarbamata |
US7378441B2 (en) * | 2004-05-07 | 2008-05-27 | Sequoia Pharmaceuticals, Inc. | Resistance-repellent retroviral protease inhibitors |
WO2006089942A1 (en) | 2005-02-25 | 2006-08-31 | Tibotec Pharmaceuticals Ltd. | Protease inhibitor precursor synthesis |
AR053845A1 (es) * | 2005-04-15 | 2007-05-23 | Tibotec Pharm Ltd | 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450 |
US20120220520A1 (en) * | 2006-10-17 | 2012-08-30 | Van T Klooster Gerben Albert Eleutherius | Bioavailable combinations for hcv treatment |
WO2014194519A1 (en) | 2013-06-07 | 2014-12-11 | Merck Sharp & Dohme Corp. | Imidazole derivatives and methods of use thereof for improving pharmacokinetics of drug |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8204879D0 (sv) | 1982-08-26 | 1982-08-26 | Haessle Ab | Novel chemical intermediates |
ATE141635T1 (de) | 1990-03-09 | 1996-09-15 | Milliken Res Corp | Organische materialien, die sulfonamidogebundene poly(oxyalkylen)gruppen tragen und ihre herstellung |
US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
JP4091653B2 (ja) * | 1992-08-25 | 2008-05-28 | ジー.ディー.サール、リミテッド、ライアビリティ、カンパニー | レトロウイルスプロテアーゼ阻害剤として有用なn−(アルカノイルアミノ−2−ヒドロキシプロピル)スルホンアミド |
PH30929A (en) | 1992-09-03 | 1997-12-23 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer. |
AU7669794A (en) * | 1993-08-24 | 1995-03-21 | G.D. Searle & Co. | Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors |
BR9407686A (pt) | 1993-10-01 | 1997-02-04 | Astra Ab | Processo e aparelho para o tratamento de um medicamento em pó finamente dividido uso do aparelho e aglomerados |
EP0804428B1 (en) | 1995-01-20 | 2007-12-26 | G.D. Searle LLC. | Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors |
US5756533A (en) * | 1995-03-10 | 1998-05-26 | G.D. Searle & Co. | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5705500A (en) * | 1995-03-10 | 1998-01-06 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6150556A (en) * | 1995-03-10 | 2000-11-21 | G. D. Dearle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
HUP9800518A3 (en) | 1995-03-10 | 1998-09-28 | G D Searle & Co Chicago | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5753660A (en) * | 1995-11-15 | 1998-05-19 | G. D. Searle & Co. | Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
NZ330739A (en) | 1996-05-20 | 1999-06-29 | Janssen Pharmaceutica Nv | Particulate solid dispersion of itraconazole and a water soluble polymer |
ATE241969T1 (de) | 1997-03-26 | 2003-06-15 | Janssen Pharmaceutica Nv | Tabletten mit einem kern, der mit einem pilzbekämpfungsmittel und einem polymeren beschichtet ist |
GB9717849D0 (en) | 1997-08-23 | 1997-10-29 | Seal Sands Chemicals Limited | Preparation of pyridene derivatives |
WO1999033793A2 (en) | 1997-12-24 | 1999-07-08 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
WO1999033792A2 (en) | 1997-12-24 | 1999-07-08 | Vertex Pharmaceuticals Incorporated | Prodrugs os aspartyl protease inhibitors |
WO1999033795A1 (en) | 1997-12-24 | 1999-07-08 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
PT2336134T (pt) | 1998-06-23 | 2016-10-19 | The Board Of Trustees Of The Univ Of Illionis | Ensaio de aptidão e métodos para reduzir a resistência do hiv à terapia |
AU4828199A (en) | 1998-06-23 | 2000-01-10 | Board Of Trustees Of The University Of Illinois, The | Multi-drug resistant retroviral protease inhibitors and associated methods |
PL367084A1 (en) * | 2001-04-09 | 2005-02-21 | Tibotec Pharmaceuticals Ltd. | Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors |
-
2002
- 2002-05-10 CN CNB028097416A patent/CN100549007C/zh not_active Expired - Fee Related
- 2002-05-10 NZ NZ529250A patent/NZ529250A/en not_active IP Right Cessation
- 2002-05-10 OA OA1200300277A patent/OA13134A/en unknown
- 2002-05-10 KR KR1020037013145A patent/KR100878853B1/ko not_active IP Right Cessation
- 2002-05-10 CZ CZ2003-3290A patent/CZ304524B6/cs not_active IP Right Cessation
- 2002-05-10 HU HU0400438A patent/HUP0400438A3/hu not_active IP Right Cessation
- 2002-05-10 AP APAP/P/2003/002904A patent/AP1652A/en active
- 2002-05-10 MX MXPA03010258A patent/MXPA03010258A/es active IP Right Grant
- 2002-05-10 IL IL15809302A patent/IL158093A0/xx not_active IP Right Cessation
- 2002-05-10 SK SK1490-2003A patent/SK287952B6/sk not_active IP Right Cessation
- 2002-05-10 JP JP2002589479A patent/JP4467889B2/ja not_active Expired - Fee Related
- 2002-05-10 ES ES02735354T patent/ES2325809T3/es not_active Expired - Lifetime
- 2002-05-10 WO PCT/EP2002/005212 patent/WO2002092595A1/en active IP Right Grant
- 2002-05-10 PL PL366780A patent/PL209029B1/pl unknown
- 2002-05-10 BR BR0209594-7A patent/BR0209594A/pt not_active IP Right Cessation
- 2002-05-10 EP EP02735354A patent/EP1387842B1/en not_active Expired - Lifetime
- 2002-05-10 DK DK02735354T patent/DK1387842T3/da active
- 2002-05-10 US US10/474,485 patent/US7622490B2/en not_active Expired - Fee Related
- 2002-05-10 EA EA200301234A patent/EA009590B1/ru not_active IP Right Cessation
- 2002-05-10 EE EEP200300547A patent/EE05307B1/et not_active IP Right Cessation
- 2002-05-10 PT PT02735354T patent/PT1387842E/pt unknown
- 2002-05-10 AR ARP020101722A patent/AR035970A1/es active IP Right Grant
- 2002-05-10 AU AU2002310818A patent/AU2002310818B2/en not_active Ceased
- 2002-05-10 AT AT02735354T patent/ATE429431T1/de active
- 2002-05-10 DE DE60232067T patent/DE60232067D1/de not_active Expired - Lifetime
- 2002-05-10 CA CA2444895A patent/CA2444895C/en not_active Expired - Fee Related
-
2003
- 2003-10-06 ZA ZA2003/07799A patent/ZA200307799B/en unknown
- 2003-11-03 BG BG108309A patent/BG66350B1/bg unknown
- 2003-11-10 NO NO20034988A patent/NO326883B1/no not_active IP Right Cessation
- 2003-12-10 HR HRP20031026AA patent/HRP20031026B1/xx not_active IP Right Cessation
-
2004
- 2004-08-04 HK HK04105776.5A patent/HK1062912A1/xx not_active IP Right Cessation
-
2009
- 2009-07-21 CY CY20091100774T patent/CY1109247T1/el unknown
- 2009-10-07 US US12/575,216 patent/US7863306B2/en not_active Expired - Fee Related
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Effective date: 20101231 |
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Effective date: 20160510 |